Gene Symbol: Dclk2
Description: doublecortin-like kinase 2
Alias: 6330415M09Rik, AU044875, CL2, CLICK2, Click-II, Dcamkl2, serine/threonine-protein kinase DCLK2, caMK-like CREB regulatory kinase 2, doublecortin and CaM kinase-like 2, doublecortin-like and CAM kinase-like 2
Koizumi H, Tanaka T, Gleeson J. Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration. Neuron. 2006;49:55-66 pubmed
..Surprisingly, RNAi-mediated knockdown of either gene results in similar migration defects. These results indicate the Dcx microtubule-associated protein family is required for proper neuronal migration and axonal wiring. ..
Tuy F, Saillour Y, Kappeler C, Chelly J, Francis F. Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice. Dev Neurosci. 2008;30:171-86 pubmed
..However, a minor change in expression at the protein level was detected. The Dclk2 gene is less well characterized than Dclk1 and we show here that it is expressed both in proliferating cells and ..
Kerjan G, Koizumi H, Han E, Dubé C, Djakovic S, Patrick G, et al
. Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A. 2009;106:6766-71 pubmed publisher
..functional redundancy with murin Dcx, we targeted one of the closest homologues, doublecortin-like kinase 2 (Dclk2)...
Ohmae S, Takemoto Kimura S, Okamura M, Adachi Morishima A, Nonaka M, Fuse T, et al
. Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV. J Biol Chem. 2006;281:20427-39 pubmed
..mouse CaMKI/CaMKIV-related kinases, CLICK-I (CL1)/doublecortin and CaM kinase-Like (DCAMKL)1, CLICK-II (CL2)/DCAMKL2, and CLICK-I,II-related (CLr)/DCAMKL3, the kinase domains of which had an intermediate homology not only to CaMKI/..
Shin E, Kashiwagi Y, Kuriu T, Iwasaki H, Tanaka T, Koizumi H, et al
. Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation. Nat Commun. 2013;4:1440 pubmed publisher
..Thus, doublecortin-like kinases are critical regulators of dendritic development by means of their specific targeting to the distal dendrites, and their local control of dendritic growth and synapse maturation. ..
Kim S, Zhang S, Choi K, Reister R, Do C, Baykiz A, et al
. An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures. Biol Psychiatry. 2009;65:425-31 pubmed publisher
..The RNF41 and its binding partners suggest molecular pathways underlying behavior, highlighting a potential role for the ubiquitin proteasome system in psychiatric illness. ..
Tsang W, Shek K, Lee T, Chow K. An evolutionarily conserved nested gene pair - Mab21 and Lrba/Nbea in metazoan. Genomics. 2009;94:177-87 pubmed publisher
Fourniol F, Perderiset M, Houdusse A, Moores C. Structural studies of the doublecortin family of MAPs. Methods Cell Biol. 2013;115:27-48 pubmed publisher
..Our work has provided mechanistic insight into the evolutionarily conserved DCX family of MT-stabilizing proteins and also into more general regulatory mechanisms of the MT cytoskeleton. ..
Nawabi H, Belin S, Cartoni R, Williams P, Wang C, LatremoliÃ¨re A, et al
. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron. 2015;88:704-19 pubmed publisher
..Overexpression of DCLK2 accelerated growth cone re-formation in vitro and enhanced the initiation and elongation of axon re-growth after ..