Gene Symbol: Dctn2
Description: dynactin 2
Alias: 2310042E05Rik, C130077D06Rik, C87049, DCTN-50, GMP23-48K, RBP50, p50, dynactin subunit 2, 50 kDa dynein-associated polypeptide, dynactin complex 50 kDa subunit, growth cone membrane protein 23-48K, p50 dynamitin
Species: mouse
Products:     Dctn2

Top Publications

  1. Hoogenraad C, Akhmanova A, Howell S, Dortland B, De Zeeuw C, Willemsen R, et al. Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. EMBO J. 2001;20:4041-54 pubmed
    ..Taken together, these data suggest that mammalian BICD2 plays a role in the dynein- dynactin interaction on the surface of membranous organelles, by associating with these complexes. ..
  2. Abe T, Tanaka H, Iwanaga T, Odani S, Kuwano R. The presence of the 50-kDa subunit of dynactin complex in the nerve growth cone. Biochem Biophys Res Commun. 1997;233:295-9 pubmed
    ..We found that one such protein, gmp23-48k, corresponds to the 50-kDa subunit (p50) of the dynactin complex...
  3. Moore C, Zernicka Goetz M. PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles. Reproduction. 2005;130:311-20 pubmed
    ..In addition, the microtubule-associated proteins CLASP2 (a CLIP associating protein) and dynactin-p50 are found on kinetochores and a subset of microtubule-organising centres...
  4. Dixit R, Ross J, Goldman Y, Holzbaur E. Differential regulation of dynein and kinesin motor proteins by tau. Science. 2008;319:1086-9 pubmed publisher
    ..The differential modulation of dynein and kinesin motility suggests that MAPs can spatially regulate the balance of microtubule-dependent axonal transport. ..
  5. Lee S, Sunil N, Tejada J, Shea T. Differential roles of kinesin and dynein in translocation of neurofilaments into axonal neurites. J Cell Sci. 2011;124:1022-31 pubmed publisher
    ..These findings suggest that anterograde axonal transport of linear NFs is more dependent upon association with translocating MTs (which are themselves translocated by dynein) than is transport of NF puncta or oligomers. ..
  6. Splinter D, Razafsky D, Schlager M, Serra Marques A, Grigoriev I, Demmers J, et al. BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol Biol Cell. 2012;23:4226-41 pubmed publisher
    ..Our results demonstrate that dynein recruitment to cargo requires concerted action of multiple dynein cofactors...
  7. Uetake Y, Terada Y, Matuliene J, Kuriyama R. Interaction of Cep135 with a p50 dynactin subunit in mammalian centrosomes. Cell Motil Cytoskeleton. 2004;58:53-66 pubmed
    ..To identify Cep135-interacting molecules, we screened yeast two-hybrid libraries. One clone encoded dynamitin, a p50 dynactin subunit, which localized at the centrosome and has been shown to be involved in anchoring microtubules to ..
  8. Yogo K, Mizutamari M, Mishima K, Takenouchi H, Ishida Kitagawa N, Sasaki T, et al. Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Endocrinology. 2006;147:3307-17 pubmed
    ..These results demonstrate that c-Src enhances the translocation of SHIP to podosomes and regulates its function there through the SH2 domain, leading to an attenuation of bone resorption. ..
  9. Abe T, Honda T, Takei K, Mikoshiba K, Hoffman Kim D, Jay D, et al. Dynactin is essential for growth cone advance. Biochem Biophys Res Commun. 2008;372:418-22 pubmed publisher
    ..These results indicate that dynactin, especially the interaction between dynamitin and p150(Glued), plays an essential role in growth cone advance. ..

More Information


  1. Ohbayashi N, Maruta Y, Ishida M, Fukuda M. Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. J Cell Sci. 2012;125:1508-18 pubmed publisher
    ..These findings reveal a new mechanism by which the dynein-dynactin motor complex recognizes Mreg on mature melanosomes through interaction with RILP and is involved in the centripetal movement of melanosomes. ..
  2. Papal S, Cortese M, Legendre K, Sorusch N, Dragavon J, Sahly I, et al. The giant spectrin ?V couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum Mol Genet. 2013;22:3773-88 pubmed publisher
  3. Xu M, Li X, Xiong J, Xia M, Gulbins E, Zhang Y, et al. Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes. Biochim Biophys Acta. 2013;1833:3228-3236 pubmed publisher
  4. Lien W, Gelfand V, Vasioukhin V. Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic. J Cell Biol. 2008;183:989-97 pubmed publisher
  5. Chatin B, Colombier P, Gamblin A, Allouis M, Le Bouffant F. Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5. Biochem J. 2014;463:339-49 pubmed publisher
    ..5 at the cell surface when dynactin-dependent transport was inhibited. The present study strongly suggests that dynamitin is involved in the regulation of Nav1.5 cell-surface density. ..