Dbx1

Summary

Gene Symbol: Dbx1
Description: developing brain homeobox 1
Alias: AI426026, Dbx, homeobox protein DBX1, Mmox C, developing brain homeobox protein 1
Species: mouse
Products:     Dbx1

Top Publications

  1. Lanuza G, Gosgnach S, Pierani A, Jessell T, Goulding M. Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements. Neuron. 2004;42:375-86 pubmed
    ..a discrete subset of commissural spinal interneurons, whose fate is controlled by the activity of the homeobox gene Dbx1, has a critical role in controlling the left-right alternation of motor neurons innervating hindlimb muscles...
  2. Bai C, Stephen D, Joyner A. All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell. 2004;6:103-15 pubmed
    ..Therefore, in the spinal cord all Hh signaling is Gli dependent. Furthermore, a combination of Gli2 and Gli3 is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors. ..
  3. Pierani A, Brenner Morton S, Chiang C, Jessell T. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Cell. 1999;97:903-15 pubmed
    ..for this parallel pathway emerged from an analysis of the induction of ventral progenitors that express the Dbx homeodomain proteins and of Evx1/2 (V0) and En1 (V1) neurons...
  4. Wang X, Hayes J, Picardo M, Del Negro C. Automated cell-specific laser detection and ablation of neural circuits in neonatal brain tissue. J Physiol. 2013;591:2393-401 pubmed publisher
  5. Teissier A, Griveau A, Vigier L, Piolot T, Borello U, Pierani A. A novel transient glutamatergic population migrating from the pallial-subpallial boundary contributes to neocortical development. J Neurosci. 2010;30:10563-74 pubmed publisher
    ..Using genetic tracing in mice, we have identified a population of glutamatergic neurons generated by Dbx1-expressing progenitors at the pallial-subpallial boundary predominantly at embryonic day 12.5 (E12...
  6. Gray P, Hayes J, Ling G, Llona I, Tupal S, Picardo M, et al. Developmental origin of preBötzinger complex respiratory neurons. J Neurosci. 2010;30:14883-95 pubmed publisher
    ..in mice, that the "core" of preBötC SST(+)/NK1R(+)/SST 2a receptor(+) (SST2aR) neurons, are derived from Dbx1-expressing progenitors...
  7. Shoji H, Ito T, Wakamatsu Y, Hayasaka N, Ohsaki K, Oyanagi M, et al. Regionalized expression of the Dbx family homeobox genes in the embryonic CNS of the mouse. Mech Dev. 1996;56:25-39 pubmed
    Here we report the identification of a novel homeobox gene family Dbx in mouse, which consists of Dbx and Dbx2. The two genes share similar structural organization and are encoded by different chromosomes...
  8. Hanashima C, Fernandes M, Hebert J, Fishell G. The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes. J Neurosci. 2007;27:11103-11 pubmed
  9. Picardo M, Weragalaarachchi K, Akins V, Del Negro C. Physiological and morphological properties of Dbx1-derived respiratory neurons in the pre-Botzinger complex of neonatal mice. J Physiol. 2013;591:2687-703 pubmed publisher
    ..rhythm-generating preBötC neurons derive from a single genetic line that expresses the transcription factor Dbx1, but the cellular mechanisms of rhythmogenesis remain incompletely understood...
  10. Flames N, Pla R, Gelman D, Rubenstein J, Puelles L, Marin O. Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. J Neurosci. 2007;27:9682-95 pubmed
    ..Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains. ..

Detail Information

Publications90

  1. Lanuza G, Gosgnach S, Pierani A, Jessell T, Goulding M. Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements. Neuron. 2004;42:375-86 pubmed
    ..a discrete subset of commissural spinal interneurons, whose fate is controlled by the activity of the homeobox gene Dbx1, has a critical role in controlling the left-right alternation of motor neurons innervating hindlimb muscles...
  2. Bai C, Stephen D, Joyner A. All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell. 2004;6:103-15 pubmed
    ..Therefore, in the spinal cord all Hh signaling is Gli dependent. Furthermore, a combination of Gli2 and Gli3 is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors. ..
  3. Pierani A, Brenner Morton S, Chiang C, Jessell T. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Cell. 1999;97:903-15 pubmed
    ..for this parallel pathway emerged from an analysis of the induction of ventral progenitors that express the Dbx homeodomain proteins and of Evx1/2 (V0) and En1 (V1) neurons...
  4. Wang X, Hayes J, Picardo M, Del Negro C. Automated cell-specific laser detection and ablation of neural circuits in neonatal brain tissue. J Physiol. 2013;591:2393-401 pubmed publisher
  5. Teissier A, Griveau A, Vigier L, Piolot T, Borello U, Pierani A. A novel transient glutamatergic population migrating from the pallial-subpallial boundary contributes to neocortical development. J Neurosci. 2010;30:10563-74 pubmed publisher
    ..Using genetic tracing in mice, we have identified a population of glutamatergic neurons generated by Dbx1-expressing progenitors at the pallial-subpallial boundary predominantly at embryonic day 12.5 (E12...
  6. Gray P, Hayes J, Ling G, Llona I, Tupal S, Picardo M, et al. Developmental origin of preBötzinger complex respiratory neurons. J Neurosci. 2010;30:14883-95 pubmed publisher
    ..in mice, that the "core" of preBötC SST(+)/NK1R(+)/SST 2a receptor(+) (SST2aR) neurons, are derived from Dbx1-expressing progenitors...
  7. Shoji H, Ito T, Wakamatsu Y, Hayasaka N, Ohsaki K, Oyanagi M, et al. Regionalized expression of the Dbx family homeobox genes in the embryonic CNS of the mouse. Mech Dev. 1996;56:25-39 pubmed
    Here we report the identification of a novel homeobox gene family Dbx in mouse, which consists of Dbx and Dbx2. The two genes share similar structural organization and are encoded by different chromosomes...
  8. Hanashima C, Fernandes M, Hebert J, Fishell G. The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes. J Neurosci. 2007;27:11103-11 pubmed
  9. Picardo M, Weragalaarachchi K, Akins V, Del Negro C. Physiological and morphological properties of Dbx1-derived respiratory neurons in the pre-Botzinger complex of neonatal mice. J Physiol. 2013;591:2687-703 pubmed publisher
    ..rhythm-generating preBötC neurons derive from a single genetic line that expresses the transcription factor Dbx1, but the cellular mechanisms of rhythmogenesis remain incompletely understood...
  10. Flames N, Pla R, Gelman D, Rubenstein J, Puelles L, Marin O. Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. J Neurosci. 2007;27:9682-95 pubmed
    ..Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains. ..
  11. Yun K, Potter S, Rubenstein J. Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon. Development. 2001;128:193-205 pubmed
    ..The role of Pax6 in dorsalizing the telencephalon is similar to its role in the spinal cord, supporting the hypothesis that some dorsoventral patterning mechanisms are used at all axial levels of the central nervous system. ..
  12. Zimmer C, Lee J, Griveau A, Arber S, Pierani A, Garel S, et al. Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cells. Development. 2010;137:293-302 pubmed publisher
    ..Together, our results shed light on the mechanisms specifying rostral CR cells and further emphasise the crucial role of telencephalic signalling centres in the generation of distinct CR cell populations. ..
  13. Lu S, Bogarad L, Murtha M, Ruddle F. Expression pattern of a murine homeobox gene, Dbx, displays extreme spatial restriction in embryonic forebrain and spinal cord. Proc Natl Acad Sci U S A. 1992;89:8053-7 pubmed
    Homeobox genes specify regional identity during development. A homeobox sequence that we have named Dbx was isolated from 13.5-day embryonic mouse telencephalon cDNA. The Dbx homeodomain shows highest sequence homology to Drosophila H2...
  14. Pierani A, Moran Rivard L, Sunshine M, Littman D, Goulding M, Jessell T. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. Neuron. 2001;29:367-84 pubmed
    ..derive from adjacent progenitor domains that are distinguished by expression of the homeodomain proteins Dbx1 and Dbx2...
  15. Bielle F, Griveau A, Narboux Nême N, Vigneau S, Sigrist M, Arber S, et al. Multiple origins of Cajal-Retzius cells at the borders of the developing pallium. Nat Neurosci. 2005;8:1002-12 pubmed
    ..The homeodomain transcription factor Dbx1 is expressed in restricted progenitor domains of the developing pallium: the ventral pallium (VP) and the septum...
  16. Inoue T, Ogawa M, Mikoshiba K, Aruga J. Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly. J Neurosci. 2008;28:4712-25 pubmed publisher
    ..These findings indicate that the Zic genes play critical roles in cortical development through regulating the proliferation of meningeal cells and the pial BM assembly. ..
  17. Martinelli D, Fan C. Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev. 2007;21:1231-43 pubmed
    ..Our data support a model in which GAS1 helps transform the Hedgehog protein gradient into the observed activity gradient. We propose that Gas1 is an evolutionarily novel, vertebrate-specific Hedgehog pathway regulator. ..
  18. Hirata T, Li P, Lanuza G, Cocas L, Huntsman M, Corbin J. Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala. Nat Neurosci. 2009;12:141-9 pubmed publisher
    ..distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala...
  19. Alvarez Bolado G, Paul F, Blaess S. Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions. Neural Dev. 2012;7:4 pubmed publisher
    ..Our work sets the stage for a deeper developmental analysis of this complex and important brain region. ..
  20. Stenman J, Wang B, Campbell K. Tlx controls proliferation and patterning of lateral telencephalic progenitor domains. J Neurosci. 2003;23:10568-76 pubmed
    ..Our results show that, although Gsh2 and Tlx have additive effects on striatal development, they differentially regulate the establishment of ventral pallial identity. ..
  21. Gelman D, Martini F, Nóbrega Pereira S, Pierani A, Kessaris N, Marin O. The embryonic preoptic area is a novel source of cortical GABAergic interneurons. J Neurosci. 2009;29:9380-9 pubmed publisher
  22. Nouri N, Awatramani R. A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons. Development. 2017;144:916-927 pubmed publisher
    ..the mdFP into two microdomains, defined by engrailed 1 (En1) and developing brain homeobox 1 (Dbx1)...
  23. Pachikara A, Dolson D, Martinu L, Riccomagno M, Jeong Y, Epstein D. Activation of Class I transcription factors by low level Sonic hedgehog signaling is mediated by Gli2-dependent and independent mechanisms. Dev Biol. 2007;305:52-62 pubmed
    ..the adjacent hindbrain by inducing, rather than repressing, the expression of several Class I genes (Pax6, Dbx1, Dbx2). The Shh dependent activation of Class I genes was mediated, in part, by Gli2...
  24. Wu J, Capelli P, Bouvier J, Goulding M, Arber S, Fortin G. A V0 core neuronal circuit for inspiration. Nat Commun. 2017;8:544 pubmed publisher
    ..Here using virus-based circuit-mapping approaches in mice, the authors reveal the lineage, neurotransmitter phenotype, and connectivity patterns of phrenic premotor neurons, which are a crucial component of the inspiratory circuit. ..
  25. Allen B, Song J, Izzi L, Althaus I, Kang J, Charron F, et al. Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. Dev Cell. 2011;20:775-87 pubmed publisher
    ..Most strikingly, genetic loss-of-function experiments indicate an obligatory requirement for GAS1, CDO, and BOC in HH pathway activity in multiple tissues. ..
  26. Bulgakov O, Eggenschwiler J, Hong D, Anderson K, Li T. FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. Development. 2004;131:2149-59 pubmed
    ..Although it is expressed broadly, FKBP8 is required to antagonize SHH signaling primarily in neural tissues, suggesting that hedgehog signal transduction is subject to cell-type specific modulation during mammalian development. ..
  27. Pattyn A, Vallstedt A, Dias J, Sander M, Ericson J. Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain. Development. 2003;130:4149-59 pubmed
    ..Thus, both visceral and somatic motoneuron differentiation appear to rely on the combined activity of cell intrinsic determinants, rather than on a single key determinant of neuronal cell fate. ..
  28. Hua Z, Jeon S, Caterina M, Nathans J. Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system. Proc Natl Acad Sci U S A. 2014;111:E3005-14 pubmed publisher
  29. Nomura T, Takahashi M, Hara Y, Osumi N. Patterns of neurogenesis and amplitude of Reelin expression are essential for making a mammalian-type cortex. PLoS ONE. 2008;3:e1454 pubmed publisher
    ..These lines of evidence shed light on the developmental programs underlying the evolution of the mammalian specific laminated cortex...
  30. Ikeya M, Lee S, Johnson J, McMahon A, Takada S. Wnt signalling required for expansion of neural crest and CNS progenitors. Nature. 1997;389:966-70 pubmed
    ..Given the widespread expression of different Wnt genes in discrete areas of the mammalian neural tube, this may represent a general model for the action of Wnt signalling in the developing CNS. ..
  31. Holtz A, Peterson K, Nishi Y, Morin S, Song J, Charron F, et al. Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development. 2013;140:3423-34 pubmed publisher
    ..Overall, these data reveal an essential role for ligand-dependent feedback inhibition of vertebrate HH signaling governed collectively by PTCH1, PTCH2 and HHIP1. ..
  32. Genethliou N, Panayiotou E, Panayi H, Orford M, Mean R, Lapathitis G, et al. Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord. Biochem Biophys Res Commun. 2009;382:69-73 pubmed publisher
    ..These data provide important insights into specific functions of PAX6 and NKX2.2 during glial cell specification that have so far remained largely unexplored. ..
  33. Kinameri E, Inoue T, Aruga J, Imayoshi I, Kageyama R, Shimogori T, et al. Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. PLoS ONE. 2008;3:e3859 pubmed publisher
    ..Our data demonstrate that Prdm genes are regulated by the Notch-Hes pathway and represent strong candidates to control neural class specification and the sequential progression of mammalian CNS neurogenesis. ..
  34. Thélie A, Desiderio S, Hanotel J, Quigley I, Van Driessche B, Rodari A, et al. Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus. Development. 2015;142:3416-28 pubmed publisher
    ..dependent on retinoic acid and Pax6, and that it is restricted to p1 progenitors, due to the repressive action of Dbx1 and Nkx6-1/2 expressed in the adjacent p0 and p2 domains...
  35. Teissier A, Waclaw R, Griveau A, Campbell K, Pierani A. Tangentially migrating transient glutamatergic neurons control neurogenesis and maintenance of cerebral cortical progenitor pools. Cereb Cortex. 2012;22:403-16 pubmed publisher
  36. Stenman J, Yu R, Evans R, Campbell K. Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development. 2003;130:1113-22 pubmed
    ..This correlates well with the malformation of the lateral and basolateral amygdala in Tlx mutants, both of which have been suggested to derive from ventral portions of the pallium. ..
  37. Miles G, Hartley R, Todd A, Brownstone R. Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion. Proc Natl Acad Sci U S A. 2007;104:2448-53 pubmed
    ..These results highlight a unique component of spinal motor networks that is critical in ensuring that sufficient output is generated by motoneurons to drive motor behavior. ..
  38. Kottick A, Del Negro C. Synaptic Depression Influences Inspiratory-Expiratory Phase Transition in Dbx1 Interneurons of the preBötzinger Complex in Neonatal Mice. J Neurosci. 2015;35:11606-11 pubmed publisher
    ..generates the rhythm underlying inspiratory breathing movements and its core interneurons are derived from Dbx1-expressing precursors...
  39. Dixit R, Wilkinson G, Cancino G, Shaker T, Adnani L, Li S, et al. Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex. J Neurosci. 2014;34:539-53 pubmed publisher
    ..Neurog1 and Neurog2 thus have unique and redundant functions in the piriform cortex, controlling the timing of differentiation of early-born CR/lot cells and specifying the identities of later-born layer II/III neurons. ..
  40. Sokolowski K, Tran T, Esumi S, Kamal Y, Oboti L, Lischinsky J, et al. Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei. Neural Dev. 2016;11:12 pubmed publisher
    ..Here, focusing on the embryonically expressed homeodomain-containing gene Developing Brain Homeobox 1 (Dbx1), we explored the relationship between embryonic lineage, post-natal neuronal identity and lineage-specific ..
  41. Mangale V, Hirokawa K, Satyaki P, Gokulchandran N, Chikbire S, Subramanian L, et al. Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate. Science. 2008;319:304-9 pubmed publisher
    ..In addition to providing functional evidence for Lhx2 selector activity, these findings show that the cortical hem is a hippocampal organizer. ..
  42. Carney R, Cocas L, Hirata T, Mansfield K, Corbin J. Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2. Cereb Cortex. 2009;19:745-59 pubmed publisher
    ..Thus, in addition to their well-characterized cross-repressive roles in dorsal/ventral patterning our analyses reveal important novel functions of Gsh2 and Pax6 in the regulation of PSB progenitor pool specification and patterning. ..
  43. Yun K, Mantani A, Garel S, Rubenstein J, Israel M. Id4 regulates neural progenitor proliferation and differentiation in vivo. Development. 2004;131:5441-8 pubmed
    ..These observations, together with evidence for the premature differentiation of early cortical stem cells, indicate that Id4 has a unique and complex function in regulating neural stem cell proliferation and differentiation. ..
  44. Vallstedt A, Muhr J, Pattyn A, Pierani A, Mendelsohn M, Sander M, et al. Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification. Neuron. 2001;31:743-55 pubmed
  45. Waclaw R, Ehrman L, Pierani A, Campbell K. Developmental origin of the neuronal subtypes that comprise the amygdalar fear circuit in the mouse. J Neurosci. 2010;30:6944-53 pubmed publisher
    ..Additional support for a dLGE origin of the ITCs was obtained in conditional mutants of the dLGE gene Sp8. Thus, our findings indicate diverse origins for the neuronal components that comprise the amygdalar fear circuit. ..
  46. Chiara F, Badaloni A, Croci L, Yeh M, Cariboni A, Hoerder Suabedissen A, et al. Early B-cell factors 2 and 3 (EBF2/3) regulate early migration of Cajal-Retzius cells from the cortical hem. Dev Biol. 2012;365:277-89 pubmed publisher
    ..These findings provide evidence that Ebfs directly regulate CR cell development. ..
  47. Vue T, Aaker J, Taniguchi A, Kazemzadeh C, Skidmore J, Martin D, et al. Characterization of progenitor domains in the developing mouse thalamus. J Comp Neurol. 2007;505:73-91 pubmed
    ..To determine if pTH-C is composed of subdomains, we characterized expression of the homeodomain protein Dbx1 and the bHLH protein Olig2...
  48. Gaber Z, Butler S, Novitch B. PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors. PLoS Biol. 2013;11:e1001676 pubmed publisher
    ..Together, these findings reveal a novel transcriptional strategy for spatially tuning the responsiveness of distinct neural progenitor groups to broadly distributed mitogenic signals in the embryonic environment. ..
  49. Ledonne F, Orduz D, Mercier J, Vigier L, Grove E, Tissir F, et al. Targeted Inactivation of Bax Reveals a Subtype-Specific Mechanism of Cajal-Retzius Neuron Death in the Postnatal Cerebral Cortex. Cell Rep. 2016;17:3133-3141 pubmed publisher
    ..These results underlie the existence of an exquisitely refined control of developmental cell death and provide a model to test the effect of maintaining immature circuits in the adult neocortex. ..
  50. Vyas A, Saha B, Lai E, Tole S. Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disrupted. J Comp Neurol. 2003;466:545-53 pubmed
    ..Furthermore, our in vitro data reveal that, if mechanisms outside the lateral telencephalon are involved in the specification of the paleocortex, they must act extremely early, prior to E10.5. ..
  51. Anderson T, Garcia A, Baertsch N, Pollak J, Bloom J, Wei A, et al. A novel excitatory network for the control of breathing. Nature. 2016;536:76-80 pubmed
  52. Yackle K, Schwarz L, Kam K, Sorokin J, Huguenard J, Feldman J, et al. Breathing control center neurons that promote arousal in mice. Science. 2017;355:1411-1415 pubmed publisher
    ..Conditional, bilateral genetic ablation of the ~175 Cdh9/Dbx1 double-positive preBötC neurons in adult mice left breathing intact but increased calm behaviors and ..
  53. Shetty A, Godbole G, Maheshwari U, Padmanabhan H, Chaudhary R, Muralidharan B, et al. Lhx2 regulates a cortex-specific mechanism for barrel formation. Proc Natl Acad Sci U S A. 2013;110:E4913-21 pubmed publisher
    ..These genes may mediate Lhx2 function in the formation of specialized neurocircuitry necessary for neocortical function. ..
  54. Zagoraiou L, Akay T, Martin J, Brownstone R, Jessell T, Miles G. A cluster of cholinergic premotor interneurons modulates mouse locomotor activity. Neuron. 2009;64:645-62 pubmed publisher
    ..Thus, V0(C) interneurons represent a defined class of spinal cholinergic interneurons with an intrinsic neuromodulatory role in the control of locomotor behavior. ..
  55. Gelman D, Griveau A, Dehorter N, Teissier A, Varela C, Pla R, et al. A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area. J Neurosci. 2011;31:16570-80 pubmed publisher
    ..Using genetic fate mapping and in utero transplantation experiments, we demonstrate that Dbx1-expressing progenitor cells in the POA give rise to a small but highly diverse cohort of cortical interneurons, ..
  56. Craven S, Lim K, Ye W, Engel J, de Sauvage F, Rosenthal A. Gata2 specifies serotonergic neurons downstream of sonic hedgehog. Development. 2004;131:1165-73 pubmed
    ..Our findings reveal that the identity of closely related 5-HT subclasses occurs through distinct responses of adjacent rostrocaudal progenitor domains to broad ventral inducers. ..
  57. Yoder J, Litman G. The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13. Gene. 2000;261:235-42 pubmed
    ..five full-length zebrafish cDNAs, fth1, slc3a2, prkri, cd81, and pc, as well as one putative human gene, DBX were identified and their map positions ascertained...
  58. Grindley J, Hargett L, Hill R, Ross A, Hogan B. Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon. Mech Dev. 1997;64:111-26 pubmed
    ..Thus, PAX6 is essential for the normal development and regionalization of the diencephalon. ..
  59. Johnson K, Smith L, Johnson D, Rhodes J, Rinchik E, Thayer M, et al. Mapping of the ARIX homeodomain gene to mouse chromosome 7 and human chromosome 11q13. Genomics. 1996;33:527-31 pubmed
    ..3-q13.4. These map locations extend and further define regions of conserved synteny between mouse and human genomes and identify a new candidate gene for inherited developmental disorders linked to human 11q13. ..
  60. Wong R, Wlodarczyk B, Min K, Scott M, Kartiko S, Yu W, et al. Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube. Hum Mol Genet. 2008;17:587-601 pubmed
    ..The mutant Fkbp8 allele is a new experimental model which will be useful in dissecting the pathogenesis of spinal NTDs, and enhance our understanding of the etiology of human NTDs...
  61. Tupal S, Huang W, Picardo M, Ling G, Del Negro C, Zoghbi H, et al. Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice. elife. 2014;3:e02265 pubmed publisher
    ..We tested the roles of Atoh1-, Phox2b-, and Dbx1-derived neurons (three groups that have known roles in respiration) in the generation and coordination of ..
  62. Barber M, Arai Y, Morishita Y, Vigier L, Causeret F, Borello U, et al. Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Controls the Size of Higher-Order Cortical Areas. Curr Biol. 2015;25:2466-78 pubmed publisher
    ..Our findings thus identify novel roles for neuronal migration and VAMP3-dependent vesicular trafficking in cortical wiring. ..
  63. Lebel M, Mo R, Shimamura K, Hui C. Gli2 and Gli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain. Dev Biol. 2007;302:345-55 pubmed
    ..Taken together, these observations indicate that Gli2 and Gli3 perform rhombomere-specific function during DV patterning of the hindbrain. ..
  64. Rogers N, McAninch D, Thomas P. Dbx1 is a direct target of SOX3 in the spinal cord. PLoS ONE. 2014;9:e95356 pubmed publisher
    ..Nineteen genes with abnormal expression were identified, including the homeobox gene Dbx1. Analysis of Sox3 null embryos revealed that Dbx1 was significantly reduced in the neural tube and developing brain ..
  65. Trousse F, Poluch S, Pierani A, Dutriaux A, Bock H, Nagasawa T, et al. CXCR7 Receptor Controls the Maintenance of Subpial Positioning of Cajal-Retzius Cells. Cereb Cortex. 2015;25:3446-57 pubmed publisher
    ..Finally, conditional Cxcr7 deletion in cells derived from Dbx1-expressing progenitors indicates an essential role of CXCR7 in controlling the positioning of a subpopulation of ..
  66. Ishibashi M, McMahon A. A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Development. 2002;129:4807-19 pubmed
  67. Arbeille E, Reynaud F, Sanyas I, Bozon M, Kindbeiter K, Causeret F, et al. Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis. Nat Commun. 2015;6:6366 pubmed publisher
    ..Thus, extrinsic control mediated by the Semaphorin signalling orients progenitor divisions in neurogenic zones. ..
  68. Koizumi H, Mosher B, Tariq M, Zhang R, Koshiya N, Smith J. Voltage-Dependent Rhythmogenic Property of Respiratory Pre-Bötzinger Complex Glutamatergic, Dbx1-Derived, and Somatostatin-Expressing Neuron Populations Revealed by Graded Optogenetic Inhibition. Eneuro. 2016;3: pubmed publisher
    ..Additionally, developmental expression of the transcription factor Dbx1 or expression of the neuropeptide somatostatin (Sst), has been proposed as a marker for the rhythmogenic pre-BötC ..
  69. Causeret F, Sumia I, Pierani A. Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner. Cell Death Differ. 2016;23:323-32 pubmed publisher
    ..Our findings thus reveal a new Wnt-independent function for Kremen1 and Dickkopf1 in the regulation of cell survival with potential implications in cancer therapies. ..
  70. Stuebner S, Faus Kessler T, Fischer T, Wurst W, Prakash N. Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect. Dev Dyn. 2010;239:246-60 pubmed publisher
    ..Fzd3 and Fzd6 thus control proper midbrain morphogenesis by a yet unknown mechanism in the mouse. ..
  71. Kanatani S, Honda T, Aramaki M, Hayashi K, Kubo K, Ishida M, et al. The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain. Proc Natl Acad Sci U S A. 2015;112:E4985-94 pubmed publisher
    ..Taken together, these results reveal that COUP-TFII/Nrp2 is a molecular switch determining the pathway and destination of migrating GABAergic neurons born in the POa. ..
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