Gene Symbol: Dcc
Description: deleted in colorectal carcinoma
Alias: C030036D22Rik, Igdcc1, netrin receptor DCC, tumor suppressor protein DCC
Species: mouse
Products:     Dcc

Top Publications

  1. Manitt C, Labelle Dumais C, Eng C, Grant A, Mimee A, Stroh T, et al. Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents. PLoS ONE. 2010;5:e11463 pubmed publisher
    ..The guidance cue netrin-1 organizes neuronal networks by attracting or repelling cellular processes through DCC (deleted in colorectal cancer) and UNC-5 homologue (UNC5H) receptors, respectively...
  2. Cotrufo T, Andrés R, Ros O, Perez Branguli F, Muhaisen A, Fuschini G, et al. Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip. Eur J Neurosci. 2012;36:3152-64 pubmed publisher
    ..Previous results provided evidence of a signaling mechanism that couples chemotropic deleted in colorectal cancer (DCC)/Netrin-1 axonal guidance and exocytosis through Syntaxin1(Sytx1)/TI-VAMP SNARE proteins...
  3. Argaw A, Duff G, Zabouri N, Cécyre B, Chainé N, Cherif H, et al. Concerted action of CB1 cannabinoid receptor and deleted in colorectal cancer in axon guidance. J Neurosci. 2011;31:1489-99 pubmed publisher
    ..Finally, we found that pharmacological modulation of CB1R affected the trafficking of Deleted in colorectal cancer (DCC) receptor to the plasma membrane in a PKA-dependent manner...
  4. Grant A, Hoops D, Labelle Dumais C, Prevost M, Rajabi H, Kolb B, et al. Netrin-1 receptor-deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine. Eur J Neurosci. 2007;26:3215-28 pubmed
    ..We have hypothesized that variations in the function of DCC (deleted in colorectal cancer), a netrin-1 receptor highly expressed by DA neurones, may result in altered ..
  5. Gad J, Keeling S, Wilks A, Tan S, Cooper H. The expression patterns of guidance receptors, DCC and Neogenin, are spatially and temporally distinct throughout mouse embryogenesis. Dev Biol. 1997;192:258-73 pubmed
    To gain a better understanding of the role of DCC and Neogenin in neural and nonneural tissues during vertebrate development we have carried out in situ hybridization studies to determine their expression patterns throughout the mid to ..
  6. Yee K, Simon H, Tessier Lavigne M, O Leary D. Extension of long leading processes and neuronal migration in the mammalian brain directed by the chemoattractant netrin-1. Neuron. 1999;24:607-22 pubmed
    ..mice implicates the axonal chemoattractant netrin-1, functioning via its receptor Deleted in Colorectal Cancer (DCC), in attracting the leading process to the ventral midline...
  7. Bonnin A, Torii M, Wang L, Rakic P, Levitt P. Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nat Neurosci. 2007;10:588-97 pubmed
    ..5-HT(1B) and 5-HT(1D) receptor expression in the fetal forebrain overlaps with that of the axon guidance receptors DCC and Unc5c. In coculture assays, axons originating from anterior and posterior halves of the embryonic day 14...
  8. Alcantara S, Ruiz M, de Castro F, Soriano E, Sotelo C. Netrin 1 acts as an attractive or as a repulsive cue for distinct migrating neurons during the development of the cerebellar system. Development. 2000;127:1359-72 pubmed
    ..Thus, molecular mechanisms considered as primarily involved in axonal guidance appear also to steer neuronal cell migration. ..
  9. Auger M, Schmidt E, Manitt C, Dal Bo G, Pasterkamp R, Flores C. unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model. Eur J Neurosci. 2013;38:2853-63 pubmed publisher
    b>DCC and UNC5 homologs (UNC5H) are guidance cue receptors highly expressed by mesocorticolimbic dopamine neurons...

More Information


  1. Goldman J, Ashour M, Magdesian M, Tritsch N, Harris S, Christofi N, et al. Netrin-1 promotes excitatory synaptogenesis between cortical neurons by initiating synapse assembly. J Neurosci. 2013;33:17278-89 pubmed publisher
    ..We report that netrin-1 and its receptor DCC are widely expressed by neurons in the developing mammalian cortex during synapse formation and are enriched at ..
  2. Ly A, Nikolaev A, Suresh G, Zheng Y, Tessier Lavigne M, Stein E. DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell. 2008;133:1241-54 pubmed publisher
    ..They are guided in part by netrin-1, made by midline cells, which attracts the axons by activating the netrin receptor DCC. However, previous studies suggest that additional receptor components are required...
  3. Leyva D az E, del Toro D, Menal M, Cambray S, Sus n R, Tessier Lavigne M, et al. FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons. Curr Biol. 2014;24:494-508 pubmed publisher
    ..of Slit1, both Robo1 and FLRT3 receptors are required to induce Netrin-1 attraction by the upregulation of surface DCC through the activation of protein kinase A...
  4. Engelkamp D, Rashbass P, Seawright A, van Heyningen V. Role of Pax6 in development of the cerebellar system. Development. 1999;126:3585-96 pubmed
    ..Our results suggest that Pax6 plays a strong role during hindbrain migration processes and at least part of its activity is mediated through regulation of the netrin receptor Unc5h3. ..
  5. Kim J, Lavan D, Chen N, Flores C, Cooper H, Lawrence A. Netrin-1 receptor-deficient mice show age-specific impairment in drug-induced locomotor hyperactivity but still self-administer methamphetamine. Psychopharmacology (Berl). 2013;230:607-16 pubmed publisher
    ..Deleted in colorectal cancer (DCC), a receptor for the guidance cue netrin-1, is involved in this reorganization...
  6. Fazeli A, Dickinson S, Hermiston M, Tighe R, Steen R, Small C, et al. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature. 1997;386:796-804 pubmed
    The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q...
  7. Gad J, Keeling S, Shu T, Richards L, Cooper H. The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina. Exp Eye Res. 2000;70:711-22 pubmed
    ..been demonstrated that the guidance of retinal ganglion cell (rgc) axons through the optic disc is dependent on the DCC/netrin-1 axonal guidance system...
  8. Braisted J, Catalano S, Stimac R, Kennedy T, Tessier Lavigne M, Shatz C, et al. Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection. J Neurosci. 2000;20:5792-801 pubmed
    ..b>DCC and neogenin, receptors implicated in mediating the attractant effects of netrin-1, are expressed in dorsal ..
  9. Zhu X, Wang C, Dai P, Xie Y, Song N, Liu Y, et al. Myosin X regulates netrin receptors and functions in axonal path-finding. Nat Cell Biol. 2007;9:184-92 pubmed
    ..We find that Myo X interacts with the netrin receptor deleted in colorectal cancer (DCC) and neogenin, a DCC-related protein...
  10. Dillon A, Fujita S, Matise M, Jarjour A, Kennedy T, Kollmus H, et al. Molecular control of spinal accessory motor neuron/axon development in the mouse spinal cord. J Neurosci. 2005;25:10119-30 pubmed
    ..that Gli2 is required for the initial extension of axons from SACMN cell bodies, and that netrin-1 and its receptor Dcc are required for the proper dorsal migration of these cells and the dorsally directed extension of SACMN axons ..
  11. Flores C, Manitt C, Rodaros D, Thompson K, Rajabi H, Luk K, et al. Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine. Mol Psychiatry. 2005;10:606-12 pubmed
    Netrins are guidance cues that play a fundamental role in organizing the developing brain. The netrin receptor, DCC (deleted in colorectal cancer), is highly expressed by dopaminergic (DA) neurons...
  12. Xu B, Goldman J, Rymar V, Forget C, Lo P, Bull S, et al. Critical roles for the netrin receptor deleted in colorectal cancer in dopaminergic neuronal precursor migration, axon guidance, and axon arborization. Neuroscience. 2010;169:932-49 pubmed publisher
    b>DCC (deleted in colorectal cancer), a receptor for the axon guidance cue netrin-1, is highly expressed by mesencephalic dopaminergic (DA) neurons during development; however, the contribution of DCC to DA development remains largely ..
  13. Manitt C, Mimee A, Eng C, Pokinko M, Stroh T, Cooper H, et al. The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry. J Neurosci. 2011;31:8381-94 pubmed publisher
    Netrins are guidance cues involved in neural connectivity. We have shown that the netrin-1 receptor DCC (deleted in colorectal cancer) is involved in the functional organization of the mesocorticolimbic dopamine (DA) system...
  14. Burgess R, Jucius T, Ackerman S. Motor axon guidance of the mammalian trochlear and phrenic nerves: dependence on the netrin receptor Unc5c and modifier loci. J Neurosci. 2006;26:5756-66 pubmed
    ..nerve misprojections nor the phrenic nerve phenotype was observed in B6 embryos lacking the netrin receptors DCC or Neogenin1, or the ligand netrin1, indicating these signaling molecules are dispensable for guidance of these ..
  15. Cotrufo T, Perez Branguli F, Muhaisen A, Ros O, Andres R, Baeriswyl T, et al. A signaling mechanism coupling netrin-1/deleted in colorectal cancer chemoattraction to SNARE-mediated exocytosis in axonal growth cones. J Neurosci. 2011;31:14463-80 pubmed publisher
    ..Here, we show that the Netrin-1 receptor deleted in colorectal cancer (DCC) forms a protein complex with the t-SNARE (target SNARE) protein Syntaxin-1 (Sytx1)...
  16. Krimpenfort P, Song J, Proost N, Zevenhoven J, Jonkers J, Berns A. Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours. Nature. 2012;482:538-41 pubmed publisher
    Since its discovery in the early 1990s the deleted in colorectal cancer (DCC) gene, located on chromosome 18q21, has been proposed as a tumour suppressor gene as its loss is implicated in the majority of advanced colorectal and many ..
  17. Horn K, Glasgow S, Gobert D, Bull S, Luk T, Girgis J, et al. DCC expression by neurons regulates synaptic plasticity in the adult brain. Cell Rep. 2013;3:173-85 pubmed publisher
    The transmembrane protein deleted in colorectal cancer (DCC) and its ligand, netrin-1, regulate synaptogenesis during development, but their function in the mature central nervous system is unknown...
  18. Osborne P, Halliday G, Cooper H, Keast J. Localization of immunoreactivity for deleted in colorectal cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents. Neuroscience. 2005;131:671-81 pubmed
    b>DCC (deleted in colorectal cancer)-the receptor of the netrin-1 neuronal guidance factor-is expressed and is active in the central nervous system (CNS) during development, but is down-regulated during maturation...
  19. Grant A, Speed Z, Labelle Dumais C, Flores C. Post-pubertal emergence of a dopamine phenotype in netrin-1 receptor-deficient mice. Eur J Neurosci. 2009;30:1318-28 pubmed publisher
    ..shown that adult mice that develop with reduced levels of the netrin-1 receptor [deleted in colorectal cancer (DCC)] display selective reorganization of mesocortical DA circuitry, show enhanced mesocortical DA function and exhibit ..
  20. Cooper H, Armes P, Britto J, Gad J, Wilks A. Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo. Oncogene. 1995;11:2243-54 pubmed
    Loss of DCC gene expression has now been demonstrated in a wide variety of metastatic cancers. Here we present the nucleotide sequence and predicted amino acid sequence of mouse DCC...
  21. de Diego I, Kyriakopoulou K, Karagogeos D, Wassef M. Multiple influences on the migration of precerebellar neurons in the caudal medulla. Development. 2002;129:297-306 pubmed
    ..Consistent with this observation, while neurons in the superficial migration expressed the Dcc-netrin receptor, the migrating olivary neurons did not express Dcc before they reached the midline...
  22. Deiner M, Kennedy T, Fazeli A, Serafini T, Tessier Lavigne M, Sretavan D. Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. Neuron. 1997;19:575-89 pubmed
    ..on neuroepithelial cells at the disk surrounding exiting RGC axons, and RGC axons express the netrin receptor, DCC (deleted in colorectal cancer). In vitro, anti-DCC antibodies reduced RGC neurite outgrowth responses to netrin-1...
  23. Ren T, Zhang J, Plachez C, Mori S, Richards L. Diffusion tensor magnetic resonance imaging and tract-tracing analysis of Probst bundle structure in Netrin1- and DCC-deficient mice. J Neurosci. 2007;27:10345-9 pubmed
    ..dye tract-tracing studies, we analyzed the Probst bundles in both Netrin1 and deleted in colorectal cancer (DCC) mutant mice...
  24. Yetnikoff L, Eng C, Benning S, Flores C. Netrin-1 receptor in the ventral tegmental area is required for sensitization to amphetamine. Eur J Neurosci. 2010;31:1292-302 pubmed publisher
    ..neural organization during development, the netrin-1 guidance cue and its receptor, deleted in colorectal cancer (DCC), continue to be expressed in the adult brain...
  25. Driskell R, Giangreco A, Jensen K, Mulder K, Watt F. Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development. 2009;136:2815-23 pubmed publisher
    ..We have thus demonstrated a previously unrecognised heterogeneity in dermal papilla cells and shown that Sox2-positive cells specify particular hair follicle types. ..
  26. Xu K, Wu Z, Renier N, Antipenko A, Tzvetkova Robev D, Xu Y, et al. Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. Science. 2014;344:1275-9 pubmed publisher
    Netrins are secreted proteins that regulate axon guidance and neuronal migration. Deleted in colorectal cancer (DCC) is a well-established netrin-1 receptor mediating attractive responses...
  27. Barallobre M, Del Rio J, Alcantara S, Borrell V, Aguado F, Ruiz M, et al. Aberrant development of hippocampal circuits and altered neural activity in netrin 1-deficient mice. Development. 2000;127:4797-810 pubmed
    ..We show that netrin 1 and its receptor, Dcc, are expressed in the developing fimbria and in projection neurons, respectively, and that netrin 1 promotes the ..
  28. Manitt C, Eng C, Pokinko M, Ryan R, Torres Berrio A, Lopez J, et al. dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients. Transl Psychiatry. 2013;3:e338 pubmed publisher
    ..The mechanisms governing this protracted and unique development are unknown. Here we identify dcc as the first DA neuron gene to regulate mPFC connectivity during adolescence and dissect the mechanisms involved...
  29. Bouchard J, Horn K, Stroh T, Kennedy T. Depolarization recruits DCC to the plasma membrane of embryonic cortical neurons and enhances axon extension in response to netrin-1. J Neurochem. 2008;107:398-417 pubmed publisher
    The netrin-1 receptor Deleted in Colorectal Cancer (DCC) is required for the formation of major axonal projections by embryonic cortical neurons, including the corpus callosum, hippocampal commissure, and cortico-thalamic tracts...
  30. Finger J, Bronson R, Harris B, Johnson K, Przyborski S, Ackerman S. The netrin 1 receptors Unc5h3 and Dcc are necessary at multiple choice points for the guidance of corticospinal tract axons. J Neurosci. 2002;22:10346-56 pubmed
    ..The netrin 1 receptor DCC and its Caenorhabditis elegans homolog UNC-40 have been implicated in directing the guidance of axons toward netrin ..
  31. Fothergill T, Donahoo A, Douglass A, Zalucki O, Yuan J, Shu T, et al. Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion. Cereb Cortex. 2014;24:1138-51 pubmed publisher
    ..These results provide the first evidence for how callosal axons integrate multiple guidance cues to navigate the midline. ..
  32. Engelkamp D. Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation. Mech Dev. 2002;118:191-7 pubmed
    ..Unc5h1 expression is restricted to the central nervous system, whereas, sites of Unc5h4 expression are in the developing limb and mammary gland. ..
  33. Shi M, Guo C, Dai J, Ding Y. DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain. Mol Cell Neurosci. 2008;39:529-38 pubmed publisher
    ..We show that the Netrin receptor DCC is expressed in LC neurons and is required for their tangential migration...
  34. SMITH K, Ohkubo Y, Maragnoli M, Rasin M, Schwartz M, Sestan N, et al. Midline radial glia translocation and corpus callosum formation require FGF signaling. Nat Neurosci. 2006;9:787-97 pubmed
    ..Hence, FGFs have an important role in the transition from radial glia to astrocytes by stimulating somal translocation of radial glial cells. ..
  35. Graef I, Wang F, Charron F, Chen L, Neilson J, Tessier Lavigne M, et al. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 2003;113:657-70 pubmed
    ..The precise parsing of signals for elongation turning and survival could allow independent control of these processes during development. ..
  36. Ahmed G, Shinmyo Y, Ohta K, Islam S, Hossain M, Naser I, et al. Draxin inhibits axonal outgrowth through the netrin receptor DCC. J Neurosci. 2011;31:14018-23 pubmed publisher
    ..Draxin interacts with subnanomolar affinity to the netrin receptor DCC, in a region of DCC distinct from its netrin-binding domain...
  37. Fearon E, Cho K, Nigro J, Kern S, Simons J, Ruppert J, et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 1990;247:49-56 pubmed
    ..Expressed exons were used as probes for cDNA screening to obtain clones that encoded a portion of a gene termed DCC; this cDNA was encoded by at least eight exons within the 370-kb genomic region...
  38. Serafini T, Colamarino S, Leonardo E, Wang H, Beddington R, Skarnes W, et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell. 1996;87:1001-14 pubmed
    ..These results establish netrin-1 as a guidance cue that likely collaborates with other diffusible cues to guide axons in vivo. ..
  39. Saueressig H, Burrill J, Goulding M. Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons. Development. 1999;126:4201-12 pubmed
  40. Shoja Taheri F, DeMarco A, Mastick G. Netrin1-DCC-Mediated Attraction Guides Post-Crossing Commissural Axons in the Hindbrain. J Neurosci. 2015;35:11707-18 pubmed publisher
    ..After initial attraction to the floor plate using Netrin1 activation of its main attractive receptor, DCC (deleted in colorectal cancer), axons cross the ventral midline, and many turn to grow longitudinally on the ..
  41. Kocabas A, Duarte T, Kumar S, Hynes M. Widespread Differential Expression of Coding Region and 3' UTR Sequences in Neurons and Other Tissues. Neuron. 2015;88:1149-1156 pubmed publisher
    ..Our findings raise questions about the role of isolated 3' UTR sequences in regulation of protein expression and highlight the importance of separately examining 3' UTR and CDS sequences in gene expression analyses. ..
  42. Ratcliffe E, Setru S, Chen J, Li Z, D Autréaux F, Gershon M. Netrin/DCC-mediated attraction of vagal sensory axons to the fetal mouse gut. J Comp Neurol. 2006;498:567-80 pubmed
    ..The crest-derived cells express the netrin receptor deleted in colorectal cancer (DCC) and migrate toward netrins expressed by the intestinal mucosa and pancreas; this attraction is required for the ..
  43. Belle M, Godefroy D, Dominici C, Heitz Marchaland C, Zelina P, Hellal F, et al. A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous system. Cell Rep. 2014;9:1191-201 pubmed publisher
    ..fasciculus retroflexus (FR) and analyzed the development of this commissural tract in mutants of the Slit/Robo and DCC/Netrin pathways...
  44. Wang M, Wang Y, You M, Devereux T. Analysis of the Par2 modifier of pulmonary adenoma formation in mice. Exp Lung Res. 2005;31:193-204 pubmed
    ..The authors recently conducted studies to positionally clone the Par2 gene. This review summarizes the effort and progress towards the identification of Par2 candidates. ..
  45. Sgadò P, Ferretti E, Grbec D, Bozzi Y, Simon H. The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons. Neural Dev. 2012;7:24 pubmed publisher
    ..In Pbx1-deficient dopaminergic neurons, the high affinity netrin-1 receptor, deleted in colon cancer (DCC), is down-regulated...
  46. Ren X, Ming G, Xie Y, Hong Y, Sun D, Zhao Z, et al. Focal adhesion kinase in netrin-1 signaling. Nat Neurosci. 2004;7:1204-12 pubmed
    ..Here we report that the netrin receptor DCC (deleted in colorectal cancer) interacts with the focal adhesion kinase (FAK), a kinase implicated in ..
  47. Lee G, Matsushita H, Kitagawa T. Fine chromosomal localization of the mouse Par2 gene that confers resistance against urethane-induction of pulmonary adenomas. Oncogene. 2001;20:3979-85 pubmed
    ..The map information obtained in this study should enable subsequent positional cloning of the Par2 gene...
  48. Lane C, Qi J, Fawcett J. NCK is critical for the development of deleted in colorectal cancer (DCC) sensitive spinal circuits. J Neurochem. 2015;134:1008-14 pubmed publisher
    ..Recently, deleted in colorectal cancer (DCC) has been shown to be important in the development of spinal circuits necessary for gait...
  49. Rajasekharan S, Baker K, Horn K, Jarjour A, Antel J, Kennedy T. Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA. Development. 2009;136:415-26 pubmed publisher
    ..describe a novel role for the chemotropic guidance cue netrin 1 and its receptor deleted in colorectal carcinoma (Dcc) in the remodeling of oligodendrocyte processes...
  50. Løes S, Luukko K, Hals Kvinnsland I, Salminen M, Kettunen P. Developmentally regulated expression of Netrin-1 and -3 in the embryonic mouse molar tooth germ. Dev Dyn. 2003;227:573-7 pubmed
    ..Hence, it is possible that Netrin-3 may regulate pioneer axon growth toward and within the embryonic tooth target field. ..
  51. Leggere J, Saito Y, Darnell R, Tessier Lavigne M, Junge H, Chen Z. NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. elife. 2016;5: pubmed publisher
    ..Interestingly, Nova mutants display similar defects as the knockout of the Dcc transmembrane receptor...
  52. Kim T, Lee H, Seo I, Bae H, Suh D, Wu J, et al. Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron. J Neurochem. 2005;95:1-8 pubmed
    ..Netrin-1 induced the ubiquitination and proteolytic cleavage of Deleted in Colorectal Cancer (DCC), a transmembrane receptor for netrin, in dissociated cortical neurons...
  53. Miyoshi G, Fishell G. Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate. Neuron. 2012;74:1045-58 pubmed publisher
    ..Thus, the dynamic expression of FoxG1 during migration within the intermediate zone is essential for the proper assembly of the cerebral cortex. ..
  54. Matise M, Lustig M, Sakurai T, Grumet M, Joyner A. Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord. Development. 1999;126:3649-59 pubmed
  55. Kim Y, Wang S, Tymanskyj S, Ma L, Tao H, Zhang L. Dcc Mediates Functional Assembly of Peripheral Auditory Circuits. Sci Rep. 2016;6:23799 pubmed publisher
    ..Here, we report in the developing mouse cochlea that deleted in colorectal cancer (Dcc) contributes to the proper organization of spiral ganglion neurons (SGNs) within the Rosenthal's canal and of SGN ..
  56. Gitz D, Eells J, Pennock D. The dcc mutation affects ciliary length in Tetrahymena thermophila. J Eukaryot Microbiol. 1993;40:668-76 pubmed
    ..The mutation was named dcc for defective in ciliogenesis and cytokinesis.
  57. Geisen M, di Meglio T, Pasqualetti M, Ducret S, Brunet J, Chedotal A, et al. Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling. PLoS Biol. 2008;6:e142 pubmed publisher
    ..Unlike DV migration, which is controlled by the Netrin-1/Dcc attractive pathway, little is known about the molecular mechanisms guiding PN migration along the AP axis...
  58. Dominici C, Moreno Bravo J, Puiggros S, Rappeneau Q, Rama N, Vieugué P, et al. Floor-plate-derived netrin-1 is dispensable for commissural axon guidance. Nature. 2017;545:350-354 pubmed publisher
    ..These results show that the classical view that attraction of commissural axons is mediated by a gradient of floor-plate-derived netrin-1 is inaccurate and that netrin-1 primarily acts locally by promoting growth cone adhesion. ..
  59. Castets M, Broutier L, Molin Y, Brevet M, Chazot G, Gadot N, et al. DCC constrains tumour progression via its dependence receptor activity. Nature. 2011;482:534-7 pubmed publisher
    The role of deleted in colorectal carcinoma (DCC) as a tumour suppressor has been a matter of debate for the past 15 years...
  60. Hollis Moffatt J, Hook S, Merriman T. Colocalization of mouse autoimmune diabetes loci Idd21.1 and Idd21.2 with IDDM6 (human) and Iddm3 (rat). Diabetes. 2005;54:2820-5 pubmed
    ..1-21.2 in mouse. Further genetic localization of Idd21.1 and Idd21.2 could expedite characterization of the human IDDM6 region. ..
  61. Bloch Gallego E, Ezan F, Tessier Lavigne M, Sotelo C. Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neurons. J Neurosci. 1999;19:4407-20 pubmed
    ..First, we show that the pattern of expression of netrin receptors DCC (for deleted in colorectal cancer), neogenin (a DCC-related protein), and members of the Unc5 family in wild-type ..
  62. Kavety B, Jenkins N, Fletcher C, Copeland N, Morgan J. Genomic structure and mapping of precerebellin and a precerebellin-related gene. Brain Res Mol Brain Res. 1994;27:152-6 pubmed
    ..Cbln1 was positioned to the central region of mouse chromosome 8, 2.3 cM distal of JunB and 6.0 cM proximal of Mt1, while Cbln2 mapped to the distal end of mouse chromosome 18, 1.7 cM telomeric of Mbp. ..
  63. Murali D, Kawaguchi Niida M, Deng C, Furuta Y. Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-? signaling system in the embryonic mouse retina. Invest Ophthalmol Vis Sci. 2011;52:2930-7 pubmed publisher
    ..In addition, genetic requirements for Smad4 in the embryonic retina are evident predominantly in the developmental events regulated by the BMP branch of the TGF-? signaling pathway. ..