Dicer1

Summary

Gene Symbol: Dicer1
Description: dicer 1, ribonuclease type III
Alias: 1110006F08Rik, D12Ertd7e, mKIAA0928, Dicer1, Dcr-1 homolog, double-strand-specific ribonuclease mDCR-1, endoribonuclease Dicer
Species: mouse

Top Publications

  1. ncbi Dicer is essential for mouse development
    Emily Bernstein
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Genet 35:215-7. 2003
  2. pmc Characterization of the short RNAs bound by the P19 suppressor of RNA silencing in mouse embryonic stem cells
    J Mauro Calabrese
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02144, USA
    RNA 12:2092-102. 2006
  3. doi Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage
    Sergei B Koralov
    Immune Disease Institute and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Cell 132:860-74. 2008
  4. pmc Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes
    Oliver H Tam
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 453:534-8. 2008
  5. pmc Dicer is required for female reproductive tract development and fertility in the mouse
    Gabriel Gonzalez
    Department of Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Reprod Dev 76:678-88. 2009
  6. pmc miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex
    Davide De Pietri Tonelli
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 135:3911-21. 2008
  7. doi Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration
    Sébastien S Hébert
    Centre de Recherche du CHUQ CHUL, Axe Neurosciences, Quebec, Canada
    Hum Mol Genet 19:3959-69. 2010
  8. pmc Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus
    Tigwa H Davis
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 28:4322-30. 2008
  9. pmc Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis
    Jr Shiuan Yang
    Department of Developmental Biology, Sloan Kettering Institute, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:15163-8. 2010
  10. pmc A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing
    Joshua E Babiarz
    The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143, USA
    RNA 17:1489-501. 2011

Research Grants

Scientific Experts

Detail Information

Publications115 found, 100 shown here

  1. ncbi Dicer is essential for mouse development
    Emily Bernstein
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Genet 35:215-7. 2003
    To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells...
  2. pmc Characterization of the short RNAs bound by the P19 suppressor of RNA silencing in mouse embryonic stem cells
    J Mauro Calabrese
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02144, USA
    RNA 12:2092-102. 2006
    ..Our results support the previous observation that endogenous siRNAs are not abundant molecules in mouse ES cells...
  3. doi Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage
    Sergei B Koralov
    Immune Disease Institute and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Cell 132:860-74. 2008
    ....
  4. pmc Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes
    Oliver H Tam
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 453:534-8. 2008
    ..Our findings indicate a function for pseudogenes in regulating gene expression by means of the RNA interference pathway and may, in part, explain the evolutionary pressure to conserve argonaute-mediated catalysis in mammals...
  5. pmc Dicer is required for female reproductive tract development and fertility in the mouse
    Gabriel Gonzalez
    Department of Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Reprod Dev 76:678-88. 2009
    ....
  6. pmc miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex
    Davide De Pietri Tonelli
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 135:3911-21. 2008
    ..5. Our results support the emerging concept that progenitors are less dependent on miRNAs than their differentiated progeny, and raise interesting perspectives as to the expansion of somatic stem cells...
  7. doi Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration
    Sébastien S Hébert
    Centre de Recherche du CHUQ CHUL, Axe Neurosciences, Quebec, Canada
    Hum Mol Genet 19:3959-69. 2010
    ..In summary, these results support the hypothesis that changes in the miRNA network may contribute to a neurodegenerative phenotype by affecting tau phosphorylation...
  8. pmc Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus
    Tigwa H Davis
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 28:4322-30. 2008
    ....
  9. pmc Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis
    Jr Shiuan Yang
    Department of Developmental Biology, Sloan Kettering Institute, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:15163-8. 2010
    ..Beyond the demonstration of an alternative strategy to direct gene silencing, these observations open the way for transgenic rescue of Dicer conditional knockouts...
  10. pmc A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing
    Joshua E Babiarz
    The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143, USA
    RNA 17:1489-501. 2011
    ..endo-siRNAs) are distinct subclasses of small RNAs that bypass the DGCR8/DROSHA Microprocessor but still require DICER1 for their biogenesis. What role, if any, they have in mammals remains unknown...
  11. pmc Dicer1 functions as a haploinsufficient tumor suppressor
    Madhu S Kumar
    Massachusetts Institute of Technology Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts 02139, USA
    Genes Dev 23:2700-4. 2009
    ..To explore this question, we analyzed the consequences of conditional Dicer1 mutation (Dicer1 "floxed" or Dicer1(fl)) on several mouse models of cancer...
  12. pmc Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing
    Chryssa Kanellopoulou
    The Dana Farber Cancer Institute, Department of Cancer Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:489-501. 2005
    ..Our data suggest that Dicer participates in multiple, fundamental biological processes in a mammalian organism, ranging from stem cell differentiation to the maintenance of centromeric heterochromatin structure and centromeric silencing...
  13. pmc Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure
    Jian Fu Chen
    Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 105:2111-6. 2008
    ..Together, our studies demonstrate essential roles for Dicer in cardiac contraction and indicate that miRNAs play critical roles in normal cardiac function and under pathological conditions...
  14. pmc Aberrant T cell differentiation in the absence of Dicer
    Stefan A Muljo
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 202:261-9. 2005
    ..Independent of their proliferation defect, Dicer-deficient helper T cells preferentially expressed interferon-gamma, the hallmark effector cytokine of the Th1 lineage...
  15. pmc Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina
    Devid Damiani
    Neuroscience Institute, Italian National Research Council, 56100 Pisa, Italy
    J Neurosci 28:4878-87. 2008
    ..The observation that progressive retinal degeneration occurred after removal of Dicer raises the possibility that miRNAs are involved in retinal neurodegenerative disorders...
  16. doi Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
    Toshiaki Watanabe
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
    Nature 453:539-43. 2008
    ..Our results reveal a role for endogenous siRNAs in mammalian oocytes and show that organisms lacking RdRP activity can produce functional endogenous siRNAs from naturally occurring dsRNAs...
  17. pmc T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer
    Bradley S Cobb
    Lymphocyte Development Group, Medical Research Council Clinical Sciences Centre, Imperial College London, London W12 0NN, England, UK
    J Exp Med 201:1367-73. 2005
    ..Thus, although Dicer seems to be critical for the development of the early embryo, it may have limited impact on the implementation of some lineage-specific gene expression programs...
  18. pmc Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration
    Trinna L Cuellar
    Department of Microbiology and Immunology, Diabetes Center, Biomedical Sciences Graduate Program, and Departments of Ophthalmology and Physiology, University of California, San Francisco, CA 94122 0534, USA
    Proc Natl Acad Sci U S A 105:5614-9. 2008
    ..These studies highlight the complicated nature of Dicer ablation in the brain and provide a useful mouse model for studying dopaminoceptive neuron function...
  19. pmc MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord
    Kang Zheng
    College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China
    J Neurosci 30:8245-50. 2010
    ..By contrast, the early patterning and development of motor neurons were not affected in the mutant spinal cord tissue...
  20. pmc miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors
    Tal Melkman-Zehavi
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 30:835-45. 2011
    ..While islet architecture is intact and differentiation markers are maintained, Dicer1-deficient β-cells show a dramatic decrease in insulin content and insulin mRNA...
  21. pmc Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice
    Garrett A Soukup
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Dev Biol 328:328-41. 2009
    ..The correlation of differential and delayed depletion of mature miRNAs with the derailment of inner ear development demonstrates that miRNAs are crucial for inner ear neurosensory development and neurosensory-dependent morphogenesis...
  22. pmc The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease
    Mark M W Chong
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 205:2005-17. 2008
    ..Thus, miRNA-dependent regulation is critical for preventing spontaneous inflammation and autoimmunity...
  23. pmc Analysis of microRNA turnover in mammalian cells following Dicer1 ablation
    Michael P Gantier
    Centre for Cancer Research, Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
    Nucleic Acids Res 39:5692-703. 2011
    ..Accordingly, we measured miRNA decay rates in mouse embryonic fibroblasts following loss of Dicer1 enzymatic activity...
  24. pmc Characterization of Dicer-deficient murine embryonic stem cells
    Elizabeth P Murchison
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 102:12135-40. 2005
    ..These studies provide a conditional model of RNAi deficiency in mammals that will permit the dissection of the biological roles of the RNAi machinery in cultured mammalian cells...
  25. pmc Dicer function is essential for lung epithelium morphogenesis
    Kelley S Harris
    Laboratory of Genetics, University of Wisconsin, 425 G Henry Mall, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 103:2208-13. 2006
    ..The aberrant Fgf10 expression may contribute to the Dicer morphological defects. However, the mechanism by which DICER functions in the epithelium to influence Fgf10 expression in the mesenchyme remains unknown...
  26. pmc DGCR8-dependent microRNA biogenesis is essential for skin development
    Rui Yi
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, and Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:498-502. 2009
    ..Our results underscore a specific importance of microRNAs in controlling mammalian skin development...
  27. pmc Critical roles for Dicer in the female germline
    Elizabeth P Murchison
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA
    Genes Dev 21:682-93. 2007
    ..Our studies identify Dicer as central to a regulatory network that controls oocyte gene expression programs and that promotes genomic integrity in a cell type notoriously susceptible to aneuploidy...
  28. pmc RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells
    Yoko Kawase-Koga
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    J Cell Sci 123:586-94. 2010
    ..Our results demonstrate important functions for Dicer in regulating NSC development by maintaining proper signaling pathways related to cell survival and differentiation...
  29. pmc Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system
    Yoko Kawase-Koga
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Dev Dyn 238:2800-12. 2009
    ..Our studies of different timings of Dicer deletion demonstrate the importance of the Dicer-mediated microRNA pathway in regulating distinct phases of neurogenesis and gliogenesis during the CNS development...
  30. pmc The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 102:10898-903. 2005
    ..Thus, Dicer is required for the formation of normal mouse limbs. Strikingly, however, we did not detect defects in basic patterning or in tissue-specific differentiation of Dicer-deficient limb buds...
  31. pmc Dicer is required for the transition from early to late progenitor state in the developing mouse retina
    Sean A Georgi
    Neurobiology and Behavior Program, Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 30:4048-61. 2010
    ..We conclude that Dicer is necessary for the developmental change in competence of the retinal progenitor cells...
  32. pmc MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function
    Sebastian Albinsson
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Arterioscler Thromb Vasc Biol 30:1118-26. 2010
    ..Here, we investigated the role of miRNAs in VSM by deleting the rate-limiting enzyme in miRNA synthesis, Dicer...
  33. pmc Sertoli cell Dicer is essential for spermatogenesis in mice
    Marilena D Papaioannou
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
    Dev Biol 326:250-9. 2009
    ..Overall, our results reveal novel essential roles played by the Dicer-dependent pathway in mammalian reproductive function, and thus pave the way for new insights into human infertility...
  34. ncbi Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression
    Motoyuki Otsuka
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunity 27:123-34. 2007
    ..We show that because of impaired miRNA production, mice with a variant Dicer1 allele (Dicer1(d/d)) were more susceptible to vesicular stomatitis virus (VSV) infection...
  35. pmc A role for Dicer in immune regulation
    Bradley S Cobb
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, England, UK
    J Exp Med 203:2519-27. 2006
    ..These results suggest that T reg cell development involves Dicer-generated RNAs...
  36. ncbi Impaired microRNA processing enhances cellular transformation and tumorigenesis
    Madhu S Kumar
    MIT Center for Cancer Research, Cambridge, Massachusetts 02139, USA
    Nat Genet 39:673-7. 2007
    ..Furthermore, conditional deletion of Dicer1 enhanced tumor development in a K-Ras-induced mouse model of lung cancer...
  37. pmc DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
    Hiroki Kaneko
    Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
    Nature 471:325-30. 2011
    ..Here we show that the microRNA (miRNA)-processing enzyme DICER1 is reduced in the RPE of humans with GA, and that conditional ablation of Dicer1, but not seven other miRNA-..
  38. pmc Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse
    Tripti Gaur
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Dev Biol 340:10-21. 2010
    ..We propose that Dicer generated miRs are essential for two periods of bone formation, to promote osteoblast differentiation before birth, and control bone accrual in the adult...
  39. pmc MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression
    Zichao Zhang
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 285:34718-28. 2010
    ..the role of microRNAs (miRNAs) in pituitary development, a group of pituitary-specific miRNAs were identified, and Dicer1 was then conditionally knocked out using the Pitx2-Cre mouse, resulting in the loss of mature miRNAs in the ..
  40. pmc Tie2cre-induced inactivation of the miRNA-processing enzyme Dicer disrupts invariant NKT cell development
    Li Zhou
    Henry Ford Immunology Program, and Department of Dermatology, Henry Ford Hospital, Detroit, MI 48202, USA
    Proc Natl Acad Sci U S A 106:10266-71. 2009
    ..Our data indicate that miRNAs expressed in hematopoietic cells and endothelial cells are potent regulators of iNKT cell development, function, and homeostasis...
  41. pmc Canonical and alternate functions of the microRNA biogenesis machinery
    Mark M W Chong
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 24:1951-60. 2010
    ..Together, these findings extend the range of function of RNaseIII enzymes beyond canonical miRNA biogenesis, and help explain the nonoverlapping phenotypes caused by Drosha and Dicer deficiency...
  42. pmc Dicer is required for survival of differentiating neural crest cells
    Ahmet Zehir
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Dev Biol 340:459-67. 2010
    ..Our results show that Dicer and miRNAs, are required for survival of NC-derived tissues by preventing apoptosis during differentiation...
  43. pmc Cerebellar neurodegeneration in the absence of microRNAs
    Anne Schaefer
    Laboratory of Molecular and Cellular Neuroscience and 2Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 204:1553-8. 2007
    ..The progressive neurodegeneration in the absence of Dicer raises the possibility of an involvement of miRNAs in neurodegenerative disorders...
  44. pmc Male germ cells express abundant endogenous siRNAs
    Rui Song
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 108:13159-64. 2011
    ..Overall, our work has unveiled another hidden layer of regulation imposed by small noncoding RNAs during male germ cell development...
  45. doi Dicer1 is required for differentiation of the mouse male germline
    Danielle M Maatouk
    Department of Microbiology and Immunology, University of California San Francisco Diabetes Center, San Francisco, California 94143, USA
    Biol Reprod 79:696-703. 2008
    ..The enzyme Dicer1 is required for miRNA processing, and mouse knockouts of Dicer1 are embryonic lethal before 7.5 days postcoitus...
  46. pmc Essential role for Dicer during skeletal muscle development
    Jason R O'Rourke
    Department of Molecular Genetics and Microbiology and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL 32610 0266, USA
    Dev Biol 311:359-68. 2007
    ..These observations demonstrate key roles for Dicer in skeletal muscle and implicate miRNAs as critical components required for embryonic myogenesis...
  47. pmc MicroRNAs are essential for development and function of inner ear hair cells in vertebrates
    Lilach M Friedman
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Proc Natl Acad Sci U S A 106:7915-20. 2009
    ..A conditional knock-out mouse for Dicer1 demonstrated that miRNAs are crucial for postnatal survival of functional hair cells of the inner ear...
  48. doi Dicer activity in neural crest cells is essential for craniofacial organogenesis and pharyngeal arch artery morphogenesis
    Xuguang Nie
    Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mech Dev 128:200-7. 2011
    ..Taken together, our results show that Dicer activity in NCCs is essential for craniofacial development and pharyngeal arch artery morphogenesis...
  49. doi miRNAs control tracheal chondrocyte differentiation
    Ben Gradus
    Department of Molecular Genetics, Weizmann Institute of Science, Israel
    Dev Biol 360:58-65. 2011
    ..Specific inhibition of miR-125b and miR-30a/c in chondrocytes or Dicer1 knockout in the trachea, de-repress Snail1...
  50. pmc Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects
    Yannick Romero
    Department of Genetic Medicine and Development, University of Geneva Medical School, University of Geneva, Geneva, Switzerland
    PLoS ONE 6:e25241. 2011
    ..b>DICER1, an RNAse III endonuclease, is essential for the biogenesis of several classes of small RNAs, including microRNAs (..
  51. doi The RNase III enzyme Dicer is essential for germinal center B-cell formation
    Shengli Xu
    Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore
    Blood 119:767-76. 2012
    ..Taken together, our data suggest that Dicer and probably miRNAs are critical for GC B-cell formation during B-cell terminal differentiation...
  52. pmc Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease
    Scott J Harvey
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Soc Nephrol 19:2150-8. 2008
    ..The unique architecture of podocytes may make them especially susceptible to cytoskeletal alterations initiated by aberrant miRNA dynamics...
  53. pmc Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo
    I Lambertz
    Laboratory For Molecular Cancer Biology, VIB UGent, Ghent B9052, Belgium
    Cell Death Differ 17:633-41. 2010
    ..To explore this possibility in more detail in vivo, we have manipulated Dicer1 gene dosage in a mouse model of retinoblastoma...
  54. doi Dicer1 deletion in myeloid-committed progenitors causes neutrophil dysplasia and blocks macrophage/dendritic cell development in mice
    Mir Farshid Alemdehy
    Department of Hematology, Erasmus University Medical Center, Dr Molewaterplein 50, Rotterdam, The Netherlands
    Blood 119:4723-30. 2012
    ..To address this issue, we deleted Dicer1, which encodes an essential RNase III enzyme for miRNA biogenesis, in murine CCAAT/enhancer-binding protein α (C/..
  55. pmc Perturbations of microRNA function in mouse dicer mutants produce retinal defects and lead to aberrant axon pathfinding at the optic chiasm
    Rita Pinter
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London, United Kingdom
    PLoS ONE 5:e10021. 2010
    ..However, their involvement in axon guidance decisions is less clear...
  56. pmc Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs
    Therese Andersson
    Gurdon Institute, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e13453. 2010
    ....
  57. ncbi RNAi and expression of retrotransposons MuERV-L and IAP in preimplantation mouse embryos
    Petr Svoboda
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Dev Biol 269:276-85. 2004
    ....
  58. pmc Deletion of Dicer in somatic cells of the female reproductive tract causes sterility
    Ankur K Nagaraja
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 22:2336-52. 2008
    ..Cre recombinase is driven by the anti-Müllerian hormone receptor type 2 promoter, we conditionally inactivated Dicer1 in the mesenchyme of the developing Müllerian ducts and postnatally in ovarian granulosa cells and mesenchyme-..
  59. ncbi MicroRNA expression is required for pancreatic islet cell genesis in the mouse
    Francis C Lynn
    Diabetes Center, Hormone Research Institute, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0534, USA
    Diabetes 56:2938-45. 2007
    ..We tested the hypothesis that microRNAs (miRNAs), which limit gene expression through posttranscriptional silencing, modulate the gene expression cascades involved in pancreas development...
  60. doi Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract
    Laura M Pastorelli
    Mammalian Genetics Unit, MRC Harwell, Oxfordshire, OX11 0RD, UK
    Mamm Genome 20:140-51. 2009
    ..Many studies investigating miRNA function focus on the processing enzyme Dicer1, which is an RNAseIII protein essential for the biogenesis of active miRNAs through its cleavage of precursor RNA ..
  61. pmc Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis
    Yajaira Suarez
    Department of Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, Amistad Research Building, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 105:14082-7. 2008
    ..Thus, endothelial miRNAs regulate postnatal angiogenesis and VEGF induces the expression of miRNAs implicated in the regulation of an integrated angiogenic response...
  62. pmc MicroRNAs dynamically remodel gastrointestinal smooth muscle cells
    Chanjae Park
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, United States of America
    PLoS ONE 6:e18628. 2011
    ..Taken together, our data suggest that SMC miRNAs are required for the development and survival of SMCs in the GI tract...
  63. pmc Dicer1 is essential for female fertility and normal development of the female reproductive system
    Xiaoman Hong
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA
    Endocrinology 149:6207-12. 2008
    The ribonuclease III endonuclease, Dicer1 (also known as Dicer), is essential for the synthesis of the 19-25 nucleotide noncoding RNAs known as micro-RNAs (miRNAs)...
  64. doi Inactivation of Dicer1 has a severe cumulative impact on the formation of mature germ cells in mouse testes
    Dekang Liu
    Key Laboratory of National Reproductive Medicine, Department of Cell Biology and Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 210029, China
    Biochem Biophys Res Commun 422:114-20. 2012
    b>Dicer1, an RNase III endonuclease, is indispensable for the maturation of miRNA and siRNA, which control gene expression through the RNAi pathway...
  65. pmc miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation
    Ankur Saxena
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:87-91. 2010
    ..In sum, we demonstrate here a specific developmental process, that of outflow tract morphogenesis, being hindered by the deletion of miRNAs during cardiogenesis...
  66. pmc Dicer-dependent pathways regulate chondrocyte proliferation and differentiation
    Tatsuya Kobayashi
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:1949-54. 2008
    ..Our results demonstrate the critical role of the Dicer-dependent pathway in the regulation of chondrocyte proliferation and differentiation during skeletal development...
  67. pmc Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage
    Zhihua Du
    Departments of Pharmaceutical Chemistry and Biochemistry and Biophysics, University of California, San Francisco, CA 94158 2517, USA
    Proc Natl Acad Sci U S A 105:2391-6. 2008
    ..N-terminal residues of this alpha-helix have the potential to engage in minor groove interaction with dsRNA substrates...
  68. pmc Dicer is required for proliferation, viability, migration and differentiation in corticoneurogenesis
    H S McLoughlin
    Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52240, USA
    Neuroscience 223:285-95. 2012
    ..These results significantly extend earlier works, and emphasize the impact of miRNAs on neural progenitor cell proliferation, apoptosis, migration, and differentiation in the developing mammalian brain...
  69. pmc MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival
    Maria Pia Arrate
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 70:6083-92. 2010
    ..Thus, Dicer does not function as a haploinsufficient tumor suppressor in B cells and is required for B-cell lymphoma development and survival...
  70. pmc Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop
    Jun An Chen
    Departments of Pathology and Cell Biology, Neurology, and Neuroscience, Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 69:721-35. 2011
    ....
  71. doi Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds
    Jing Zhao
    Molecular Nociception Group, Wolfson Institute for Biomedical Research, Research Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 30:10860-71. 2010
    ..MicroRNA microarray and deep sequencing identified known and novel nociceptor microRNAs in mouse Nav1.8+ sensory neurons that may regulate nociceptor gene expression...
  72. ncbi Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs
    Rui Yi
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Nat Genet 38:356-62. 2006
    ..To explore the functional significance of this finding, we conditionally targeted Dicer1 gene ablation in embryonic skin progenitors...
  73. pmc Characterization of the TRBP domain required for dicer interaction and function in RNA interference
    Sylvanne M Daniels
    Virus Cell Interactions Laboratory, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    BMC Mol Biol 10:38. 2009
    ..While Dicer and Ago2 are RNases, TRBP is the double-stranded RNA binding protein (dsRBP) that loads small interfering RNA into the RISC. TRBP binds directly to Dicer through its C-terminal domain...
  74. pmc miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts
    Anna M Eiring
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Cell 140:652-65. 2010
    ..Altogether, these data reveal the dual ability of a microRNA to control cell fate both through base pairing with mRNA targets and through a decoy activity that interferes with the function of regulatory proteins...
  75. doi Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling
    Paula A da Costa Martins
    Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands
    Circulation 118:1567-76. 2008
    ..Dicer, an RNAse III endonuclease critical for processing of pre-microRNAs (miRNAs) into mature 22-nucleotide miRNAs, has proven a useful target to dissect the significance of miRNAs biogenesis in mammalian biology...
  76. ncbi Molecular characterization of a mouse cDNA encoding Dicer, a ribonuclease III ortholog involved in RNA interference
    Rhonda H Nicholson
    Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, Michigan 48202, USA
    Mamm Genome 13:67-73. 2002
    ..The highly conserved set of functional domains and the occurrence of a single-copy gene strongly indicate that the encoded protein is the RNase III ortholog responsible for dsRNA processing in the RNAi pathway...
  77. pmc MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis
    Katsuhiko Hayashi
    Wellcome Trust Cancer Research United Kingdom Gurdon Institute, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 3:e1738. 2008
    ..Although it has been clear that piRNAs play a role in repression of retrotransposons during spermatogenesis, the function of miRNA in mouse germ cells has been unclear...
  78. pmc A MicroRNA feedback circuit in midbrain dopamine neurons
    Jongpil Kim
    Departments of Pathology and Neurology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, College of Physicians and Surgeons 15 403, 630 West 168th Street, New York, NY 10032, USA
    Science 317:1220-4. 2007
    ..We propose a role for this feedback circuit in the fine-tuning of dopaminergic behaviors such as locomotion...
  79. pmc The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles
    Thomas Andl
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Biol 16:1041-9. 2006
    ..These results reveal critical roles for Dicer in the skin and implicate miRNAs in key aspects of epidermal and hair-follicle development and function...
  80. ncbi Genomic imprinting in Dicer1-hypomorphic mice
    M Fukasawa
    Biosignal Genome Resource Center, Department of Molecular and Cellular Biology, Gunma University, Maebashi, Japan
    Cytogenet Genome Res 113:138-43. 2006
    ..the function of RNA interference (RNAi) in transcriptional silencing in mammals, we analyzed genomic imprinting in Dicer1-hypomorphic mice, in which Dicer1 expression was significantly reduced...
  81. pmc Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction
    Anne Schaefer
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 207:1843-51. 2010
    ..Comparison of miRNAs affected by Ago2 deficiency with miRNAs that are enriched and/or up-regulated in Drd2-neurons in response to cocaine identified a set of miRNAs that are likely to play a role in cocaine addiction...
  82. pmc The regulatory role of Dicer in folliculogenesis in mice
    Lei Lei
    Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, USA
    Mol Cell Endocrinol 315:63-73. 2010
    ..In the mouse ovary, the Dicer1 protein was expressed in both oocyte and granulosa cells of the follicle...
  83. ncbi Dicer is required for embryonic angiogenesis during mouse development
    Wei J Yang
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 280:9330-5. 2005
    ....
  84. ncbi Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors
    Noboru Doi
    Department of Biophysics, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, 113 0033, Bunkyo ku, Tokyo, Japan
    Curr Biol 13:41-6. 2003
    ..Immunoprecipitation experiments suggest that, in human and mouse cells, complex formation occurs between Dicer and eIF2C1 or 2 and that the PIWI domain of eIF2C is essential for the formation of this complex...
  85. pmc Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells
    Rajini Mudhasani
    Department of Cell Biology, University of Massachusetts Medical School, North Worcester, MA 01655, USA
    J Cell Biol 181:1055-63. 2008
    ..These results reveal that loss of miRNA biogenesis activates a DNA damage checkpoint, up-regulates p19(Arf)-p53 signaling, and induces senescence in primary cells...
  86. pmc TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
    Xiaohua Su
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Nature 467:986-90. 2010
    ....
  87. doi The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2
    Agnieszka Rybak
    Center for Anatomy, Institute of Cell Biology and Neurobiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Nat Cell Biol 11:1411-20. 2009
    ..Furthermore, mLin41 cooperated with the pluripotency factor Lin-28 in suppressing let-7 activity, revealing a dual control mechanism regulating let-7 in stem cells...
  88. pmc Dicer is regulated by cellular stresses and interferons
    Jennifer L Wiesen
    Roswell Park Cancer Institute, Laboratory of Molecular Medicine, Department of Immunology, Elm and Carlton Streets, Buffalo, NY 14263, United States
    Mol Immunol 46:1222-8. 2009
    ..The effects of stresses and interferons are primarily post-transcriptional. The findings suggest that Dicer is a stress response component and identifies interferons as potentially important regulators of Dicer expression...
  89. pmc Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development
    Yan Li
    Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Dyn 238:2388-400. 2009
    ..5 and E14.5 but decreased as the lens degenerated. Our data indicated an indispensible role for Dicer and miRNAs in lens and corneal development...
  90. doi A MicroRNA targeting dicer for metastasis control
    Graziano Martello
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy
    Cell 141:1195-207. 2010
    ..These findings suggest a new pathway by which Dicer inhibition drifts epithelial cancer toward a less-differentiated, mesenchymal fate to foster metastasis...
  91. pmc Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice
    Motoyuki Otsuka
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 118:1944-54. 2008
    The microRNA (miRNA) processing enzyme Dicer1 is required for zygotic and embryonic development, but the early embryonic lethality of Dicer1 null alleles in mice has limited our ability to address the role of Dicer1 in normal mouse growth ..
  92. ncbi Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
    Stefan Schoeftner
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre CNIO, 28029 Madrid, Spain
    Nat Cell Biol 10:228-36. 2008
    ..Our results indicate that TelRNAs are novel components of mammalian telomeres, which are anticipated to be fundamental for understanding telomere biology and telomere-related diseases, such as cancer and ageing...
  93. ncbi Dicer1 expression in preimplantation mouse embryos: Involvement of Oct3/4 transcription at the blastocyst stage
    Xiang Shun Cui
    National Research Laboratory, Department of Animal Sciences, Chungbuk National University, Gaesin dong, Cheongju, Chungbuk 361 763, Seoul, Republic of Korea
    Biochem Biophys Res Commun 352:231-6. 2007
    b>Dicer1, an RNAse III enzyme, is a key factor for the production of microRNAs involved in post-transcriptional gene silencing...
  94. pmc MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development
    Auinash Kalsotra
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 24:653-8. 2010
    ..These findings define a hierarchy in which rapid postnatal up-regulation of specific miRNAs controls expression of alternative splicing regulators and the subsequent splicing transitions of their downstream targets...
  95. ncbi Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner
    Giovanni Lugli
    University of Illinois at Chicago, UIC Psychiatric Institute, Chicago, Illinois, USA
    J Neurochem 94:896-905. 2005
    ..This supports the hypothesis that dicer could be involved in synaptic plasticity...
  96. pmc Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain
    Giovanni Lugli
    Department of Psychiatry and Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois, USA
    J Neurochem 106:650-61. 2008
    ....
  97. pmc The microRNA-processing enzyme dicer maintains juxtaglomerular cells
    Maria Luisa S Sequeira-Lopez
    Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Am Soc Nephrol 21:460-7. 2010
    ..We conclude that microRNAs maintain the renin-producing juxtaglomerular cells and the morphologic integrity and function of the kidney...
  98. pmc Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 136:2304-2315.e1-4. 2009
    ..We describe experiments to address the physiologic roles of these new regulators of gene expression in the liver that are as of yet largely undefined...
  99. pmc Dicer is required for maintaining adult pancreas
    Sumiyo Morita
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Showa Machi Maebashi, Japan
    PLoS ONE 4:e4212. 2009
    b>Dicer1, an essential component of RNA interference and the microRNA pathway, has many important roles in the morphogenesis of developing tissues. Dicer1 null mice have been reported to die at E7...
  100. doi Dicer-dependent microRNA pathway controls invariant NKT cell development
    Maya Fedeli
    Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, H San Raffaele Scientific Institute, Milan, Italy
    J Immunol 183:2506-12. 2009
    ..Together, these results define a critical role of the Dicer-dependent miRNA pathway in the physiology of iNKT cells...
  101. doi Meiotic maturation failure induced by DICER1 deficiency is derived from primary oocyte ooplasm
    Deidre M Mattiske
    Department of Zoology, The University of Melbourne, Gate 12, Royal Parade, Parkville, Victoria 3010, Australia
    Reproduction 137:625-32. 2009
    ..Mouse primary oocytes deficient in the key RNAi enzyme DICER1 exhibit pronounced defects in chromosome congression and spindle formation during meiotic maturation...

Research Grants30

  1. Alzheimer disease biomarkers in lens
    PETER FREDERIKSE; Fiscal Year: 2009
    ..These studies build on our earlier studies to understand the role of AbetaPP and Abeta in the lens which are already providing a new and specific conceptual basis for understanding cataract and its links with the brain. ..
  2. Formation of the intervertebral disk: a molecular approach
    Brian Harfe; Fiscal Year: 2009
    ....
  3. Alzheimer disease biomarkers in lens
    Peter H Frederikse; Fiscal Year: 2010
    ..These studies build on our earlier studies to understand the role of AbetaPP and Abeta in the lens which are already providing a new and specific conceptual basis for understanding cataract and its links with the brain. ..
  4. Formation of the intervertebral disk: a molecular approach
    Brian Harfe; Fiscal Year: 2009
    ..Their ability to survive, proliferates, and form all nucleus pulposus cell types will be determined using molecular markers. ..
  5. Formation of the intervertebral disk: a molecular approach
    BRIAN DAVID HARFE; Fiscal Year: 2010
    ....
  6. Role of microRNAs in mammalian ear development and neurosensory specification
    Garrett A Soukup; Fiscal Year: 2010
    ..Understanding how these small RNAs influence such processes is expected to impact molecular therapeutic strategies designed to regenerate sensory cells and restoring hearing. ..
  7. Role of microRNAs in skeletal development
    Tatsuya Kobayashi; Fiscal Year: 2010
    ..This proposal is aimed to establish the role of microRNAs in the skeletal system and to provide a basis for potential therapeutic interventions for skeletal diseases. ..
  8. Age-related changes in the intervertebral disk.
    BRIAN DAVID HARFE; Fiscal Year: 2010
    ....
  9. ALZHEIMER PATHOPHYSIOLOGY IN HUMAN CATARACT FORMATION
    PETER FREDERIKSE; Fiscal Year: 2002
    ..abstract_text> ..
  10. Identify and characterize novel Wnt pathway genes
    Brian Harfe; Fiscal Year: 2006
    ..The PIs have experience working with C. elegans, mice and chick model systems and are positioned to take full advantage of each system. ..
  11. The Role of TIMP-1 in Uterine Physiology
    Warren Nothnick; Fiscal Year: 2005
    ..These studies will broaden our understanding on the role of TIMP-1 in uterine physiology and may help to develop new strategies to treat uterine disorders such as infertility, endometriosis and uterine cancer. ..
  12. Small RNAs in skeletogenesis
    Tatsuya Kobayashi; Fiscal Year: 2007
    ..Understanding roles of sRNAs in skeletal tissues would not only reveal another level of regulation of gene expression, but also may provide novel therapeutic targets for genetic intervention in disease conditions. ..
  13. Alzheimer disease biomarkers in lens
    PETER FREDERIKSE; Fiscal Year: 2007
    ..These studies build on our earlier studies to understand the role of AbetaPP and Abeta in the lens which are already providing a new and specific conceptual basis for understanding cataract and its links with the brain. ..
  14. Development of the renin-expressing cell
    MARIA SEQUEIRA LOPEZ; Fiscal Year: 2007
    ..This work has the potential to open new avenues for the understanding, prevention and treatment of hypertension, birth defects and kidney diseases. ..
  15. Estrogen regulation of uterine microRNAs: Novel factors in MMP-9 regulation
    Warren Nothnick; Fiscal Year: 2007
    ..Enhancing our understanding on the regulation of MMP-9 expression may lead to the establishment of novel approaches to counteract mis-expression of this protease and the diseases associated with it. ..
  16. Age-related changes in the intervertebral disk.
    Brian Harfe; Fiscal Year: 2007
    ....
  17. COBRE: CREIGHTON UNIVERISTY: P1:ROLE OF MICRORNAS IN DEVELOPMENT OF THE EAR
    Garrett A Soukup; Fiscal Year: 2009
    ..Specific Aim 3. To identify downstream effector genes through which EGFR regulates the development of the PNS. ..