Gene Symbol: Dhx9
Description: DEAH (Asp-Glu-Ala-His) box polypeptide 9
Alias: AI326842, Ddx9, HEL-5, NDHII, RHA, mHEL-5, ATP-dependent RNA helicase A, D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 9, DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 9, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9, DEAH box protein 9, RNA helicase, RNA helicase A, leukophysin, nuclear DNA helicase II
Species: mouse
Products:     Dhx9

Top Publications

  1. Lee T, Pelletier J. Dependence of p53-deficient cells on the DHX9 DExH-box helicase. Oncotarget. 2017;8:30908-30921 pubmed publisher
    b>DHX9 is a DExH-box helicase family member with key regulatory roles in a broad range of cellular processes...
  2. Yamazaki K, Oki T, Tanaka I. Cloning of 5'-flanking region and a polymorphic CTT trinucleotide repeat within 5'-untranslated region of mouse R-type calcium channel alpha1-subunit (Cchra1) gene, and its genetic mapping. Gene. 1998;214:199-204 pubmed
    ..Using this polymorphism, the Cchra1 was mapped to the region of chromosome 1 where the synteny to human chromosome 1q was conserved. ..
  3. Lee C, da Costa Soares V, Newberger C, Manova K, Lacy E, Hurwitz J. RNA helicase A is essential for normal gastrulation. Proc Natl Acad Sci U S A. 1998;95:13709-13 pubmed
    b>RNA helicase A (RHA) is the human homologue of the Drosophila maleless protein, an essential factor for the development of male flies...
  4. Frank D, Mendelsohn C, Ciccone E, Svensson K, Ohlsson R, Tycko B. A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. Mamm Genome. 1999;10:1150-9 pubmed
    ..The data also define a new subfamily of PH domain genes. ..
  5. Lee T, Paquet M, Larsson O, Pelletier J. Tumor cell survival dependence on the DHX9 DExH-box helicase. Oncogene. 2016;35:5093-105 pubmed publisher
    The NTP-dependent DExH/D-box helicase DHX9 is a key participant in a number of gene regulatory steps, including transcriptional, translational, and microRNA-mediated control, DNA replication and maintenance of genomic stability...
  6. Ishiguro A, Aruga J. Functional role of Zic2 phosphorylation in transcriptional regulation. FEBS Lett. 2008;582:154-8 pubmed
    ..It activates the transcription of target genes by DNA binding and recruitment of RNA helicase A (RHA). We recently reported that the Zic2-RHA interaction is decreased by phosphatase treatment in vitro...
  7. Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm N, et al. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017;546:667-670 pubmed publisher
    ..Our data show that, via RNA helicase Dhx9, Nlrp9b recognizes short double-stranded RNA stretches and forms inflammasome complexes with the adaptor ..
  8. Aktas T, Avşar Ilık İ, Maticzka D, Bhardwaj V, Pessoa Rodrigues C, Mittler G, et al. DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature. 2017;544:115-119 pubmed publisher
    ..Here we show that DHX9, an abundant nuclear RNA helicase, binds specifically to inverted-repeat Alu elements that are transcribed as parts of genes...
  9. Padmanabhan K, Robles M, Westerling T, Weitz C. Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. 2012;337:599-602 pubmed publisher
    ..We found that mouse PER complexes included RNA helicases DDX5 and DHX9, active RNA polymerase II large subunit, Per and Cry pre-mRNAs, and SETX, a helicase that promotes transcriptional ..

More Information


  1. Fujimoto M, Oshima K, Shinkawa T, Wang B, Inouye S, Hayashida N, et al. Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses. J Biol Chem. 2008;283:29961-70 pubmed publisher
    ..These results suggest novel mechanisms of gene regulation controlled by HSF4 in non-classic heat shock response and in lens development. ..
  2. Zhang S, Köhler C, Hemmerich P, Grosse F. Nuclear DNA helicase II (RNA helicase A) binds to an F-actin containing shell that surrounds the nucleolus. Exp Cell Res. 2004;293:248-58 pubmed
    b>Nuclear DNA helicase II (NDH II), alternatively named RNA helicase A (RHA), is an F-actin binding protein that is particularly enriched in the nucleolus of mouse cells...
  3. Ding S, Wu X, Li G, Han M, Zhuang Y, Xu T. Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell. 2005;122:473-83 pubmed
    ..These data provide a first and critical step toward a highly efficient transposon system for a variety of genetic manipulations including transgenesis and insertional mutagenesis in mice and other vertebrates. ..
  4. Zhu Y, Liu S, Yin Q, Xu T, Wu X, Zhuang Y. Generation of Dhx9-deficient clones in T-cell development with a mitotic recombination technique. Genesis. 2012;50:543-51 pubmed
    ..1/CD45.2 heterozygous background. We have applied this system in the analysis of a lethal mutation in the Dhx9 gene. Mosaic analysis revealed a stage-specific role for Dhx9 during T-cell maturation...
  5. Wolstenholme J, Rissman E, Bekiranov S. Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. Genes Brain Behav. 2013;12:166-80 pubmed publisher
    ..Our results also indicate an interaction between gonadal development and sex chromosome number that could further elucidate the role of sex chromosome genes and hormones in the sexual differentiation of behavior. ..
  6. Zhang S, Herrmann C, Grosse F. Nucleolar localization of murine nuclear DNA helicase II (RNA helicase A). J Cell Sci. 1999;112 ( Pt 16):2693-703 pubmed
    b>Nuclear DNA helicase II (NDH II) is a highly conserved member of the DEXH superfamily of eukaryotic helicases, whose physiological role is still unclear...
  7. Lee C, Eki T, Okumura K, da Costa Soares V, Hurwitz J. Molecular analysis of the cDNA and genomic DNA encoding mouse RNA helicase A. Genomics. 1998;47:365-71 pubmed
    b>RNA helicase A is an enzyme that possesses both RNA and DNA helicase activities. In this report, we describe the isolation of a mouse cDNA encoding RNA helicase A...
  8. Miazek A, Brockhaus M, Langen H, Braun A, Kisielow P. Intrathymic education of alpha beta and gamma delta T cells is accompanied by cell surface expression of RNA/DNA helicase [corrected]. Eur J Immunol. 1997;27:3269-82 pubmed