Daxx

Summary

Gene Symbol: Daxx
Description: Fas death domain-associated protein
Alias: death domain-associated protein 6, death-domain associated protein
Species: mouse
Products:     Daxx

Top Publications

  1. Zhao L, Liu J, Sidhu G, Niu Y, Liu Y, Wang R, et al. Negative regulation of p53 functions by Daxx and the involvement of MDM2. J Biol Chem. 2004;279:50566-79 pubmed
    ..Here we show that via its acidic domain, Daxx binds to the COOH-terminal domain of p53, whose positive charges are critical for this interaction, as Lys to Arg ..
  2. Ishov A, Vladimirova O, Maul G. Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX. J Cell Sci. 2004;117:3807-20 pubmed
    ..Here, we show that the transcription repressor Daxx and the SWI/SNF protein ATRX are both associated with two intranuclear domains: ND10/PML bodies and heterochromatin...
  3. Elsaesser S, Allis C. HIRA and Daxx constitute two independent histone H3.3-containing predeposition complexes. Cold Spring Harb Symp Quant Biol. 2010;75:27-34 pubmed publisher
    ..Here, we show that, before deposition, H3.3 exists in two biochemically distinct complexes, associated with either Daxx or HIRA, Ubinuclein-1, and Cabin-1...
  4. Yang X, Khosravi Far R, Chang H, Baltimore D. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 1997;89:1067-76 pubmed
    ..We have identified a novel signaling protein, termed Daxx, that binds specifically to the Fas death domain...
  5. Michaelson J, Bader D, Kuo F, Kozak C, Leder P. Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development. Genes Dev. 1999;13:1918-23 pubmed
    The mammalian Daxx gene has been identified in a diverse set of yeast interaction trap experiments. Although a facilitating role for Daxx in Fas-induced apoptosis has been suggested, Daxx's physiologic function remains unknown...
  6. Drané P, Ouararhni K, Depaux A, Shuaib M, Hamiche A. The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. Genes Dev. 2010;24:1253-65 pubmed publisher
    ..3 replication-independent deposition. We found that the death domain-associated protein DAXX and the chromatin remodeling factor ATRX (alpha-thalassemia/mental retardation syndrome protein) are specifically ..
  7. Chang C, Naik M, Huang Y, Jeng J, Liao P, Kuo H, et al. Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation. Mol Cell. 2011;42:62-74 pubmed publisher
    ..Using the transcriptional coregulator Daxx as a model, we show that SUMO paralog-selective binding and conjugation are regulated by phosphorylation of the ..
  8. Ecsedy J, Michaelson J, Leder P. Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol Cell Biol. 2003;23:950-60 pubmed
    We describe an interaction between homeodomain-interacting protein kinase 1 (HIPK1) and Daxx, two transcriptional regulators important in transducing growth-regulatory signals...
  9. Chang H, Nishitoh H, Yang X, Ichijo H, Baltimore D. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science. 1998;281:1860-3 pubmed
    ..The Fas death receptor can activate the Jun NH2-terminal kinase (JNK) pathway through the receptor-associated protein Daxx. Daxx was found to activate the JNK kinase kinase ASK1, and overexpression of a kinase-deficient ASK1 mutant ..

More Information

Publications66

  1. Puto L, Reed J. Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation. Genes Dev. 2008;22:998-1010 pubmed publisher
    The apoptosis-modulating protein Daxx functions as a transcriptional repressor that binds to and suppresses the activity of nuclear factor-kappaB member RelB, among other transcription factors...
  2. Goldberg A, Banaszynski L, Noh K, Lewis P, Elsaesser S, Stadler S, et al. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell. 2010;140:678-91 pubmed publisher
    ..Immunoaffinity purification and mass spectrometry reveal that the proteins Atrx and Daxx associate with H3.3 in a Hira-independent manner. Atrx is required for Hira-independent localization of H3...
  3. Lewis P, Elsaesser S, Noh K, Stadler S, Allis C. Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A. 2010;107:14075-80 pubmed publisher
    ..We previously identified the death domain associated protein (Daxx) and the alpha-thalassemia X-linked mental retardation protein (ATRX) as H3...
  4. Escobar Cabrera E, Okon M, Lau D, Dart C, Bonvin A, McIntosh L. Characterizing the N- and C-terminal Small ubiquitin-like modifier (SUMO)-interacting motifs of the scaffold protein DAXX. J Biol Chem. 2011;286:19816-29 pubmed publisher
    b>DAXX is a scaffold protein with diverse roles that often depend upon binding SUMO via its N- and/or C-terminal SUMO-interacting motifs (SIM-N and SIM-C)...
  5. Muromoto R, Yamamoto T, Yumioka T, Sekine Y, Sugiyama K, Shimoda K, et al. Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3. FEBS Lett. 2003;540:223-8 pubmed
    b>Daxx has been shown to play an essential in type I interferon (IFN-alpha/beta)-mediated suppression of B cell development and apoptosis...
  6. Li J, Qian L, Dowling J, Curcione C, Kurup D, Zhang J. Daxx plays a novel role in T cell survival but is dispensable in Fas-induced apoptosis. PLoS ONE. 2017;12:e0174011 pubmed publisher
    b>Daxx was originally isolated as a Fas-binding protein. However, the in vivo function of Daxx in Fas-induced apoptosis has remained enigmatic. Fas plays an important role in homeostasis in the immune system...
  7. Lee Y, Dayma Y, Park M, Kim K, Yoo S, Kim E. Daxx is a key downstream component of receptor interacting protein kinase 3 mediating retinal ischemic cell death. FEBS Lett. 2013;587:266-71 pubmed publisher
    ..An in silico analysis followed by experimental validation identified death associated protein (Daxx) as a novel substrate of RIP3...
  8. Salsman J, Rapkin L, Margam N, Duncan R, Bazett Jones D, Dellaire G. Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres. Cell Death Dis. 2017;8:e2724 pubmed publisher
    ..Myotube formation was associated with marked chromatin reorganization and the relocalization of DAXX from PML NBs to chromocentres...
  9. Pan W, Yi F, Cao L, Liu X, Shen Z, Bu Y, et al. DAXX silencing suppresses mouse ovarian surface epithelial cell growth by inducing senescence and DNA damage. Gene. 2013;526:287-94 pubmed publisher
    ..Death-associated protein DAXX along with PML (promyelocytic leukemia protein) nuclear bodies (PML-NBs) reportedly play roles in transcriptional ..
  10. Cappadocia L, Mascle X, Bourdeau V, Tremblay Belzile S, Chaker Margot M, Lussier Price M, et al. Structural and functional characterization of the phosphorylation-dependent interaction between PML and SUMO1. Structure. 2015;23:126-38 pubmed publisher
    ..We examined the role that phosphorylation plays in the binding of the phosphoSIMs of PML and Daxx to SUMO1 at the atomic level...
  11. Arakawa T, Nakatani T, Oda M, Kimura Y, Sekita Y, Kimura T, et al. Stella controls chromocenter formation through regulation of Daxx expression in 2-cell embryos. Biochem Biophys Res Commun. 2015;466:60-5 pubmed publisher
    ..3-specific chaperone Daxx were reduced in Stella-null embryos...
  12. Lessard Beaudoin M, Laroche M, Demers M, Duclos C, Denault J, Grenier G, et al. Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice. Biogerontology. 2016;17:817-828 pubmed
    Death-associated protein 6 (DAXX) is a ubiquitous protein implicated in various cellular processes such as apoptosis, tumorigenesis, development and transcription...
  13. Tang J, Qu L, Zhang J, Wang W, Michaelson J, Degenhardt Y, et al. Critical role for Daxx in regulating Mdm2. Nat Cell Biol. 2006;8:855-62 pubmed
    ..Here, we show that death domain-associated protein (Daxx) is required for Mdm2 stability...
  14. Zhong S, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi P. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J Exp Med. 2000;191:631-40 pubmed
    ..b>Daxx was identified as a molecule important for the cytoplasmic transduction of the Fas proapoptotic stimulus...
  15. Dionne K, Zhuang Y, Leser J, Tyler K, Clarke P. Daxx upregulation within the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis. J Virol. 2013;87:3447-60 pubmed publisher
    ..Death-associated protein 6 (Daxx) is a cellular protein that mechanistically links Fas signaling to JNK signaling in several models of apoptosis...
  16. Kawai T, Akira S, Reed J. ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. Mol Cell Biol. 2003;23:6174-86 pubmed
    ..We show here that ZIPK is present in PODs, where it colocalizes with and binds to proapoptotic protein Daxx. Arsenic trioxide (As(2)O(3)) and gamma interferon (IFN-gamma), which accentuate POD formation, increased the ..
  17. Croxton R, Puto L, De Belle I, Thomas M, Torii S, Hanaii F, et al. Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB. Cancer Res. 2006;66:9026-35 pubmed
    b>Daxx is a nuclear protein that localizes to PML oncogenic domains, sensitizes cells to apoptosis, and functions as a transcriptional repressor...
  18. Fisher P, Hedeler C, Wolstencroft K, Hulme H, Noyes H, Kemp S, et al. A systematic strategy for large-scale analysis of genotype phenotype correlations: identification of candidate genes involved in African trypanosomiasis. Nucleic Acids Res. 2007;35:5625-33 pubmed
    ..Pathways represented in the results identified Daxx as one of the candidate genes within the Tir1 QTL region...
  19. Lopez P, Vidal F, Martin L, Lopez Fernandez L, Rual J, Rosen B, et al. Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell. Mol Cell Biol. 2002;22:3488-96 pubmed
    ..In Sertoli cells, it colocalizes with the PML and Daxx proteins in punctate nuclear bodies...
  20. Shimoda K, Kamesaki K, Numata A, Aoki K, Matsuda T, Oritani K, et al. Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation. J Immunol. 2002;169:4707-11 pubmed
    IFN-alpha inhibits B lymphocyte development, and the nuclear protein Daxx has been reported to be essential for this biological activity...
  21. Roubille F, Combes S, Leal Sanchez J, Barrere C, Cransac F, Sportouch Dukhan C, et al. Myocardial expression of a dominant-negative form of Daxx decreases infarct size and attenuates apoptosis in an in vivo mouse model of ischemia/reperfusion injury. Circulation. 2007;116:2709-17 pubmed
    Apoptosis has been described extensively in acute myocardial infarction and chronic heart failure. Because Daxx (death-associated protein) appears to be essential for stress-induced cell death and acts as an antisurvival molecule, we ..
  22. Ishov A, Vladimirova O, Maul G. Daxx-mediated accumulation of human cytomegalovirus tegument protein pp71 at ND10 facilitates initiation of viral infection at these nuclear domains. J Virol. 2002;76:7705-12 pubmed
    ..Intracellular trafficking of pp71 is facilitated through binding to a coiled-coil region of Daxx. The C-terminal domain of Daxx then interacts with SUMO-modified PML, resulting in the deposition of pp71 at ND10...
  23. Song M, Song S, Kim S, Oh H, Lim D. The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. EMBO J. 2008;27:1863-74 pubmed publisher
    ..Importantly, RASSF1A associates with MDM2 and death-domain-associated protein (DAXX) in the nucleus, thereby disrupting the interactions between MDM2, DAXX, and the deubiquitinase, HAUSP, and ..
  24. Emelyanov A, Kovac C, Sepulveda M, Birshtein B. The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells. J Biol Chem. 2002;277:11156-64 pubmed
    ..Using a yeast two-hybrid assay to identify potential coregulators of Pax5, we identified Daxx, a protein that is highly conserved, ubiquitously expressed, and essential for embryonic mouse development...
  25. Feng Z, Wang L, Sun Y, Jiang Z, Domsic J, An C, et al. Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase. Cancer Res. 2017;77:401-411 pubmed publisher
    Neuroendocrine tumors (NET) often harbor loss-of-function mutations in the MEN1 and DAXX tumor suppressor genes...
  26. Lalioti V, Vergarajauregui S, Tsuchiya Y, Hernandez Tiedra S, Sandoval I. Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B. J Cell Physiol. 2009;218:416-26 pubmed publisher
    We have previously reported the physical interaction between Daxx, the adaptor protein that mediates activation of the Jun amino-terminal kinase (JNK), and GLUT4, the insulin-dependent glucose transporter, interaction that involves their ..
  27. Kon N, Zhong J, Kobayashi Y, Li M, Szabolcs M, Ludwig T, et al. Roles of HAUSP-mediated p53 regulation in central nervous system development. Cell Death Differ. 2011;18:1366-75 pubmed publisher
  28. Yun H, Yoon J, Lee J, Noh K, Yoon K, Oh S, et al. Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling. EMBO J. 2011;30:2465-76 pubmed publisher
    ..The molecular mechanism of AICD, however, has remained unclear. Here, we show that Daxx and mammalian Ste20-like kinase-1 (MST1) mediate apoptosis elicited by interferon-? (IFN-?) in microglia...
  29. Ma Q, Devarajan P. Induction of proapoptotic Daxx following ischemic acute kidney injury. Kidney Int. 2008;74:310-8 pubmed publisher
    Transcriptome profiling has shown that the pro-apoptotic death-domain-associated protein Daxx is rapidly induced in the kidney of animals following ischemic injury...
  30. Ishida N, Oritani K, Shiraga M, Yoshida H, Kawamoto S, Ujiie H, et al. Differential effects of a novel IFN-zeta/limitin and IFN-alpha on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes. Exp Hematol. 2005;33:495-503 pubmed
    ..In addition, the antisense oligonucleotides against Crk and Daxx, downstream molecules of Tyk2, greatly rescued the IFN-zeta/limitin- and IFN-alpha-induced reduction of ..
  31. Morozov V, Massoll N, Vladimirova O, Maul G, Ishov A. Regulation of c-met expression by transcription repressor Daxx. Oncogene. 2008;27:2177-86 pubmed
    ..Here, we demonstrate Daxx as a repressor of c-met transcription...
  32. Michod D, Bartesaghi S, Khelifi A, Bellodi C, Berliocchi L, Nicotera P, et al. Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation. Neuron. 2012;74:122-35 pubmed publisher
    ..3 deposition is involved in neuronal activity-dependent events. Here, we analyze the role of the histone chaperone DAXX in the regulation of H3.3 incorporation at activity-dependent gene loci...
  33. Muromoto R, Ishida M, Sugiyama K, Sekine Y, Oritani K, Shimoda K, et al. Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation. J Immunol. 2006;177:1160-70 pubmed
    b>Daxx has been shown to play an essential role in type I IFN-mediated suppression of B cell development and apoptosis...
  34. Lalioti V, Vergarajauregui S, Pulido D, Sandoval I. The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1. J Biol Chem. 2002;277:19783-91 pubmed
    ..Using as bait C-GLUT4, we have isolated the carboxyl domain of Daxx (C-Daxx), the adaptor protein associated with the Fas and the type II TGF-beta (TbetaRII) receptors (1,2 )...
  35. McDonough H, Charles P, Hilliard E, Qian S, Min J, Portbury A, et al. Stress-dependent Daxx-CHIP interaction suppresses the p53 apoptotic program. J Biol Chem. 2009;284:20649-59 pubmed publisher
    ..In this report, we demonstrate a stress-dependent interaction between CHIP and Daxx (death domain-associated protein)...
  36. Aoki K, Shimoda K, Oritani K, Matsuda T, Kamezaki K, Muromoto R, et al. Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx. Exp Hematol. 2003;31:1317-22 pubmed
    ..the activation of Jak kinase and Stat proteins, and the induction of interferon regulatory factor-1 (IRF-1) and Daxx were examined using the mouse pre-B-cell line 18.81, wild-type, and Tyk2-deficient mouse bone marrow cells...
  37. Saeed U, Ray A, Valli R, Kumar A, Ravindranath V. DJ-1 loss by glutaredoxin but not glutathione depletion triggers Daxx translocation and cell death. Antioxid Redox Signal. 2010;13:127-44 pubmed publisher
    ..mRNA, downregulation of glutaredoxin 1 but not glutathione depletion caused loss of DJ-1 protein, translocation of Daxx (a death-associated protein) from nucleus, and cell death...
  38. Leal Sanchez J, Couzinet A, Rossin A, Abdel Sater F, Chakrabandhu K, Luci C, et al. Requirement for Daxx in mature T-cell proliferation and activation. Cell Death Differ. 2007;14:795-806 pubmed
    The protein Daxx promotes Fas-mediated cell death through activation of apoptosis signal-regulating kinase 1, leading to the activation of the MAPKs JNK and p38...
  39. Lin D, Huang Y, Jeng J, Kuo H, Chang C, Chao T, et al. Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol Cell. 2006;24:341-54 pubmed
    ..b>Daxx, a transcriptional corepressor, was reported to repress the transcriptional potential of several transcription ..
  40. Subramanian S, Yim Y, Liu K, Tus K, Zhou X, Wakeland E. Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb. J Immunol. 2005;175:1062-72 pubmed
    ..Sle1 Sles1)F(1)s. These findings localize and characterize the suppressive properties of Sles1 and implicate 129 as a useful strain for aiding in the identification of this elusive epistatic modifier gene. ..
  41. Delbarre E, Ivanauskiene K, Spirkoski J, Shah A, Vekterud K, Moskaug J, et al. PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX. Genome Res. 2017;27:913-921 pubmed publisher
    ..Loss of PML impairs deposition of H3.3 by ATRX and DAXX in PADs but preserves the H3.3 loading function of HIRA in these regions...
  42. Yao Z, Zhang Q, Li X, Zhao D, Liu Y, Zhao K, et al. Death domain-associated protein 6 (Daxx) selectively represses IL-6 transcription through histone deacetylase 1 (HDAC1)-mediated histone deacetylation in macrophages. J Biol Chem. 2014;289:9372-9 pubmed publisher
    As a multifunctional nuclear protein, death domain-associated protein 6 (Daxx) regulates a wide range of biological processes, including cell apoptosis and gene transcription...
  43. Raoul C, Buhler E, Sadeghi C, Jacquier A, Aebischer P, Pettmann B, et al. Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL. Proc Natl Acad Sci U S A. 2006;103:6007-12 pubmed
    ..and SOD1(G85R), but not in control motoneurons, this up-regulation results in activation of Fas, leading through Daxx to phosphorylation of p38 and further NO synthesis...
  44. Chang F, McGhie J, Chan F, Tang M, Anderson M, Mann J, et al. PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells. Nucleic Acids Res. 2013;41:4447-58 pubmed publisher
    ..Our study demonstrates that PML bodies act as epigenetic regulators by serving as platforms for the assembly of the telomeric chromatin to ensure a faithful inheritance of epigenetic information at the telomere. ..
  45. Muromoto R, Kuroda M, Togi S, Sekine Y, Nanbo A, Shimoda K, et al. Functional involvement of Daxx in gp130-mediated cell growth and survival in BaF3 cells. Eur J Immunol. 2010;40:3570-80 pubmed publisher
    Death domain-associated protein (Daxx) is a multifunctional protein that modulates both cell death and transcription...
  46. Perlman R, Schiemann W, Brooks M, Lodish H, Weinberg R. TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nat Cell Biol. 2001;3:708-14 pubmed
    ..that interact physically with the cytoplasmic domain of the type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of Jun amino-terminal kinase (JNK) and ..
  47. Rochat Steiner V, Becker K, Micheau O, Schneider P, Burns K, Tschopp J. FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation. J Exp Med. 2000;192:1165-74 pubmed
    ..Fas-associated death domain (FADD), which couples Fas to procaspase-8, and Daxx, which couples Fas to the Jun NH(2)-terminal kinase pathway, bind independently to the Fas death domain...
  48. Salomoni P, Guernah I, Pandolfi P. The PML-nuclear body associated protein Daxx regulates the cellular response to CD40. Cell Death Differ. 2006;13:672-5 pubmed
  49. Muromoto R, Sugiyama K, Takachi A, Imoto S, Sato N, Yamamoto T, et al. Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1. J Immunol. 2004;172:2985-93 pubmed
    b>Daxx has been shown to play an essential role in type I IFN-alphabeta-mediated suppression of B cell development and apoptosis...
  50. Elsässer S, Noh K, Diaz N, Allis C, Banaszynski L. Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells. Nature. 2015;522:240-244 pubmed publisher
    ..containing α-thalassaemia/mental retardation syndrome X-linked (ATRX) and death-domain-associated protein (DAXX). We demonstrate that recruitment of DAXX, H3...
  51. Donath S, An J, Lee S, Gertz K, Datwyler A, Harms U, et al. Interaction of ARC and Daxx: A Novel Endogenous Target to Preserve Motor Function and Cell Loss after Focal Brain Ischemia in Mice. J Neurosci. 2016;36:8132-48 pubmed publisher
    ..Functionally, TAT.ARC treatment inhibited DAXX-ASK1-JNK signaling in the ischemic brain...
  52. He Q, Kim H, Huang R, Lu W, Tang M, Shi F, et al. The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation. Cell Stem Cell. 2015;17:273-86 pubmed publisher
    ..Here we explore the processes involved by investigating the role of the chromatin factors Daxx and Atrx...
  53. Zobalova R, Swettenham E, Chladova J, Dong L, Neuzil J. Daxx inhibits stress-induced apoptosis in cardiac myocytes. Redox Rep. 2008;13:263-70 pubmed publisher
    The role of the death-associated protein Daxx in modulation of apoptosis induced in cardiac myocytes by oxidative stress was studied...
  54. Baker S, Reddy E. Modulation of life and death by the TNF receptor superfamily. Oncogene. 1998;17:3261-70 pubmed
    ..FADD/MORT-1, RIP), TRAF domain containing proteins (TRAF1-6) as well as new members and adaptor proteins such as DAXX have provided new insights to our understanding of signaling mechanisms associated with this family of receptors...
  55. Lan H, Wu C, Shih H, Chung B. Death-associated protein 6 (Daxx) mediates cAMP-dependent stimulation of Cyp11a1 (P450scc) transcription. J Biol Chem. 2012;287:5910-6 pubmed publisher
    ..We found Daxx, a HIPK kinase substrate in the apoptosis pathway, was phosphorylated by HIPK3 at Ser-669 in response to cAMP ..
  56. Zydek M, Uecker R, Tavalai N, Stamminger T, Hagemeier C, Wiebusch L. General blockade of human cytomegalovirus immediate-early mRNA expression in the S/G2 phase by a nuclear, Daxx- and PML-independent mechanism. J Gen Virol. 2011;92:2757-69 pubmed publisher
    ..However, we found that neither Daxx nor PML, the main players of ND10-based immunity, are required for the block to viral gene expression in the S/G2 ..
  57. Nagasawa T, Takakuwa T, Takayama H, Dong Z, Miyagawa S, Itami S, et al. Fas gene mutations in mycosis fungoides: analysis of laser capture-microdissected specimens from cutaneous lesions. Oncology. 2004;67:130-4 pubmed
    ..These findings suggest that the accumulation of lymphoid cells with Fas mutations provides, in part, a basis for the development or maintenance of MF. ..