Gene Symbol: Ddx17
Description: DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
Alias: 2610007K22Rik, A430025E01Rik, AI047725, C80929, Gm926, p72, DEAD box protein 17
Wilson B, Giguere V. Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis. BMC Genomics. 2007;8:419 pubmed
..We have used the DEAD-box proteins p68(Ddx5) and p72(Ddx17) as models for this coexpression frequency analysis as there are defined functions for these proteins in splicing ..
Nagamori I, Yomogida K, Adams P, Sassone Corsi P, Nojima H. Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation. J Biol Chem. 2006;281:15073-81 pubmed
..Finally, we demonstrate that the Tisp40DeltaTM-CREMtau heterodimer acts as a recruiter of HIRA, a histone chaperone, to CRE. Taken together, we propose that Tisp40 is an important transcriptional regulator during spermiogenesis. ..
Dardenne E, Pierredon S, Driouch K, Gratadou L, Lacroix Triki M, Espinoza M, et al
. Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness. Nat Struct Mol Biol. 2012;19:1139-46 pubmed publisher
..Here, we report that the mouse and human RNA helicases Ddx17 and Ddx5 contribute to tumor-cell invasiveness by regulating alternative splicing of several DNA- and chromatin-..
Mori M, Triboulet R, Mohseni M, Schlegelmilch K, Shrestha K, Camargo F, et al
. Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell. 2014;156:893-906 pubmed publisher
..At low cell density, nuclear YAP binds and sequesters p72 (DDX17), a regulatory component of the miRNA-processing machinery...
Krol J, Krol I, Alvarez C, Fiscella M, Hierlemann A, Roska B, et al
. A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture. Nat Commun. 2015;6:7305 pubmed publisher
..Our results suggest that the precise timing of glia-neuron interaction controlled by noncoding RNAs and Ddx3x is important for the even distribution of cells across layers. ..
Remenyi J, Bajan S, Fuller Pace F, Arthur J, Hutvagner G. The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132. Sci Rep. 2016;6:22848 pubmed publisher
..The DEAD box helicase p72/DDX17 was identified as a factor that facilitates the specific processing of miR-132.
Germann S, Gratadou L, Zonta E, Dardenne E, Gaudineau B, Fougere M, et al
. Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Oncogene. 2012;31:4536-49 pubmed publisher
Ddx5 and ddx17 are two highly related RNA helicases involved in both transcription and splicing. These proteins coactivate transcription factors involved in cancer such as the estrogen receptor alpha, p53 and beta-catenin...
Dardenne E, Polay Espinoza M, Fattet L, Germann S, Lambert M, Neil H, et al
. RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation. Cell Rep. 2014;7:1900-13 pubmed publisher
The RNA helicases DDX5 and DDX17 are members of a large family of highly conserved proteins that are involved in gene-expression regulation; however, their in vivo targets and activities in biological processes such as cell ..