Dab1

Summary

Gene Symbol: Dab1
Description: disabled 1
Alias: AI956902, C630028C02Rik, scm, scr, scrambler, yot, disabled homolog 1, yotari
Species: mouse
Products:     Dab1

Top Publications

  1. Trommsdorff M, Gotthardt M, Hiesberger T, Shelton J, Stockinger W, Nimpf J, et al. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell. 1999;97:689-701 pubmed
    ..These findings suggest that VLDLR and ApoER2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1. ..
  2. Sweet H, Bronson R, Johnson K, Cook S, Davisson M. Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mamm Genome. 1996;7:798-802 pubmed
    A novel spontaneous neurological mutation, scrambler (scm), appeared in the inbred mouse strain DC/Le (dancer) in 1991. Mice homozygous for this recessive mutation are recognized by an unstable gait and whole-body tremor...
  3. Morimura T, Hattori M, Ogawa M, Mikoshiba K. Disabled1 regulates the intracellular trafficking of reelin receptors. J Biol Chem. 2005;280:16901-8 pubmed
    ..It is generally believed that tyrosine phosphorylation of Disabled1 (Dab1) by Src family tyrosine kinases is the most critical downstream event in Reelin signaling...
  4. Honda T, Nakajima K. Mouse Disabled1 (DAB1) is a nucleocytoplasmic shuttling protein. J Biol Chem. 2006;281:38951-65 pubmed
    Disabled1 (DAB1) is an intracellular mediator of the Reelin-signaling pathway and essential for correct neuronal positioning during brain development. So far, DAB1 has been considered a cytoplasmic protein...
  5. Howell B, Herrick T, Hildebrand J, Zhang Y, Cooper J. Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development. Curr Biol. 2000;10:877-85 pubmed
    ..In vivo, absence of Reln correlates with up-regulation of the docking protein Dab1 and decreased Dab1 tyrosine phosphorylation...
  6. Gonzalez J, Russo C, Goldowitz D, Sweet H, Davisson M, Walsh C. Birthdate and cell marker analysis of scrambler: a novel mutation affecting cortical development with a reeler-like phenotype. J Neurosci. 1997;17:9204-11 pubmed
    ..Here we show that the scrambler mutant mouse exhibits a loss of lamination in the cortex and hippocampus that is indistinguishable from that ..
  7. Howell B, Hawkes R, Soriano P, Cooper J. Neuronal position in the developing brain is regulated by mouse disabled-1. Nature. 1997;389:733-7 pubmed
    ..Because mDab1 is expressed in wild-type cortical neurons, and Reelin expression is normal in mdab1 mutants, mDab1 may be part of a Reelin-regulated or parallel pathway that controls the final positioning of neurons. ..
  8. Rice D, Sheldon M, D ARCANGELO G, Nakajima K, Goldowitz D, Curran T. Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain. Development. 1998;125:3719-29 pubmed
    ..Dab1) results in widespread abnormalities in laminar structures throughout the brain and ataxia in reeler and scrambler mice...
  9. Miyata T, Ono Y, Okamoto M, Masaoka M, Sakakibara A, Kawaguchi A, et al. Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum. Neural Dev. 2010;5:23 pubmed publisher

More Information

Publications70

  1. Ware M, Fox J, Gonzalez J, Davis N, Lambert de Rouvroit C, Russo C, et al. Aberrant splicing of a mouse disabled homolog, mdab1, in the scrambler mouse. Neuron. 1997;19:239-49 pubmed
    ..The scrambler (scm) mouse shows abnormal cortical lamination that is indistinguishable from reeler...
  2. Pramatarova A, Chen K, Howell B. A genetic interaction between the APP and Dab1 genes influences brain development. Mol Cell Neurosci. 2008;37:178-86 pubmed
    The Dab1 docking protein is required for the proper organization of brain laminae and for a signal transduction pathway initiated by Reelin binding to the ApoER2 and VLDLR receptors on the cell surface of neurons...
  3. Keshvara L, Benhayon D, Magdaleno S, Curran T. Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1. J Biol Chem. 2001;276:16008-14 pubmed
    ..Mice with disruptions in reelin, dab1, or both vldlr and apoER2 are ataxic, and they exhibit severe lamination defects within several brain structures...
  4. Hammond V, So E, Gunnersen J, Valcanis H, Kalloniatis M, Tan S. Layer positioning of late-born cortical interneurons is dependent on Reelin but not p35 signaling. J Neurosci. 2006;26:1646-55 pubmed
    ..First, early-born and late-born interneurons behaved differently in mice lacking Reelin or disabled 1 (Dab1)...
  5. Stockinger W, Brandes C, Fasching D, Hermann M, Gotthardt M, Herz J, et al. The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2. J Biol Chem. 2000;275:25625-32 pubmed
    ..This complex might participate in ApoER2-specific reelin signaling and thus would explain the different phenotype of mice lacking the ApoER2 from that of VLDLR-deficient mice. ..
  6. Franco S, Martinez Garay I, Gil Sanz C, Harkins Perry S, Muller U. Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex. Neuron. 2011;69:482-97 pubmed publisher
    ..Here, we show that Dab1, an essential component of the reelin pathway, is required in radially migrating neurons for glia-independent somal ..
  7. Matsuki T, Matthews R, Cooper J, van der Brug M, Cookson M, Hardy J, et al. Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment. Cell. 2010;143:826-36 pubmed publisher
    The Reelin ligand regulates a Dab1-dependent signaling pathway required for brain lamination and normal dendritogenesis, but the specific mechanisms underlying these actions remain unclear...
  8. Ballif B, Arnaud L, Arthur W, Guris D, Imamoto A, Cooper J. Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Curr Biol. 2004;14:606-10 pubmed
    ..Reelin action requires tyrosine phosphorylation of the intracellular protein Dab1 by Src-family kinases. However, little is known about signaling pathways downstream of Dab1...
  9. Uchida T, Baba A, Pérez Martínez F, Hibi T, Miyata T, Luque J, et al. Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stages. J Neurosci. 2009;29:10653-62 pubmed publisher
    ..binds to apolipoprotein E receptor 2 and very low-density lipoprotein receptor and induces phosphorylation of Dab1. However, when and where these reactions occur is essentially unknown, and the primary function(s) of Reelin remain ..
  10. Hartfuss E, Forster E, Bock H, Hack M, Leprince P, Luque J, et al. Reelin signaling directly affects radial glia morphology and biochemical maturation. Development. 2003;130:4597-609 pubmed
    ..We could further demonstrate that this signaling requires Dab1, as the increase in Blbp upon reelin addition failed to occur in Dab1-/- mice...
  11. Andrade N, Komnenovic V, Blake S, Jossin Y, Howell B, Goffinet A, et al. ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin. Proc Natl Acad Sci U S A. 2007;104:8508-13 pubmed
    ..show that ApoER2 and possibly very-low-density lipoprotein receptor (VLDLR) and their intracellular adapter protein Dab1 are involved in chain formation most likely independent of Reelin...
  12. Schmid R, Jo R, Shelton S, Kreidberg J, Anton E. Reelin, integrin and DAB1 interactions during embryonic cerebral cortical development. Cereb Cortex. 2005;15:1632-6 pubmed
    ..Furthermore, Dab1, a member of the reelin signaling pathway, can complex with the cytoplasmic region of beta1 integrin in a reelin-..
  13. Bock H, Jossin Y, May P, Bergner O, Herz J. Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1. J Biol Chem. 2004;279:33471-9 pubmed
    The cytoplasmic adaptor protein Disabled-1 (Dab1) is necessary for the regulation of neuronal positioning in the developing brain by the secreted molecule Reelin...
  14. Huang Y, Magdaleno S, Hopkins R, Slaughter C, Curran T, Keshvara L. Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins. Biochem Biophys Res Commun. 2004;318:204-12 pubmed
    Disabled 1 (Dab1) functions as a critical adapter protein in the Reelin signaling pathway to direct proper positioning of neurons during brain development...
  15. Jossin Y, Goffinet A. Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth. Mol Cell Biol. 2007;27:7113-24 pubmed
    ..the mTor (mammalian target of rapamycin)-S6K1 (S6 kinase 1) pathway is activated by Reelin and that this depends on Dab1 (Disabled-1) phosphorylation and activation of PI3K and Akt (protein kinase B)...
  16. Niu S, Renfro A, Quattrocchi C, Sheldon M, D ARCANGELO G. Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway. Neuron. 2004;41:71-84 pubmed
    ..neuronal positioning in cortical brain structures through the VLDLR and ApoER2 receptors and the adaptor protein Dab1. In addition to cellular disorganization, dendrite abnormalities are present in the brain of reeler mice lacking ..
  17. Howell B, Herrick T, Cooper J. Reelin-induced tyrosine [corrected] phosphorylation of disabled 1 during neuronal positioning. Genes Dev. 1999;13:643-8 pubmed
    The reelin (reln) and disabled 1 (dab1) genes both ensure correct neuronal positioning during brain development. We have found that the intracellular Dab1 protein receives a tyrosine phosphorylation signal from extracellular Reln protein...
  18. Hashimoto Torii K, Torii M, Sarkisian M, Bartley C, Shen J, Radtke F, et al. Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron. 2008;60:273-84 pubmed publisher
    ..Finally, our in vitro biochemical studies show that Reelin signaling inhibits Notch ICD degradation via Dab1. Together, our results indicate that neuronal migration in the developing cerebral cortex requires a Reelin-Notch ..
  19. Herrick T, Cooper J. A hypomorphic allele of dab1 reveals regional differences in reelin-Dab1 signaling during brain development. Development. 2002;129:787-96 pubmed
    The disabled 1 (Dab1) p80 protein is essential for reelin signaling during brain development...
  20. Díaz Ruiz C, Parlato R, Aguado F, Ureña J, Burgaya F, MARTINEZ A, et al. Regulation of neural migration by the CREB/CREM transcription factors and altered Dab1 levels in CREB/CREM mutants. Mol Cell Neurosci. 2008;39:519-28 pubmed publisher
    ..These changes are associated with decreased Dab1 expression in CREB1(Nescre)CREM(-/-) mutants...
  21. Weiss K, Johanssen C, Tielsch A, Herz J, Deller T, Frotscher M, et al. Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice. J Comp Neurol. 2003;460:56-65 pubmed
    ..radial glial scaffold in the dentate gyrus of reeler mice, lacking the extracellular matrix protein Reelin, in scrambler mice, deficient in the intracellular adaptor protein disabled1 (Dab1), which is required for the transmission of ..
  22. Pramatarova A, Ochalski P, Chen K, Gropman A, Myers S, MIN K, et al. Nck beta interacts with tyrosine-phosphorylated disabled 1 and redistributes in Reelin-stimulated neurons. Mol Cell Biol. 2003;23:7210-21 pubmed
    The tyrosine phosphorylation sites of the Disabled 1 (Dab1) docking protein are essential for the transmission of the Reelin signal, which regulates neuronal placement...
  23. Feng L, Allen N, Simo S, Cooper J. Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development. Genes Dev. 2007;21:2717-30 pubmed
    ..negative feedback is the Reelin-induced degradation of the critical intracellular signaling component, Disabled-1 (Dab1)...
  24. Kuo G, Arnaud L, Kronstad O Brien P, Cooper J. Absence of Fyn and Src causes a reeler-like phenotype. J Neurosci. 2005;25:8578-86 pubmed
    ..Biochemical and in vitro experiments implicate Src and Fyn in the Reelin-dependent tyrosine phosphorylation of Dab1, which controls the positioning of radially migrating neurons in many brain regions...
  25. Olson E, Kim S, Walsh C. Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression. J Neurosci. 2006;26:1767-75 pubmed
    Reelin and Disabled 1 (Dab1) are essential for positioning migrating neurons in the developing neocortex...
  26. Villeda S, Akopians A, Babayan A, Basbaum A, Phelps P. Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord. Neuroscience. 2006;139:1385-96 pubmed
    ..of Reelin and Disabled-1 (the protein product of the reeler gene, and the intracellular adaptor protein, Dab1, involved in its signaling pathway) in adjacent regions of the developing dorsal horn, from early to late embryonic ..
  27. Rossel M, Loulier K, Feuillet C, Alonso S, Carroll P. Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons. Development. 2005;132:1175-85 pubmed
    ..Mice mutant at the Dab1 locus, called scrambler, exhibit the same phenotype, a failure of final migration...
  28. Magdaleno S, Keshvara L, Curran T. Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice. Neuron. 2002;33:573-86 pubmed
    ..These results indicate that Reelin does not function simply as a positional signal. Rather, it appears to participate in multiple events critical for neuronal migration and cell positioning. ..
  29. Assadi A, Zhang G, Beffert U, McNeil R, Renfro A, Niu S, et al. Interaction of reelin signaling and Lis1 in brain development. Nat Genet. 2003;35:270-6 pubmed
    ..that regulates layer formation by interacting with VLDLR and ApoER2 (Lrp8) receptors, thereby phosphorylating the Dab1 signaling molecule. Lis1 associates with microtubules and modulates neuronal migration...
  30. Matsuki T, Pramatarova A, Howell B. Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis. J Cell Sci. 2008;121:1869-75 pubmed publisher
    ..The receptor-dependent, reelin-induced tyrosine phosphorylation of the Dab1 docking protein is an established prerequisite for biological responses to this ligand...
  31. Sheldon M, Rice D, D ARCANGELO G, Yoneshima H, Nakajima K, Mikoshiba K, et al. Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Nature. 1997;389:730-3 pubmed
    ..Here we report that scrambler and yotari arise from mutations in mdab1, a mouse gene related to the Drosophila gene disabled (dab)...
  32. Jossin Y, Gui L, Goffinet A. Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons. J Neurosci. 2007;27:4243-52 pubmed
  33. Brich J, Shie F, Howell B, Li R, Tus K, Wakeland E, et al. Genetic modulation of tau phosphorylation in the mouse. J Neurosci. 2003;23:187-92 pubmed
    ..Disabled-1 (Dab1) is a cytoplasmic adapter protein that interacts with apolipoprotein E (ApoE) receptors and controls neuronal ..
  34. Bock H, Herz J. Reelin activates SRC family tyrosine kinases in neurons. Curr Biol. 2003;13:18-26 pubmed
    ..This induces tyrosine phosphorylation of the adaptor protein Disabled-1 (Dab1), which interacts with a shared sequence motif in the cytoplasmic tails of both receptors...
  35. Pla R, Borrell V, Flames N, Marin O. Layer acquisition by cortical GABAergic interneurons is independent of Reelin signaling. J Neurosci. 2006;26:6924-34 pubmed
  36. Yang H, Jensen P, Goldowitz D. The community effect and Purkinje cell migration in the cerebellar cortex: analysis of scrambler chimeric mice. J Neurosci. 2002;22:464-70 pubmed
    ..The scrambler mutant mouse, which is phenotypically identical to the reeler mouse, is due to a mutation in the disabled-1 gene ..
  37. Sekine K, Honda T, Kawauchi T, Kubo K, Nakajima K. The outermost region of the developing cortical plate is crucial for both the switch of the radial migration mode and the Dab1-dependent "inside-out" lamination in the neocortex. J Neurosci. 2011;31:9426-39 pubmed publisher
    ..with sequential changes of the migratory mode regulated by several signaling cascades, including the Reelin-Disabled homolog 1 (Dab1) pathway...
  38. MacLaurin S, Krucker T, Fish K. Hippocampal dendritic arbor growth in vitro: regulation by Reelin-Disabled-1 signaling. Brain Res. 2007;1172:1-9 pubmed
    The cytoplasmic adaptor protein Disabled-1 (Dab1), which is a key component of the Reelin-signaling pathway, has been suggested to be required for neuronal dendritic development...
  39. Rice D, Nusinowitz S, Azimi A, Martinez A, Soriano E, Curran T. The reelin pathway modulates the structure and function of retinal synaptic circuitry. Neuron. 2001;31:929-41 pubmed
    ..These results imply that, in addition to its essential role during neuronal migration, the Reelin pathway contributes to the formation of neuronal circuits in the central nervous system. ..
  40. Suetsugu S, Tezuka T, Morimura T, Hattori M, Mikoshiba K, Yamamoto T, et al. Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1. Biochem J. 2004;384:1-8 pubmed
    ..These findings suggest that mDab1 regulates the actin cytoskeleton through N-WASP, which is negatively regulated by phosphorylation-mediated ubiquitination of mDab1. ..
  41. Forster E, Tielsch A, Saum B, Weiss K, Johanssen C, Graus Porta D, et al. Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus. Proc Natl Acad Sci U S A. 2002;99:13178-83 pubmed
    ..Moreover, recombinant Reelin induced branching of glial processes in vitro. Our data suggest that Reelin affects glial differentiation via Disabled 1 and beta(1)-class integrin-dependent signaling pathways. ..
  42. Howell B, Gertler F, Cooper J. Mouse disabled (mDab1): a Src binding protein implicated in neuronal development. EMBO J. 1997;16:121-32 pubmed
    ..The properties of mDab1 and genetic analysis of Dab in Drosophila suggest that these molecules function in key signal transduction pathways involved in the formation of neural networks. ..
  43. Ballif B, Arnaud L, Cooper J. Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases. Brain Res Mol Brain Res. 2003;117:152-9 pubmed
    ..VLDLR and ApoER2, leading to tyrosine phosphorylation of the associated intracellular adaptor protein Disabled-1 (Dab1)...
  44. Homayouni R, Magdaleno S, Keshvara L, Rice D, Curran T. Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain. Brain Res Mol Brain Res. 2003;115:121-9 pubmed
    ..receptor and apolipoprotein E receptor-2, and signaling through the intracellular adapter protein Disabled-1 (Dab1)...
  45. Arnaud L, Ballif B, Forster E, Cooper J. Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Curr Biol. 2003;13:9-17 pubmed
    Disabled-1 (Dab1) is an intracellular adaptor protein that regulates migrations of various classes of neurons during mammalian brain development...
  46. Pramatarova A, Ochalski P, Lee C, Howell B. Mouse disabled 1 regulates the nuclear position of neurons in a Drosophila eye model. Mol Cell Biol. 2006;26:1510-7 pubmed
    ..Here we show that Disabled 1 (Dab1), which is required for neuronal positioning in mammals, regulates the nuclear position of postmitotic neurons in a ..
  47. Isosaka T, Hattori K, Yagi T. NMDA-receptor proteins are upregulated in the hippocampus of postnatal heterozygous reeler mice. Brain Res. 2006;1073-1074:11-9 pubmed
    ..Thus, the NMDA-R protein level is regulated by the Reelin protein level in a Fyn-dependent manner in the mouse brain...
  48. McAvoy S, Zhu Y, Perez D, James C, Smith D. Disabled-1 is a large common fragile site gene, inactivated in multiple cancers. Genes Chromosomes Cancer. 2008;47:165-74 pubmed
    ..Mice DAB1 inactivation results in the neurological mutant Scrambler, having similarities to mice with the inactivation of PARK2 (Quaker), GRID2 (Lurcher), and RORA (Staggerer)...
  49. Honda T, Nakajima K. Proper Level of Cytosolic Disabled-1, Which Is Regulated by Dual Nuclear Translocation Pathways, Is Important for Cortical Neuronal Migration. Cereb Cortex. 2016;26:3219-36 pubmed publisher
    ..In addition, rescue experiments using yotari, an autosomal recessive mutant of dab1, revealed that cells expressing Dab1 NLS1 mutant tend to distribute at more ..
  50. Yamamoto T, Sakakibara S, Mikoshiba K, Terashima T. Ectopic corticospinal tract and corticothalamic tract neurons in the cerebral cortex of yotari and reeler mice. J Comp Neurol. 2003;461:61-75 pubmed
    Reeler and yotari mice, which are mutant for Reelin or Dab1, respectively, show disorders of cerebral cortical lamination...
  51. Ohshima T, Suzuki H, Morimura T, Ogawa M, Mikoshiba K. Modulation of Reelin signaling by Cyclin-dependent kinase 5. Brain Res. 2007;1140:84-95 pubmed
    ..Disabled-1 (Dab1), an adapter protein, mediates Reelin signaling and becomes tyrosine-phosphorylated on the binding of Reelin to its ..
  52. Ohshima T, Gilmore E, Longenecker G, Jacobowitz D, Brady R, Herrup K, et al. Migration defects of cdk5(-/-) neurons in the developing cerebellum is cell autonomous. J Neurosci. 1999;19:6017-26 pubmed
    ..Despite similarities of the cdk5(-/-) phenotype to that reported in reeler and mdab-1(-/-) (scrambler/yotari) mutant brains, reelin and disabled-1 mRNA were found to be normal in cdk5(-/-) brain...
  53. Kwon I, Cho S, Kim M, Tsai M, Mitsuda N, Suh Kim H, et al. Expression of Disabled 1 suppresses astroglial differentiation in neural stem cells. Mol Cell Neurosci. 2009;40:50-61 pubmed publisher
    ..we established a culture of neurospheres derived from the embryonic forebrain of the Dab1(-/-) mice, yotari. Differentiating Dab1(-/-) neurospheres exhibited a higher expression of GFAP, an astrocytic marker, at the ..
  54. Luque J, Morante Oria J, Fairen A. Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development. Brain Res Dev Brain Res. 2003;140:195-203 pubmed
    ..receptor machinery, including the lipoprotein receptors ApoER2 and VLDLR along with the cytoplasmic adaptor protein Dab1, is located in radial glia precursors whose processes span the entire cortical wall from the ventricular zone to ..
  55. Tomassy G, Berger D, Chen H, Kasthuri N, Hayworth K, Vercelli A, et al. Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex. Science. 2014;344:319-24 pubmed publisher
    ..Our data indicate that the profile of longitudinal distribution of myelin is an integral feature of neuronal identity and may have evolved as a strategy to modulate long-distance communication in the neocortex. ..
  56. Cooper J, Howell B. Lipoprotein receptors: signaling functions in the brain?. Cell. 1999;97:671-4 pubmed
  57. Jin K, Jiang H, Mo Z, Xiang M. Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors. J Neurosci. 2010;30:11902-16 pubmed publisher
  58. Stewart L, Potok M, Camper S, Stifani S. Runx1 expression defines a subpopulation of displaced amacrine cells in the developing mouse retina. J Neurochem. 2005;94:1739-45 pubmed
    ..These findings identify Runx1 as a novel marker for a restricted amacrine cell subtype and suggest a role for this gene in regulating the post-mitotic development of these cells. ..
  59. Ohkubo N, Lee Y, Morishima A, Terashima T, Kikkawa S, Tohyama M, et al. Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. FASEB J. 2003;17:295-7 pubmed
    ..double-knockouts lacking the VLDL receptor (VLDLR) and ApoE receptor2 (ApoER2), and mice lacking disabled-1 (Dab1) display increased levels of phosphorylated tau...
  60. Matsuki T, Zaka M, Guerreiro R, van der Brug M, Cooper J, Cookson M, et al. Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. PLoS ONE. 2012;7:e31152 pubmed publisher
    ..Tau is hyperphosphorylated in the hippocampus of dab1-null mice in a strain-dependent manner; however, it has not been clear if the Tau phosphorylation phenotype is a ..
  61. Nakamura K, Beppu M, Sakai K, Yagyu H, Matsumaru S, Kohno T, et al. The C-terminal region of Reelin is necessary for proper positioning of a subset of Purkinje cells in the postnatal cerebellum. Neuroscience. 2016;336:20-29 pubmed publisher
    ..However, in mice lacking the secreted protein Reelin or its downstream adaptor protein Dab1, the majority of PCs are located ectopically in the deep cerebellar mass...