Gene Symbol: DEC2
Description: basic helix-loop-helix family, member e41
Alias: 6430520M22Rik, Bhlhb2l, Bhlhb3, DEC2, Sharp1, class E basic helix-loop-helix protein 41, bHLH transcriptional factor Dec2, basic helix-loop-helix domain containing, class B3, class B basic helix-loop-helix protein 3, differentially expressed in chondrocytes protein 2
Species: mouse
Products:     DEC2

Top Publications

  1. Kondo J, Sato F, Fujimoto K, Kusumi T, Imanaka T, Kawamoto T, et al. 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation. Int J Mol Med. 2006;17:1053-6 pubmed
    The basic helix-loop-helix (bHLH) transcription factors, DEC2 and DEC1, play critical roles in the circadian rhythm of the suprachiasmatic nucleus (SCN)...
  2. Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, et al. Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature. 2002;419:841-4 pubmed
    ..We found that Dec1 and Dec2, basic helix-loop-helix transcription factors, repressed Clock/Bmal1-induced transactivation of the mouse Per1 ..
  3. Bode B, Shahmoradi A, Taneja R, Rossner M, Oster H. Genetic interaction of Per1 and Dec1/2 in the regulation of circadian locomotor activity. J Biol Rhythms. 2011;26:530-40 pubmed publisher
    ..An accessory loop involving the transcription factors DEC1 and DEC2 has been described that also impinges on CLOCK/BMAL1-mediated transactivation...
  4. Yang X, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, et al. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol. 2009;10:1260-6 pubmed publisher
    ..Here we show that the basic helix-loop-helix transcription factor Dec2 was selectively expressed in T(H)2 cells...
  5. Azmi S, Ozog A, Taneja R. Sharp-1/DEC2 inhibits skeletal muscle differentiation through repression of myogenic transcription factors. J Biol Chem. 2004;279:52643-52 pubmed
    ..Our data suggest that protein-protein interactions between Sharp-1, MyoD, and E47 resulting in interference with MyoD function underlies Sharp-1-mediated repression of myogenic differentiation. ..
  6. Fujimoto K, Hamaguchi H, Hashiba T, Nakamura T, Kawamoto T, Sato F, et al. Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements. Int J Mol Med. 2007;19:925-32 pubmed
    b>Dec2, a member of the basic helix-loop-helix (bHLH) superfamily, has been shown to function as a transcriptional repressor and is implicated in cell proliferation and differentiation...
  7. Fujimoto K, Shen M, Noshiro M, Matsubara K, Shingu S, Honda K, et al. Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins. Biochem Biophys Res Commun. 2001;280:164-71 pubmed
    ..We report here the identification and characterization of human, mouse and rat DEC2, a novel member of the DEC subfamily...
  8. Azmi S, Sun H, Ozog A, Taneja R. mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression. J Biol Chem. 2003;278:20098-109 pubmed
    ..In this study, we have characterized the DNA-binding and transcriptional properties of the bHLH factor mSharp-1/DEC2. mSharp-1 belongs to the Hairy/Enhancer of Split subfamily of bHLH factors and exhibits the highest structural and ..
  9. Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda K, Honma S, et al. Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur J Biochem. 2004;271:4409-19 pubmed
    ..Moreover, mutant DEC1 also counteracted DEC2-mediated suppressive activity in a dominant-negative manner...

More Information


  1. He Y, Jones C, Fujiki N, Xu Y, Guo B, Holder J, et al. The transcriptional repressor DEC2 regulates sleep length in mammals. Science. 2009;325:866-70 pubmed publisher
    ..These mice represent a model of human sleep homeostasis that provides an opportunity to probe the effect of sleep on human physical and mental health. ..
  2. Gulbagci N, Li L, Ling B, Gopinadhan S, Walsh M, Rossner M, et al. SHARP1/DEC2 inhibits adipogenic differentiation by regulating the activity of C/EBP. EMBO Rep. 2009;10:79-86 pubmed publisher
    b>SHARP1, a basic helix-loop-helix transcription factor, is expressed in many cell types; however, the mechanisms by which it regulates cellular differentiation remain largely unknown...
  3. Nakashima A, Kawamoto T, Honda K, Ueshima T, Noshiro M, Iwata T, et al. DEC1 modulates the circadian phase of clock gene expression. Mol Cell Biol. 2008;28:4080-92 pubmed publisher
    ..Overexpression of Dec1 delayed the phase of clock genes such as Dec1, Dec2, Per1, and Dbp that contain E boxes in their regulatory regions, whereas it had little effect on the circadian ..
  4. Azmi S, Taneja R. Embryonic expression of mSharp-1/mDEC2, which encodes a basic helix-loop-helix transcription factor. Mech Dev. 2002;114:181-5 pubmed
    ..The diversity of its expression pattern suggests that mSharp-1 may regulate the differentiation of several cell types during vertebrate development. ..
  5. Bode B, Taneja R, Rossner M, Oster H. Advanced light-entrained activity onsets and restored free-running suprachiasmatic nucleus circadian rhythms in per2/dec mutant mice. Chronobiol Int. 2011;28:737-50 pubmed publisher
    ..The basic helix-loop-helix transcription factors DEC1 (BHLHE40) and DEC2 (BHLHE41) can interact with this core TTL, forming an accessory feedback mechanism...
  6. Rossner M, Oster H, Wichert S, Reinecke L, Wehr M, Reinecke J, et al. Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice. PLoS ONE. 2008;3:e2762 pubmed publisher
    ..circadian expression and cell culture experiments, the basic Helix-Loop-Helix (bHLH) transcription factors SHARP-1(Dec2) and SHARP-2(Stra13/Dec1) were proposed as novel negative regulators of the molecular clock...
  7. Sato F, Bhawal U, Kawamoto T, Fujimoto K, Imaizumi T, Imanaka T, et al. Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression. Genes Cells. 2008;13:131-44 pubmed publisher
    DEC1 (BHLHB2/Sharp2/Stra13) and DEC2 (BHLHB3/Sharp1) are basic-helix-loop-helix (bHLH) transcription factors, involved in cellular differentiation, responses to hypoxia and circadian rhythms...
  8. Kreslavsky T, Vilagos B, Tagoh H, Poliakova D, Schwickert T, Wöhner M, et al. Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. Nat Immunol. 2017;18:442-455 pubmed publisher
    ..Bhlhe41 directly repressed the expression of cell-cycle regulators and inhibitors of BCR signaling while enabling pro-survival cytokine signaling. Thus, Bhlhe41 controls the development, BCR repertoire and self-renewal of B-1a cells. ..
  9. Suzuki M, Sato F, Bhawal U. The basic helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates Twist1 through an E-box element. Biochem Biophys Res Commun. 2014;455:390-5 pubmed publisher
    Differentiated embryo chondrocyte 2 (DEC2/Sharp-1/Bhlhe41), a basic helix-loop-helix (bHLH) transcription factor, has been shown to regulate the transcription of target genes by binding to their E-box elements...
  10. Pham T, Kwon J, Shin J. Berberine exerts anti-adipogenic activity through up-regulation of C/EBP inhibitors, CHOP and DEC2. Biochem Biophys Res Commun. 2011;413:376-82 pubmed publisher, we show that berberine up-regulated the expression of two different sets of C/EBP inhibitors, CHOP and DEC2, while down-modulating C/EBP?, PPAR? and other adipogenic markers and effectors in differentiating 3T3-L1 ..
  11. Kawamoto T, Noshiro M, Furukawa M, Honda K, Nakashima A, Ueshima T, et al. Effects of fasting and re-feeding on the expression of Dec1, Per1, and other clock-related genes. J Biochem. 2006;140:401-8 pubmed
    ..clock systems, we examined the effect of fasting on circadian expression of clock genes including Dec1 and Dec2 in mice...
  12. Yamada K, Miyamoto K. Basic helix-loop-helix transcription factors, BHLHB2 and BHLHB3; their gene expressions are regulated by multiple extracellular stimuli. Front Biosci. 2005;10:3151-71 pubmed
    ..BHLHB2 (also referred to as the DEC1/Eip1/SHARP-2/Stra13/Clast5) and BHLHB3 (also referred to as the DEC2/SHARP-1/SHARP1), are transcription factors that contain a unique orange domain...
  13. Cho Y, Noshiro M, Choi M, Morita K, Kawamoto T, Fujimoto K, et al. The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. Mol Pharmacol. 2009;76:1360-9 pubmed publisher
    The basic helix-loop-helix proteins differentiated embryo chondrocyte 1 (DEC1) and DEC2 are involved in circadian rhythm control...
  14. Liu J, Chung T, Li J, Taneja R. Sharp-1 modulates the cellular response to DNA damage. FEBS Lett. 2010;584:619-24 pubmed publisher
    ..Our studies identify a novel function for Sharp-1 in cell cycle arrest and DNA damage-induced apoptosis. Inappropriate Sharp-1 expression may therefore be associated with tumorigenesis. ..
  15. Butler M, Honma S, Fukumoto T, Kawamoto T, Fujimoto K, Noshiro M, et al. Dec1 and Dec2 expression is disrupted in the suprachiasmatic nuclei of Clock mutant mice. J Biol Rhythms. 2004;19:126-34 pubmed
    DEC1 and DEC2 are basic helix-loop-helix transcription factors that functionally resemble negative feedback components of the mammalian circadian clock...
  16. Acharjee S, Chung T, Gopinadhan S, Shankar S, Wang Y, Li L, et al. Sharp-1 regulates TGF-? signaling and skeletal muscle regeneration. J Cell Sci. 2014;127:599-608 pubmed publisher
    ..These results demonstrate that Sharp-1 regulates muscle regenerative capacity, at least in part, by modulation of TGF-? signaling. ..
  17. Ozaki N, Noshiro M, Kawamoto T, Nakashima A, Honda K, Fukuzaki Dohi U, et al. Regulation of basic helix-loop-helix transcription factors Dec1 and Dec2 by ROR? and their roles in adipogenesis. Genes Cells. 2012;17:109-21 pubmed publisher
    DEC1 and DEC2, members of the basic helix-loop-helix superfamily, are involved in various biological phenomena including clock systems, cell differentiation and metabolism...
  18. Dardente H, Cermakian N. Molecular circadian rhythms in central and peripheral clocks in mammals. Chronobiol Int. 2007;24:195-213 pubmed
  19. Hamaguchi H, Fujimoto K, Kawamoto T, Noshiro M, Maemura K, Takeda N, et al. Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Biochem J. 2004;382:43-50 pubmed
    b>Dec2, a member of the basic helix-loop-helix superfamily, is a recently confirmed regulatory protein for the clockwork system...
  20. Liu Z, Li Z, Mao K, Zou J, Wang Y, Tao Z, et al. Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling. J Immunol. 2009;183:6320-9 pubmed publisher
    ..In the present study, we demonstrate that Dec2, a transcription factor belonging to the bHLH (basic helix-loop-helix) superfamily, is progressively induced during ..
  21. Shahmoradi A, Radyushkin K, Rossner M. Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex. Proc Natl Acad Sci U S A. 2015;112:E3582-9 pubmed publisher
    The bHLH transcription factors SHARP1 and SHARP2 are partially redundant modulators of the circadian system...
  22. Liu B, Wang T, Mei W, Li D, Cai R, Zuo Y, et al. Small ubiquitin-like modifier (SUMO) protein-specific protease 1 de-SUMOylates Sharp-1 protein and controls adipocyte differentiation. J Biol Chem. 2014;289:22358-64 pubmed publisher
    ..SENP1 enhances adipogenesis through de-SUMOylation of Sharp-1, which then releases Sharp-1 repression of PPAR? expression and adipocyte differentiation. These results reveal SENP1 as a novel regulator in adipogenesis. ..
  23. Kawamoto T, Noshiro M, Sato F, Maemura K, Takeda N, Nagai R, et al. A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem Biophys Res Commun. 2004;313:117-24 pubmed
    ..a basic helix-loop-helix transcription factor: CLOCK/BMAL increased the promoter activity of Dec1, and DEC1 and DEC2 as well as PERs and CRYs suppressed the induced expression...
  24. Tsang A, Sánchez Moreno C, Bode B, Rossner M, Garaulet M, Oster H. Tissue-specific interaction of Per1/2 and Dec2 in the regulation of fibroblast circadian rhythms. J Biol Rhythms. 2012;27:478-89 pubmed publisher
    ..genetic interaction at the cellular level, we isolated fibroblasts from different tissues of Per1, Per2, and Dec2 single and double mutant mice...
  25. Noshiro M, Furukawa M, Honma S, Kawamoto T, Hamada T, Honma K, et al. Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice. J Biol Rhythms. 2005;20:404-18 pubmed
    DEC1 and DEC2-basic helix-loop-helix transcription factors-exhibit a circadian expression in the suprachiasmatic nucleus and other peripheral tissues and seem to play roles in regulating the mammalian circadian rhythm by suppressing the ..
  26. Goriki A, Hatanaka F, Myung J, Kim J, Yoritaka T, Tanoue S, et al. A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 2014;12:e1001839 pubmed publisher
  27. Ling B, Gopinadhan S, Kok W, Shankar S, Gopal P, Bharathy N, et al. G9a mediates Sharp-1-dependent inhibition of skeletal muscle differentiation. Mol Biol Cell. 2012;23:4778-85 pubmed publisher
    ..Our findings provide new insights into Sharp-1-dependent regulation of myogenesis and identify epigenetic mechanisms that could be targeted in myopathies characterized by elevated Sharp-1 levels. ..
  28. Baier P, Brzózka M, Shahmoradi A, Reinecke L, Kroos C, Wichert S, et al. Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders. PLoS ONE. 2014;9:e110310 pubmed publisher
    ..The bHLH transcription factors SHARP1/DEC2/BHLHE41 and SHARP2/DEC1/BHLHE40 are modulators of the circadian system and SHARP1/DEC2/BHLHE40 has been shown ..
  29. Montagner M, Enzo E, Forcato M, Zanconato F, Parenti A, Rampazzo E, et al. SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors. Nature. 2012;487:380-4 pubmed publisher
    ..Here we show that SHARP1 (also known as BHLHE41 or DEC2) is a crucial regulator of the invasive and metastatic phenotype in triple-negative ..
  30. Guillaumond F, Lacoche S, Dulong S, Grechez Cassiau A, Filipski E, Li X, et al. Altered Stra13 and Dec2 circadian gene expression in hypoxic cells. Biochem Biophys Res Commun. 2008;369:1184-9 pubmed publisher
    ..Here we show that Stra13 and Dec2, two circadian transcriptional regulators which play a crucial role in cell proliferation and apoptosis are ..