Gene Symbol: Dcx
Description: doublecortin
Alias: Dbct, neuronal migration protein doublecortin, doublecortex, doublin, lis-X, lissencephalin-X, lissencephaly, X-linked (doublecortin)
Species: mouse
Products:     Dcx

Top Publications

  1. Rasin M, Gazula V, Breunig J, Kwan K, Johnson M, Liu Chen S, et al. Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci. 2007;10:819-27 pubmed
    ..Thus, by regulating RGC adhesion and polarity, Numb and Numbl are required for the tissue architecture of neurogenic niches and the cerebral cortex. ..
  2. Koizumi H, Higginbotham H, Poon T, Tanaka T, Brinkman B, Gleeson J. Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrain. Nat Neurosci. 2006;9:779-86 pubmed
    ..Here we show that doublecortin (DCX), a widely used marker for newly generated neurons, when deleted in mice results in a severe morphological defect ..
  3. Zhang Y, Ryan J, Di Cesare P, Liu J, Walsh C, You Z. Doublecortin is expressed in articular chondrocytes. Biochem Biophys Res Commun. 2007;363:694-700 pubmed
    ..In this study, we found that doublecortin (DCX) was expressed in articular chondrocytes but not in chondrocytes from the cartilaginous anlagen or growth plates...
  4. Lizarraga S, Margossian S, Harris M, Campagna D, Han A, Blevins S, et al. Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Development. 2010;137:1907-17 pubmed publisher
    ..Our findings suggest that the reduction in brain size observed in humans with mutations in CDK5RAP2 is associated with impaired centrosomal function and with changes in mitotic spindle orientation during progenitor proliferation. ..
  5. Pawlisz A, Mutch C, Wynshaw Boris A, Chenn A, Walsh C, Feng Y. Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination. Hum Mol Genet. 2008;17:2441-55 pubmed publisher
    ..Our data suggest that maintaining the shape and cell-cell interactions of radial glial neuroepithelial progenitors by the Lis1-Nde1 complex is essential for their self renewal during the early phase of corticogenesis. ..
  6. Friocourt G, Chafey P, Billuart P, Koulakoff A, Vinet M, Schaar B, et al. Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system. Mol Cell Neurosci. 2001;18:307-19 pubmed
    ..Taken together these data indicate that a certain proportion of Doublecortin interacts with AP-1 and/or AP-2 in vivo and are consistent with a potential involvement of Doublecortin in protein sorting or vesicular trafficking. ..
  7. Gleeson J, Allen K, Fox J, Lamperti E, Berkovic S, Scheffer I, et al. Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. Cell. 1998;92:63-72 pubmed
    ..Doublecortin, along with the newly characterized mDab1, may define an Abl-dependent pathway regulating neuronal migration. ..
  8. Gdalyahu A, Ghosh I, Levy T, Sapir T, Sapoznik S, Fishler Y, et al. DCX, a new mediator of the JNK pathway. EMBO J. 2004;23:823-32 pubmed
    Mutations in the X-linked gene DCX result in lissencephaly in males, and abnormal neuronal positioning in females, suggesting a role for this gene product during neuronal migration...
  9. Friocourt G, Kappeler C, Saillour Y, Fauchereau F, Rodriguez M, Bahi N, et al. Doublecortin interacts with the ubiquitin protease DFFRX, which associates with microtubules in neuronal processes. Mol Cell Neurosci. 2005;28:153-64 pubmed
    Doublecortin (DCX) is a microtubule-associated protein involved in neuronal migration, which causes X-linked lissencephaly and subcortical laminar heterotopia (SCLH) when mutated...

More Information


  1. Karalay O, Doberauer K, Vadodaria K, Knobloch M, Berti L, Miquelajauregui A, et al. Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2011;108:5807-12 pubmed publisher
  2. Vreugdenhil E, Kolk S, Boekhoorn K, Fitzsimons C, Schaaf M, Schouten T, et al. Doublecortin-like, a microtubule-associated protein expressed in radial glia, is crucial for neuronal precursor division and radial process stability. Eur J Neurosci. 2007;25:635-48 pubmed
    ..Although the microtubule-associated proteins doublecortin (DCX) and doublecortin-like kinase (DCLK) are critically involved in dynamic rearrangement of the cytoskeletal machinery ..
  3. Kerjan G, Koizumi H, Han E, Dubé C, Djakovic S, Patrick G, et al. Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A. 2009;106:6766-71 pubmed publisher
    Mutations in doublecortin (DCX) are associated with intractable epilepsy in humans, due to a severe disorganization of the neocortex and hippocampus known as classical lissencephaly...
  4. Tanaka T, Serneo F, Tseng H, Kulkarni A, Tsai L, Gleeson J. Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration. Neuron. 2004;41:215-27 pubmed
    Mutations in the doublecortin (DCX) gene in human or targeted disruption of the cdk5 gene in mouse lead to similar cortical lamination defects in the developing brain. Here we show that Dcx is phosphorylated by Cdk5...
  5. Yoo D, Yoo K, Choi J, Kim W, Lee C, Choi J, et al. Time course of postnatal distribution of doublecortin immunoreactive developing/maturing neurons in the somatosensory cortex and hippocampal CA1 region of C57BL/6 mice. Cell Mol Neurobiol. 2011;31:729-36 pubmed publisher
    ..to oxidative stress, of the mouse at various early postnatal days (P) 1, 7, 14, and 21 using doublecortin (DCX, a marker for neuroblasts)...
  6. Graham M, Ruma Haynes P, Capes Davis A, Dunn J, Tan T, Valova V, et al. Multisite phosphorylation of doublecortin by cyclin-dependent kinase 5. Biochem J. 2004;381:471-81 pubmed
    Doublecortin (DCX) is a 40 kDa microtubule-associated protein required for normal neural migration and cortical layering during development. Mutations in the human DCX gene cause a disruption of cortical neuronal migration...
  7. Paik J, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun W, et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell. 2009;5:540-53 pubmed publisher
    ..Thus, the FoxO family coordinately regulates diverse genes and pathways to govern key aspects of NSC homeostasis in the mammalian brain. ..
  8. Gleeson J, Lin P, Flanagan L, Walsh C. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron. 1999;23:257-71 pubmed
    Doublecortin (DCX) is required for normal migration of neurons into the cerebral cortex, since mutations in the human gene cause a disruption of cortical neuronal migration...
  9. Wang X, Qiu R, Tsark W, Lu Q. Rapid promoter analysis in developing mouse brain and genetic labeling of young neurons by doublecortin-DsRed-express. J Neurosci Res. 2007;85:3567-73 pubmed
    ..neural promoter/enhancers in the developing mouse brain and its application in the isolation of the doublecortin (DCX) promoter/enhancer for genetic labeling of young neurons...
  10. Matsuo N, Kawamoto S, Matsubara K, Okubo K. Cloning and developmental expression of the murine homolog of doublecortin. Biochem Biophys Res Commun. 1998;252:571-6 pubmed
    ..The m-doublecortin mRNA was absent in the ventricular zone where neuronal precursors proliferate, and interestingly it was found in various brain structures that are not typically affected in patients with this syndrome. ..
  11. Bazelot M, Simonnet J, Dinocourt C, Bruel Jungerman E, Miles R, Fricker D, et al. Cellular anatomy, physiology and epileptiform activity in the CA3 region of Dcx knockout mice: a neuronal lamination defect and its consequences. Eur J Neurosci. 2012;35:244-56 pubmed publisher
    ..The protein product of this gene affects neuronal migration during development. Human doublecortin (DCX) mutations are associated with lissencephaly, subcortical band heterotopia, and syndromes of intellectual ..
  12. Mao Y, Ge X, Frank C, Madison J, Koehler A, Doud M, et al. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell. 2009;136:1017-31 pubmed publisher
    ..Together, these results implicate DISC1 in GSK3beta/beta-catenin signaling pathways and provide a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders. ..
  13. Saaltink D, Håvik B, Verissimo C, Lucassen P, Vreugdenhil E. Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis. J Comp Neurol. 2012;520:2805-23 pubmed publisher
    ..a microtubule-associated protein involved in embryonic neurogenesis that is highly homologous to doublecortin (DCX), in the adult mouse brain...
  14. Dijkmans T, van Hooijdonk L, Fitzsimons C, Vreugdenhil E. The doublecortin gene family and disorders of neuronal structure. Cent Nerv Syst Agents Med Chem. 2010;10:32-46 pubmed
    ..In addition, to generate new hypotheses for further research, we analyzed the serine, threonine and proline-rich domain for predicted protein interactions. ..
  15. Friocourt G, Liu J, Antypa M, Rakic S, Walsh C, Parnavelas J. Both doublecortin and doublecortin-like kinase play a role in cortical interneuron migration. J Neurosci. 2007;27:3875-83 pubmed
    ..Two genes, LIS1 and doublecortin (DCX), have been shown to be responsible for a large proportion of cases of type I lissencephaly...
  16. Bielas S, Serneo F, Chechlacz M, Deerinck T, Perkins G, Allen P, et al. Spinophilin facilitates dephosphorylation of doublecortin by PP1 to mediate microtubule bundling at the axonal wrist. Cell. 2007;129:579-91 pubmed
    ..a Protein-phosphatase 1 (PP1) targeting protein, is responsible for the dephosphorylation of the MAP Doublecortin (Dcx) Ser 297 selectively at the "wrist" of growing axons, leading to activation...
  17. Hevner R, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, et al. Tbr1 regulates differentiation of the preplate and layer 6. Neuron. 2001;29:353-66 pubmed
    ..These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development. ..
  18. Pramparo T, Youn Y, Yingling J, Hirotsune S, Wynshaw Boris A. Novel embryonic neuronal migration and proliferation defects in Dcx mutant mice are exacerbated by Lis1 reduction. J Neurosci. 2010;30:3002-12 pubmed publisher
    Heterozygous LIS1 mutations and males with loss of the X-linked DCX result in lissencephaly, a neuronal migration defect...
  19. Koizumi H, Tanaka T, Gleeson J. Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration. Neuron. 2006;49:55-66 pubmed
    The potential role of doublecortin (Dcx), encoding a microtubule-associated protein, in brain development has remained controversial...
  20. Campbell C, Piper M, Plachez C, Yeh Y, Baizer J, Osinski J, et al. The transcription factor Nfix is essential for normal brain development. BMC Dev Biol. 2008;8:52 pubmed publisher
    ..The delays seen in eye and ear opening and the brain morphology defects appear independent of the nutritional deprivation, as rescue of perinatal lethality with soft dough does not eliminate these defects. ..
  21. Philips G, Stair C, Young Lee H, Wroblewski E, Berberoglu M, Brown N, et al. Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type. Dev Biol. 2005;279:308-21 pubmed
    ..Subsequently, precocious neurons adopted a generic rather than a specific retinal neuron fate. Thus, Pax6 regulates the timing of retinal neurogenesis and couples it with specific neuron differentiation programs. ..
  22. Pawlisz A, Feng Y. Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes. PLoS Biol. 2011;9:e1001172 pubmed publisher
  23. Ohshima T, Hirasawa M, Tabata H, Mutoh T, Adachi T, Suzuki H, et al. Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development. 2007;134:2273-82 pubmed
    ..In addition, proper radial neuronal migration generates an inside-out pattern of cerebral cortex formation and normal axonal trajectories of cortical pyramidal neurons. ..
  24. Tuy F, Saillour Y, Kappeler C, Chelly J, Francis F. Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice. Dev Neurosci. 2008;30:171-86 pubmed
    The doublecortin (DCX) gene, mutated in X-linked human lissencephaly, has 2 close paralogs, doublecortin-like kinase 1 and 2 (Dclk1 and 2)...
  25. Liu J, Schubert C, Fu X, Fourniol F, Jaiswal J, Houdusse A, et al. Molecular basis for specific regulation of neuronal kinesin-3 motors by doublecortin family proteins. Mol Cell. 2012;47:707-21 pubmed publisher
    Doublecortin (Dcx) defines a growing family of microtubule (MT)-associated proteins (MAPs) involved in neuronal migration and process outgrowth...
  26. Nosten Bertrand M, Kappeler C, Dinocourt C, Denis C, Germain J, Phan Dinh Tuy F, et al. Epilepsy in Dcx knockout mice associated with discrete lamination defects and enhanced excitability in the hippocampus. PLoS ONE. 2008;3:e2473 pubmed publisher
    Patients with Doublecortin (DCX) mutations have severe cortical malformations associated with mental retardation and epilepsy. Dcx knockout (KO) mice show no major isocortical abnormalities, but have discrete hippocampal defects...
  27. Deuel T, Liu J, Corbo J, Yoo S, Rorke Adams L, Walsh C. Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth. Neuron. 2006;49:41-53 pubmed
    Although mutations in the human doublecortin gene (DCX) cause profound defects in cortical neuronal migration, a genetic deletion of Dcx in mice produces a milder defect...
  28. Haslinger A, Schwarz T, Covic M, Lie D. Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis. Eur J Neurosci. 2009;29:2103-14 pubmed publisher
    ..These data indicate that Sox11 is involved in the transcriptional regulation of specific gene expression programs in adult neurogenesis at the stage of the immature neuron. ..
  29. Tanaka T, Koizumi H, Gleeson J. The doublecortin and doublecortin-like kinase 1 genes cooperate in murine hippocampal development. Cereb Cortex. 2006;16 Suppl 1:i69-73 pubmed
    The doublecortin (Dcx) and doublecortin-like kinase 1 (Dclk) genes are developmentally expressed neuronal microtubule-associated proteins...
  30. Paliouras G, Hamilton L, Aumont A, Joppé S, Barnabe Heider F, Fernandes K. Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain. J Neurosci. 2012;32:15012-26 pubmed publisher
    ..These findings establish fundamental links between mTOR signaling, proliferation, and aging-associated quiescence in the adult forebrain NSC niche. ..
  31. Omori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, et al. Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. J Hum Genet. 1998;43:169-77 pubmed
    ..Human KIAA0369 was mapped by fluorescence in situ hybridization (FISH) to chromosome 13q13-q14.1. The presence of genes related to neuropathy has been reported in this locus. ..
  32. Simon R, Brylka H, Schwegler H, Venkataramanappa S, Andratschke J, Wiegreffe C, et al. A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis. EMBO J. 2012;31:2922-36 pubmed publisher
    ..Together, our data define an important novel regulatory pathway in hippocampal development, by linking transcriptional functions of Bcl11b to Desmoplakin, a molecule known to act on cell adhesion. ..
  33. Jagasia R, Steib K, Englberger E, Herold S, Faus Kessler T, Saxe M, et al. GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. J Neurosci. 2009;29:7966-77 pubmed publisher
    ..of the neurogenic transcription factor NeuroD and of the neuronal microtubule-associated protein, doublecortin (DCX), and compromises the survival of newborn neurons...
  34. Kappeler C, Saillour Y, Baudoin J, Tuy F, Alvarez C, Houbron C, et al. Branching and nucleokinesis defects in migrating interneurons derived from doublecortin knockout mice. Hum Mol Genet. 2006;15:1387-400 pubmed
    Type I lissencephaly results from mutations in the doublecortin (DCX) and LIS1 genes. We generated Dcx knockout mice to further understand the pathophysiological mechanisms associated with this cortical malformation...
  35. Lin P, Gleeson J, Corbo J, Flanagan L, Walsh C. DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization. J Neurosci. 2000;20:9152-61 pubmed
    Doublecortin (DCX) is a microtubule-associated protein required for neuronal migration to the cerebral cortex...
  36. Klempin F, Kronenberg G, Cheung G, Kettenmann H, Kempermann G. Properties of doublecortin-(DCX)-expressing cells in the piriform cortex compared to the neurogenic dentate gyrus of adult mice. PLoS ONE. 2011;6:e25760 pubmed publisher
    ..Doublecortin (DCX) is a cytoskeleton-associated protein that is expressed transiently in the course of adult neurogenesis...
  37. Spampanato J, Sullivan R, Turpin F, Bartlett P, Sah P. Properties of doublecortin expressing neurons in the adult mouse dentate gyrus. PLoS ONE. 2012;7:e41029 pubmed publisher
    ..Doublecortin (DCX) is an early marker that is expressed in immature granule cells that are beginning migration and dendritic growth ..
  38. Couillard Despres S, Winner B, Schaubeck S, Aigner R, Vroemen M, Weidner N, et al. Doublecortin expression levels in adult brain reflect neurogenesis. Eur J Neurosci. 2005;21:1-14 pubmed
    ..Doublecortin (DCX) has recently been used as a marker for neurogenesis...
  39. Corbo J, Deuel T, Long J, LaPorte P, Tsai E, Wynshaw Boris A, et al. Doublecortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci. 2002;22:7548-57 pubmed
    Doublecortin (DCX) is a microtubule-associated protein that is required for normal neocortical and hippocampal development in humans...
  40. Francis F, Koulakoff A, Boucher D, Chafey P, Schaar B, Vinet M, et al. Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons. Neuron. 1999;23:247-56 pubmed
    ..Our data suggest that the cortical dysgeneses associated with the loss of Doublecortin function might result from abnormal cytoskeletal dynamics in neuronal cell development. ..
  41. Feng Y, Walsh C. Mitotic spindle regulation by Nde1 controls cerebral cortical size. Neuron. 2004;44:279-93 pubmed
    ..Our data show that mitotic spindle function and orientation are essential for normal development of mammalian cerebral cortex. ..
  42. Divya T, Lalitha S, Parvathy S, Subashini C, Sanalkumar R, Dhanesh S, et al. Regulation of Tlx3 by Pax6 is required for the restricted expression of Chrnα3 in Cerebellar Granule Neuron progenitors during development. Sci Rep. 2016;6:30337 pubmed publisher
  43. Tsai P, Ohab J, Kertesz N, Groszer M, Matter C, Gao J, et al. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006;26:1269-74 pubmed
    ..Our results suggest that both EPO and EPOR are essential for early embryonic neural development and that the classical EPOR is important for adult neurogenesis and for migration of regenerating neurons during post-injury recovery. ..
  44. Jiang B, Kumar S, Loh W, Manikandan J, Ling E, Tay S, et al. Global gene expression analysis of cranial neural tubes in embryos of diabetic mice. J Neurosci Res. 2008;86:3481-93 pubmed publisher
  45. Hernández Acosta N, Cabrera Socorro A, Morlans M, Delgado F, Suárez Solá M, Sottocornola R, et al. Dynamic expression of the p53 family members p63 and p73 in the mouse and human telencephalon during development and in adulthood. Brain Res. 2011;1372:29-40 pubmed publisher
  46. Petkau T, Neal S, Orban P, MacDonald J, Hill A, Lu G, et al. Progranulin expression in the developing and adult murine brain. J Comp Neurol. 2010;518:3931-47 pubmed publisher
    ..Our results suggest that progranulin plays distinct roles in neurons and microglia, both of which likely contribute to overall neuronal health and function. ..
  47. Liu Y, Curtis M, Gibbons H, Mee E, Bergin P, Teoh H, et al. Doublecortin expression in the normal and epileptic adult human brain. Eur J Neurosci. 2008;28:2254-65 pubmed publisher
    ..Here we showed that cells expressing doublecortin (Dcx), a microtubule-associated protein expressed in migrating neuroblasts, were present in the hippocampus and temporal ..
  48. Boekhoorn K, Sarabdjitsingh A, Kommerie H, de Punder K, Schouten T, Lucassen P, et al. Doublecortin (DCX) and doublecortin-like (DCL) are differentially expressed in the early but not late stages of murine neocortical development. J Comp Neurol. 2008;507:1639-52 pubmed publisher
    ..The microtubule-associated proteins doublecortin (DCX) and doublecortin-like (DCL) are critically involved in neuronal migration and division, and may function in a ..
  49. Winpenny E, Lebel Potter M, Fernandez M, Brill M, Gotz M, Guillemot F, et al. Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cells. Neural Dev. 2011;6:12 pubmed publisher
  50. Horisawa K, Imai T, Okano H, Yanagawa H. 3'-Untranslated region of doublecortin mRNA is a binding target of the Musashi1 RNA-binding protein. FEBS Lett. 2009;583:2429-34 pubmed publisher
    ..By screening using an mRNA display technique, we found that doublecortin (dcx) mRNA is a specific binding target of Msi1 in vitro...
  51. Brown L, Brown S. Zic2 is expressed in pluripotent cells in the blastocyst and adult brain expression overlaps with makers of neurogenesis. Gene Expr Patterns. 2009;9:43-9 pubmed publisher
    ..The presence of Zic2 in pluripotent cells of the embryo as well as in dividing neural cells in the adult suggests that this transcription factor may have a role in maintaining pluripotency. ..
  52. Götz R, Wiese S, Takayama S, Camarero G, Rossoll W, Schweizer U, et al. Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci. 2005;8:1169-78 pubmed
    ..Our data show that Bag1 is a physiological mediator of extracellular survival signals linked to the cellular mechanisms that prevent apoptosis in hematopoietic and neuronal progenitor cells. ..
  53. Noguchi H, Murao N, Kimura A, Matsuda T, Namihira M, Nakashima K. DNA Methyltransferase 1 Is Indispensable for Development of the Hippocampal Dentate Gyrus. J Neurosci. 2016;36:6050-68 pubmed publisher
    ..Furthermore, we found that Dnmt1 regulates the expression of key extracellular signaling components during developmental stages while modulating intracellular mechanisms for proliferation and neuronal production of NSCs in the adult. ..
  54. Zhou C, Borello U, Rubenstein J, Pleasure S. Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway. Neuroscience. 2006;142:1119-31 pubmed
    ..This analysis demonstrates that canonical Wnt signaling is required for a diverse array of developmental processes in the neocortex in addition to the previously known roles in regulating precursor proliferation and patterning. ..
  55. Coulthard L, Hawksworth O, Li R, Balachandran A, Lee J, Sepehrband F, et al. Complement C5aR1 Signaling Promotes Polarization and Proliferation of Embryonic Neural Progenitor Cells through PKCζ. J Neurosci. 2017;37:5395-5407 pubmed publisher
    ..This work demonstrates mechanisms through which dysregulation of complement causes developmental disease and highlights the potential risk of complement inhibition for therapeutic purposes in pregnancy. ..
  56. Cornell B, Wachi T, Zhukarev V, Toyo oka K. Regulation of neuronal morphogenesis by 14-3-3epsilon (Ywhae) via the microtubule binding protein, doublecortin. Hum Mol Genet. 2016;25:4405-4418 pubmed publisher
    ..Our findings provide the first evidence of cellular pathology in 17p13.3 microduplication syndrome. ..
  57. Dragich J, Kuwajima T, Hirose Ikeda M, Yoon M, Eenjes E, Bosco J, et al. Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain. elife. 2016;5: pubmed publisher
    ..These findings further support the growing indication that macroautophagy plays a key role in the developing CNS. ..
  58. Zou D, McSweeney C, Sebastian A, Reynolds D, Dong F, Zhou Y, et al. A critical role of RBM8a in proliferation and differentiation of embryonic neural progenitors. Neural Dev. 2015;10:18 pubmed publisher
    ..Our studies provide some insight into causes of mental illnesses and will facilitate the development of new therapeutic strategies for neurodevelopmental illnesses. ..
  59. Ogawa R, Ma Y, Yamaguchi M, Ito T, Watanabe Y, Ohtani T, et al. Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration. Development. 2015;142:51-61 pubmed publisher
    ..Pax7(+)MyoD(+) myoblasts (classical daughter cells), and are specifically marked by expression of the doublecortin (Dcx) gene...
  60. Egan C, Nyman U, Skotte J, Streubel G, Turner S, O Connell D, et al. CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression. Dev Cell. 2013;26:223-36 pubmed publisher
    ..These findings provide insights into the regulatory role of CHD5 during neurogenesis and suggest how inactivation of this candidate tumor suppressor might contribute to neuroblastoma. ..
  61. Shibasaki T, Tokunaga A, Sakamoto R, Sagara H, Noguchi S, Sasaoka T, et al. PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus. Cereb Cortex. 2013;23:1824-35 pubmed publisher
    ..5. These findings demonstrated that PTB depletion in the dorsal telencephalon is causally involved in the development of HC and that PTB is important for the maintenance of AJs in the NSCs of the dorsal telencephalon. ..
  62. Khacho M, Clark A, Svoboda D, Maclaurin J, Lagace D, Park D, et al. Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis. Hum Mol Genet. 2017;26:3327-3341 pubmed publisher
    ..These data demonstrate that mitochondrial dysfunction, as observed in genetic mitochondrial and neurodegenerative diseases, underlies the decline of brain function and cognition due to impaired stem cell maintenance and neurogenesis. ..
  63. Liang H, Xiao G, Yin H, Hippenmeyer S, Horowitz J, Ghashghaei H. Neural development is dependent on the function of specificity protein 2 in cell cycle progression. Development. 2013;140:552-61 pubmed publisher
    ..Our findings implicate Sp2-dependent mechanisms as novel regulators of cell cycle progression, the absence of which disrupts neurogenesis in the embryonic and postnatal brain. ..
  64. Hirai S, Cui D, Miyata T, Ogawa M, Kiyonari H, Suda Y, et al. The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. J Neurosci. 2006;26:11992-2002 pubmed
    ..These data suggest that DLK plays a significant role in the coordinated regulation of radial migration and axon projection by modulating JNK activity. ..
  65. Lavado A, Oliver G. Six3 is required for ependymal cell maturation. Development. 2011;138:5291-300 pubmed publisher
    ..In its absence, ependymal cells fail to suppress radial glia characteristics, resulting in a defective lateral wall, abnormal neuroblast migration and differentiation, and hydrocephaly. ..