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Genomes and Genes
| DctSummaryGene Symbol: Dct Description: dopachrome tautomerase Alias: TRP-2, TRP2, Tyrp-2, Tyrp2, slaty, slt, L-dopachrome Delta-isomerase, L-dopachrome tautomerase, SLATY locus protein, tyrosinase-related protein 2, tyrosinase-related protein-2 Species: mouse Top Publications
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Publications
Functional properties of cloned melanogenic proteinsV J Hearing
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
Pigment Cell Res 5:264-70. 1992..They map to the albino, brown, and slaty loci in mice, and encode proteins with similar structures and features, but with distinct catalytic capacities...- Comparative analysis of melanins and melanosomes produced by various coat color mutantsG Prota
Department of Organic and Biological Chemistry, University of Naples, Italy
Pigment Cell Res 8:153-63. 1995..A good correlation was found for expression of (and enzyme activities associated with) TRP1 and TRP2 with eumelanin synthesis and eumelanosome production. - The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somitesP Soriano
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Development 124:2691-700. 1997..These results indicate that PDGFs may exert their functions during early embryogenesis by affecting cell survival and patterning... - TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cellsB R Wong
The Rockefeller University, New York, New York 10021, USA
J Biol Chem 272:25190-4. 1997..These results suggest a role for this TNF-related ligand in the regulation of the T cell-dependent immune response... - The pink-eyed dilution locus controls the biogenesis of melanosomes and levels of melanosomal proteins in the eyeS J Orlow
The Ronald O Perelman Department of Dermatology and the Department of Cell Biology, NYU School of Medicine, 560 First Avenue, New York, NY, 10016, USA
Exp Eye Res 68:147-54. 1999..Our results demonstrate that mutations at the p locus affect the size, number, shape and contents of melanosomes, implicating the p gene product in the normal biogenesis of this organelle... 
The transcription factor Sox10 is a key regulator of peripheral glial developmentS Britsch
Max Delbruck Center for Molecular Medicine, D 13122 Berlin, Germany
Genes Dev 15:66-78. 2001..Haploinsufficiency of Sox10 can thus cause pigmentation and megacolon defects, which are also observed in Sox10(Dom)/+ mice and in patients with Waardenburg-Hirschsprung disease caused by heterozygous SOX10 mutations...- A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomeraseK Tsukamoto
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
EMBO J 11:519-26. 1992..We now report that TRP-2 (tyrosinase related protein-2), which maps to and is mutated at the slaty locus in mice, encodes a protein with DOPAchrome tautomerase activity. - Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse modelE M Southard-Smith
Mouse Embryology Section, Laboratory of Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4472, USA
Nat Genet 18:60-4. 1998..Our studies suggest that Sox10 is essential for proper peripheral nervous system development. We propose SOX10 as a candidate disease gene for individuals with HSCR whose disease does not have an identified genetic origin... - Analysis of SOX10 function in neural crest-derived melanocyte development: SOX10-dependent transcriptional control of dopachrome tautomeraseS B Potterf
Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
Dev Biol 237:245-57. 2001..for the Sox10(Dom) mutation entirely lack neural crest-derived cells expressing the lineage marker KIT, MITF, or DCT. Moreover, neural crest cell cultures derived from homozygous embryos do not give rise to pigmented cells... - A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutationCherie Rao
Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02476, USA
Development 130:4665-72. 2003..elegans. Our results suggest that the role of ADAMTS proteases in the regulation of cell migration has been conserved in mammalian development... - Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanomaArlo J Miller
Dana Farber Cancer Institute and Children s Hospital, Department of Pediatric Hematology Oncology, Boston, Massachusetts, USA
Cancer Res 64:509-16. 2004..These studies identify MITF as a major transcriptional regulator of TRPM1 and suggest that its prognostic value may be linked to MITF-mediated regulation of cellular differentiation... - Melanocytes and pigmentation are affected in dopachrome tautomerase knockout miceLaurence Guyonneau
Molecular Oncology, Swiss Institute for Experimental Cancer Research, National Center of Competence in Research, 1066 Epalinges, Switzerland
Mol Cell Biol 24:3396-403. 2004..In comparison to the knockout, the slaty mutation (Dct(slt)/Dct(slt)) has less melanin and affects growth of primary melanocytes severely... - The role of Pax2 in mouse inner ear developmentQuianna Burton
National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
Dev Biol 272:161-75. 2004.... - Requirement for Mab21l2 during development of murine retina and ventral body wallRyuichi Yamada
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, 630 0101, Japan
Dev Biol 274:295-307. 2004..Our results reveal that Mab21l2 plays crucial roles in retina and in ventral body wall formation... - Tyrosinase-related protein-2 and -1 are trafficked on distinct routes in B16 melanoma cellsGabriela Negroiu
Institute of Biochemistry of the Romanian Academy, Splaiul Independentei 296, 060031 Bucharest 17, Romania
Biochem Biophys Res Commun 328:914-21. 2005..These data show that highly structural homologous glycoproteins use distinct trafficking pathways in the same cell... - Tyrosinase processing and intracellular trafficking is disrupted in mouse primary melanocytes carrying the underwhite (uw) mutation. A model for oculocutaneous albinism (OCA) type 4Gertrude E Costin
Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Sci 116:3203-12. 2003..dark vesicles that contain tyrosinase and two other melanogenic enzymes, Tyrp1 (tyrosinase-related protein 1) and Dct (DOPAchrome tautomerase); this secretory process is not seen in wild-type melanocytes... - Mutation of melanosome protein RAB38 in chocolate miceStacie K Loftus
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:4471-6. 2002..This study demonstrates the utility of expression profile analysis to identify mammalian disease genes... 
Impaired stria vascularis integrity upon loss of E-cadherin in basal cellsMark Oliver Trowe
Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
Dev Biol 359:95-107. 2011....- Specific expression of the retinoic acid-synthesizing enzyme RALDH2 during mouse inner ear developmentR Romand
Laboratoire de Neurobiologie, Universite Blaise Pascal, 63177 Cedex, Aubiere, France
Mech Dev 106:185-9. 2001..Raldh2 mesenchymal expression did not correlate with migrating neural crest-derived melanoblasts. These restricted expression domains may correspond to specific sites of RA synthesis during inner ear morphogenesis... - Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutantC S Lee
Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland 21210, USA
Dev Biol 236:17-29. 2001..This defect is specific to the ventral region of the RPE. Using molecular markers for RPE (Mi and Tyrp2) and NR (Math5), we demonstrate that there is a gradual loss of Mi and Tyrp2 expression and an appearance of Math5 .. - Tyrosinase gene expression in zebrafish embryosE Camp
Department of Molecular Biosciences Genetics, University of Adelaide, 5005 Adelaide, Australia
Dev Genes Evol 211:150-3. 2001..A wave of gene activation and cell migration is then observed moving towards the posterior of the animal. DOPA staining for tyrosinase activity shows the presence of active enzyme in embryos at least 3 h before visible pigmentation... - Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survivalB Wehrle-Haller
Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403 1254, USA
Dev Biol 232:471-83. 2001..We further suggest that the MGF mediates MP migration through a signaling pathway that does not involve RAS... - Cloning and analysis of gene regulation of a novel LPS-inducible cDNAC G Lee
Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
Immunogenetics 41:263-70. 1995..By interspecific back-cross analysis, Irg1 was mapped to mouse chromosome 14 linked to Tyrp2 and Rap2a. The IRG1 message appears 1... - Vax genes ventralize the embryonic eyeStina H Mui
Molecular Neurobiology Laboratory, The Salk Institute La Jolla, California 92037, USA
Genes Dev 19:1249-59. 2005.... - Altered melanocyte differentiation and retinal pigmented epithelium transdifferentiation induced by Mash1 expression in pigment cell precursorsJessica L Lanning
Department of Dermatology, Henry Ford Health System, Detroit, Michigan, USA
J Invest Dermatol 125:805-17. 2005..factor Mash1 was expressed early in pigment cell development in transgenic mice from the dopachrome tautomerase (Dct) promoter. Dct:Mash1 transgenic founders exhibit variable microphthalmia and patchy coat color hypopigmentation... - The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10Pooja Agarwal
Cardiovascular Research Institute, University of California, San Francisco, CA 94158 2517, USA
Development 138:2555-65. 2011.... - Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neuronsRolf W Stottmann
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
Dev Dyn 240:755-65. 2011..Our results also demonstrate a requirement for BMP signaling in patterning of dorsal neural tube cell fate and in neural crest cell formation, and imply a critical period shortly before neural tube closure... - The developmental role of Agouti in color pattern evolutionMarie Manceau
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Science 331:1062-5. 2011..Thus, natural selection favors late-acting, tissue-specific changes in embryonic Agouti expression to produce large changes in adult color pattern... - Hair follicle stem cells provide a functional niche for melanocyte stem cellsShintaro Tanimura
Department of Stem Cell Medicine, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
Cell Stem Cell 8:177-87. 2011.... - Key roles for transforming growth factor beta in melanocyte stem cell maintenanceEmi K Nishimura
Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo 101 0062, Japan
Cell Stem Cell 6:130-40. 2010..These data demonstrate that the TGF-beta signaling pathway is one of the key niche factors that regulate melanocyte stem cell immaturity and quiescence... - Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skinIgor Adameyko
Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden
Cell 139:366-79. 2009..These results reveal SCPs as a cellular origin of melanocytes, and have broad implications on the molecular mechanisms regulating skin pigmentation during development, in health and pigmentation disorders... - NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferationKristina Buac
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Pigment Cell Melanoma Res 22:773-84. 2009..We propose that targeting ERBB3 activation and downstream genes identified in this study may provide novel therapeutic interventions for malignant melanoma... - The transcription factor Sox5 modulates Sox10 function during melanocyte developmentC Claus Stolt
Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
Nucleic Acids Res 36:5427-40. 2008..Both binding site competition and recruitment of corepressors thus help Sox5 to modulate the activity of Sox10 in the melanocyte lineage... - Timeline and distribution of melanocyte precursors in the mouse heartFlavia Carneiro Brito
Department of Biological Sciences, Florida International University, Miami, Florida 33199, USA
Pigment Cell Melanoma Res 21:464-70. 2008..In this study, we tracked cardiac melanoblasts using in situ hybridization with a dopachrome tautomerase (Dct) probe and Dct-LacZ transgenic mice... - High levels of melanin-related metabolites in plasma from pink-eyed dilution miceKazumasa Wakamatsu
Pigment Cell Res 20:222-4. 2007 - Changes of melanosome morphology associated with the differentiation of epidermal melanocytes in slaty miceTomohisa Hirobe
Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
Anat Rec (Hoboken) 290:981-93. 2007The slaty (Dct(slt)) mutation is known to reduce the activity of dopachrome tautomerase, which converts dopachrome to 5,6-dihydroxyindole-2-carboxylic acid in the pathway of eumelanin synthesis and to inhibit melanosome maturation in .. - Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndromeTom Van de Putte
Laboratory of Molecular Biology Celgen, KULeuven, Herestraat 49, B 3000 Leuven, Belgium
Hum Mol Genet 16:1423-36. 2007.... - The slaty mutation affects the morphology and maturation of melanosomes in the mouse melanocytesTomohisa Hirobe
Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba, Japan
Pigment Cell Res 19:454-9. 2006The slaty (Dct(slt)) mutation is known to reduce the activity of dopachrome tautomerase in melanocytes and to reduce the melanin content in skin, hairs and eyes... - Dopachrome tautomerase (Dct) regulates neural progenitor cell proliferationZhongxian Jiao
Department of Neurology, Henry Ford Health Sciences Center, 2799 West Grand Boulevard, Detroit, MI 48202, USA
Dev Biol 296:396-408. 2006DOPAchrome tautomerase (Dct) functions downstream of tyrosinase in the biosynthetic pathway of eumelanin by catalyzing the conversion of dopachrome to 5,5-dihydroxyindole-2-carboxylic acid (DHICA) in pigment cells... - Molecular mechanisms underlying inner ear patterning defects in kreisler mutantsDaniel Choo
Department of Otolaryngology Head and Neck Surgery, Center for Hearing and Deafness Research, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, OH 45229 3039, USA
Dev Biol 289:308-17. 2006..The data also identify Gbx2, Dlx5, Wnt2b and Otx2 as key otic genes ultimately affected by perturbation of the kr/mafB-hindbrain pathway... - Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eyeR Ashery-Padan
Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Goettingen D 37077, Germany
Genes Dev 14:2701-11. 2000.... - MGF (KIT ligand) is a chemokinetic factor for melanoblast migration into hair folliclesS A Jordan
MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom
Dev Biol 225:424-36. 2000..We have utilised an organ culture for embryonic skin taken from Dct-lacZ transgenic mice... - Tyrosinase and related proteins in mammalian pigmentationV del Marmol
LOCE, Institut J Bordet, Universite Libre de Bruxelles, Belgium
FEBS Lett 381:165-8. 1996..We will discuss recent findings on genomic organization, and on the proteins and their presumed function, which is important for eumelanin synthesis in mouse and man... - Fine structure mapping and deletion analysis of the murine piebald locusD L Metallinos
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey 08544
Genetics 136:217-23. 1994..Two anchor loci of chromosome 14, slaty and hypogonadal, in addition to simple sequence length repeat markers, were used to localize s to a 2-cM interval .. - Assignment of the tyrosinase-related protein-2 gene (TYRP2) to human chromosome 13q31-q32 by fluorescence in situ hybridization: extended synteny with mouse chromosome 14R A Sturm
Centre for Molecular Biology and Biotechnology, University of Queensland, Brisbane, Australia
Genomics 21:293-6. 1994 - Functional analysis of the slaty gene product (TRP2) as dopachrome tautomerase and the effect of a point mutation on its catalytic functionG Kroumpouzos
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
Biochem Biophys Res Commun 202:1060-8. 1994..Recently, a gene encoding a homologue of the melanogenic enzyme tyrosinase (termed tyrosinase related protein 2 or TRP2) was cloned and was subsequently mapped to the slaty locus on chromosome 14... - Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytesW J Pavan
Department of Molecular Biology, Princeton University, NJ 08544 1014
Proc Natl Acad Sci U S A 91:7159-63. 1994..The non-uniform distribution of melanoblasts in wild-type mice suggests that piebald acts stochastically to affect melanocyte development... - High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complexS J Orlow
Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York
J Invest Dermatol 103:196-201. 1994.... - Dopachrome tautomerase is a zinc-containing enzymeF Solano
Dept of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, Spain
Biochem Biophys Res Commun 204:1243-50. 1994..This enzyme, also named TRP2, belongs to the family of the tyrosinase related proteins... - The role of Pax-6 in eye and nasal developmentJ C Grindley
Developmental Genetics Section, Western General Hospital, Edinburgh, UK
Development 121:1433-42. 1995.... - Mutations at the W locus affect survival of neural crest-derived melanocytes in the mouseJ Cable
MRC Institute of Hearing Research, University Park, Nottingham, UK
Mech Dev 50:139-50. 1995..These results suggest that mutations of the c-kit receptor tyrosine kinase encoded at the W locus do not alter early migration or differentiation of melanoblasts but severely affect melanoblasts survival... - Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathwayB Wehrle-Haller
Institute of Neuroscience, University of Oregon, Eugene 97403
Development 121:731-42. 1995..In contrast, membrane-bound Steel factor appears to promote melanocyte precursor survival in the dermis... - Changes in expression of putative antigens encoded by pigment genes in mouse melanomas at different stages of malignant progressionS J Orlow
Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York 10016, USA
Proc Natl Acad Sci U S A 92:10152-6. 1995..within and among tumors in levels of mRNAs and proteins encoded by the wild-type alleles at the albino, brown, slaty, and silver loci... - A cDNA encoding tyrosinase-related protein maps to the brown locus in mouseI J Jackson
Medical Research Council Clinical, Western General Hospital, Edinburgh, United Kingdom
Proc Natl Acad Sci U S A 85:4392-6. 1988..All b mutations in laboratory strains are associated with the same diagnostic Taq I fragment, suggesting that all derive from the same original mutation. I discuss possible function(s) of the tyrosinase-related protein... - Identification of genes differentially expressed in B16 murine melanoma sublines with different metastatic potentialsT Ishiguro
Laboratory of Biomedical Research, University of Tokyo, Japan
Cancer Res 56:875-9. 1996..TI-241 may regulate the expression of various genes as a transcription factor in the complex process of metastasis... - Tyrosinase-related protein-2 (DCT; TYRP2) maps to bovine chromosome 12G A Hawkins
DNA Research and Testing Laboratory, ABS Global, Inc, DeForest, Wisconsin 53532, USA
Mamm Genome 7:474-5. 1996 - The genetics of pigmentation: from fancy genes to complex traitsG S Barsh
Department of Pediatrics, Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305 5428, USA
Trends Genet 12:299-305. 1996..Recent developments show that homologous genes in humans are responsible not only for rare diseases, such as albinism and piebaldism, but also for common phenotypic variations, such as red hair and fair skin... - Tyrosinase-related protein 2 promoter targets transgene expression to ocular and neural crest-derived tissuesS Zhao
Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
Dev Biol 216:154-63. 1999..we generated transgenic mice carrying the lacZ reporter gene linked to the tyrosinase-related protein 2 (TRP2) promoter... - Altered cell-surface targeting of stem cell factor causes loss of melanocyte precursors in Steel17H mutant miceB Wehrle-Haller
Department of Pathology, Centre Medical Universitaire, 1, rue Michel Servet, Geneva 4, 1211, Switzerland
Dev Biol 210:71-86. 1999.... - Hepatocyte growth factor/scatter factor-MET signaling in neural crest-derived melanocyte developmentL Kos
Laboratory for Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4472, USA
Pigment Cell Res 12:13-21. 1999..c. These results demonstrate that HGF/SF-MET signaling influences, but is not required for, the initial development of neural crest-derived melanocytes in vivo and in vitro... - Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differentlyA Nakayama
Laboratory of Developmental Neurogenetics, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Mech Dev 70:155-66. 1998..In wild type embryos, Mitf expression in neuropithelium and neural crest precedes that of the melanoblast marker Dct, is then co-expressed with Dct, and gradually fades away except in cells in hair follicles... - Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factorK Opdecamp
Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Development 124:2377-86. 1997..In the trunk region of wild-type embryos, Mitf-expressing cells that coexpressed the melanoblast marker Dct and the tyrosine kinase receptor Kit were found in the dorsolateral neural crest migration pathway... - Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryosF Bernex
URA INRA de Génétique Moleculaire, Ecole Nationale Veterinaire d Alfort, Maisons Alfort, France
Development 122:3023-33. 1996..Nevertheless, we assume that the Kit/SCF pathway could be involved in the growth of transformed endothelial, epithelial and endocrine cells... - Comparative linkage mapping of human chromosome 13 and bovine chromosome 12H S Sun
Department of Animal Sciences, University of Wisconsin, Madison 53706, USA
Genomics 39:47-54. 1997..One intrachromosomal rearrangement was detected in this linkage group relative to human, and this rearrangement was confirmed by fluorescence in situ hybridization results... - A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locusI J Jackson
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
EMBO J 11:527-35. 1992..The gene encoding TRP-2 maps to mouse chromosome 14, in the region of the coat colour mutation slaty. We show that the TRP-2 of slaty mice has a single amino acid difference from wild-type TRP-2; a substitution of .. - Pigmentation genes: the tyrosinase gene family and the pmel 17 gene familyB S Kwon
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202
J Invest Dermatol 100:134S-140S. 1993..the tyrosinase gene family, which is comprised of tyrosinase (c locus), gp75 (b locus) and DOPAchrome tautomerase (slt locus)... - Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggersMark D Levin
Penn Cardiovascular Institute and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 119:3420-36. 2009..The melanin synthesis enzyme dopachrome tautomerase (DCT) is involved in intracellular calcium and reactive species regulation in melanocytes... - Tyrosinase stabilization by Tyrp1 (the brown locus protein)T Kobayashi
Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda Maryland 20892, USA
J Biol Chem 273:31801-5. 1998..Tyrp1 (or TRP1) and 3,4-dihydroxyphenylalanine-chrome tautomerase (Dct or TRP2) encoded at the Tyrp1/brown and Dct/slaty loci, respectively... - Syntenic assignment of dopamine tautomerase (DCT) to bovine chromosome 12H S Sun
Department of Animal Sciences, University of Wisconsin, Madison, California 53706, USA
Anim Genet 27:421-2. 1996.... - Excess tyrosine restores the morphology and maturation of melanosomes affected by the murine slaty mutationTomohisa Hirobe
Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba, Japan
Zoolog Sci 24:338-45. 2007The slaty (Dct(slt)) mutation is known to reduce the activity of dopachrome tautomerase in melanocytes and to reduce the melanin content in the skin, hairs, and eyes... - Multiple roles of Notch signaling in the regulation of epidermal developmentMariko Moriyama
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, MGH East, Building 149, 13th Street, Charlestown, MA 02129, USA
Dev Cell 14:594-604. 2008..Overall, we conclude that Notch signaling orchestrates the balance between differentiation and immature programs in suprabasal cells during epidermal development... - Modulation of melanogenic protein expression during the switch from eu- to pheomelanogenesisT Kobayashi
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Sci 108:2301-9. 1995..g. TRP1 encoded at the brown locus and TRP2 encoded at the slaty locus) regulate eumelanogenesis catalytically at steps distal to tyrosinase (as 5,6-dihydroxyindole-2-carboxylic .. - Genetic evidence does not support direct regulation of EDNRB by SOX10 in migratory neural crest and the melanocyte lineageRamin Mollaaghababa Hakami
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4472, USA
Mech Dev 123:124-34. 2006..Given that SOX10 directly activates Ednrb in the enteric nervous system, our results suggest that SOX10 may differentially activate target genes based on the particular cellular context... - HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligoCecele J Denman
Department of Pathology Oncology Institute, Loyola University Chicago, Chicago, Illinois 60153, USA
J Invest Dermatol 128:2041-8. 2008..Cytotoxicity toward targets loaded with a K(b)-restricted tyrosinase-related protein 2-derived peptide correlated with depigmentation. The data presented strongly support a role for HSP70i in progressive depigmentation in vivo...
Research Grants
- Genetics of Dark Skin in MiceGregory Barsh; Fiscal Year: 2006....
- SIGNAL TRANSDUCTION AND MOUSE DEVELOPMENTPhilippe Soriano; Fiscal Year: 2007..These studies should help us understand growth factor regulatory mechanisms, and provide information on the specificity and interplay of growth factor signaling pathways in physiological processes. ..
- A preclinical trial of intratympanic antivirals for CMV-related hearing lossDaniel Choo; Fiscal Year: 2007..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..
- MEDICAL SCIENTIST TRAINING PROGRAMGregory Barsh; Fiscal Year: 2007..We propose to continue this trend of innovation and interdisciplinary training, in which training grant resources are leveraged, and 9 - 10 individuals are admitted per year for a program length of 7- 8 years. ..
- Attractin and Mahoganoid in Spongy NeurodegenerationGregory Barsh; Fiscal Year: 2007..Investigating the biochemical, cellular, and genetic relationships between Atrn, Mahoganoid, and PrP is likely to provide general insight into the pathogenesis of spongy degeneration. ..
- A preclinical trial of intratympanic antivirals for CMV-related hearing lossDaniel I Choo; Fiscal Year: 2010..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..
- Genetic dissection of pigment dispersing iris diseaseMICHAEL GARY ANDERSON; Fiscal Year: 2010..Our objective in this proposal is to test the genetic pathways contributing to phenotypes of this mouse strain and test the significance of these genes among human pseudoexfoliation patients. ..
- A preclinical trial of intratympanic antivirals for CMV-related hearing lossDaniel Choo; Fiscal Year: 2009..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..
- REGULATION OF ENERGY BALANCE BY MELANOCORTIN ANTAGONISTSGregory Barsh; Fiscal Year: 2003..abstract_text> ..
- Molecular Development of the Endolymphatic Duct and SacDaniel Choo; Fiscal Year: 2005..Significantly, this proposal includes challenging but achievable goals that will provide important knowledge to the field of inner ear development. ..
- Genetic dissection of pigment dispersing iris diseaseMICHAEL GARY ANDERSON; Fiscal Year: 2010..Our objective in this proposal is to test the genetic pathways contributing to phenotypes of this mouse strain and test the significance of these genes among human pseudoexfoliation patients. ..