Dcn

Summary

Gene Symbol: Dcn
Description: decorin
Alias: DSPG2, PG40, PGII, PGS2, SLRR1B, decorin, bone proteoglycan II
Species: mouse
Products:     Dcn

Top Publications

  1. Merline R, Lazaroski S, Babelova A, Tsalastra Greul W, Pfeilschifter J, Schluter K, et al. Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration. J Physiol Pharmacol. 2009;60 Suppl 4:5-13 pubmed
    Although deficiency of the small leucine-rich proteoglycan decorin aggravates diabetic nephropathy in mice, the precise mechanisms of action are not fully understood...
  2. Brandan E, Retamal C, Cabello Verrugio C, Marzolo M. The low density lipoprotein receptor-related protein functions as an endocytic receptor for decorin. J Biol Chem. 2006;281:31562-71 pubmed
    b>Decorin is a small leucine-rich proteoglycan that modulates the activity of transforming growth factor type beta and other growth factors and thereby influences the processes of proliferation and differentiation in a wide array of ..
  3. Zhang G, Ezura Y, Chervoneva I, Robinson P, Beason D, Carine E, et al. Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development. J Cell Biochem. 2006;98:1436-49 pubmed
    ..Small leucine-rich proteoglycans have been implicated in the regulation of fibrillogenesis and decorin is the prototypic member of this family...
  4. Chen S, Birk D. The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly. FEBS J. 2013;280:2120-37 pubmed publisher
    ..SLRPs regulate assembly of the extracellular matrix, which defines the microenvironment, modulating both the extracellular matrix and cellular functions, with an impact on tissue function. ..
  5. Bi X, Tong C, Dockendorff A, Bancroft L, Gallagher L, Guzman G, et al. Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. Carcinogenesis. 2008;29:1435-40 pubmed publisher
    b>Decorin is a member of the small leucine-rich proteoglycan gene family and plays an important role in suppressing cancer cell growth and metastasis...
  6. Schaefer L, Tsalastra W, Babelova A, Baliova M, Minnerup J, Sorokin L, et al. Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin. Am J Pathol. 2007;170:301-15 pubmed
    b>Decorin, a small leucine-rich proteoglycan, affects the synthesis of the elastic fiber component fibrillin-1 in the kidney via hitherto unknown mechanisms...
  7. Seidler D, Mohamed N, Bocian C, Stadtmann A, Hermann S, Schafers K, et al. The role for decorin in delayed-type hypersensitivity. J Immunol. 2011;187:6108-19 pubmed publisher
    b>Decorin, a small leucine-rich proteoglycan, regulates extracellular matrix organization, growth factor-mediated signaling, and cell growth...
  8. Marchica C, Pinelli V, Borges M, Zummer J, Narayanan V, Iozzo R, et al. A role for decorin in a murine model of allergen-induced asthma. Am J Physiol Lung Cell Mol Physiol. 2011;300:L863-73 pubmed publisher
    b>Decorin (Dcn) is an extracellular matrix proteoglycan, which affects airway mechanics, airway-parenchymal interdependence, airway smooth muscle proliferation and apoptosis, and transforming growth factor-? bioavailability...
  9. Scholzen T, Solursh M, Suzuki S, Reiter R, Morgan J, Buchberg A, et al. The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation. J Biol Chem. 1994;269:28270-81 pubmed
    b>Decorin, a proteoglycan known to interact with collagen and growth factors, may play key roles during ontogenesis, tissue remodeling, and cancer...
  10. Stock C, Jungmann O, Seidler D. Decorin and chondroitin-6 sulfate inhibit B16V melanoma cell migration and invasion by cellular acidification. J Cell Physiol. 2011;226:2641-50 pubmed publisher
    ..Time-lapse microscopy revealed that in B16V cells exposed to either decorin or chondroitin sulfates migration and invasion decreased by more than 50%...

Detail Information

Publications87

  1. Merline R, Lazaroski S, Babelova A, Tsalastra Greul W, Pfeilschifter J, Schluter K, et al. Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration. J Physiol Pharmacol. 2009;60 Suppl 4:5-13 pubmed
    Although deficiency of the small leucine-rich proteoglycan decorin aggravates diabetic nephropathy in mice, the precise mechanisms of action are not fully understood...
  2. Brandan E, Retamal C, Cabello Verrugio C, Marzolo M. The low density lipoprotein receptor-related protein functions as an endocytic receptor for decorin. J Biol Chem. 2006;281:31562-71 pubmed
    b>Decorin is a small leucine-rich proteoglycan that modulates the activity of transforming growth factor type beta and other growth factors and thereby influences the processes of proliferation and differentiation in a wide array of ..
  3. Zhang G, Ezura Y, Chervoneva I, Robinson P, Beason D, Carine E, et al. Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development. J Cell Biochem. 2006;98:1436-49 pubmed
    ..Small leucine-rich proteoglycans have been implicated in the regulation of fibrillogenesis and decorin is the prototypic member of this family...
  4. Chen S, Birk D. The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly. FEBS J. 2013;280:2120-37 pubmed publisher
    ..SLRPs regulate assembly of the extracellular matrix, which defines the microenvironment, modulating both the extracellular matrix and cellular functions, with an impact on tissue function. ..
  5. Bi X, Tong C, Dockendorff A, Bancroft L, Gallagher L, Guzman G, et al. Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. Carcinogenesis. 2008;29:1435-40 pubmed publisher
    b>Decorin is a member of the small leucine-rich proteoglycan gene family and plays an important role in suppressing cancer cell growth and metastasis...
  6. Schaefer L, Tsalastra W, Babelova A, Baliova M, Minnerup J, Sorokin L, et al. Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin. Am J Pathol. 2007;170:301-15 pubmed
    b>Decorin, a small leucine-rich proteoglycan, affects the synthesis of the elastic fiber component fibrillin-1 in the kidney via hitherto unknown mechanisms...
  7. Seidler D, Mohamed N, Bocian C, Stadtmann A, Hermann S, Schafers K, et al. The role for decorin in delayed-type hypersensitivity. J Immunol. 2011;187:6108-19 pubmed publisher
    b>Decorin, a small leucine-rich proteoglycan, regulates extracellular matrix organization, growth factor-mediated signaling, and cell growth...
  8. Marchica C, Pinelli V, Borges M, Zummer J, Narayanan V, Iozzo R, et al. A role for decorin in a murine model of allergen-induced asthma. Am J Physiol Lung Cell Mol Physiol. 2011;300:L863-73 pubmed publisher
    b>Decorin (Dcn) is an extracellular matrix proteoglycan, which affects airway mechanics, airway-parenchymal interdependence, airway smooth muscle proliferation and apoptosis, and transforming growth factor-? bioavailability...
  9. Scholzen T, Solursh M, Suzuki S, Reiter R, Morgan J, Buchberg A, et al. The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation. J Biol Chem. 1994;269:28270-81 pubmed
    b>Decorin, a proteoglycan known to interact with collagen and growth factors, may play key roles during ontogenesis, tissue remodeling, and cancer...
  10. Stock C, Jungmann O, Seidler D. Decorin and chondroitin-6 sulfate inhibit B16V melanoma cell migration and invasion by cellular acidification. J Cell Physiol. 2011;226:2641-50 pubmed publisher
    ..Time-lapse microscopy revealed that in B16V cells exposed to either decorin or chondroitin sulfates migration and invasion decreased by more than 50%...
  11. Wu Z, Horgan C, Carr O, Owens R, Iozzo R, Lechner B. Biglycan and decorin differentially regulate signaling in the fetal membranes. Matrix Biol. 2014;35:266-75 pubmed publisher
    ..Notably, a subtype of Ehlers-Danlos Syndrome is caused by expression of abnormal biglycan and decorin proteoglycans...
  12. Zhang G, Chen S, Goldoni S, Calder B, Simpson H, Owens R, et al. Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan. J Biol Chem. 2009;284:8888-97 pubmed publisher
    b>Decorin and biglycan are class I small leucine-rich proteoglycans (SLRPs) involved in regulation of collagen fibril and matrix assembly...
  13. Rühland C, Schonherr E, Robenek H, Hansen U, Iozzo R, Bruckner P, et al. The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis. FEBS J. 2007;274:4246-55 pubmed
    b>Decorin is a multifunctional small leucine-rich proteoglycan involved in the regulation of collagen fibrillogenesis...
  14. Corsi A, Xu T, Chen X, Boyde A, Liang J, Mankani M, et al. Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues. J Bone Miner Res. 2002;17:1180-9 pubmed
    b>Decorin (dcn) and biglycan (bgn), two members of the family of small leucine-rich proteoglycans (SLRPs), are the predominant proteoglycans expressed in skin and bone, respectively...
  15. Seidler D, Schaefer L, Robenek H, Iozzo R, Kresse H, Schonherr E. A physiologic three-dimensional cell culture system to investigate the role of decorin in matrix organisation and cell survival. Biochem Biophys Res Commun. 2005;332:1162-70 pubmed
    ..Proteoglycans, like decorin, affect these complex interactions...
  16. Liang F, Brown E, Wang T, Iozzo R, Fikrig E. Protective niche for Borrelia burgdorferi to evade humoral immunity. Am J Pathol. 2004;165:977-85 pubmed
    ..B. burgdorferi expresses several ligand-binding lipoproteins, including the decorin-binding proteins (Dbps) A and B, which may mediate attachment to decorin, a major component of the host ..
  17. Baghy K, Dezso K, László V, Fullár A, Péterfia B, Paku S, et al. Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice. Lab Invest. 2011;91:439-51 pubmed publisher
    Accumulation of connective tissue is a typical feature of chronic liver diseases. Decorin, a small leucine-rich proteoglycan, regulates collagen fibrillogenesis during development, and by directly blocking the bioactivity of transforming ..
  18. Iozzo R, Chakrani F, Perrotti D, McQuillan D, Skorski T, Calabretta B, et al. Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis. Proc Natl Acad Sci U S A. 1999;96:3092-7 pubmed
    Ectopic expression of decorin in a wide variety of transformed cells results in growth arrest and the inability to generate tumors in nude mice...
  19. San Martin S, Soto Suazo M, De Oliveira S, Aplin J, Abrahamsohn P, Zorn T. Small leucine-rich proteoglycans (SLRPs) in uterine tissues during pregnancy in mice. Reproduction. 2003;125:585-95 pubmed
    ..are important in the regulation of collagen fibrillogenesis, and the present study analysed four members (decorin, biglycan, lumican and fibromodulin) of the family of small leucine-rich proteoglycans (SLRPs) in the uterus from ..
  20. Al Haj Zen A, Caligiuri G, Sainz J, Lemitre M, Demerens C, Lafont A. Decorin overexpression reduces atherosclerosis development in apolipoprotein E-deficient mice. Atherosclerosis. 2006;187:31-9 pubmed
    Atherosclerosis results from accumulation of macrophages and extracellular matrix in the arterial wall. Decorin, a small matrix proteoglycan, is able to regulate cell proliferation, migration and growth factors' activity...
  21. Hakkinen L, Strassburger S, Kahari V, Scott P, Eichstetter I, Lozzo R, et al. A role for decorin in the structural organization of periodontal ligament. Lab Invest. 2000;80:1869-80 pubmed
    b>Decorin is a small leucine-rich proteoglycan that interacts with several matrix molecules, including various types of collagen and growth factors, and suppresses the growth of neoplastic cells by an epidermal growth factor (EGF) receptor-..
  22. Brown E, Wooten R, Johnson B, Iozzo R, Smith A, Dolan M, et al. Resistance to Lyme disease in decorin-deficient mice. J Clin Invest. 2001;107:845-52 pubmed
    ..BORRELIA: burgdorferi, the causative agent of Lyme disease (LD), expresses two surface-exposed decorin-binding adhesins, DbpA and DbpB...
  23. San Martin S, Zorn T. The small proteoglycan biglycan is associated with thick collagen fibrils in the mouse decidua. Cell Mol Biol (Noisy-le-grand). 2003;49:673-8 pubmed
    ..is associated with the presence of thick collagen fibrils in decidualised regions of the endometrium and that decorin is associated exclusively with thin collagen fibrils in non-decidualised endometrial areas...
  24. Merline R, Moreth K, Beckmann J, Nastase M, Zeng Brouwers J, Tralhão J, et al. Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21. Sci Signal. 2011;4:ra75 pubmed publisher
    ..Here, we show that the soluble form of the extracellular matrix proteoglycan decorin controls inflammation and tumor growth through PDCD4 (programmed cell death 4) and miR-21 (microRNA-21) by two ..
  25. Araki K, Wakabayashi H, Shintani K, Morikawa J, Matsumine A, Kusuzaki K, et al. Decorin suppresses bone metastasis in a breast cancer cell line. Oncology. 2009;77:92-9 pubmed publisher
    b>Decorin, the prototype of an expanding family of small leucine-rich proteoglycans, is involved in a number of cellular processes including matrix assembly, fibrillogenesis and the control of cell proliferation...
  26. Mochida Y, Parisuthiman D, Pornprasertsuk Damrongsri S, Atsawasuwan P, Sricholpech M, Boskey A, et al. Decorin modulates collagen matrix assembly and mineralization. Matrix Biol. 2009;28:44-52 pubmed publisher
    b>Decorin (DCN) is one of the major matrix proteoglycans in bone...
  27. Schonherr E, Sunderkotter C, Schaefer L, Thanos S, Grassel S, Oldberg A, et al. Decorin deficiency leads to impaired angiogenesis in injured mouse cornea. J Vasc Res. 2004;41:499-508 pubmed
    ..We investigated consequences of the targeted ablation of decorin (DCN), biglycan (BGN) and fibromodulin (FMOD) genes on inflammation-induced angiogenesis in the cornea...
  28. Danielson K, Baribault H, Holmes D, Graham H, Kadler K, Iozzo R. Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol. 1997;136:729-43 pubmed
    b>Decorin is a member of the expanding group of widely distributed small leucine-rich proteoglycans that are expected to play important functions in tissue assembly...
  29. Morcavallo A, Buraschi S, Xu S, Belfiore A, Schaefer L, Iozzo R, et al. Decorin differentially modulates the activity of insulin receptor isoform A ligands. Matrix Biol. 2014;35:82-90 pubmed publisher
    The proteoglycan decorin, a key component of the tumor stroma, regulates the action of several tyrosine-kinase receptors, including the EGFR, Met and the IGF-IR...
  30. Borges M, Narayanan V, Iozzo R, Ludwig M. Deficiency of decorin induces expression of Foxp3 in CD4⁺CD25⁺ T cells in a murine model of allergic asthma. Respirology. 2015;20:904-11 pubmed publisher
    b>Decorin (Dcn), an extracellular matrix proteoglycan, has several important biological functions, and its deposition is altered in the airway wall of humans with asthma and animal models of asthma...
  31. Loster J, Immervoll T, Schmitt John T, Graw J. Cat3vl and Cat3vao cataract mutations on mouse chromosome 10: phenotypic characterization, linkage studies and analysis of candidate genes. Mol Gen Genet. 1997;257:97-102 pubmed
    ..So far, negative results have been obtained for the genes encoding the proteoglycans lumican and decorin, the nuclear orphan receptor Tr2-11 and the transcription factor Elk3...
  32. Engebretsen K, Waehre A, Bjørnstad J, Skrbic B, Sjaastad I, Behmen D, et al. Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse. J Appl Physiol (1985). 2013;114:988-97 pubmed publisher
    ..Thus, in a well-characterized aortic banding-debanding mouse model, we examined the SLRPs decorin and lumican and enzymes responsible for synthesis of their glycosaminoglycan (GAG) chains...
  33. Camp J, Badsha F, Florio M, Kanton S, Gerber T, Wilsch Bräuninger M, et al. Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. Proc Natl Acad Sci U S A. 2015;112:15672-7 pubmed publisher
    ..Our comparison of in vivo and in vitro cortical single-cell transcriptomes illuminates the genetic features underlying human cortical development that can be studied in organoid cultures. ..
  34. Ueda K, Yoshimura K, Yamashita O, Harada T, Morikage N, Hamano K. Possible dual role of decorin in abdominal aortic aneurysm. PLoS ONE. 2015;10:e0120689 pubmed publisher
    ..b>Decorin, a small leucine-rich repeat proteoglycan, has been suggested to regulate inflammation and stabilize the ..
  35. Mellgren A, Bruland O, Vedeler A, Saraste J, Schönheit J, Bredrup C, et al. Development of congenital stromal corneal dystrophy is dependent on export and extracellular deposition of truncated decorin. Invest Ophthalmol Vis Sci. 2015;56:2909-15 pubmed publisher
    ..It is caused by mutations in the decorin gene (DCN) leading to the expression of a truncated form of decorin...
  36. Coan P, Conroy N, Burton G, Ferguson Smith A. Origin and characteristics of glycogen cells in the developing murine placenta. Dev Dyn. 2006;235:3280-94 pubmed
    ..be facilitated by temporally regulated expression of matrix metalloproteinase 9 and the imprinted gene product, Decorin. Expression of the clearance receptor for type II insulin-like growth factor (IGF-II), IGF2R, in a short ..
  37. Baghy K, Horvath Z, Regős E, Kiss K, Schaff Z, Iozzo R, et al. Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis. FEBS J. 2013;280:2150-64 pubmed publisher
    b>Decorin, a secreted small leucine-rich proteoglycan, acts as a tumor repressor in a variety of cancers, mainly by blocking the action of several receptor tyrosine kinases such as the receptors for hepatocyte, epidermal and insulin-like ..
  38. Park I, Qian D, Kiel M, Becker M, Pihalja M, Weissman I, et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003;423:302-5 pubmed
    ..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs. ..
  39. Gordon J, Freedman B, Zuskov A, Iozzo R, Birk D, Soslowsky L. Achilles tendons from decorin- and biglycan-null mouse models have inferior mechanical and structural properties predicted by an image-based empirical damage model. J Biomech. 2015;48:2110-5 pubmed publisher
    ..the mechanical and structural differences observed in mouse Achilles tendons lacking class I SLRPs; either decorin or biglycan...
  40. Zhang Y, Mori T, Iseki K, Hagino S, Takaki H, Takeuchi M, et al. Differential expression of decorin and biglycan genes during palatogenesis in normal and retinoic acid-treated mice. Dev Dyn. 2003;226:618-26 pubmed
    ..In the present study, we focused on two small leucine-rich proteoglycans, decorin and biglycan, because they assembled extracellular matrix molecules such as collagens and modulated signaling ..
  41. Gubbiotti M, Neill T, Frey H, Schaefer L, Iozzo R. Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy. Matrix Biol. 2015;48:14-25 pubmed publisher
    ..b>Decorin, a secreted proteoglycan, evokes autophagy in endothelial cells and mitophagy in breast carcinoma cells...
  42. Dugan T, Yang V, McQuillan D, Hook M. Decorin binds fibrinogen in a Zn2+-dependent interaction. J Biol Chem. 2003;278:13655-62 pubmed
    We have previously shown that decorin, a member of the small leucine-rich proteoglycan family of extracellular matrix proteoglycans/glycoproteins is a Zn(2+) metalloprotein at physiological Zn(2+) concentrations (Yang, V. W-C...
  43. Wadhwa S, Bi Y, Ortiz A, Embree M, Kilts T, Iozzo R, et al. Impaired posterior frontal sutural fusion in the biglycan/decorin double deficient mice. Bone. 2007;40:861-6 pubmed
    Biglycan (Bgn) and decorin (Dcn) are highly expressed in numerous tissues in the craniofacial complex. However, their expression and function in the cranial sutures are unknown...
  44. Dupuis L, Kern C. Small leucine-rich proteoglycans exhibit unique spatiotemporal expression profiles during cardiac valve development. Dev Dyn. 2014;243:601-11 pubmed publisher
    ..Cardiac expression using antibodies specific for biglycan (BGN), decorin (DCN), fibromodulin (FMOD), and lumican (LUM) revealed distinct patterns among the SLRPs in mesenchymal-derived ..
  45. Gronau T, Krüger K, Prein C, Aszodi A, Gronau I, Iozzo R, et al. Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin. Ann Rheum Dis. 2017;76:442-449 pubmed publisher
    Interterritorial regions of articular cartilage matrix are rich in decorin, a small leucine-rich proteoglycan and important structural protein, also involved in many signalling events...
  46. Matsushima N, Ohyanagi T, Tanaka T, Kretsinger R. Super-motifs and evolution of tandem leucine-rich repeats within the small proteoglycans--biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin. Proteins. 2000;38:210-25 pubmed
    ..a family of nine small proteoglycans, forming three distinct subfamilies: class I contains biglycan/PG-I and decorin/PG-II; class II: lumican, fibromodulin, PRELP, keratocan, and osteoadherin; and class III: epiphycan/PG-Lb and ..
  47. Monnier P, Martinet C, Pontis J, Stancheva I, Ait Si Ali S, Dandolo L. H19 lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1. Proc Natl Acad Sci U S A. 2013;110:20693-8 pubmed publisher
    ..This results in a precise control of the level of expression of growth factors in the embryo. ..
  48. Horvath Z, Kovalszky I, Fullár A, Kiss K, Schaff Z, Iozzo R, et al. Decorin deficiency promotes hepatic carcinogenesis. Matrix Biol. 2014;35:194-205 pubmed publisher
    ..A key constituent for the hepatic microenvironment is the small leucine-rich proteoglycan decorin, known to interfere with cellular events of tumorigenesis mainly by blocking various receptor tyrosine kinases (..
  49. Ohmori T, Tanigawa S, Kaku Y, Fujimura S, Nishinakamura R. Sall1 in renal stromal progenitors non-cell autonomously restricts the excessive expansion of nephron progenitors. Sci Rep. 2015;5:15676 pubmed publisher
    ..The mutant mice also exhibited cystic kidneys after birth and died before adulthood. We found that Decorin, which inhibits Bmp-mediated nephron differentiation, was upregulated in the mutant stroma...
  50. Kishioka Y, Thomas M, Wakamatsu J, Hattori A, Sharma M, Kambadur R, et al. Decorin enhances the proliferation and differentiation of myogenic cells through suppressing myostatin activity. J Cell Physiol. 2008;215:856-67 pubmed publisher
    b>Decorin, a small leucine-rich proteoglycan, plays an important role in the regulation of cell growth...
  51. Rana M, Théveniau Ruissy M, De Bono C, Mesbah K, Francou A, Rammah M, et al. Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart. Circ Res. 2014;115:790-9 pubmed publisher
    ..Our results provide new insights into the pathogenesis of congenital heart defects and 22q11.2 deletion syndrome phenotypes. ..
  52. Benet M, Dulman R, Suzme R, de Miera E, Vega M, Nguyen T, et al. Wild type N-ras displays anti-malignant properties, in part by downregulating decorin. J Cell Physiol. 2012;227:2341-51 pubmed publisher
    ..Through mRNA and microRNA (miRNAs) expression profiling we have identified genes (decorin) and miRNAs (mir-29A, let-7b) modulated by wt N-ras potentially responsible for the anti-malignant effect...
  53. Schaefer L, Mihalik D, Babelova A, Krzyzankova M, Grone H, Iozzo R, et al. Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury. Am J Pathol. 2004;165:383-96 pubmed
    There is growing evidence that the two small leucine-rich proteoglycans biglycan and decorin regulate the assembly of connective tissues and alter cell behavior during development and pathological processes...
  54. Zhao J, Sime P, Bringas P, Gauldie J, Warburton D. Adenovirus-mediated decorin gene transfer prevents TGF-beta-induced inhibition of lung morphogenesis. Am J Physiol. 1999;277:L412-22 pubmed
    ..vivo culture, we examined the capacity of a naturally occurring inhibitor of TGF-beta activity, the proteoglycan decorin, to overcome the inhibitory effects of exogenous TGF-beta...
  55. Mao Y, Francis West P, Irvine K. Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching. Development. 2015;142:2574-85 pubmed publisher
  56. Sato E, Zhang L, Dorschner R, Adase C, Choudhury B, Gallo R. Activation of Parathyroid Hormone 2 Receptor Induces Decorin Expression and Promotes Wound Repair. J Invest Dermatol. 2017;137:1774-1783 pubmed publisher
    ..a parathyroid hormone ligand family member that was recently identified to be expressed in the skin, can induce decorin expression and enhance wound repair...
  57. Dourte L, Pathmanathan L, Jawad A, Iozzo R, Mienaltowski M, Birk D, et al. Influence of decorin on the mechanical, compositional, and structural properties of the mouse patellar tendon. J Biomech Eng. 2012;134:031005 pubmed publisher
    ..b>Decorin content was varied in a dose dependent manner using decorin null, decorin heterozygote, and wild type mice...
  58. Horvat S, Medrano J. Interval mapping of high growth (hg), a major locus that increases weight gain in mice. Genetics. 1995;139:1737-48 pubmed
    ..The interval mapping and test-cross results indicate that hg is not allelic with candidate genes Igf1 or decorin (Dcn), a gene that was mapped close to hg in this study...
  59. Zhu J, Li Y, Shen W, Qiao C, Ambrosio F, Lavasani M, et al. Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis. J Biol Chem. 2007;282:25852-63 pubmed
    ..myostatin in skeletal muscle fibrosis, as well as its interaction with both transforming growth factor-beta1 and decorin. We discovered that myostatin stimulated fibroblast proliferation in vitro and induced its differentiation into ..
  60. Kanzleiter T, Rath M, Görgens S, Jensen J, Tangen D, Kolnes A, et al. The myokine decorin is regulated by contraction and involved in muscle hypertrophy. Biochem Biophys Res Commun. 2014;450:1089-94 pubmed publisher
    ..The small leucine-rich proteoglycan decorin has been described as a myokine for some time...
  61. Ward M, Ajuwon K. Regulation of pre-adipocyte proliferation and apoptosis by the small leucine-rich proteoglycans, biglycan and decorin. Cell Prolif. 2011;44:343-51 pubmed publisher
    ..Pre-adipocytes were seeded on plates coated with biglycan and decorin and were allowed to differentiate...
  62. You Y, Okada S, Ly S, Jandeleit Dahm K, Barit D, Namikoshi T, et al. Role of Nox2 in diabetic kidney disease. Am J Physiol Renal Physiol. 2013;304:F840-8 pubmed publisher
    ..The present results demonstrate that lack of Nox2 does not protect against diabetic kidney disease in type 1 diabetes, despite a reduction in macrophage infiltration. The lack of renoprotection may be due to upregulation of renal Nox4. ..
  63. Henry S, Takanosu M, Boyd T, Mayne P, Eberspaecher H, Zhou W, et al. Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family. J Biol Chem. 2001;276:12212-21 pubmed
    ..The deduced amino acid sequence is about 50% identical (and 70% similar) to decorin and biglycan...
  64. Yang Y, Xu W, Neill T, Hu Z, Wang C, Xiao X, et al. Systemic Delivery of an Oncolytic Adenovirus Expressing Decorin for the Treatment of Breast Cancer Bone Metastases. Hum Gene Ther. 2015;26:813-25 pubmed publisher
    ..dcn, and a nonreplicating adenovirus, Ad(E1-).dcn, both containing the human decorin gene. Our in vitro studies showed that Ad...
  65. Raefski A, Carone B, Kaur A, Krueger W, O Neill M. Wnt pathway anomalies in developing amygdalae of Turner syndrome-like mice. J Mol Neurosci. 2007;32:111-9 pubmed
    ..In silico pathway analysis of both X-linked and autosomal mis-regulated genes suggests that modulation of Wnt signaling is a critical factor in the normal growth and development of the amygdala. ..
  66. Gutierrez J, Osses N, Brandan E. Changes in secreted and cell associated proteoglycan synthesis during conversion of myoblasts to osteoblasts in response to bone morphogenetic protein-2: role of decorin in cell response to BMP-2. J Cell Physiol. 2006;206:58-67 pubmed
    ..An important and specific increase in the synthesis of secreted decorin was observed in BMP-2-treated cells, as compared to untreated myoblasts and myoblasts induced to differentiate ..
  67. Bozóky B, Savchenko A, Guven H, Ponten F, Klein G, Szekely L. Decreased decorin expression in the tumor microenvironment. Cancer Med. 2014;3:485-91 pubmed publisher
    b>Decorin is a small leucine-rich proteoglycan, synthesized and deposited by fibroblasts in the stroma where it binds to collagen I...
  68. Pan Z, Sikandar S, Witherspoon M, Dizon D, Nguyen T, Benirschke K, et al. Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice. Dev Dyn. 2008;237:316-27 pubmed publisher
    ..Our study demonstrates Alkbh1 performs important functions in placental trophoblast lineage differentiation and participates in mechanisms of transcriptional regulation. ..
  69. Chen S, Sun M, Meng X, Iozzo R, Kao W, Birk D. Pathophysiological mechanisms of autosomal dominant congenital stromal corneal dystrophy: C-terminal-truncated decorin results in abnormal matrix assembly and altered expression of small leucine-rich proteoglycans. Am J Pathol. 2011;179:2409-19 pubmed publisher
    ..It is linked to a frameshift mutation in decorin, resulting in a C-terminal truncation lacking 33 amino acids that includes the "ear" repeat, a feature ..
  70. Maccarana M, Svensson R, Knutsson A, Giannopoulos A, Pelkonen M, Weis M, et al. Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. PLoS ONE. 2017;12:e0184028 pubmed publisher
    ..Also, decorin and biglycan were doubled in Aspn-/- skin...
  71. Hiroki E, Abe S, Iwanuma O, Sakiyama K, Yanagisawa N, Shiozaki K, et al. A comparative study of myostatin, follistatin and decorin expression in muscle of different origin. Anat Sci Int. 2011;86:151-9 pubmed publisher
    ..b>Decorin-a small leucine-rich proteoglycan-traps myostatin and modulates its activity towards myogenic cells in the ECM...
  72. Mimura T, Han K, Onguchi T, Chang J, Kim T, Kojima T, et al. MT1-MMP-mediated cleavage of decorin in corneal angiogenesis. J Vasc Res. 2009;46:541-50 pubmed publisher
    b>Decorin has been shown to have antiangiogenic properties. In this study, we evaluate the involvement of membrane type 1-matrix metalloproteinase (MT1-MMP), a proangiogenic enzyme, in decorin cleavage in the cornea...
  73. Kemaladewi D, de Gorter D, Aartsma Rus A, van Ommen G, Ten Dijke P, t Hoen P, et al. Cell-type specific regulation of myostatin signaling. FASEB J. 2012;26:1462-72 pubmed publisher
    ..Together, our results identify a molecular mechanism that explains the cell-type specific aspects of signaling by myostatin and other TGF-? family members. ..
  74. Buraschi S, Neill T, Goyal A, Poluzzi C, Smythies J, Owens R, et al. Decorin causes autophagy in endothelial cells via Peg3. Proc Natl Acad Sci U S A. 2013;110:E2582-91 pubmed publisher
    Soluble decorin affects the biology of several receptor tyrosine kinases by triggering receptor internalization and degradation...
  75. Biressi S, Tagliafico E, Lamorte G, Monteverde S, Tenedini E, Roncaglia E, et al. Intrinsic phenotypic diversity of embryonic and fetal myoblasts is revealed by genome-wide gene expression analysis on purified cells. Dev Biol. 2007;304:633-51 pubmed
  76. Droguett R, Cabello Verrugio C, Riquelme C, Brandan E. Extracellular proteoglycans modify TGF-beta bio-availability attenuating its signaling during skeletal muscle differentiation. Matrix Biol. 2006;25:332-41 pubmed
    ..b>Decorin, biglycan and betaglycan are proteoglycans that bind TGF-beta during skeletal muscle differentiation...
  77. Fantauzzo K, Christiano A. Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis. Development. 2012;139:203-14 pubmed publisher
    ..Our findings identify Trps1 as a novel regulator of the Wnt signaling pathway and of early hair follicle progenitors in the developing vibrissa follicle. ..
  78. Chen S, Sun M, Iozzo R, Kao W, Birk D. Intracellularly-retained decorin lacking the C-terminal ear repeat causes ER stress: a cell-based etiological mechanism for congenital stromal corneal dystrophy. Am J Pathol. 2013;183:247-56 pubmed publisher
    b>Decorin, a small leucine-rich proteoglycan (SLRP), is involved in the pathophysiology of human congenital stromal corneal dystrophy (CSCD). This disease is characterized by corneal opacities and vision impairment...
  79. Säämänen A, Salminen H, Rantakokko A, Heinegard D, Vuorio E. Murine fibromodulin: cDNA and genomic structure, and age-related expression and distribution in the knee joint. Biochem J. 2001;355:577-85 pubmed
    ..was determined, and its age-related expression and distribution were characterized in knee epiphyses, with decorin studied for reference...
  80. Danielson K, Siracusa L, Donovan P, Iozzo R. Decorin, epiphycan, and lumican genes are closely linked on murine Chromosome 10 and are deleted in lethal steel mutants. Mamm Genome. 1999;10:201-3 pubmed
  81. Shaw L, Johnson P, Kimber S. Gene expression profiling of the developing mouse kidney and embryo. In Vitro Cell Dev Biol Anim. 2010;46:155-65 pubmed publisher
    ..We then analysed their expression in other developing tissues. Results show Dcn, Hoxc9, Mest, Wt1 and Ywhaq were expressed at moderate to high levels during the window of metanephric ..
  82. Fetting J, Guay J, Karolak M, Iozzo R, Adams D, Maridas D, et al. FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney. Development. 2014;141:17-27 pubmed publisher
    ..We found that the gene encoding the small leucine-rich proteoglycan decorin (DCN) is repressed by FOXD1 in cortical interstitial cells, and we show that compound genetic inactivation of Dcn ..
  83. Cabello Verrugio C, Santander C, Cofré C, Acuña M, Melo F, Brandan E. The internal region leucine-rich repeat 6 of decorin interacts with low density lipoprotein receptor-related protein-1, modulates transforming growth factor (TGF)-?-dependent signaling, and inhibits TGF-?-dependent fibrotic response in skeletal muscl. J Biol Chem. 2012;287:6773-87 pubmed publisher
    b>Decorin is a small proteoglycan, composed of 12 leucine-rich repeats (LRRs) that modulates the activity of transforming growth factor type ? (TGF-?) and other growth factors, and thereby influences proliferation and differentiation in a ..
  84. Liu B, Jiang Z, Wang C, Hu Z, Ji W, Cai C, et al. [Effect of decorin gene transfection on human gastric carcinoma xenograft growth in nude mice]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012;28:1009-12 pubmed
    To investigate the effect of decorin (DCN) gene transfection on the growth of nude mice xenograft bearing human gastric carcinoma cell SGC-7901 and study the possible mechanism...