cysteine rich secretory protein 4
Gene Symbol: cysteine rich secretory protein 4
Description: cysteine-rich secretory protein 4
Alias: 9230112K08Rik, cysteine-rich secretory protein 4
Gibbs G, Orta G, Reddy T, Koppers A, Martínez López P, de la Vega Beltrán J, et al
. Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function. Proc Natl Acad Sci U S A. 2011;108:7034-9 pubmed publisher
..Collectively, these data identify CRISP4 as an endogenous regulator of TRPM8 with a role in normal sperm function. ..
Jalkanen J, Huhtaniemi I, Poutanen M. Mouse cysteine-rich secretory protein 4 (CRISP4): a member of the Crisp family exclusively expressed in the epididymis in an androgen-dependent manner. Biol Reprod. 2005;72:1268-74 pubmed
Nolan M, Wu L, Bang H, Jelinsky S, Roberts K, Turner T, et al
. Identification of rat cysteine-rich secretory protein 4 (Crisp4) as the ortholog to human CRISP1 and mouse Crisp4. Biol Reprod. 2006;74:984-91 pubmed
..Our data identify rat Crisp4 as the true ortholog to human CRISP1 and mouse Crisp4, and demonstrate its interaction with spermatozoa in the epididymis. ..
Turunen H, Sipila P, Krutskikh A, Toivanen J, Mankonen H, Hämäläinen V, et al
. Loss of cysteine-rich secretory protein 4 (Crisp4) leads to deficiency in sperm-zona pellucida interaction in mice. Biol Reprod. 2012;86:1-8 pubmed publisher
..We also demonstrate that iCre recombinase is expressed in a pattern similar to endogenous Crisp4 and is able to initiate the recombination event with its target sequences in vivo...
Borges B, García Galiano D, da Silveira Cruz Machado S, Han X, Gavrilina G, Saunders T, et al
. Obesity-Induced Infertility in Male Mice Is Associated With Disruption of Crisp4 Expression and Sperm Fertilization Capacity. Endocrinology. 2017;158:2930-2943 pubmed publisher
..Our findings indicate that the obesity-induced decline in sperm motility and fertilization capacity results in part from the disruption of epididymal CRISP4 expression and secretion. ..