Dcn

Summary

Gene Symbol: Dcn
Description: decorin
Alias: DSPG2, PG40, PGII, PGS2, SLRR1B, mDcn, bone proteoglycan II
Species: mouse

Top Publications

  1. ncbi Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration
    R Merline
    Pharmazentrum frankfurt ZAFES, Institut fur Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe Universität Frankfurt am Main, Germany
    J Physiol Pharmacol 60:5-13. 2009
  2. pmc Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility
    K G Danielson
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biol 136:729-43. 1997
  3. ncbi Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
  4. doi Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice
    Kornélia Baghy
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Lab Invest 91:439-51. 2011
  5. ncbi The small proteoglycan biglycan is associated with thick collagen fibrils in the mouse decidua
    S San Martin
    Laboratory of Biology of Reproduction, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900 Sao Paulo, SP Brazil
    Cell Mol Biol (Noisy-le-grand) 49:673-8. 2003
  6. pmc Decorin modulates collagen matrix assembly and mineralization
    Yoshiyuki Mochida
    Dental Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, United States
    Matrix Biol 28:44-52. 2009
  7. ncbi Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues
    A Corsi
    Department of Experimental Medicine, Universita dell Aquila, Italy
    J Bone Miner Res 17:1180-9. 2002
  8. ncbi Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development
    Guiyun Zhang
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biochem 98:1436-49. 2006
  9. doi Decorin suppresses bone metastasis in a breast cancer cell line
    Kentaro Araki
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan
    Oncology 77:92-9. 2009
  10. ncbi The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis
    Claus Rühland
    Department of Physiological Chemistry and Pathobiochemistry, University of Munster, Germany
    FEBS J 274:4246-55. 2007

Scientific Experts

  • Daniela G Seidler
  • Sara M Weis
  • P M Coan
  • Sunil Wadhwa
  • Liliana Schaefer
  • Lisa Shaw
  • R V Iozzo
  • Ayman Al Haj Zen
  • L Hakkinen
  • Elke Schonherr
  • E L Brown
  • Telma Mt Zorn
  • Enrique Brandan
  • Claudio Cabello-Verrugio
  • Shoujun Chen
  • Kornélia Baghy
  • Xiuli Bi
  • David E Birk
  • Guiyun Zhang
  • Oliver Jungmann
  • Christian Stock
  • Rick T Owens
  • Mara S Ludwig
  • Marian F Young
  • S San Martin
  • Young Hyun You
  • Carla Bocian
  • Giorgio Giacomo Galli
  • Ilona Kovalszky
  • Jean Denis Bénazet
  • Mei Sun
  • Michiko Ichii
  • Winston W Y Kao
  • Zsuzsa Schaff
  • Rosetta Merline
  • M Ward
  • Cinzia L Marchica
  • Emi Hiroki
  • K P Goetsch
  • Grace Guzman
  • Wenjin Liu
  • Yanjun Gu
  • Wancai Yang
  • Kumar Sharma
  • Yoshiaki Ito
  • Tsuyoshi Hikake
  • Yuxiang Zhang
  • Naoto Haruyama
  • R Merline
  • Kentaro Araki
  • Yoshiyuki Mochida
  • Susan M Faust
  • Valentina Pinelli
  • Zishu Pan
  • Yasuhiro Kishioka
  • Cristian Santander
  • Francesco G Salerno
  • Kevin Jon Williams
  • Stefano Biressi
  • Adam S Raefski
  • Jinhong Zhu
  • Claus Rühland
  • Manoranjan Santra
  • David J McQuillan
  • K G Danielson
  • Jaime Gutierrez
  • Millicent M Sullivan
  • Rebeca Droguett
  • Anita Fust
  • Umashankar Singh
  • Yanming Bi
  • Magnus Hook
  • Fang Ting Liang
  • Ken Iseki
  • Tetsuji Mori
  • Michael D Ross
  • In Kyung Park
  • Sachihiko Yokoya
  • Tracey A Dugan
  • Seita Hagino
  • Akio Wanaka
  • Hugo C Olguin
  • Manolis Mavroidis
  • Yosuke Mizuno
  • Mauricio Soto-Suazo
  • A Corsi
  • Zsolt Horvath
  • Karin Jandeleit-Dahm
  • Shinichi Okada
  • Katalin Kiss

Detail Information

Publications87

  1. ncbi Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration
    R Merline
    Pharmazentrum frankfurt ZAFES, Institut fur Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe Universität Frankfurt am Main, Germany
    J Physiol Pharmacol 60:5-13. 2009
    ..In the present study we used decorin-deficient mice (Dcn(-/-)) to further elucidate the molecular mechanisms involved in the protective action of decorin in diabetes...
  2. pmc Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility
    K G Danielson
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biol 136:729-43. 1997
    ..These findings demonstrate a fundamental role for decorin in regulating collagen fiber formation in vivo...
  3. ncbi Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
    ..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs...
  4. doi Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice
    Kornélia Baghy
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Lab Invest 91:439-51. 2011
    ..In this study we used decorin-null (Dcn-/-) mice to establish the role of decorin in experimental liver fibrosis and repair...
  5. ncbi The small proteoglycan biglycan is associated with thick collagen fibrils in the mouse decidua
    S San Martin
    Laboratory of Biology of Reproduction, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900 Sao Paulo, SP Brazil
    Cell Mol Biol (Noisy-le-grand) 49:673-8. 2003
    ..These results strongly indicate that biglycan plays a role in collagen fibrillogenesis and probably participates in the determination of collagen fibril thickness in the mouse decidua...
  6. pmc Decorin modulates collagen matrix assembly and mineralization
    Yoshiyuki Mochida
    Dental Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, United States
    Matrix Biol 28:44-52. 2009
    Decorin (DCN) is one of the major matrix proteoglycans in bone...
  7. ncbi Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues
    A Corsi
    Department of Experimental Medicine, Universita dell Aquila, Italy
    J Bone Miner Res 17:1180-9. 2002
    Decorin (dcn) and biglycan (bgn), two members of the family of small leucine-rich proteoglycans (SLRPs), are the predominant proteoglycans expressed in skin and bone, respectively...
  8. ncbi Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development
    Guiyun Zhang
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biochem 98:1436-49. 2006
    ..Our findings indicate that decorin is a key regulatory molecule and that the temporal switch from biglycan to decorin is an important event in the coordinate regulation of fibrillogenesis and tendon development...
  9. doi Decorin suppresses bone metastasis in a breast cancer cell line
    Kentaro Araki
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan
    Oncology 77:92-9. 2009
    ..These results demonstrate a novel role for decorin in the reduction or prevention of tumor metastases in this breast cancer model and could eventually lead to improved therapies for metastatic breast cancer...
  10. ncbi The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis
    Claus Rühland
    Department of Physiological Chemistry and Pathobiochemistry, University of Munster, Germany
    FEBS J 274:4246-55. 2007
    ..Glycosaminoglycan-free decorin, generated by mutating Ser4 of the mature protein core into Ala (DCN-S4A), showed reduced inhibition of fibrillogenesis compared with the decorin proteoglycan...
  11. doi Decorin and chondroitin-6 sulfate inhibit B16V melanoma cell migration and invasion by cellular acidification
    Christian Stock
    Institute of Physiology II, Munster University, UKM, Munster, Germany
    J Cell Physiol 226:2641-50. 2011
    ..We show a so far unknown function of decorin and chondroitin-6-sulfate: their ability to inhibit B16V cell migration by intracellular acidification...
  12. ncbi Small leucine-rich proteoglycans (SLRPs) in uterine tissues during pregnancy in mice
    S San Martin
    Laboratory of Biology of Reproduction, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Reproduction 125:585-95. 2003
    ..As decorin has been shown to inhibit lateral association of collagen fibrils, its disappearance between day 2 and day 5 of pregnancy may be a prerequisite for the formation of large fibrils in decidua in mice...
  13. pmc Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation
    Xiuli Bi
    Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Carcinogenesis 29:1435-40. 2008
    ..To elucidate the importance of decorin in intestinal carcinogenesis, a decorin-deficient (Dcn(-/-)) mouse model was employed...
  14. pmc Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis
    R V Iozzo
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 96:3092-7. 1999
    ....
  15. ncbi A role for decorin in the structural organization of periodontal ligament
    L Hakkinen
    Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
    Lab Invest 80:1869-80. 2000
    ..The findings demonstrate that decorin plays a role in the organization of collagen fibrils and regulates cell proliferation in the periodontal ligament...
  16. pmc Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin
    Liliana Schaefer
    Departments of Internal Medicine D, University of Munster, Munster, Germany
    Am J Pathol 170:301-15. 2007
    ..This study provides evidence for the involvement of decorin and the IGF-I receptor/mTOR/p70 S6 kinase signaling pathway in the translational regulation of fibrillin-1...
  17. ncbi A physiologic three-dimensional cell culture system to investigate the role of decorin in matrix organisation and cell survival
    Daniela G Seidler
    Department of Physiological Chemistry and Pathobiochemistry, Waldeyerstr 15, University Hospital Munster, University of Munster, D 48149 Munster, Germany
    Biochem Biophys Res Commun 332:1162-70. 2005
    ..In the early phases of the three-dimensional culture, decorin reduced apoptosis. However, following the establishment of a three-dimensional matrix, the cells did not require decorin for their survival...
  18. pmc The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis
    Oliver Jungmann
    Insitute of Physiological Chemistry and Pathobiochemistry, University Hospital Munster, Munster, Germany
    PLoS ONE 7:e50809. 2012
    ..Decorin-null (Dcn(-/-)) mice display a phenotype similar to that of EDS patients...
  19. doi The role for decorin in delayed-type hypersensitivity
    Daniela G Seidler
    Institute of Physiological Chemistry and Pathobiochemistry, D 48149 Munster, Germany
    J Immunol 187:6108-19. 2011
    ..in a mouse model of contact allergy (oxazolone-mediated delayed-type hypersensitivity [DTH]) in decorin-deficient (Dcn(-/-)) and wild-type mice...
  20. ncbi Decorin deficiency leads to impaired angiogenesis in injured mouse cornea
    Elke Schonherr
    Institute of Physiological Chemistry and Pathobiochemistry, University and University Hospital of Münster, Munster, Germany
    J Vasc Res 41:499-508. 2004
    ..We investigated consequences of the targeted ablation of decorin (DCN), biglycan (BGN) and fibromodulin (FMOD) genes on inflammation-induced angiogenesis in the cornea...
  21. pmc Protective niche for Borrelia burgdorferi to evade humoral immunity
    Fang Ting Liang
    Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Pathol 165:977-85. 2004
    ..These data suggest that spirochetal DbpA may interact with host decorin during infection and such interactions could be a mechanism that B. burgdorferi uses to evade humoral immunity and establish chronic infection...
  22. pmc Resistance to Lyme disease in decorin-deficient mice
    E L Brown
    The Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Albert B Alkek Institute of Biosciences and Technology, Houston, Texas 77030, USA
    J Clin Invest 107:845-52. 2001
    ..A decorin-deficient (Dcn(-/-)) mouse was recently developed and found to have a relatively mild phenotype...
  23. ncbi A novel modulatory mechanism of transforming growth factor-beta signaling through decorin and LRP-1
    Claudio Cabello-Verrugio
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad Millennium Institute for Fundamental and Applied Biology MIFAB, Pontificia Universidad Catolica de Chile, Casilla 114 D Santiago, Chile
    J Biol Chem 282:18842-50. 2007
    ..Decorin null (Dcn null) myoblasts showed a diminished TGF-beta response that is restored by decorin re-expression...
  24. ncbi The low density lipoprotein receptor-related protein functions as an endocytic receptor for decorin
    Enrique Brandan
    Centro de Regulación Celular y Patología Joaquín V Luco, CRCP, Departamento de Biologia Celular y Molecular, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Biol Chem 281:31562-71. 2006
    ..These findings point to LRP-mediated catabolism as a new control pathway for the biological activities of decorin, specifically for its ability to influence extracellular matrix signaling...
  25. ncbi The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation
    T Scholzen
    Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    J Biol Chem 269:28270-81. 1994
    ..In contrast, the major parenchymal organs were only weakly positive for decorin mRNA. These findings suggest that decorin may play a role in epithelial/mesenchymal interactions during organ development and shaping...
  26. pmc Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury
    Liliana Schaefer
    Medizinische Klinik und Poliklinik D, Albert Schweitzer Str 33, 48149 Munster, Germany
    Am J Pathol 165:383-96. 2004
    ..Our results indicate a novel role for decorin and biglycan during pressure-induced renal injury by stimulating fibrillin-1 expression...
  27. doi Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21
    Rosetta Merline
    1Pharmazentrum Frankfurt, Institut fur Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe Universität Frankfurt am Main, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Sci Signal 4:ra75. 2011
    ..Thus, by stimulating proinflammatory PDCD4 and decreasing the abundance of miR-21, decorin signaling boosts inflammatory activity in sepsis and suppresses tumor growth...
  28. pmc Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone
    Giorgio Giacomo Galli
    Biotech Research and Innovation Centre and Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark
    PLoS Genet 8:e1002711. 2012
    ..Collectively, our results define a novel role for Prdm5 in sustaining the transcriptional program necessary to the proper assembly of osteoblastic extracellular matrix...
  29. pmc Role of Nox2 in diabetic kidney disease
    Young Hyun You
    Center for Renal Translational Medicine, Division of Nephrology Hypertension, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Am J Physiol Renal Physiol 304:F840-8. 2013
    ..The present results demonstrate that lack of Nox2 does not protect against diabetic kidney disease in type 1 diabetes, despite a reduction in macrophage infiltration. The lack of renoprotection may be due to upregulation of renal Nox4...
  30. pmc The internal region leucine-rich repeat 6 of decorin interacts with low density lipoprotein receptor-related protein-1, modulates transforming growth factor (TGF)-β-dependent signaling, and inhibits TGF-β-dependent fibrotic response in skeletal muscles
    Claudio Cabello-Verrugio
    Centro de Regulación Celular y Patología, Centro de Regeneración y Envejecimiento, Departamento de Biologia Celular y Molecular, Pontificia Universidad Catolica de Chile, Santiago
    J Biol Chem 287:6773-87. 2012
    ..Furthermore, using an in vivo approach, we also demonstrate that the LRR6 region of decorin can inhibit TGF-β mediated action in response to skeletal muscle injury...
  31. pmc The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells
    Michiko Ichii
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Blood 119:1683-92. 2012
    ..Furthermore, hematopoietic stem cell numbers in the BM and spleen were elevated in decorin-knockout mice. These findings define one mechanism through which canonical Wnt signaling could shape niches supportive of hematopoiesis...
  32. pmc Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice
    Xiuli Bi
    School of Life Sciences, Liaoning University, Shenyang 110036, China
    Carcinogenesis 33:326-30. 2012
    ..Using a decorin knockout mouse model (Dcn(-/-) mice) and manipulated expression of decorin in human colorectal cancer cells, we found that E-cadherin, a ..
  33. doi Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds
    Jean Denis Bénazet
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, Basel, Switzerland
    Development 139:4250-60. 2012
    ..In summary, our analysis reveals that SMAD4 is required to initiate: (1) formation of the Sox9-positive digit ray primordia; and (2) aggregation and chondrogenic differentiation of all limb skeletal elements...
  34. pmc Intracellularly-retained decorin lacking the C-terminal ear repeat causes ER stress: a cell-based etiological mechanism for congenital stromal corneal dystrophy
    Shoujun Chen
    Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612 4799, USA
    Am J Pathol 183:247-56. 2013
    ....
  35. pmc Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis
    Kornélia Baghy
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    FEBS J 280:2150-64. 2013
    ....
  36. doi A comparative study of myostatin, follistatin and decorin expression in muscle of different origin
    Emi Hiroki
    Department of Anatomy, Tokyo Dental College, Masago, Mihama ku, Chiba City, Japan
    Anat Sci Int 86:151-9. 2011
    ..Interestingly, both muscles showed the same process of muscular formation, but with different time frames, which could be related to muscle origin...
  37. pmc Decorin potentiates interferon-γ activity in a model of allergic inflammation
    Carla Bocian
    Institute of Physiological Chemistry and Pathobiochemistry, Waldeyerstrasse 15, 48149 Munster, Germany
    J Biol Chem 288:12699-711. 2013
    ..Decorin-deficient (Dcn(-/-)) mice show reduced edema formation during the first 24 h with a concurrent attenuated recruitment of CD8(+) ..
  38. ncbi Wnt pathway anomalies in developing amygdalae of Turner syndrome-like mice
    Adam S Raefski
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA
    J Mol Neurosci 32:111-9. 2007
    ..In silico pathway analysis of both X-linked and autosomal mis-regulated genes suggests that modulation of Wnt signaling is a critical factor in the normal growth and development of the amygdala...
  39. doi Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice
    Zishu Pan
    Department of Medicine, University of California, Irvine, Irvine, California 92697, USA
    Dev Dyn 237:316-27. 2008
    ..Our study demonstrates Alkbh1 performs important functions in placental trophoblast lineage differentiation and participates in mechanisms of transcriptional regulation...
  40. ncbi Effect of PEEP on induced constriction is enhanced in decorin-deficient mice
    Francesco G Salerno
    Respiratory Unit, University of Foggia and Fondazione Salvatore Maugeri, Cassano Murge, BA Italy
    Am J Physiol Lung Cell Mol Physiol 293:L1111-7. 2007
    Decorin (Dcn), a small leucine-rich proteoglycan, is present in the extracellular matrix of the airways and lung tissues, contributes to lung mechanical properties, and its deposition is altered in asthma...
  41. pmc Decorin deficiency enhances progressive nephropathy in diabetic mice
    Kevin Jon Williams
    Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Am J Pathol 171:1441-50. 2007
    ..In this study, we used low-dose streptozotocin to induce type 1 diabetes in wild-type (C57BL/6J Dcn(+/+)), Dcn(-/-), and Dcn(+/-) mice and studied the mice for up to 1 year of diabetes...
  42. pmc Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan
    Guiyun Zhang
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 284:8888-97. 2009
    ....
  43. doi A role for decorin in a murine model of allergen-induced asthma
    Cinzia L Marchica
    Meakins Christie Laboratories, McGill University Health Center, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 300:L863-73. 2011
    Decorin (Dcn) is an extracellular matrix proteoglycan, which affects airway mechanics, airway-parenchymal interdependence, airway smooth muscle proliferation and apoptosis, and transforming growth factor-β bioavailability...
  44. pmc Pathophysiological mechanisms of autosomal dominant congenital stromal corneal dystrophy: C-terminal-truncated decorin results in abnormal matrix assembly and altered expression of small leucine-rich proteoglycans
    Shoujun Chen
    Department of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida
    Am J Pathol 179:2409-19. 2011
    ....
  45. pmc The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis
    Wenjin Liu
    Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Cell Biol 30:4797-807. 2010
    ..In addition to defects in tendon collagen fibrillogenesis, Mkx(-/-) mutant mice exhibited abnormal tendon sheaths. These results identify Mkx as an important regulator of tendon development...
  46. ncbi Adenovirus-mediated decorin gene transfer prevents TGF-beta-induced inhibition of lung morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, Department of Surgery, Childrens Hospital Los Angeles Research Institute, University of Southern California School of Dentistry, Los Angeles 90033, USA
    Am J Physiol 277:L412-22. 1999
    ....
  47. doi Regulation of pre-adipocyte proliferation and apoptosis by the small leucine-rich proteoglycans, biglycan and decorin
    M Ward
    Department of Animal Sciences, Purdue University, West Lafayette, IN, USA
    Cell Prolif 44:343-51. 2011
    ..These studies indicate that SLRPs may compose a regulatory factor in adipose tissue expansion, through hyperplasia...
  48. pmc Differential expression of decorin, EGFR and cyclin D1 during mammary gland carcinogenesis in TA2 mice with spontaneous breast cancer
    Yanjun Gu
    Department of Pathology, Tianjin Cancer Hospital and Institute, Tianjin Medical University, Tianjin 300060, China
    J Exp Clin Cancer Res 29:6. 2010
    ..In this study, we investigate differential gene expression, especially the expression of decorin, EGFR and cyclin D1, during mammary gland epithelial cell carcinogenesis in TA2 mice...
  49. pmc The Mohawk homeobox gene is a critical regulator of tendon differentiation
    Yoshiaki Ito
    Department of Systems Biomedicine, National Research Institute for Child Health and Development, Tokyo 157 8535, Japan
    Proc Natl Acad Sci U S A 107:10538-42. 2010
    ..These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells...
  50. pmc TGFbeta neutralization within cardiac allografts by decorin gene transfer attenuates chronic rejection
    Susan M Faust
    Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    J Immunol 183:7307-13. 2009
    ..These findings indicate that neutralizing intragraft TGFbeta inhibits the cytokine's fibrotic activities, but does not reverse its beneficial systemic immunosuppressive qualities...
  51. doi Decorin modulates collagen I-stimulated, but not fibronectin-stimulated, migration of C2C12 myoblasts
    K P Goetsch
    Department of Biochemistry, School of Biochemistry, Genetics and Microbiology, University of KwaZulu Natal, Scottsville, South Africa
    Matrix Biol 30:109-17. 2011
    ..Furthermore, the synergistic, rather than additive, effect observed suggests a direct modification of collagen I signalling by decorin mediated, at least in part, by ROCK-2 rather than ROCK-1...
  52. pmc Genetic evidence for key roles of decorin and biglycan in dentin mineralization
    Naoto Haruyama
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Matrix Biol 28:129-36. 2009
    ..Using DSPP/biglycan (Dspp(-/-)Bgn(-/0)) and DSPP/decorin (Dspp(-/-)Dcn(-/-)) double knockout mice, here we determined that the enlarged predentin layer in Dspp(-/-) teeth is rescued in ..
  53. ncbi Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis
    Jinhong Zhu
    Stem Cell Research Center, Children s Hospital of Pittsburgh, Rangos Research Center, and Department of Bioengineering, University of Pittsburgh, Pennsylvania 15213 2583, USA
    J Biol Chem 282:25852-63. 2007
    ..In summary, these findings define a fibrogenic property of myostatin and suggest the existence of co-regulatory relationships between transforming growth factor-beta1, myostatin, and decorin...
  54. ncbi Decorin binds fibrinogen in a Zn2+-dependent interaction
    Tracey A Dugan
    Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas Medical Center, Houston 77030, USA
    J Biol Chem 278:13655-62. 2003
    ..Thus, Zn(2+) appears to play a pivotal role in the interactions and biological function of decorin...
  55. ncbi Differential expression of glycosaminoglycans and proteoglycans in the migratory pathway of the primordial germ cells of the mouse
    Mauricio Soto-Suazo
    Laboratory of Biology of Reproduction, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508 900, Brazil
    Histochem Cell Biol 118:69-78. 2002
    ....
  56. pmc Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction
    Liliana Schaefer
    Department of Internal Medicine D, Physiological Chemistry and Pathobiochemistry, and Arteriosclerosis Research, University of Munster, Munster, Germany
    Am J Pathol 160:1181-91. 2002
    ....
  57. pmc Extensive induction of important mediators of fibrosis and dystrophic calcification in desmin-deficient cardiomyopathy
    Manolis Mavroidis
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Am J Pathol 160:943-52. 2002
    ....
  58. ncbi Expression and localization of proteoglycans during limb myogenic activation
    H Olguin
    Centro de Regulación Celular y Patología, Departamento de Biología Celular y Moleculare Facultad de Ciencias Biológicas, MIFAB, P Universidad Catolica de Chile, Santiago, Chile
    Dev Dyn 221:106-15. 2001
    ..This article is the first report of myogenic activation and proteoglycan expression during limb muscle formation...
  59. pmc Murine fibromodulin: cDNA and genomic structure, and age-related expression and distribution in the knee joint
    A M Säämänen
    Skeletal Research Programme, Department of Medical Biochemistry and Molecular Biology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Biochem J 355:577-85. 2001
    ..As fibromodulin is deposited closer to cells than decorin, it may have a primary role in collagen fibrillogenesis, whereas decorin might be involved in the maintenance of fibril structures in the interterritorial matrix...
  60. ncbi Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family
    S P Henry
    Graduate School of Biomedical Sciences, University of Texas, Houston, Texas, 77030, USA
    J Biol Chem 276:12212-21. 2001
    ..3 where asporin is part of a SLRP gene cluster that includes extracellular matrix protein 2, osteoadherin, and osteoglycin. Further analysis shows that, with the exception of biglycan, all known SLRP genes reside in three gene clusters...
  61. ncbi Biglycan-like extracellular matrix genes of agnathans and teleosts
    S Shintani
    Max Planck Institut fur Biologie, Abteilung Immungenetik, Corrensstrasse 42, D 72076, Tubingen, Germany
    J Mol Evol 51:363-73. 2000
    ..The BGL gene presumably turned into a typical biglycan only in the tetrapod lineages. The presumed acquisitions of new functions appear to have been accompanied by changes in the evolutionary rate...
  62. ncbi Super-motifs and evolution of tandem leucine-rich repeats within the small proteoglycans--biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin
    N Matsushima
    School of Health Sciences, Sapporo Medical University, Hokkaido, Japan
    Proteins 38:210-25. 2000
    ..Our analyses indicate that classes I/II and III evolved along different paths after the establishment of the precursor ST, and classes I and II also diverged after the establishment of the precursor (STT)4...
  63. ncbi Decorin, epiphycan, and lumican genes are closely linked on murine Chromosome 10 and are deleted in lethal steel mutants
    K G Danielson
    Department of Pathology, Anatomy and Cell Biology, Room 249 Jefferson Alumni Hall, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, Pennsylvania 19107, USA
    Mamm Genome 10:201-3. 1999
  64. ncbi Cat3vl and Cat3vao cataract mutations on mouse chromosome 10: phenotypic characterization, linkage studies and analysis of candidate genes
    J Loster
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Germany
    Mol Gen Genet 257:97-102. 1997
    ..The recovery of the Cat3 mutations demonstrates the importance of the corresponding locus for proper eye development...
  65. ncbi Fine genetic mapping of the region surrounding the high growth (hg) locus in mouse chromosome 10: targeting random amplified polymorphic DNA (RAPD) markers
    S Horvat
    Department of Animal Science, University of California, Davis, California 95616 8521, USA
    Mamm Genome 7:312-4. 1996
  66. pmc Interval mapping of high growth (hg), a major locus that increases weight gain in mice
    S Horvat
    Department of Animal Science, University of California, Davis 95616 8521, USA
    Genetics 139:1737-48. 1995
    ..The interval mapping and test-cross results indicate that hg is not allelic with candidate genes Igf1 or decorin (Dcn), a gene that was mapped close to hg in this study...
  67. pmc Transforming growth factor-beta 3 is required for secondary palate fusion
    G Proetzel
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267, USA
    Nat Genet 11:409-14. 1995
    ..No craniofacial abnormalities were observed. This result demonstrates that TGF-beta 3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects...
  68. ncbi Differential expression of decorin and biglycan genes during palatogenesis in normal and retinoic acid-treated mice
    Yuxiang Zhang
    Department of Anesthesiology, School of Medicine, Fukushima Medical University, Fukushima City, Fukushima, Japan
    Dev Dyn 226:618-26. 2003
    ..Up-regulation of decorin gene expression in the retinoic acid-treated mice might influence the pathogenesis of cleft palate...
  69. ncbi Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues
    P Bianco
    Bone Research Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892
    J Histochem Cytochem 38:1549-63. 1990
    ....
  70. ncbi Origin and characteristics of glycogen cells in the developing murine placenta
    P M Coan
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge, United Kingdom
    Dev Dyn 235:3280-94. 2006
    ..Thus stereology and immunohistochemistry have provided useful insights into Jz development and function of the glycogen cells...
  71. ncbi Matricellular hevin regulates decorin production and collagen assembly
    Millicent M Sullivan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    J Biol Chem 281:27621-32. 2006
    ..Our observations support the capacity of hevin to modulate the structure of dermal extracellular matrix, specifically by its regulation of decorin levels and collagen fibril assembly...
  72. ncbi Extracellular proteoglycans modify TGF-beta bio-availability attenuating its signaling during skeletal muscle differentiation
    Rebeca Droguett
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, MIFAB, P Universidad Catolica de Chile, Santiago, Chile
    Matrix Biol 25:332-41. 2006
    ..In contrast, during the differentiation of decorin-null myoblasts (Dcn null), which lack decorin expression, the binding of TGF-beta to TGF-betaRI and -betaRII increased concomitantly ..
  73. ncbi Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1
    Umashankar Singh
    Department of Development and Genetics, Evolutionary Biology Center, Uppsala University, Sweden
    Dev Dyn 234:1034-45. 2005
    ..This strongly suggested that altered expression of Car2 and Ncam1 is a downstream event in placental hyperplasia...
  74. ncbi Decorin overexpression reduces atherosclerosis development in apolipoprotein E-deficient mice
    Ayman Al Haj Zen
    Inserm EMI 0016, Rene Descartes Medical School Necker, University Paris 5, 156, rue de Vaugirard, 75015 Paris, France
    Atherosclerosis 187:31-9. 2006
    ..5 x 10(9) plaque-forming units/mouse) containing human decorin gene (Ad-Dcn) or beta-galactosidase (LacZ), or PBS...
  75. ncbi Extracellular matrix proteoglycans control the fate of bone marrow stromal cells
    Yanming Bi
    Craniofacial and Skeletal Diseases Branch, NIDCR, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Biol Chem 280:30481-9. 2005
    ..Overall, the predominant effect of the increased TGF-beta signaling in bgn/dcn-deficient bone marrow stromal cells is a "switch in fate" from growth to apoptosis, leading to decreased numbers of ..
  76. ncbi A role for decorin in the remodeling of myocardial infarction
    Sara M Weis
    Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093, USA
    Matrix Biol 24:313-24. 2005
    ..This might contribute to aneurysmal ventricular dilatation, remote hypertrophy, and depressed ventricular function...
  77. ncbi Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy
    Michael D Ross
    Department of Medicine, Divisions of Nephrology and Infectious Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:33248-55. 2003
    ..Thus, podocan defines a new class within the SLR protein family and is a previously unrecognized component of the sclerotic glomerular lesion that develops in the course of experimental HIVAN...
  78. ncbi Alterations in lung mechanics in decorin-deficient mice
    Anita Fust
    Meakins Christie Laboratories, Shriner s Hospital for Crippled Children, McGill University, Montreal, Quebec, Canada H2X 2P2
    Am J Physiol Lung Cell Mol Physiol 288:L159-66. 2005
    ..mechanics would be altered in a mutant mouse in which the single decorin gene was abrogated by targeted deletion (Dcn-/-)...
  79. ncbi Inhibition of myoblast migration via decorin expression is critical for normal skeletal muscle differentiation
    Hugo C Olguin
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, MIFAB, P Universidad Catolica de Chile, Santiago, Chile
    Dev Biol 259:209-24. 2003
    ..Decorin may be involved in the establishment and/or coordination of a critical myoblast density, through inhibition of migration, that permits normal muscle differentiation during embryonic myogenesis...
  80. ncbi Asb4, Ata3, and Dcn are novel imprinted genes identified by high-throughput screening using RIKEN cDNA microarray
    Yosuke Mizuno
    Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama 230 0045, Japan
    Biochem Biophys Res Commun 290:1499-505. 2002
    ..The 25 candidates also included genes that showed no imprinting-associated expression in normal diploid embryos. We describe a feasible high-throughput method of screening for novel imprinted genes by using the RIKEN cDNA microarray...
  81. pmc Impaired posterior frontal sutural fusion in the biglycan/decorin double deficient mice
    Sunil Wadhwa
    Division of Orthodontics, School of Dental Medicine, Department of Craniofacial Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 40:861-6. 2007
    Biglycan (Bgn) and decorin (Dcn) are highly expressed in numerous tissues in the craniofacial complex. However, their expression and function in the cranial sutures are unknown...
  82. doi Decorin enhances the proliferation and differentiation of myogenic cells through suppressing myostatin activity
    Yasuhiro Kishioka
    Meat Science Laboratory, Division of Bioresources and Bioproduction, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    J Cell Physiol 215:856-67. 2008
    ..These results clearly show that decorin enhances the proliferation and differentiation of C2C12 myoblasts through suppressing myostatin activity...
  83. ncbi Increased decorin mRNA in diabetic mouse kidney and in mesangial and tubular cells cultured in high glucose
    A Mogyorosi
    Renal Electrolyte and Hypertension Division, Department of Medicine, and the Penn Center for the Molecular Studies of Kidney Diseases, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6144, USA
    Am J Physiol 275:F827-32. 1998
    ....
  84. ncbi Protection of adult mouse progenitor cells and human glioma cells by de novo decorin expression in an oxygen- and glucose-deprived cell culture model system
    Manoranjan Santra
    Neurology Research, Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    J Cereb Blood Flow Metab 26:1311-22. 2006
    ..Therefore, our data suggest that decorin is a potent trophic factor that protects neuronal progenitor cells and glioma cells from OGD...
  85. ncbi Changes in secreted and cell associated proteoglycan synthesis during conversion of myoblasts to osteoblasts in response to bone morphogenetic protein-2: role of decorin in cell response to BMP-2
    Jaime Gutierrez
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, MIFAB, P Universidad Catolica de Chile, Santiago, Chile
    J Cell Physiol 206:58-67. 2006
    ..These results are the first biochemical evidence and analysis for the effect of BMP-2 on the synthesis of proteoglycan during osteogenic conversion of myoblasts and suggest a role for decorin in cell response to BMP-2...
  86. ncbi Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development
    Tsuyoshi Hikake
    Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, 960 1295 Fukushima, Japan
    Anat Embryol (Berl) 206:373-80. 2003
    ..These results suggest that the OASIS gene might be related to proteoglycan expression and may play an important role in the differentiation of the odontoblast and cells in inner enamel epithelium...
  87. ncbi Intrinsic phenotypic diversity of embryonic and fetal myoblasts is revealed by genome-wide gene expression analysis on purified cells
    Stefano Biressi
    Stem Cell Research Institute, DIBIT, H San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Dev Biol 304:633-51. 2007
    ....

Research Grants3

  1. Accelerated Osteoarthritis in the TMJ of Biglycan/Fibromodulin DKO Mice
    Sunil Wadhwa; Fiscal Year: 2007
    ..Greater understanding on the role of mechanical loading in the progression of TMJ-OA and the development of specific biomarkers for TMJ-OA may lead to new treatment modalities for patients who suffer from TMJ-OA. ..
  2. Estrogen Receptor Beta Regulation of Mandibular Condylar Growth
    Sunil Wadhwa; Fiscal Year: 2010
    ..This proposal examines the mechanism behind estrogen inhibition of growth and differentiation of the mandibular condylar cartilage, which will give further insight into the age and gender predilection of TMD. ..