Gene Symbol: Cysltr1
Description: cysteinyl leukotriene receptor 1
Alias: BB147369, CysLT1R, Cyslt1, cysteinyl leukotriene receptor 1, LTD4 receptor, cysteinyl leukotriene 1 receptor short isoform, cysteinyl leukotriene D4 receptor
Species: mouse
Products:     Cysltr1

Top Publications

  1. Martin V, Sawyer N, Stocco R, Unett D, Lerner M, Abramovitz M, et al. Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors. Biochem Pharmacol. 2001;62:1193-200 pubmed
    ..Functional elucidation of mCysLT(1)R properties as described here will enable further experiments to clarify the selective role of LTD(4) in murine models of inflammation and asthma. ..
  2. Jiang Y, Borrelli L, Kanaoka Y, Bacskai B, Boyce J. CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Blood. 2007;110:3263-70 pubmed
    ..Negative regulation of CysLT(1)-induced mitogenic signaling responses of MCs by CysLT(2) demonstrates physiologically relevant functions for GPCR heterodimers on primary cells central to inflammation. ..
  3. Maekawa A, Kanaoka Y, Lam B, Austen K. Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. Proc Natl Acad Sci U S A. 2001;98:2256-61 pubmed
    ..Thus, the dominant mouse isoform with the N-terminal amino acid extension encoded by an additional exon has the same ligand response profile as the spliced form and the human receptor. ..
  4. Jiang Y, Kanaoka Y, Feng C, Nocka K, Rao S, Boyce J. Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling. J Immunol. 2006;177:2755-9 pubmed
    ..that IL-4, which induces LTC4S expression by mast cells (MCs), requires cys-LTs, the cys-LT type 1 receptor (CysLT1), and Gi proteins to promote MC proliferation...
  5. Queto T, Gaspar Elsas M, Masid de Brito D, Vasconcelos Z, Ferraris F, Penido C, et al. Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow. J Leukoc Biol. 2010;87:885-93 pubmed publisher
    ..were evaluated, in the absence or presence of: a) the 5-LO inhibitor zileuton, the FLAP inhibitor MK886, or the CysLT1R antagonists, montelukast and MK571; b) mutations that inactivate 5-LO, LTC4S, or CysLT1R; and c) neutralizing mAb ..
  6. Jiang Y, Borrelli L, Bacskai B, Kanaoka Y, Boyce J. P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. J Immunol. 2009;182:1129-37 pubmed
    Cysteinyl leukotrienes (cys-LTs) induce inflammatory responses through type 1 (CysLT1R) and type 2 (CysLT2R) cys-LT receptors and activate mast cells in vitro...
  7. Maekawa A, Austen K, Kanaoka Y. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. J Biol Chem. 2002;277:20820-4 pubmed
    ..Thus, the cysLTs generated in vivo by either monocytes/macrophages or mast cells utilize CysLT(1)R for the response of the microvasculature in acute inflammation. ..
  8. Maekawa A, Kanaoka Y, Xing W, Austen K. Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. Proc Natl Acad Sci U S A. 2008;105:16695-700 pubmed publisher
    ..Our findings establish the existence of a third receptor, CysLT(E)R, that responds preferentially to LTE(4), the most abundant cys-LT in biologic fluids, and thus reveal a new target for therapeutic intervention. ..
  9. Luo J, Zhang Z, Yu S, Zhao B, Zhao C, Wang X, et al. [Rotenone-induced changes of cysteinyl leukotriene receptor 1 expression in BV2 microglial cells]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011;40:131-8 pubmed
    To prepare and identify a polyclonal antibody (pAb) against (mouse) cysteinyl leukotriene receptor 1 (CysLT(1)) and to investigate the changes of CysLT(1) receptor expression in BV2 microglial cells after rotenone treatment...

More Information


  1. Ogasawara H, Ishii S, Yokomizo T, Kakinuma T, Komine M, Tamaki K, et al. Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution. J Biol Chem. 2002;277:18763-8 pubmed
  2. Kanaoka Y, Maekawa A, Austen K. Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. J Biol Chem. 2013;288:10967-72 pubmed publisher
    ..b>Cysltr1/Cysltr2(-/-) mice, lacking the two defined receptors, exhibited a comparable dose-dependent vascular leak to ..
  3. Prinz I, Gregoire C, Mollenkopf H, Aguado E, Wang Y, Malissen M, et al. The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells. J Immunol. 2005;175:713-9 pubmed
    ..These results suggest that CysLT(1) is likely involved in the recruitment of activated alphabeta and gammadelta T cells to inflamed tissues. ..
  4. Doherty T, Khorram N, Lund S, Mehta A, Croft M, Broide D. Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. J Allergy Clin Immunol. 2013;132:205-13 pubmed publisher
    Cysteinyl leukotrienes (CysLTs) contribute to asthma pathogenesis, in part through cysteinyl leukotriene receptor 1 (CysLT1R). Recently discovered lineage-negative type 2 innate lymphoid cells (ILC2s) potently produce IL-5 and IL-13...
  5. Storch U, Blodow S, Gudermann T, Mederos y Schnitzler M. Cysteinyl leukotriene 1 receptors as novel mechanosensors mediating myogenic tone together with angiotensin II type 1 receptors-brief report. Arterioscler Thromb Vasc Biol. 2015;35:121-6 pubmed publisher
    ..Moreover, our findings suggest that myogenic tone is determined by AT1 and CysLT1 receptors acting together as mechanosensors via Gq/11-protein activation.
  6. Cummings H, Liu T, Feng C, Laidlaw T, Conley P, Kanaoka Y, et al. Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. J Immunol. 2013;191:5807-10 pubmed publisher
    ..They signal through three specific receptors (type 1 cys-LT receptor [CysLT1R], CysLT2R, and GPR99) with overlapping ligand preferences...
  7. Wixted J, Fanning P, Gaur T, O Connell S, Silva J, Mason Savas A, et al. Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor. J Cell Physiol. 2009;221:31-9 pubmed publisher
  8. Kondeti V, Al Azzam N, Duah E, Thodeti C, Boyce J, Paruchuri S. Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3. J Allergy Clin Immunol. 2016;137:289-298 pubmed publisher
    ..Furthermore, LTD4 plus PGE2, through cysteinyl leukotriene receptor 1 (CysLT1R) and E-prostanoid receptor (EP) 3, enhanced extracellular signal-regulated kinase (Erk) and ..
  9. Osman J, Savari S, Chandrashekar N, Bellamkonda K, Douglas D, Sjölander A. Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer. Oncotarget. 2017;8:34773-34786 pubmed publisher
    b>Cysteinyl leukotriene receptor 1 (CysLT1R) has been shown to be up-regulated in the adenocarcinomas of colorectal cancer patients, which is associated with a poor prognosis...
  10. Paruchuri S, Tashimo H, Feng C, Maekawa A, Xing W, Jiang Y, et al. Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. J Exp Med. 2009;206:2543-55 pubmed publisher
    ..Although LTE4 shows negligible activity at the type 1 and 2 receptors for cys-LTs (CysLT1R and CysLT2R), it is a powerful inducer of mucosal eosinophilia and airway hyperresponsiveness in humans with ..
  11. Maekawa A, Balestrieri B, Austen K, Kanaoka Y. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. Proc Natl Acad Sci U S A. 2009;106:11685-90 pubmed publisher
    ..Taken together, our findings suggest that GPR17 is a ligand-independent, constitutive negative regulator for the CysLT(1)R that suppresses CysLT(1)R-mediated function at the cell membrane. ..
  12. McGovern T, Goldberger M, Chen M, Allard B, Hamamoto Y, Kanaoka Y, et al. CysLT1 Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma. J Immunol. 2016;197:266-77 pubmed publisher
    ..CysLT1R-deficient (CysLTr1(-/-)) mice that were exposed to Cl2 demonstrated airway hyperresponsiveness to inhaled methacholine significantly ..
  13. Tang S, Hong H, Chen L, Mei Z, Ji M, Xiang G, et al. Involvement of cysteinyl leukotriene receptor 1 in A?1-42-induced neurotoxicity in vitro and in vivo. Neurobiol Aging. 2014;35:590-9 pubmed publisher
    ..In the current study, we investigated the roles of cysteinyl leukotriene receptor 1 (CysLT1R) in A?1-42-induced neurotoxicity in vitro or in vivo...
  14. Barrett N, Rahman O, Fernandez J, Parsons M, Xing W, Austen K, et al. Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes. J Exp Med. 2011;208:593-604 pubmed publisher
    ..Direct sensitization and challenge of Ltc4s-/- and Cysltr1-/- mice confirmed that cys-LTs mediate these parameters of Df-elicited Th2 pulmonary inflammation...
  15. Yu S, Zhang X, Wang X, Xu D, Chen L, Zhang L, et al. Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitro. Acta Pharmacol Sin. 2014;35:33-40 pubmed publisher
    To investigate the roles of cysteinyl leukotriene receptors CysLT1R and CysLT2R in leukotriene D4 (LTD4)-induced activation of microglial cells in vitro. Mouse microglial cell line BV2 was transfected with pcDNA3.1(+)-hCysLT1R or pcDNA3...
  16. Wang H, Shi Q, Shi W, Zhang X, Wang X, Zhang L, et al. [Expression and distribution of cysteinyl leukotriene receptors CysLT1R and CysLT2R, and GPR17 in brain of Parkinson disease model mice]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2013;42:52-60 pubmed
    To examine the spatiotemporal profiles and localization of CysLT1R, CysLT2R and GPR17 in mice with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson disease (PD)...
  17. Oyoshi M, He R, Kanaoka Y, Elkhal A, Kawamoto S, Lewis C, et al. Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. Proc Natl Acad Sci U S A. 2012;109:4992-7 pubmed publisher
    ..Strategies that block eosinophil infiltration, cys-LT production, or the CysLT(2)R might be useful in the treatment of AD. ..
  18. Lee J, Park H, Noh A, Kang J, Chen L, Zheng T, et al. 5-Lipoxygenase mediates RANKL-induced osteoclast formation via the cysteinyl leukotriene receptor 1. J Immunol. 2012;189:5284-92 pubmed publisher
    ..Similar effects were shown with CysLT receptor (CysLTR)1/2 antagonist and small RNA for CysLTR1 in BMMs, indicating the involvement of CysLT and CysLTR1 in 5-LO-mediated osteoclastogenesis...
  19. Masid de Brito D, Queto T, Gaspar Elsas M, Xavier Elsas P. Roles of 5-lipoxygenase and cysteinyl-leukotriene type 1 receptors in the hematological response to allergen challenge and its prevention by diethylcarbamazine in a murine model of asthma. Mediators Inflamm. 2014;2014:403970 pubmed publisher
    ..Overall, 5-LO appears as indispensable to the systemic hematological response to allergen challenge, as well as to the effectiveness of DEC. ..
  20. Maekawa A, Xing W, Austen K, Kanaoka Y. GPR17 regulates immune pulmonary inflammation induced by house dust mites. J Immunol. 2010;185:1846-54 pubmed publisher
    ..These findings reveal a constitutive negative regulation of CysLT(1)R functions by GPR17 in both the Ag presentation and downstream phases of allergic pulmonary inflammation...
  21. Shi W, Zhao C, Zhao B, Shi Q, Zhang L, Wang Y, et al. Aggravated inflammation and increased expression of cysteinyl leukotriene receptors in the brain after focal cerebral ischemia in AQP4-deficient mice. Neurosci Bull. 2012;28:680-92 pubmed publisher
    ..AQP4 may play an inhibitory role in postischemic inflammation. ..
  22. Tang S, Wang X, Hong H, Long Y, Li Y, Xiang G, et al. Leukotriene D4 induces cognitive impairment through enhancement of CysLT? R-mediated amyloid-? generation in mice. Neuropharmacology. 2013;65:182-92 pubmed publisher
    ..LTD4 also induced expression of cysteinyl leukotriene receptor 1 (CysLT(1)R) and NF-?B p65 in the hippocampus and cortex. Pretreatment with pranlukast (1...
  23. Lund S, Portillo A, Cavagnero K, Baum R, Naji L, Badrani J, et al. Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation. J Immunol. 2017;199:1096-1104 pubmed publisher
    ..Levels of CysLT1R, CysLT2R, and candidate leukotriene E4 receptor P2Y12 mRNAs were increased in ILC2s...
  24. Mollerup J, Jørgensen S, Hougaard C, Hoffmann E. Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes. Biochim Biophys Acta. 2001;1517:455-9 pubmed
    ..The identified murine CysLT1 receptor differs from the hCysLT1 receptor with regard to PTX sensitivity, receptor-mediated Ca2+ influx, and ..
  25. Jørgensen S, Eriksen H, Dausell J, Jespersen T, Lambert I, Hoffmann E. Double mutation at the putative protein kinase C phosphorylation sites Thr151 plus Thr323 in the mouse leukotrieneD4 receptor eliminates homologous desensitization. Cell Physiol Biochem. 2013;31:366-78 pubmed publisher
    ..via CysLT1 is involved in activation of volume sensitive K(+) channels and homologous desensitization of the LTD4 receptor impairs regulatory volume decrease (RVD)...
  26. Ding Q, Fang S, Zhou Y, Zhang L, Zhang W, Chen Z, et al. Cysteinyl leukotriene receptor 1 partially mediates brain cryoinjury in mice. Acta Pharmacol Sin. 2007;28:945-52 pubmed
    To determine whether the cysteinyl leukotriene receptor 1 (CysLT1 receptor) modulates brain cryoinjury and whether the CysLT1 receptor antagonist pranlukast exerts a time-dependent protective effect on cryoinjury in mice...
  27. Beller T, Friend D, Maekawa A, Lam B, Austen K, Kanaoka Y. Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis. Proc Natl Acad Sci U S A. 2004;101:3047-52 pubmed
  28. Wei J, Chen S, Huang C, Guo W, Yang S, Feng B, et al. Antagonism of cysteinyl leukot-riene receptor 1 (cysLT1R) by montelukast regulates differentiation of MC3T3-E1 cells under overloaded mechanical environment. Biochem Biophys Res Commun. 2018;495:995-1001 pubmed publisher
    ..Montelukast is a selective cysteinyl leukot-riene receptor 1 (cysLT1R) antagonist, which has been used for the treatment of bronchial asthma in clinics...
  29. Savari S, Chandrashekar N, Osman J, Douglas D, Bellamkonda K, Jönsson G, et al. Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model. Carcinogenesis. 2016;37:491-9 pubmed publisher
    ..Increased expression of both the cysteinyl leukotriene receptor 1 (CysLTR1) and the enzyme responsible for the production of leukotrienes, 5-lipoxygenase, is ..
  30. Park J, Kang S, Seo M, Jou I, Woo H, Park S. Role of cysteinyl leukotriene signaling in a mouse model of noise-induced cochlear injury. Proc Natl Acad Sci U S A. 2014;111:9911-6 pubmed publisher
    ..We found that the expression of cysteinyl leukotriene type 1 receptor (CysLTR1) was increased until 3 d after noise exposure and enhanced CysLTR1 expression was mainly observed in the spiral ..
  31. Rehni A, Singh T. Modulation of leukotriene D4 attenuates the development of seizures in mice. Prostaglandins Leukot Essent Fatty Acids. 2011;85:97-106 pubmed publisher
    ..Therefore, leukotriene D(4) may be implicated in the pathogenesis of seizures. ..
  32. Sheng W, Li C, Zhang W, Yuan Y, Hu H, Fang S, et al. Distinct roles of CysLT1 and CysLT2 receptors in oxygen glucose deprivation-induced PC12 cell death. Biochem Biophys Res Commun. 2006;346:19-25 pubmed
    ..Thus, CysLT(1) and CysLT(2) receptors play distinct roles in OGD-induced PC12 cell death; CysLT(1) attenuates while CysLT(2) facilitates the cell death. ..
  33. Lotzer K, Funk C, Habenicht A. The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis. Biochim Biophys Acta. 2005;1736:30-7 pubmed
    ..We will attempt to propose strategies to further explore potential links between the 5-LO pathway and blood vessel physiology and disease progression. ..