DEC2

Summary

Gene Symbol: DEC2
Description: basic helix-loop-helix family, member e41
Alias: 6430520M22Rik, Bhlhb2l, Bhlhb3, DEC2, Sharp1, bHLH transcriptional factor Dec2, basic helix-loop-helix domain containing, class B3, class B basic helix-loop-helix protein 3, class E basic helix-loop-helix protein 41, differentially expressed in chondrocytes protein 2
Species: mouse

Top Publications

  1. ncbi 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation
    Jun Kondo
    Department of Pathology, Hirosaki University School of Medicine, Japan
    Int J Mol Med 17:1053-6. 2006
  2. ncbi Dec1 and Dec2 are regulators of the mammalian molecular clock
    Sato Honma
    Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Nature 419:841-4. 2002
  3. ncbi Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins
    K Fujimoto
    Department of Biochemistry, Hiroshima University School of Dentistry, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Biochem Biophys Res Commun 280:164-71. 2001
  4. ncbi Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment
    Xuexian O Yang
    Department of Immunology, MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 10:1260-6. 2009
  5. ncbi Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling
    Zhiduo Liu
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Immunol 183:6320-9. 2009
  6. ncbi SHARP1/DEC2 inhibits adipogenic differentiation by regulating the activity of C/EBP
    Neriman Tuba Gulbagci
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    EMBO Rep 10:79-86. 2009
  7. ncbi Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice
    Moritz J Rossner
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS ONE 3:e2762. 2008
  8. ncbi DEC1 modulates the circadian phase of clock gene expression
    Ayumu Nakashima
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Mol Cell Biol 28:4080-92. 2008
  9. ncbi Altered Stra13 and Dec2 circadian gene expression in hypoxic cells
    Fabienne Guillaumond
    Universite de Nice Sophia Antipolis, CNRS FRE3094, 28 Av Valrose, 06108 Nice, France
    Biochem Biophys Res Commun 369:1184-9. 2008
  10. ncbi Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression
    Fuyuki Sato
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Genes Cells 13:131-44. 2008

Scientific Experts

  • Moritz J Rossner
  • Fuyuki Sato
  • Mitsuhide Noshiro
  • Katsumi Fujimoto
  • Yukio Kato
  • Takeshi Kawamoto
  • Sato Honma
  • Sameena Azmi
  • Reshma Taneja
  • Zhiduo Liu
  • Ken ichi Honma
  • Ken-ichi Honma
  • Hidenori Hamaguchi
  • Jian Jun Liu
  • Bing Sun
  • Xuexian O Yang
  • Neriman Tuba Gulbagci
  • Fabienne Guillaumond
  • Ayumu Nakashima
  • Jun Kondo
  • Masae Furukawa
  • Matthew Preston Butler
  • Anne Ozog
  • K Fujimoto
  • Teng Kai Chung
  • Jiali Li
  • Guomei Lin
  • Xueliang Zhu
  • Belinda Ling
  • Jinfang Zhu
  • Xiaodong Wu
  • Li Li
  • Charlie Xiang
  • Yuan Wang
  • Kairui Mao
  • Martin Walsh
  • Seon Hee Chang
  • Chen Dong
  • Weiguang Chen
  • Yongyong Ji
  • Shuhui Sun
  • Juan Peng
  • Xikui Liu
  • Roza Nurieva
  • Klaus Armin Nave
  • Suma Gopinadhan
  • Pornpimon Angkasekwinai
  • Lin Tian
  • Jia Zou
  • Yeonseok Chung
  • Zhenhu Li
  • Zhiyun Tao
  • Xiao-Mei Li
  • Xiao Mei Li
  • Aline Grechez-Cassiau
  • Nobuoki Kohno
  • Kiyomasa K Honda
  • Taichi Ueshima
  • Elisabeth Filipski
  • Franck Delaunay
  • Sandrine Dulong
  • Samuel Lacoche
  • Tomoyuki Iwata
  • Hiroshi Kubo
  • Edurne Berra
  • Francis Levi
  • Michele Teboul
  • Noriaki Yorioka
  • Ketut Suardita
  • Ujjal K Bhawal
  • Takafumi Hashiba
  • Tadahiro Nakamura
  • Tomomi Kusumi
  • Tatsusuke Sato
  • Tadanobu Imanaka
  • Hiroshi Kijima
  • Bhawal Uk
  • Taizo Hamada
  • Norihiko Takeda
  • Ryozo Nagai
  • Tatsuya Fukumoto
  • Hidemi Kurihara
  • Koji Maemura
  • Hong Sun
  • Yumiko Takagi
  • K Matsubara
  • Y Matsuda
  • S Shingu
  • M Noshiro
  • M Shen

Detail Information

Publications18

  1. ncbi 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation
    Jun Kondo
    Department of Pathology, Hirosaki University School of Medicine, Japan
    Int J Mol Med 17:1053-6. 2006
    The basic helix-loop-helix (bHLH) transcription factors, DEC2 and DEC1, play critical roles in the circadian rhythm of the suprachiasmatic nucleus (SCN)...
  2. ncbi Dec1 and Dec2 are regulators of the mammalian molecular clock
    Sato Honma
    Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Nature 419:841-4. 2002
    ..We found that Dec1 and Dec2, basic helix-loop-helix transcription factors, repressed Clock/Bmal1-induced transactivation of the mouse Per1 ..
  3. ncbi Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins
    K Fujimoto
    Department of Biochemistry, Hiroshima University School of Dentistry, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Biochem Biophys Res Commun 280:164-71. 2001
    ..We report here the identification and characterization of human, mouse and rat DEC2, a novel member of the DEC subfamily...
  4. ncbi Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment
    Xuexian O Yang
    Department of Immunology, MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 10:1260-6. 2009
    ..Here we show that the basic helix-loop-helix transcription factor Dec2 was selectively expressed in T(H)2 cells...
  5. ncbi Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling
    Zhiduo Liu
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Immunol 183:6320-9. 2009
    ..In the present study, we demonstrate that Dec2, a transcription factor belonging to the bHLH (basic helix-loop-helix) superfamily, is progressively induced during ..
  6. ncbi SHARP1/DEC2 inhibits adipogenic differentiation by regulating the activity of C/EBP
    Neriman Tuba Gulbagci
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    EMBO Rep 10:79-86. 2009
    b>SHARP1, a basic helix-loop-helix transcription factor, is expressed in many cell types; however, the mechanisms by which it regulates cellular differentiation remain largely unknown...
  7. ncbi Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice
    Moritz J Rossner
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS ONE 3:e2762. 2008
    ..However, the molecular mechanisms leading to the disintegration of tissue-specific clocks are complex and not well understood...
  8. ncbi DEC1 modulates the circadian phase of clock gene expression
    Ayumu Nakashima
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Mol Cell Biol 28:4080-92. 2008
    ..Overexpression of Dec1 delayed the phase of clock genes such as Dec1, Dec2, Per1, and Dbp that contain E boxes in their regulatory regions, whereas it had little effect on the circadian ..
  9. ncbi Altered Stra13 and Dec2 circadian gene expression in hypoxic cells
    Fabienne Guillaumond
    Universite de Nice Sophia Antipolis, CNRS FRE3094, 28 Av Valrose, 06108 Nice, France
    Biochem Biophys Res Commun 369:1184-9. 2008
    ..Here we show that Stra13 and Dec2, two circadian transcriptional regulators which play a crucial role in cell proliferation and apoptosis are ..
  10. ncbi Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression
    Fuyuki Sato
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Genes Cells 13:131-44. 2008
    DEC1 (BHLHB2/Sharp2/Stra13) and DEC2 (BHLHB3/Sharp1) are basic-helix-loop-helix (bHLH) transcription factors, involved in cellular differentiation, responses to hypoxia and circadian rhythms...
  11. ncbi Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements
    Katsumi Fujimoto
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Int J Mol Med 19:925-32. 2007
    b>Dec2, a member of the basic helix-loop-helix (bHLH) superfamily, has been shown to function as a transcriptional repressor and is implicated in cell proliferation and differentiation...
  12. ncbi Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice
    Mitsuhide Noshiro
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Biol Rhythms 20:404-18. 2005
    DEC1 and DEC2-basic helix-loop-helix transcription factors-exhibit a circadian expression in the suprachiasmatic nucleus and other peripheral tissues and seem to play roles in regulating the mammalian circadian rhythm by suppressing the ..
  13. ncbi Sharp-1/DEC2 inhibits skeletal muscle differentiation through repression of myogenic transcription factors
    Sameena Azmi
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Biol Chem 279:52643-52. 2004
    ..Our data suggest that protein-protein interactions between Sharp-1, MyoD, and E47 resulting in interference with MyoD function underlies Sharp-1-mediated repression of myogenic differentiation...
  14. ncbi Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system
    Hidenori Hamaguchi
    Department of Dental and Medical Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Biochem J 382:43-50. 2004
    b>Dec2, a member of the basic helix-loop-helix superfamily, is a recently confirmed regulatory protein for the clockwork system...
  15. ncbi Dec1 and Dec2 expression is disrupted in the suprachiasmatic nuclei of Clock mutant mice
    Matthew Preston Butler
    Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Biol Rhythms 19:126-34. 2004
    DEC1 and DEC2 are basic helix-loop-helix transcription factors that functionally resemble negative feedback components of the mammalian circadian clock...
  16. ncbi mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression
    Sameena Azmi
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Biol Chem 278:20098-109. 2003
    ..In this study, we have characterized the DNA-binding and transcriptional properties of the bHLH factor mSharp-1/DEC2. mSharp-1 belongs to the Hairy/Enhancer of Split subfamily of bHLH factors and exhibits the highest structural and ..
  17. ncbi Embryonic expression of mSharp-1/mDEC2, which encodes a basic helix-loop-helix transcription factor
    Sameena Azmi
    Department of Biochemisty and Molecular Biology, Mount Sinai School of Medicine, Box 1020, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mech Dev 114:181-5. 2002
    ..The diversity of its expression pattern suggests that mSharp-1 may regulate the differentiation of several cell types during vertebrate development...
  18. ncbi Sharp-1 modulates the cellular response to DNA damage
    Jian Jun Liu
    Department of Physiology, National University of Singapore, Singapore, Singapore
    FEBS Lett 584:619-24. 2010
    ..Our studies identify a novel function for Sharp-1 in cell cycle arrest and DNA damage-induced apoptosis. Inappropriate Sharp-1 expression may therefore be associated with tumorigenesis...