Disc1

Summary

Gene Symbol: Disc1
Description: disrupted in schizophrenia 1
Alias: disrupted in schizophrenia 1 homolog
Species: mouse
Products:     Disc1

Top Publications

  1. Kim J, Duan X, Liu C, Jang M, Guo J, Pow Anpongkul N, et al. DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron. 2009;63:761-73 pubmed publisher
    Disrupted-in-schizophrenia 1 (DISC1), a susceptibility gene for major mental illnesses, regulates multiple aspects of embryonic and adult neurogenesis...
  2. Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K, et al. Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci U S A. 2003;100:289-94 pubmed
    ..As schizophrenia is thought to reflect defects in cortical development that are determined by cytoskeletal protein activities, the cellular disturbances we observe with mutant DISC-1 may be relevant to psychopathologic mechanisms. ..
  3. Austin C, Ky B, Ma L, Morris J, Shughrue P. Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development. Neuroscience. 2004;124:3-10 pubmed
    b>DISC1 (Disrupted-In-Schizophrenia 1) has been associated with schizophrenia in multiple genetic studies...
  4. Ishizuka K, Kamiya A, Oh E, Kanki H, Seshadri S, Robinson J, et al. DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature. 2011;473:92-6 pubmed publisher
    ..Here we report that phosphorylation of DISC1, a major susceptibility factor for several mental disorders, acts as a molecular switch from maintaining ..
  5. Shen S, Lang B, Nakamoto C, Zhang F, Pu J, Kuan S, et al. Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. J Neurosci. 2008;28:10893-904 pubmed publisher
    Disrupted-in-Schizophrenia-1 (DISC1), identified by positional cloning of a balanced translocation (1;11) with the breakpoint in intron 8 of a large Scottish pedigree, is associated with a range of neuropsychiatric disorders including ..
  6. Kamiya A, Tan P, Kubo K, Engelhard C, Ishizuka K, Kubo A, et al. Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. Arch Gen Psychiatry. 2008;65:996-1006 pubmed publisher
    ..that pericentriolar material 1 protein (PCM1) forms a complex at the centrosome with disrupted-in-schizophrenia 1 (DISC1) and Bardet-Biedl syndrome 4 protein (BBS4), which provides a crucial pathway for cortical development associated ..
  7. Kvajo M, McKellar H, Arguello P, Drew L, Moore H, Macdermott A, et al. A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition. Proc Natl Acad Sci U S A. 2008;105:7076-81 pubmed publisher
    b>DISC1 is a strong candidate susceptibility gene for schizophrenia, bipolar disorder, and depression...
  8. Lipina T, Niwa M, Jaaro Peled H, Fletcher P, Seeman P, Sawa A, et al. Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia. Genes Brain Behav. 2010;9:777-89 pubmed publisher
    Significant advances have been made in understanding the role of disrupted-in-schizophrenia-1 (DISC1) in the brain and accumulating findings suggest the possible implication of DISC1 in the regulation of dopamine (DA) function...
  9. Marley A, von Zastrow M. DISC1 regulates primary cilia that display specific dopamine receptors. PLoS ONE. 2010;5:e10902 pubmed publisher
    Mutations in the DISC1 gene are strongly associated with major psychiatric syndromes such as schizophrenia. DISC1 encodes a cytoplasmic protein with many potential interaction partners, but its cellular functions remain poorly understood...

More Information

Publications77

  1. Singh K, Ge X, Mao Y, Drane L, Meletis K, Samuels B, et al. Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron. 2010;67:33-48 pubmed publisher
    The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development...
  2. Lee F, Fadel M, Preston Maher K, Cordes S, Clapcote S, Price D, et al. Disc1 point mutations in mice affect development of the cerebral cortex. J Neurosci. 2011;31:3197-206 pubmed publisher
    Disrupted-in-Schizophrenia 1 (DISC1) is a strong candidate gene for schizophrenia and other mental disorders...
  3. Chen S, Huang P, Cheng H. Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling. Proc Natl Acad Sci U S A. 2011;108:5861-6 pubmed publisher
    ..Although the schizophrenia susceptibility gene Disrupted-in-Schizophrenia 1 (DISC1) has been implicated in various neurodevelopmental processes, its role in regulating axonal connections remains ..
  4. Schurov I, Handford E, Brandon N, Whiting P. Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment. Mol Psychiatry. 2004;9:1100-10 pubmed
    Disrupted in Schizophrenia 1 (DISC1) was identified as a potential susceptibility gene for schizophrenia due to its disruption by a balanced t(1;11) (q42;q14) translocation, which has been shown to cosegregate with major psychiatric ..
  5. Jaaro Peled H, Niwa M, Foss C, Murai R, de Los Reyes S, Kamiya A, et al. Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging. Hum Mol Genet. 2013;22:1574-80 pubmed publisher
    ..tomography (PET), autoradiography, microdialysis and molecular biology in a putative dominant-negative mutant DISC1 transgenic model...
  6. Li W, Zhou Y, Jentsch J, Brown R, Tian X, Ehninger D, et al. Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci U S A. 2007;104:18280-5 pubmed
    Disrupted-in-schizophrenia 1 (DISC1) was initially discovered through a balanced translocation (1;11)(q42.1;q14...
  7. Kvajo M, McKellar H, Drew L, Lepagnol Bestel A, Xiao L, Levy R, et al. Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice. Proc Natl Acad Sci U S A. 2011;108:E1349-58 pubmed publisher
    ..Here, we study a mouse strain with a truncating lesion in the endogenous Disc1 ortholog designed to model the effects of a schizophrenia-predisposing mutation and offer a detailed account of ..
  8. Steinecke A, Gampe C, Valkova C, Kaether C, Bolz J. Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons. J Neurosci. 2012;32:738-45 pubmed publisher
    Disrupted-in-Schizophrenia 1 (DISC1) is a prominent susceptibility gene for major psychiatric disorders...
  9. Osbun N, Li J, O Driscoll M, Strominger Z, Wakahiro M, Rider E, et al. Genetic and functional analyses identify DISC1 as a novel callosal agenesis candidate gene. Am J Med Genet A. 2011;155A:1865-76 pubmed publisher
    ..We fine mapped this deletion and show that it includes Disrupted-in-Schizophrenia 1 (DISC1), a gene implicated in schizophrenia and other psychiatric disorders...
  10. Mao Y, Ge X, Frank C, Madison J, Koehler A, Doud M, et al. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell. 2009;136:1017-31 pubmed publisher
    The Disrupted in Schizophrenia 1 (DISC1) gene is disrupted by a balanced chromosomal translocation (1; 11) (q42; q14.3) in a Scottish family with a high incidence of major depression, schizophrenia, and bipolar disorder...
  11. Abazyan B, Nomura J, Kannan G, Ishizuka K, Tamashiro K, Nucifora F, et al. Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biol Psychiatry. 2010;68:1172-81 pubmed publisher
    ..Levels of inflammatory cytokines were measured in fetal and adult brains; expression of mhDISC1, endogenous DISC1, lissencephaly type 1, nuclear distribution protein nudE-like 1, glycoprotein 130, growth factor receptor-bound ..
  12. Wang Q, Charych E, Pulito V, Lee J, Graziane N, Crozier R, et al. The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Mol Psychiatry. 2011;16:1006-23 pubmed publisher
    Disrupted in schizophrenia 1 (DISC1), a genetic risk factor for multiple serious psychiatric diseases including schizophrenia, bipolar disorder and autism, is a key regulator of multiple neuronal functions linked to both normal ..
  13. Ramsey A, Milenkovic M, Oliveira A, Escobedo Lozoya Y, Seshadri S, Salahpour A, et al. Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. Proc Natl Acad Sci U S A. 2011;108:5795-800 pubmed publisher
    ..of this phenomenon reveal synapse-specific reductions in 14-3-3? protein and in Disrupted in Schizophrenia-1 (DISC1), two schizophrenia susceptibility factors that have been implicated in the regulation of spine density...
  14. Seshadri S, Kamiya A, Yokota Y, Prikulis I, Kano S, Hayashi Takagi A, et al. Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proc Natl Acad Sci U S A. 2010;107:5622-7 pubmed publisher
    Neuregulin-1 (NRG1) and Disrupted-in-Schizophrenia-1 (DISC1) are promising susceptibility factors for schizophrenia...
  15. Millar J, Mackie S, Clapcote S, Murdoch H, Pickard B, Christie S, et al. Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness. J Physiol. 2007;584:401-5 pubmed
    Disrupted in schizophrenia 1 (DISC1) is one of the most convincing genetic risk factors for major mental illness identified to date...
  16. Koike H, Arguello P, Kvajo M, Karayiorgou M, Gogos J. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A. 2006;103:3693-7 pubmed
    Disrupted-In-Schizophrenia (DISC1) is a leading candidate schizophrenia susceptibility gene...
  17. Ma T, Abazyan S, Abazyan B, Nomura J, Yang C, Seshadri S, et al. Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. Mol Psychiatry. 2013;18:557-67 pubmed publisher
    Perturbation of Disrupted-In-Schizophrenia-1 (DISC1) and D-serine/NMDA receptor hypofunction have both been implicated in the pathophysiology of schizophrenia and other psychiatric disorders...
  18. Singh K, De Rienzo G, Drane L, Mao Y, Flood Z, Madison J, et al. Common DISC1 polymorphisms disrupt Wnt/GSK3? signaling and brain development. Neuron. 2011;72:545-58 pubmed publisher
    Disrupted in Schizophrenia-1 (DISC1) is a candidate gene for psychiatric disorders and has many roles during brain development...
  19. Kuroda K, Yamada S, Tanaka M, Iizuka M, Yano H, Mori D, et al. Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet. 2011;20:4666-83 pubmed publisher
    Disrupted-In-Schizophrenia 1 (DISC1) is a promising candidate gene for susceptibility to psychiatric disorders, including schizophrenia...
  20. Clapcote S, Lipina T, Millar J, Mackie S, Christie S, Ogawa F, et al. Behavioral phenotypes of Disc1 missense mutations in mice. Neuron. 2007;54:387-402 pubmed
    To support the role of DISC1 in human psychiatric disorders, we identified and analyzed two independently derived ENU-induced mutations in Exon 2 of mouse Disc1...
  21. Kim J, Liu C, Zhang F, Duan X, Wen Z, Song J, et al. Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia. Cell. 2012;148:1051-64 pubmed publisher
    ..Here we show that regulation of dendritic development of newborn neurons by Disrupted-in-Schizophrenia 1 (DISC1) during adult hippocampal neurogenesis requires neurotransmitter GABA-induced, NKCC1-dependent depolarization ..
  22. Niwa M, Kamiya A, Murai R, Kubo K, Gruber A, Tomita K, et al. Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron. 2010;65:480-9 pubmed publisher
    ..susceptibility factors for adult psychiatric illnesses, such as Neuregulin-1 and Disrupted-in-Schizophrenia-1 (DISC1), influence adult high brain functions, including cognition and information processing...
  23. Shoji H, Toyama K, Takamiya Y, Wakana S, Gondo Y, Miyakawa T. Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice. BMC Res Notes. 2012;5:108 pubmed publisher
    Disrupted-in-Schizophrenia 1 (DISC1) is considered to be a candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder, and major depression...
  24. Johnson A, Jaaro Peled H, Shahani N, Sedlak T, Zoubovsky S, Burruss D, et al. Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness. Proc Natl Acad Sci U S A. 2013;110:12462-7 pubmed publisher
    ..illness using transgenic mice expressing a putative dominant-negative disrupted in schizophrenia 1 (DN-DISC1)...
  25. Lipina T, Kaidanovich Beilin O, Patel S, Wang M, Clapcote S, Liu F, et al. Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3. Synapse. 2011;65:234-48 pubmed publisher
    Recent studies have identified disrupted-in-schizophrenia-1 (DISC1) as a strong genetic risk factor associated with schizophrenia...
  26. Johnstone M, Thomson P, Hall J, McIntosh A, Lawrie S, Porteous D. DISC1 in schizophrenia: genetic mouse models and human genomic imaging. Schizophr Bull. 2011;37:14-20 pubmed publisher
    ..One exception is 'Disrupted in schizophrenia 1' (DISC1), a gene locus originally identified in a large Scottish family, showing a heavy burden of major mental illnesses ..
  27. Duan X, Chang J, Ge S, Faulkner R, Kim J, Kitabatake Y, et al. Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell. 2007;130:1146-58 pubmed
    ..Here, we investigated roles of Disrupted-In-Schizophrenia 1 (DISC1), a schizophrenia susceptibility gene, in adult hippocampal neurogenesis...
  28. Lipina T, Wang M, Liu F, Roder J. Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice. Neuropharmacology. 2012;62:1252-62 pubmed publisher
    Disrupted-In-Schizophrenia-1 (DISC1) is a strong genetic risk factor associated with psychiatric disorders...
  29. Meyer K, Morris J. Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus. Gene Expr Patterns. 2008;8:494-501 pubmed publisher
    In recent years, Disrupted-In-Schizophrenia 1 (DISC1) has emerged as one of the most promising candidate genes whose disruption confers an increased risk for schizophrenia...
  30. Wang S, Liang Q, Qiao H, Li H, Shen T, Ji F, et al. DISC1 regulates astrogenesis in the embryonic brain via modulation of RAS/MEK/ERK signaling through RASSF7. Development. 2016;143:2732-40 pubmed publisher
    Disrupted in schizophrenia 1 (DISC1) is known as a high susceptibility gene for schizophrenia. Recent studies have indicated that schizophrenia might be caused by glia defects and dysfunction...
  31. Xia M, Zhu S, Shevelkin A, Ross C, Pletnikov M. DISC1, astrocytes and neuronal maturation: a possible mechanistic link with implications for mental disorders. J Neurochem. 2016;138:518-24 pubmed publisher
    Disrupted-In-Schizophrenia 1 (DISC1) is a genetic risk factor implicated in major mental disorders that involve disrupted neurodevelopment and synaptic signaling...
  32. Tropea D, Molinos I, Petit E, Bellini S, Nagakura I, O Tuathaigh C, et al. Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro. Transl Psychiatry. 2016;6:e712 pubmed publisher
    ..The gene disrupted in schizophrenia 1 (DISC1) has been associated with increased risk for neuropsychiatric conditions...
  33. Dachtler J, Elliott C, Rodgers R, Baillie G, Clapcote S. Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice. Sci Rep. 2016;6:18748 pubmed publisher
    Disrupted-in-Schizophrenia 1 (DISC1) is a risk factor for schizophrenia and affective disorders...
  34. Clapcote S, Roder J. Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics. 2006;173:2407-10 pubmed
    We report that the Disc1 gene in all extant 129 mouse inbred substrains has a deletion, previously considered specific to the 129S6/SvEv substrain, which is predicted to abolish production of the full-length protein...
  35. Brandon N, Schurov I, Camargo L, Handford E, Duran Jimeniz B, Hunt P, et al. Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site. Mol Cell Neurosci. 2005;28:613-24 pubmed
    Disrupted in schizophrenia 1 (DISC1) has been identified as a putative risk factor for schizophrenia and affective disorders through study of a Scottish family with a balanced (1;11) (q42.1;q14...
  36. Lipina T, Zai C, Hlousek D, Roder J, Wong A. Maternal immune activation during gestation interacts with Disc1 point mutation to exacerbate schizophrenia-related behaviors in mice. J Neurosci. 2013;33:7654-66 pubmed publisher
    Schizophrenia is thought to result from interactions between susceptible genotypes and environmental risk factors. DISC1 is an important gene for schizophrenia and mood disorders based on both human and animal studies...
  37. Dawson N, Kurihara M, Thomson D, Winchester C, McVie A, Hedde J, et al. Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1. Transl Psychiatry. 2015;5:e569 pubmed publisher
    Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric diseases...
  38. Taylor M, Devon R, Millar J, Porteous D. Evolutionary constraints on the Disrupted in Schizophrenia locus. Genomics. 2003;81:67-77 pubmed
    ..The order and orientation of EGLN1, TSNAX, and DISC1 genes are conserved between mammals and F. rubripes...
  39. Park C, Lee S, Hong J, Suh Y, Park S, Suh B, et al. Disrupted-in-schizophrenia 1 (DISC1) and Syntaphilin collaborate to modulate axonal mitochondrial anchoring. Mol Brain. 2016;9:69 pubmed publisher
    ..we found that neuronal activation-induced mitochondrial anchoring is regulated by Disrupted-in-schizophrenia 1 (DISC1), which is accomplished by functional association with Syntaphilin (SNPH)...
  40. Gómez Sintes R, Kvajo M, Gogos J, Lucas J. Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders. Front Behav Neurosci. 2014;8:253 pubmed publisher
    Disrupted in schizophrenia-1 (DISC1) gene is associated with several neuropsychiatric disorders as it is disrupted by a balanced translocation involving chromosomes 1 and 11 in a large Scottish pedigree with high prevalence of ..
  41. Liu J, Liu Q, Khoury J, Li Y, Han X, Li J, et al. Hypoxic preconditioning decreases nuclear factor κB activity via Disrupted in Schizophrenia-1. Int J Biochem Cell Biol. 2016;70:140-8 pubmed publisher
    ..Taken together, these results demonstrate that hypoxic pre-conditioning decreases the activation of nuclear factor κB through the transcriptional induction of Disrupted in Schizophrenia-1. ..
  42. Fukuda T, Sugita S, Inatome R, Yanagi S. CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. J Biol Chem. 2010;285:40554-61 pubmed publisher
    ..This study has identified a novel disrupted in schizophrenia 1 (DISC1)-interacting protein, named CAMDI after coiled-coil protein associated with myosin II and DISC1, which ..
  43. Brown S, Clapcote S, Millar J, Torrance H, Anderson S, Walker R, et al. Synaptic modulators Nrxn1 and Nrxn3 are disregulated in a Disc1 mouse model of schizophrenia. Mol Psychiatry. 2011;16:585-7 pubmed publisher
  44. Ren J, Zhao T, Xu Y, Ye H. Interaction between DISC1 and CHL1 in regulation of neurite outgrowth. Brain Res. 2016;1648:290-297 pubmed publisher
    Disrupted-in-schizophrenia 1 (DISC1), a gene susceptible for major mental illnesses, including schizophrenia, plays multiple roles in neural development, including neuronal proliferation, maturation, migration and neurite outgrowth...
  45. Wu Q, Li Y, Shu Y, Feng L, Zhou L, Yue Z, et al. NDEL1 was decreased in the CA3 region but increased in the hippocampal blood vessel network during the spontaneous seizure period after pilocarpine-induced status epilepticus. Neuroscience. 2014;268:276-83 pubmed publisher
    ..migration, and microtubule organization during brain development by binding to disrupted-in-schizophrenia-1 (DISC1) or lissencephaly (LIS1)...
  46. Lee F, Zai C, Cordes S, Roder J, Wong A. Abnormal interneuron development in disrupted-in-schizophrenia-1 L100P mutant mice. Mol Brain. 2013;6:20 pubmed publisher
    ..Disrupted-in-Schizophrenia 1 (DISC1), a strong susceptibility gene for schizophrenia and other mental illnesses, is involved in neurodevelopment, ..
  47. Shahani N, Seshadri S, Jaaro Peled H, Ishizuka K, Hirota Tsuyada Y, Wang Q, et al. DISC1 regulates trafficking and processing of APP and Aβ generation. Mol Psychiatry. 2015;20:874-9 pubmed publisher
    We report the novel regulation of proteolytic processing of amyloid precursor protein (APP) by DISC1, a major risk factor for psychiatric illnesses, such as depression and schizophrenia...
  48. Arime Y, Fukumura R, Miura I, Mekada K, Yoshiki A, Wakana S, et al. Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice. Behav Brain Funct. 2014;10:45 pubmed publisher
    Disrupted-in-schizophrenia 1 (DISC1) is a promising candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder and major depression...
  49. Okamoto M, Iguchi T, Hattori T, Matsuzaki S, Koyama Y, Taniguchi M, et al. DBZ regulates cortical cell positioning and neurite development by sustaining the anterograde transport of Lis1 and DISC1 through control of Ndel1 dual-phosphorylation. J Neurosci. 2015;35:2942-58 pubmed publisher
    ..Cell positioning and neuronal network formation are crucial for proper brain function. Disrupted-in-Schizophrenia 1 (DISC1) is anterogradely transported to the neurite tips, together with Lis1, and functions in neurite extension via ..
  50. Chen C, Liu H, Hsueh Y. TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology. EMBO Rep. 2017;18:169-183 pubmed publisher
    ..myeloid differentiation primary response gene 88 (MYD88) to negatively control Disrupted in schizophrenia 1 (Disc1) expression, resulting in impairment of neuronal development...
  51. Park Y, Jeong J, Lee H, Mun J, Kim J, Lee J, et al. Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. Proc Natl Acad Sci U S A. 2010;107:17785-90 pubmed publisher
    Disrupted-in-schizophrenia 1 (DISC1) has emerged as a schizophrenia-susceptibility gene affecting various neuronal functions...
  52. Park S, Jeong J, Park Y, Park K, Lee H, Lee N, et al. Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics. Sci Rep. 2015;5:8694 pubmed publisher
    Disrupted-in-schizophrenia-1 (DISC1) has emerged as a convincing susceptibility gene for multiple mental disorders, but its mechanistic link to the pathogenesis of schizophrenia related psychiatric conditions is yet to be further ..
  53. O Tuathaigh C, Fumagalli F, Desbonnet L, Perez Branguli F, Moloney G, Loftus S, et al. Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1. Schizophr Bull. 2017;43:214-225 pubmed publisher
    ..whether simultaneous disruption of the risk factors Neuregulin-1 (NRG1) and Disrupted-in-schizophrenia 1 (DISC1) would produce a disease-relevant phenotypic profile different from that observed following disruption to either ..
  54. Goudarzi S, Smith L, Schütz S, Hafizi S. Interaction of DISC1 with the PTB domain of Tensin2. Cell Mol Life Sci. 2013;70:1663-72 pubmed publisher
    The gene for Disrupted-in-Schizophrenia 1 (DISC1) is amongst the most significant risk genes for schizophrenia...
  55. Soda T, Frank C, Ishizuka K, Baccarella A, Park Y, Flood Z, et al. DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1. Mol Psychiatry. 2013;18:898-908 pubmed publisher
    Disrupted-In-Schizophrenia 1 (DISC1), a risk factor for major mental illnesses, has been studied extensively in the context of neurodevelopment...
  56. Shevelkin A, Terrillion C, Abazyan B, Kajstura T, Jouroukhin Y, Rudow G, et al. Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice. Neurobiol Dis. 2017;103:144-153 pubmed publisher
    ..As PCs express the gene Disrupted-In-Schizophrenia-1 (DISC1), and DISC1 variants have been associated with neurodevelopmental disorders, we evaluated the role of DISC1 in ..
  57. Owczarek S, Bang M, Berezin V. Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 "Signalosome". Neural Plast. 2015;2015:167308 pubmed publisher
    ..Expression of the NX1 and NX3 genes in the brain appears to be regulated by a schizophrenia-related protein, DISC1. Here, we show that soluble ecto-NX1β can regulate the expression of DISC1 and induce signaling downstream of ..
  58. Lee S, Kim S, Suh B, Sun H, Park Y, Hong J, et al. Disrupted-in-schizophrenia 1 (DISC1) regulates dysbindin function by enhancing its stability. J Biol Chem. 2015;290:7087-96 pubmed publisher
    Dysbindin and DISC1 are schizophrenia susceptibility factors playing roles in neuronal development...
  59. Chandran J, Kazanis I, Clapcote S, Ogawa F, Millar J, Porteous D, et al. Disc1 variation leads to specific alterations in adult neurogenesis. PLoS ONE. 2014;9:e108088 pubmed publisher
    Disrupted in schizophrenia 1 (DISC1) is a risk factor for a spectrum of neuropsychiatric illnesses including schizophrenia, bipolar disorder, and major depressive disorder...
  60. Lee F, Kaidanovich Beilin O, Roder J, Woodgett J, Wong A. Genetic inactivation of GSK3? rescues spine deficits in Disc1-L100P mutant mice. Schizophr Res. 2011;129:74-9 pubmed publisher
    Disrupted-in-Schizophrenia 1 (DISC1), a strong candidate gene for schizophrenia and other mental disorders, regulates neurodevelopmental processes including neurogenesis, neuronal migration, neurite outgrowth and spine development...
  61. Hayashi Y, Sawa A, Hikida T. Impaired hippocampal activity at the goal zone on the place preference task in a DISC1 mouse model. Neurosci Res. 2016;106:70-3 pubmed publisher
    ..We showed that transgenic mice expressing a dominant-negative form of DISC1, a risk gene for neuropsychiatric disorders, exhibited impaired performance in a reward-place association task ..
  62. Lipina T, Haque F, McGirr A, Boutros P, Berger T, Mak T, et al. Prophylactic valproic acid treatment prevents schizophrenia-related behaviour in Disc1-L100P mutant mice. PLoS ONE. 2012;7:e51562 pubmed publisher
    Schizophrenia is a neurodevelopmental disorder with onset early in adulthood. Disrupted-In-Schizophrenia-1 (DISC1) is a susceptibility gene for schizophrenia and other psychiatric disorders...
  63. Hartung H, Cichon N, De Feo V, Riemann S, Schildt S, Lindemann C, et al. From Shortage to Surge: A Developmental Switch in Hippocampal-Prefrontal Coupling in a Gene-Environment Model of Neuropsychiatric Disorders. Cereb Cortex. 2016;26:4265-4281 pubmed publisher
  64. Walsh J, Tighe O, Lai D, Harvey R, Karayiorgou M, Gogos J, et al. Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1. Brain Res. 2010;1348:114-9 pubmed publisher
    ..schizophrenia, including neuregulin-1 (NRG1), catechol-O-methyltranferase (COMT) and disrupted-in-schizophrenia-1 (DISC1), may play a role in modulating the physiological and psychological effects of pain stimuli in such patients...
  65. Lipina T, Roder J. Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: impact of mouse models. Neurosci Biobehav Rev. 2014;45:271-94 pubmed publisher
    Disrupted-In-Schizophrenia-1 (DISC1) has captured much attention because it predisposes individuals to a wide range of mental illnesses...
  66. Booth C, Brown J, Randall A. Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1. Eur J Neurosci. 2014;39:1074-90 pubmed publisher
    A t(1;11) balanced chromosomal translocation transects the Disc1 gene in a large Scottish family and produces genome-wide linkage to schizophrenia and recurrent major depressive disorder...
  67. Zhou M, Li W, Huang S, Song J, Kim J, Tian X, et al. mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons. Neuron. 2013;77:647-54 pubmed publisher
    ..As previously reported, we show that Disc1 knockdown specifically in adult-born dentate gyrus (DG) neurons results in increased mTOR signaling, ..
  68. Mühlhans J, Brandstätter J, Giessl A. The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors. PLoS ONE. 2011;6:e26496 pubmed publisher
    ..Recent studies indicate that Pcnt mutations are associated with a range of diseases including primordial dwarfism and ciliopathies. To date, three Pcnt splice variants from orthologous genes in mice and humans are known...