Gene Symbol: Defa2
Description: defensin, alpha, 2
Alias: CR2, Defcr-2, Defcr2, alpha-defensin 2, alpha-defensin, 2, cryptdin-1, defensin-related cryptdin-2
Selsted M, Miller S, Henschen A, Ouellette A. Enteric defensins: antibiotic peptide components of intestinal host defense. J Cell Biol. 1992;118:929-36 pubmed
Eisenhauer P, Harwig S, Lehrer R. Cryptdins: antimicrobial defensins of the murine small intestine. Infect Immun. 1992;60:3556-65 pubmed
..We purified two closely related defensins, cryptdin 1 and cryptdin 2, from a subcellular fraction of murine small intestine cells that was enriched in Paneth cells...
Ouellette A, Hsieh M, Nosek M, Cano Gauci D, Huttner K, Buick R, et al
. Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect Immun. 1994;62:5040-7 pubmed
..4 and 5 cDNAs, whose respective mature peptide-encoding regions are only 74 and 78% identical to that of cryptdin 1. Cryptdin cDNAs differ at a small number of nucleotide positions: frequent substitutions were found in codons 38 ..
O Brien E, Novak E, Keller S, Poirier C, Guenet J, Swank R. Molecular map of chromosome 19 including three genes affecting bleeding time: ep, ru, and bm. Mamm Genome. 1994;5:356-60 pubmed
..Several markers were found to be closely linked to the three genes and should be useful as entry points in their eventual molecular identification. ..
Huttner K, Selsted M, Ouellette A. Structure and diversity of the murine cryptdin gene family. Genomics. 1994;19:448-53 pubmed
Garabedian E, Humphrey P, Gordon J. A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells. Proc Natl Acad Sci U S A. 1998;95:15382-7 pubmed
..This model indicates that the neuroendocrine cell lineage of the prostate is exquisitely sensitive to transformation and provides insights about the significance of neuroendocrine differentiation in human prostate cancer. ..
Ayabe T, Satchell D, Wilson C, Parks W, Selsted M, Ouellette A. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol. 2000;1:113-8 pubmed
..Thus intestinal Paneth cells contribute to innate immunity by sensing bacteria and bacterial antigens, and discharge microbicidal peptides at effective concentrations accordingly...
Shanahan M, Tanabe H, Ouellette A. Strain-specific polymorphisms in Paneth cell ?-defensins of C57BL/6 mice and evidence of vestigial myeloid ?-defensin pseudogenes. Infect Immun. 2011;79:459-73 pubmed publisher
..Given the role of ?-defensins in shaping the composition of the enteric microflora, such polymorphisms may influence outcomes in mouse models of disease or infection...