cystathionine gamma lyase

Summary

Gene Symbol: cystathionine gamma lyase
Description: cystathionase (cystathionine gamma-lyase)
Alias: 0610010I13Rik, AI314617, BC019483, CSE, Cys3, cystathionine gamma-lyase, cysteine-protein sulfhydrase
Species: mouse
Products:     cystathionine gamma lyase

Top Publications

  1. Mustafa A, Sikka G, Gazi S, Steppan J, Jung S, Bhunia A, et al. Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res. 2011;109:1259-68 pubmed publisher
    ..Hydrogen sulfide (H(2)S) is a prominent EDRF, since mice lacking its biosynthetic enzyme, cystathionine ?-lyase (CSE), display pronounced hypertension with deficient vasorelaxant responses to acetylcholine...
  2. Mani S, Li H, Untereiner A, Wu L, Yang G, Austin R, et al. Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis. Circulation. 2013;127:2523-34 pubmed publisher
    Cystathionine ?-lyase (CSE) produces hydrogen sulfide (H2S) in the cardiovascular system...
  3. Li H, Mani S, Cao W, Yang G, Lai C, Wu L, et al. Interaction of hydrogen sulfide and estrogen on the proliferation of vascular smooth muscle cells. PLoS ONE. 2012;7:e41614 pubmed publisher
    Hydrogen sulfide (H(2)S) can be endogenously generated from cystathionine gamma-lyase (CSE) in cardiovascular system, offering a cardiovascular protection...
  4. Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, et al. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science. 2008;322:587-90 pubmed publisher
    ..Here we show that H2S is physiologically generated by cystathionine gamma-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H2S levels in the serum, heart, aorta, and other ..
  5. Köhn C, Schleifenbaum J, Szijártó I, Markó L, Dubrovska G, Huang Y, et al. Differential effects of cystathionine-?-lyase-dependent vasodilatory H2S in periadventitial vasoregulation of rat and mouse aortas. PLoS ONE. 2012;7:e41951 pubmed publisher
    ..by opening KCNQ-type voltage-dependent (K(v)) K(+) channels and (2) that H(2)S-producing cystathionine-?-lyase (CSE) in perivascular adipose tissue plays a major role in this pathway. Wire myography of rat and mouse aortas was used...
  6. Suzuki K, Olah G, Módis K, Coletta C, Kulp G, Gero D, et al. Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function. Proc Natl Acad Sci U S A. 2011;108:13829-34 pubmed publisher
    ..Replacement of H(2)S or overexpression of the H(2)S-producing enzyme cystathionine-?-lyase (CSE) attenuated the hyperglycemia-induced enhancement of ROS formation, attenuated nuclear DNA injury, reduced the ..
  7. Ishii I, Akahoshi N, Yamada H, Nakano S, Izumi T, Suematsu M. Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury. J Biol Chem. 2010;285:26358-68 pubmed publisher
  8. Mustafa A, Gadalla M, Sen N, Kim S, Mu W, Gazi S, et al. H2S signals through protein S-sulfhydration. Sci Signal. 2009;2:ra72 pubmed publisher
    ..Sulfhydration augments GAPDH activity and enhances actin polymerization. Sulfhydration thus appears to be a physiologic posttranslational modification for proteins. ..
  9. Papapetropoulos A, Pyriochou A, Altaany Z, Yang G, Marazioti A, Zhou Z, et al. Hydrogen sulfide is an endogenous stimulator of angiogenesis. Proc Natl Acad Sci U S A. 2009;106:21972-7 pubmed publisher
    ..while pharmacological inhibition of H(2)S production or K(ATP) channels or silencing of cystathionine gamma-lyase (CSE) attenuated VEGF signaling and migration of ECs...

More Information

Publications77

  1. Yang G, Wu L, Bryan S, Khaper N, Mani S, Wang R. Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells. Cardiovasc Res. 2010;86:487-95 pubmed publisher
    Cystathionine gamma-lyase (CSE)-derived H2S plays an important role in regulating cell growth. Lack of CSE expression results in development of hypertension...
  2. Jiang Z, Li C, Manuel M, Yuan S, Kevil C, McCarter K, et al. Role of hydrogen sulfide in early blood-brain barrier disruption following transient focal cerebral ischemia. PLoS ONE. 2015;10:e0117982 pubmed publisher
    ..Topical treatment with DL-propargylglycine (PAG, an inhibitor for cystathionine γ-lyase (CSE)) and aspartate (ASP, inhibitor for cysteine aminotransferase/3-mercaptopyruvate sulfurtransferase (CAT/3-MST)), ..
  3. Ahmad A, Gero D, Olah G, Szabo C. Effect of endotoxemia in mice genetically deficient in cystathionine-?-lyase, cystathionine-?-synthase or 3-mercaptopyruvate sulfurtransferase. Int J Mol Med. 2016;38:1683-1692 pubmed publisher
    ..mice and in mice with reduced expression of one of the three H2S?producing enzymes, cystathionine-?-lyase (CSE), cystathionine-?-synthase (CBS) or 3-mercaptopyruvate sulfurtransferase (3MST)...
  4. Zhang G, Wang P, Yang G, Cao Q, Wang R. The inhibitory role of hydrogen sulfide in airway hyperresponsiveness and inflammation in a mouse model of asthma. Am J Pathol. 2013;182:1188-95 pubmed publisher
    Cystathionine ?-lyase (CSE) is one of the major enzymes producing hydrogen sulfide (H2S) in lungs, participating in the regulation of respiratory functions...
  5. Shirozu K, Tokuda K, Marutani E, Lefer D, Wang R, Ichinose F. Cystathionine ?-lyase deficiency protects mice from galactosamine/lipopolysaccharide-induced acute liver failure. Antioxid Redox Signal. 2014;20:204-16 pubmed publisher
    ..Here, we examined the role of cystathionine ?-lyase (CSE, an enzyme produces H2S) in ALF induced by D-Galactosamine (GalN) and lipopolysaccharide (LPS)...
  6. Fu M, Zhang W, Yang G, Wang R. Is cystathionine gamma-lyase protein expressed in the heart?. Biochem Biophys Res Commun. 2012;428:469-74 pubmed publisher
    ..Cystathionine gamma-lyase (CSE) is believed to be the major H(2)S-generating enzyme in the heart...
  7. Okuno T, Motobayashi S, Ueno H, Nakamuro K. Identification of mouse selenomethionine alpha,gamma-elimination enzyme: cystathionine gamma-lyase catalyzes its reaction to generate methylselenol. Biol Trace Elem Res. 2005;108:245-57 pubmed
    ..The Km value for the catalysis of L-cystathionine was 0.81 mM and Vmax was 0.0013 unit/mg protein. These results suggested that cystathionine gamma-lyase catalyzes L-SeMet to generate CH3SeH by its alpha,gamma-elimination reaction. ..
  8. Sha L, Linden D, Farrugia G, Szurszewski J. Hydrogen sulfide selectively potentiates central preganglionic fast nicotinic synaptic input in mouse superior mesenteric ganglion. J Neurosci. 2013;33:12638-46 pubmed publisher
    ..The H2S-producing enzyme cystathionine-?-lyase (CSE) was expressed in both neurons and glial cells...
  9. Gaddam R, Fraser R, Badiei A, Chambers S, Cogger V, Le Couteur D, et al. Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis. PLoS ONE. 2016;11:e0160521 pubmed publisher
    Hydrogen sulfide (H2S), produced by the activity of cystathionine-gamma-lyase (CSE), is a key mediator of inflammation in sepsis. The liver sinusoidal endothelial cells (LSECs) are important target and mediator of sepsis...
  10. Hua W, Jiang J, Rong X, Wu R, Qiu H, Zhang Y, et al. The dual role of the cystathionine gamma-lyase/hydrogen sulfide pathway in CVB3-induced myocarditis in mice. Biochem Biophys Res Commun. 2009;388:595-600 pubmed publisher
    The present study found that serum H2S level, H2S production rate, CSE mRNA and CSE protein levels were increased in CVB3-induced myocarditis...
  11. Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, et al. Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice. Toxicol Appl Pharmacol. 2015;282:195-206 pubmed publisher
  12. Huang C, Yao W, Wu W, Lu Y, Wan H, Wang W. Endogenous CSE/H2 S system mediates TNF-?-induced insulin resistance in 3T3-L1 adipocytes. Cell Biochem Funct. 2013;31:468-75 pubmed publisher
    ..We show that cystathionine ?-lyase (CSE) is catalysed in 3T3-L1 adipocytes to generate H2 S and that CSE expression and activity are upregulated by TNF-? ..
  13. Kolluru G, Bir S, Yuan S, Shen X, Pardue S, Wang R, et al. Cystathionine γ-lyase regulates arteriogenesis through NO-dependent monocyte recruitment. Cardiovasc Res. 2015;107:590-600 pubmed publisher
    ..vasoactive gasotransmitter that is endogenously produced in the vasculature by the enzyme cystathionine γ-lyase (CSE)...
  14. Bos E, Wang R, Snijder P, Boersema M, Damman J, Fu M, et al. Cystathionine ?-lyase protects against renal ischemia/reperfusion by modulating oxidative stress. J Am Soc Nephrol. 2013;24:759-70 pubmed publisher
    ..hypometabolic state, which can protect organs from ischemia/reperfusion injury, but whether cystathionine ?-lyase (CSE), which produces endogenous H2S, has similar protective effects is unknown...
  15. Markó L, Szijártó I, Filipović M, Kaßmann M, Balogh A, Park J, et al. Role of Cystathionine Gamma-Lyase in Immediate Renal Impairment and Inflammatory Response in Acute Ischemic Kidney Injury. Sci Rep. 2016;6:27517 pubmed publisher
    ..The renal expression of CTH and other H2S-producing enzymes was markedly suppressed after IRI, which could be an integrated adaptive response for renal cell protection. ..
  16. Altaany Z, Ju Y, Yang G, Wang R. The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide. Sci Signal. 2014;7:ra87 pubmed publisher
    The gasotransmitter hydrogen sulfide (H(2)S), which is generated by cystathionine γ-lyase (CSE), signals by modifying proteins through S-sulfhydration and potentially other mechanisms...
  17. Pan Z, Wang H, Liu Y, Yu C, Zhang Y, Chen J, et al. Involvement of CSE/ H2S in high glucose induced aberrant secretion of adipokines in 3T3-L1 adipocytes. Lipids Health Dis. 2014;13:155 pubmed publisher
    ..The expression of cystathionine-gamma-lyase (CSE), the H2S-forming enzyme, was evaluated by Western-blotting and real-time PCR...
  18. Mitidieri E, Tramontano T, Donnarumma E, Brancaleone V, Cirino G, d Emmanuele di Villa Bianca R, et al. l-Cys/CSE/H2S pathway modulates mouse uterus motility and sildenafil effect. Pharmacol Res. 2016;111:283-289 pubmed publisher
    ..predominantly formed from l-cysteine (l-Cys) by cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE)...
  19. Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, et al. Neutral aminoaciduria in cystathionine ?-synthase-deficient mice; an animal model of homocystinuria. Am J Physiol Renal Physiol. 2014;306:F1462-76 pubmed publisher
    ..Because the bulk of neutral amino acids is absorbed via a B(0)AT1 transporter and Met has the highest substrate affinity for B(0)AT1 than other neutral amino acids, hypermethioninemia may cause hyperexcretion of neutral amino acids. ..
  20. Renga B, Mencarelli A, Migliorati M, Distrutti E, Fiorucci S. Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation. World J Gastroenterol. 2009;15:2097-108 pubmed
    To investigate whether the farnesoid X receptor (FXR) regulates expression of liver cystathionase (CSE), a gene involved in hydrogen sulfide (H(2)S) generation...
  21. Wang C, Liu Y, Duan G, Zhao W, Li X, Zhu X, et al. CBS and CSE are critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex. Antioxid Redox Signal. 2014;21:2192-207 pubmed publisher
    ..H2S), a gaseous transmitter endogenously produced by cystathionine-?-synthase (CBS) and cystathionine-?-lyase (CSE), has been found to improve mitochondrial function...
  22. Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee B, Brace L, et al. Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell. 2015;160:132-44 pubmed publisher
    ..Together, these data are consistent with evolutionary conservation of TSP-mediated H2S as a mediator of DR benefits with broad implications for clinical translation. PAPERFLICK: ..
  23. Kaneko Y, Kimura T, Taniguchi S, Souma M, Kojima Y, Kimura Y, et al. Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose. FEBS Lett. 2009;583:377-82 pubmed publisher
    ..expression of the major H(2)S-producing enzymes, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE). CBS was ubiquitously distributed in the mouse pancreas, but CSE was found only in the exocrine...
  24. Yang G, Tang G, Zhang L, Wu L, Wang R. The pathogenic role of cystathionine ?-lyase/hydrogen sulfide in streptozotocin-induced diabetes in mice. Am J Pathol. 2011;179:869-79 pubmed publisher
    ..Cystathionine ?-lyase (CSE) is a major hydrogen sulfide (H(2)S)-producing enzyme in pancreatic ? cells...
  25. Badiei A, Rivers Auty J, Ang A, Bhatia M. Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells. Appl Microbiol Biotechnol. 2013;97:7845-52 pubmed publisher
    Hydrogen sulfide is an inflammatory mediator and is produced by the activity of the enzyme cystathionine ?-lyase (CSE) in macrophages...
  26. Ang A, Rivers Auty J, Hegde A, Ishii I, Bhatia M. The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouse. Am J Physiol Gastrointest Liver Physiol. 2013;305:G712-21 pubmed publisher
    ..In this study, we sought to determine whether endogenously synthesized H2S via cystathionine-?-lyase (CSE) plays a pro- or anti-inflammatory role in caerulein-induced pancreatitis...
  27. Ju Y, Untereiner A, Wu L, Yang G. H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells. Biochim Biophys Acta. 2015;1850:2293-303 pubmed publisher
    Cystathionine gamma-lyase (CSE)-derived hydrogen sulfide (H(2)S) possesses diverse roles in the liver, affecting lipoprotein synthesis, insulin sensitivity, and mitochondrial biogenesis...
  28. Peng Y, Nanduri J, Raghuraman G, Souvannakitti D, Gadalla M, Kumar G, et al. H2S mediates O2 sensing in the carotid body. Proc Natl Acad Sci U S A. 2010;107:10719-24 pubmed
    ..Glomus cells, the site of O2 sensing in the carotid body, express cystathionine gamma-lyase (CSE), an H2S-generating enzyme, with hypoxia increasing H2S generation in a stimulus-dependent manner...
  29. Zhang L, Yang G, Untereiner A, Ju Y, Wu L, Wang R. Hydrogen sulfide impairs glucose utilization and increases gluconeogenesis in hepatocytes. Endocrinology. 2013;154:114-26 pubmed publisher
    ..Adenovirus-mediated cystathionine ?-lyase (CSE) overexpression increased endogenous H(2)S production and lowered glycogen content in HepG(2) cells...
  30. Renga B, Bucci M, Cipriani S, Carino A, Monti M, Zampella A, et al. Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids. Am J Physiol Heart Circ Physiol. 2015;309:H114-26 pubmed publisher
    ..Hydrogen sulfide (H2S) is a vasodilatory agent generated in endothelial cells by cystathionine-γ-lyase (CSE)...
  31. Ning N, Zhu J, Du Y, Gao X, Liu C, Li J. Dysregulation of hydrogen sulphide metabolism impairs oviductal transport of embryos. Nat Commun. 2014;5:4107 pubmed publisher
    ..Our findings reveal a new regulatory mechanism for oviductal embryo transport. ..
  32. Sha L, Linden D, Farrugia G, Szurszewski J. Effect of endogenous hydrogen sulfide on the transwall gradient of the mouse colon circular smooth muscle. J Physiol. 2014;592:1077-89 pubmed publisher
    ..The aim was to investigate the role of endogenous H2S. Our results showed that the CSE inhibitor dl-propargylglycine (PAG, 500 ?m) had no effect on the transwall gradient...
  33. Sen U, Givvimani S, Abe O, Lederer E, Tyagi S. Cystathionine ?-synthase and cystathionine ?-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generation. Am J Physiol Cell Physiol. 2011;300:C155-63 pubmed publisher
    ..endogenous production of H?S and better clearance of Hcy, cystathionine ?-synthase (CBS) and cystathionine ?-lyase (CSE) genes were delivered to the cells...
  34. Hartmann C, Hafner S, Scheuerle A, Möller P, Huber Lang M, Jung B, et al. The Role of Cystathionine-γ-Lyase In Blunt Chest Trauma in Cigarette Smoke Exposed Mice. Shock. 2017;47:491-499 pubmed publisher
    ..Cystathionine-γ-lyase (CSE) protects against ALI and CS exposure-induced chronic obstructive lung disease (COPD)...
  35. King A, Polhemus D, Bhushan S, Otsuka H, Kondo K, Nicholson C, et al. Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent. Proc Natl Acad Sci U S A. 2014;111:3182-7 pubmed publisher
    ..We found that mice lacking the H2S-producing enzyme cystathionine ?-lyase (CSE) exhibit elevated oxidative stress, dysfunctional eNOS, diminished NO levels, and exacerbated myocardial and ..
  36. Gupta V, Kapopara P, Khan A, Arige V, Subramanian L, Sonawane P, et al. Functional promoter polymorphisms direct the expression of cystathionine gamma-lyase gene in mouse models of essential hypertension. J Mol Cell Cardiol. 2017;102:61-73 pubmed publisher
    ..Taken together, this study reveals the molecular basis for the differential expression of Cth in mouse models of essential hypertension under basal and pathophysiological conditions. ..
  37. Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, et al. Cystathionine ?-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis. Arterioscler Thromb Vasc Biol. 2014;34:626-34 pubmed publisher
    ..We selected 5 proteins for subsequent analysis (cystathionine ?-lyase [Cth/CSE], EGF-like repeat and discoidin I-like domain-containing protein 3, integrin ? FG-GAP repeat containing 3, ..
  38. Tamizhselvi R, Moore P, Bhatia M. Hydrogen sulfide acts as a mediator of inflammation in acute pancreatitis: in vitro studies using isolated mouse pancreatic acinar cells. J Cell Mol Med. 2007;11:315-26 pubmed
    Hydrogen sulphide (H(2)S) is synthesized from L-cysteine via the action of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS). We have earlier shown that H(2)S acts as a mediator of inflammation...
  39. Rakoczy J, Lee S, Weerasekera S, Simmons D, Dawson P. Placental and fetal cysteine dioxygenase gene expression in mouse gestation. Placenta. 2015;36:956-9 pubmed publisher
    ..5 and was localised to the decidua and several fetal tissues including nasal cavities and brain. These findings suggest a role for Cdo1 in sulfate generation from mid-gestation. ..
  40. Wang K, Ahmad S, Cai M, Rennie J, Fujisawa T, Crispi F, et al. Dysregulation of hydrogen sulfide producing enzyme cystathionine ?-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia. Circulation. 2013;127:2514-22 pubmed publisher
    ..Hydrogen sulfide (H2S), a gaseous messenger produced mainly by cystathionine ?-lyase (CSE), is a proangiogenic vasodilator...
  41. Cheung S, Kwok W, To K, Lau J. Anti-atherogenic effect of hydrogen sulfide by over-expression of cystathionine gamma-lyase (CSE) gene. PLoS ONE. 2014;9:e113038 pubmed publisher
    ..Since cystathionine gamma-lyase (CSE) enzyme is responsible for producing H2S in the cardiovascular system, we hypothesized that up-regulation of CSE ..
  42. Li H, Mani S, Wu L, Fu M, Shuang T, Xu C, et al. The interaction of estrogen and CSE/H2S pathway in the development of atherosclerosis. Am J Physiol Heart Circ Physiol. 2017;312:H406-H414 pubmed publisher
    ..We previously reported that cystathionine ?-lyase knockout (CSE-KO) male mice develop atherosclerosis earlier than male wild-type (WT) mice...
  43. Okamoto M, Yamaoka M, Takei M, Ando T, Taniguchi S, Ishii I, et al. Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes. Biochem Biophys Res Commun. 2013;442:227-33 pubmed publisher
    Chronic exposure to high glucose induces the expression of cystathionine gamma-lyase (CSE), a hydrogen sulfide-producing enzyme, in pancreatic beta-cells, thereby suppressing apoptosis...
  44. Kuo M, Kim D, Jandu S, Bergman Y, Tan S, Wang H, et al. MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery. Am J Physiol Heart Circ Physiol. 2016;310:H71-9 pubmed publisher
    ..vasoregulation and evaluated the physiological relevance of two sources of H2S, namely, cystathionine-γ-lyase (CSE) and 3-mercaptypyruvate sulfertransferase (MPST)...
  45. Yang G, Ju Y, Fu M, Zhang Y, Pei Y, Racine M, et al. Cystathionine gamma-lyase/hydrogen sulfide system is essential for adipogenesis and fat mass accumulation in mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:165-176 pubmed publisher
    ..Cystathionine gamma-lyase (CSE)-derived H2S is implicated in the regulation of insulin resistance and glucose metabolism, but the ..
  46. Du H, Li J, You S, Wang Y, Wang F, Cao Y, et al. DNA methylation in cystathionine-γ-lyase (CSE) gene promoter induced by ox-LDL in macrophages and in apoE knockout mice. Biochem Biophys Res Commun. 2016;469:776-82 pubmed publisher
    ..Our and other groups demonstrated that dysregulation of cystathionine γ-lyase (CSE) -hydrogen sulfide (H2S) pathway was involved in monocyte/macrophages-mediated inflammation and atherosclerosis...
  47. Makarenko V, Nanduri J, Raghuraman G, Fox A, Gadalla M, Kumar G, et al. Endogenous H2S is required for hypoxic sensing by carotid body glomus cells. Am J Physiol Cell Physiol. 2012;303:C916-23 pubmed publisher
    H(2)S generated by the enzyme cystathionine-?-lyase (CSE) has been implicated in O(2) sensing by the carotid body...
  48. Zhao K, Ju Y, Li S, Altaany Z, Wang R, Yang G. S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair. EMBO Rep. 2014;15:792-800 pubmed publisher
    ..In the presence of H2S, activated PARP-1 recruits XRCC1 and DNA ligase III to DNA breaks to mediate DNA damage repair, and cells are protected from senescence. ..
  49. Bucci M, Papapetropoulos A, Vellecco V, Zhou Z, Zaid A, Giannogonas P, et al. cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation. PLoS ONE. 2012;7:e53319 pubmed publisher
    ..In addition, vascular tissue levels of cGMP in cystathionine gamma lyase knockouts were lower than those in wild-type control mice...
  50. Tripatara P, Patel N, Brancaleone V, Renshaw D, Rocha J, Sepodes B, et al. Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study. Eur J Pharmacol. 2009;606:205-9 pubmed publisher
  51. Yuan G, Peng Y, Khan S, Nanduri J, Singh A, Vasavda C, et al. H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea. Sci Signal. 2016;9:ra80 pubmed publisher
    ..HO-2) induces a signaling pathway that inhibits hydrogen sulfide (H2S) production by cystathionine γ-lyase (CSE), leading to suppression of carotid body activity...
  52. Untereiner A, Wang R, Ju Y, Wu L. Decreased Gluconeogenesis in the Absence of Cystathionine Gamma-Lyase and the Underlying Mechanisms. Antioxid Redox Signal. 2016;24:129-40 pubmed publisher
    To investigate the regulation of hepatic glucose production by cystathionine γ-lyase (CSE)-generated hydrogen sulfide (H2S) in hepatic glucose production under physiological conditions...
  53. Dickhout J, Carlisle R, Jerome D, Mohammed Ali Z, Jiang H, Yang G, et al. Integrated stress response modulates cellular redox state via induction of cystathionine ?-lyase: cross-talk between integrated stress response and thiol metabolism. J Biol Chem. 2012;287:7603-14 pubmed publisher
    ..Cystathionine ?-lyase (CSE) and cystathionine ?-synthase are critical enzymes in the transsulfuration pathway, which also regulate cellular ..
  54. Syhr K, Boosen M, Hohmann S, Longen S, Köhler Y, Pfeilschifter J, et al. The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain. Brain Res. 2015;1624:380-9 pubmed publisher
    ..Here we investigated the expression of the H2S releasing enzyme cystathionine γ-lyase (CSE) in the nociceptive system and characterized its role in chronic pain signaling using CSE deficient mice...
  55. Makarenko V, Peng Y, Yuan G, Fox A, Kumar G, Nanduri J, et al. CaV3.2 T-type Ca²⁺ channels in H₂S-mediated hypoxic response of the carotid body. Am J Physiol Cell Physiol. 2015;308:C146-54 pubmed publisher
    ..2 knockout (Cacna1h(-/-)) mice. Since cystathionine-γ-lyase (CSE)-derived H2S is a critical mediator of the carotid body response to hypoxia, the role of T-type VGCCs in H2S-..
  56. Dutchak P, Laxman S, Estill S, Wang C, Wang Y, Wang Y, et al. Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Rep. 2015;12:371-9 pubmed publisher
  57. Morikawa T, Kajimura M, Nakamura T, Hishiki T, Nakanishi T, Yukutake Y, et al. Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway. Proc Natl Acad Sci U S A. 2012;109:1293-8 pubmed publisher
    ..Thus, in intact adult brain cerebral cortex of HO-2-null mice, imaging mass spectrometry reveals an impaired ability to maintain ATP levels on hypoxia. ..
  58. Sbodio J, Snyder S, Paul B. Transcriptional control of amino acid homeostasis is disrupted in Huntington's disease. Proc Natl Acad Sci U S A. 2016;113:8843-8 pubmed publisher
    ..This signaling cascade may be relevant to other diseases involving redox imbalance and deficits in amino acid metabolism. ..
  59. Pong W, Stouracova R, Frank N, Kraus J, Eldred W. Comparative localization of cystathionine beta-synthase and cystathionine gamma-lyase in retina: differences between amphibians and mammals. J Comp Neurol. 2007;505:158-65 pubmed publisher
  60. Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, et al. Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine ?-lyase, an animal model of cystathioninuria. Free Radic Biol Med. 2012;52:1716-26 pubmed publisher
  61. Ishii I, Akahoshi N, Yu X, Kobayashi Y, Namekata K, Komaki G, et al. Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression. Biochem J. 2004;381:113-23 pubmed
    Cystathionine gamma-lyase (CSE) is the last key enzyme in the trans-sulphuration pathway for biosynthesis of cysteine from methionine...
  62. Mani S, Yang G, Wang R. A critical life-supporting role for cystathionine ?-lyase in the absence of dietary cysteine supply. Free Radic Biol Med. 2011;50:1280-7 pubmed publisher
    This study examined the important relationship between cystathionine ?-lyase (CSE) functionality and cysteine supply for normal growth and life span...
  63. Cai J, Shi X, Wang H, Fan J, Feng Y, Lin X, et al. Cystathionine γ lyase-hydrogen sulfide increases peroxisome proliferator-activated receptor γ activity by sulfhydration at C139 site thereby promoting glucose uptake and lipid storage in adipocytes. Biochim Biophys Acta. 2016;1861:419-29 pubmed publisher
    Adipocytes express the cystathionine γ lyase (CSE)-hydrogen sulfide (H2S) system. CSE-H2S promotes adipogenesis but ameliorates adipocyte insulin resistance...
  64. Manna P, Jain S. Vitamin D up-regulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-?-lyase (CSE) activation and H2S formation in 3T3L1 adipocytes. J Biol Chem. 2012;287:42324-32 pubmed publisher
    ..1,25(OH)(2)D(3) also caused cystathionine-?-lyase (CSE) activation and H(2)S formation in HG-treated adipocytes...
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    Cystathionine ?-lyase (CSE) produces H2S via enzymatic conversion of L-cysteine and plays a critical role in cardiovascular homeostasis...
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    ..whether MG levels and gluconeogenic enzymes are altered in kidneys of 6-22 week-old cystathionine ?-lyase knockout (CSE(-/-); H(2)S-producing enzyme) male mice. MG levels were determined by HPLC...
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    ..The gasotransmitter H(2)S is mostly generated from L-cysteine in pancreatic beta cells by cystathionine ?-lyase (CSE) and has been reported to inhibit insulin release by opening ATP-sensitive K(+) channels...
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    Hydrogen sulfide (H2S), formed mainly by the enzyme cystathionine ?-lyase (CSE) in macrophages, is emerging as a novel regulator in inflammation...