Cyp7b1

Summary

Gene Symbol: Cyp7b1
Description: cytochrome P450, family 7, subfamily b, polypeptide 1
Alias: AW261589, D3Ertd552e, hct-1, 25-hydroxycholesterol 7-alpha-hydroxylase, cytochrome P450 7B1, cytochrome P450, 7b1, hippocampal transcript 1 protein, oxysterol 7-alpha-hydroxylase
Species: mouse
Products:     Cyp7b1

Top Publications

  1. Bauman D, Bitmansour A, McDonald J, Thompson B, Liang G, Russell D. 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production. Proc Natl Acad Sci U S A. 2009;106:16764-9 pubmed publisher
    ..Conversely, inactivation of the CYP7B1 oxysterol 7alpha-hydroxylase, which degrades 25-hydroxycholesterol, decreased serum IgA...
  2. Rose K, Allan A, Gauldie S, Stapleton G, Dobbie L, Dott K, et al. Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation. J Biol Chem. 2001;276:23937-44 pubmed
    ..CYP7B is thus a major extrahepatic steroid and oxysterol hydroxylase and provides the predominant route for local metabolism of DHEA and related molecules in brain and other tissues. ..
  3. Yi T, Wang X, Kelly L, An J, Xu Y, Sailer A, et al. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity. 2012;37:535-48 pubmed publisher
    ..7?,25-OHC is synthesized from cholesterol by the stepwise actions of two enzymes, CH25H and CYP7B1, and is metabolized to a 3-oxo derivative by HSD3B7...
  4. Ferrell J, Boehme S, Li F, Chiang J. Cholesterol 7?-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders. J Lipid Res. 2016;57:1144-54 pubmed publisher
  5. Yi T, Cyster J. EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture. elife. 2013;2:e00757 pubmed publisher
    ..These findings establish an essential role for EBI2 in CD4(+) DC positioning and homeostasis and in facilitating capture and presentation of blood-borne particulate antigens. DOI:http://dx.doi.org/10.7554/eLife.00757.001. ..
  6. Pettersson H, Lundqvist J, Oliw E, Norlin M. CYP7B1-mediated metabolism of 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol): a novel pathway for potential regulation of the cellular levels of androgens and neurosteroids. Biochim Biophys Acta. 2009;1791:1206-15 pubmed publisher
    ..3alpha-Adiol) undergoes a previously unknown metabolism into hydroxymetabolites, catalyzed by CYP7B1. 3alpha-Adiol is an androgenic steroid which serves as a source for the potent androgen dihydrotestosterone and ..
  7. Guillen N, Navarro M, Arnal C, Noone E, Arbones Mainar J, Acin S, et al. Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. Physiol Genomics. 2009;37:187-98 pubmed publisher
    ..Ten genes (Fsp27, Aqp4, Cd36, Ly6d, Scd1, Hsd3b5, Syt1, Cyp7b1, and Tff3) showed significant associations among their expressions and the degree of hepatic steatosis...
  8. Umetani M, Domoto H, Gormley A, Yuhanna I, Cummins C, Javitt N, et al. 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med. 2007;13:1185-92 pubmed
    ..pharmacologic administration or genetic manipulation (by knocking out the gene encoding the catabolic enzyme CYP7B1) decreased estrogen-dependent expression of vascular nitric oxide synthase and repressed carotid artery ..
  9. Li J, Lu E, Yi T, Cyster J. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. 2016;533:110-4 pubmed publisher

More Information

Publications24

  1. Oyola M, Zuloaga D, Carbone D, Malysz A, Acevedo Rodriguez A, Handa R, et al. CYP7B1 Enzyme Deletion Impairs Reproductive Behaviors in Male Mice. Endocrinology. 2015;156:2150-61 pubmed publisher
    ..b>CYP7B1 enzyme converts 3β-diol to inactive 6α- or 7α-triols and plays an important role as a regulator of ..
  2. Wada T, Kang H, Angers M, Gong H, Bhatia S, Khadem S, et al. Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol. 2008;73:891-9 pubmed
    ..In this study, we revealed a novel function of RORalpha (NR1F1) in regulating the oxysterol 7alpha-hydroxylase (Cyp7b1), an enzyme critical for the homeostasis of cholesterol, bile acids, and oxysterols...
  3. Omoto Y, Lathe R, Warner M, Gustafsson J. Early onset of puberty and early ovarian failure in CYP7B1 knockout mice. Proc Natl Acad Sci U S A. 2005;102:2814-9 pubmed
    b>CYP7B1 is the enzyme responsible for hydroxylation and termination of the estrogenic actions of the androgen metabolite, 5alpha-androstane-3beta, 17beta-diol (3betaAdiol)...
  4. Weihua Z, Lathe R, Warner M, Gustafsson J. An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci U S A. 2002;99:13589-94 pubmed
    ..We have used ERbeta(-/-) and CYP7B1(-/-) mice to investigate the role of ERbeta and one of its ligands, 5alpha-androstane-3beta,17beta-diol (..
  5. Li Hawkins J, Lund E, Bronson A, Russell D. Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. J Biol Chem. 2000;275:16543-9 pubmed
    ..of 7alpha-hydroxylated bile acids from oxysterols requires an oxysterol 7alpha-hydroxylase encoded by the Cyp7b1 locus...
  6. Omoto Y, Imamov O, Warner M, Gustafsson J. Estrogen receptor alpha and imprinting of the neonatal mouse ventral prostate by estrogen. Proc Natl Acad Sci U S A. 2005;102:1484-9 pubmed
    ..We conclude that imprinting and branching morphogenesis of the ventral prostate are mediated by estrogen acting directly on epithelial and stromal ERalpha during the first 2 weeks of life. ..
  7. DuSell C, Nelson E, Wang X, Abdo J, Mödder U, Umetani M, et al. The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. Endocrinology. 2010;151:3675-85 pubmed publisher
    ..More studies are warranted to fully elucidate the mechanism of action of 27HC in bone and to identify ways to modulate this pathway therapeutically. ..
  8. Bean R, Seckl J, Lathe R, Martin C. Ontogeny of the neurosteroid enzyme Cyp7b in the mouse. Mol Cell Endocrinol. 2001;174:137-44 pubmed
    ..This pattern of cyp7b mRNA expression in specific organs could be consistent with a protective role in foetal development, with highest expression seen when the foetus is most vulnerable to steroid excess (i.e.) early gestation. ..
  9. Li Hawkins J, Lund E, Turley S, Russell D. Disruption of the oxysterol 7alpha-hydroxylase gene in mice. J Biol Chem. 2000;275:16536-42 pubmed
    ..with a sexually dimorphic expression pattern, were constructed by the introduction of a null mutation at the Cyp7b1 locus...
  10. Wang Y, Karu K, Meljon A, Turton J, Yau J, Seckl J, et al. 24S,25-Epoxycholesterol in mouse and rat brain. Biochem Biophys Res Commun. 2014;449:229-34 pubmed publisher
    ..By exploiting knockout mice for the enzyme oxysterol 7?-hydroxylase (Cyp7b1) we show that this enzymes is important for the subsequent metabolism of the 24S,25-epoxide.
  11. Schwarz M, Lund E, Lathe R, Bjorkhem I, Russell D. Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA. J Biol Chem. 1997;272:23995-4001 pubmed
    ..Here, we show that a mouse hepatic oxysterol 7alpha-hydroxylase is encoded by Cyp7b1, a cytochrome P450 cDNA originally isolated from the hippocampus...
  12. Stapleton G, Steel M, Richardson M, Mason J, Rose K, Morris R, et al. A novel cytochrome P450 expressed primarily in brain. J Biol Chem. 1995;270:29739-45 pubmed
  13. Lorbek G, Lewinska M, Rozman D. Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases. FEBS J. 2012;279:1516-33 pubmed publisher
    ..In line with this, Cyp7b1 knockouts are also apparently normal, whereas human CYP7B1 mutations lead to a congenital bile acid synthesis ..
  14. Umetani M, Ghosh P, Ishikawa T, Umetani J, Ahmed M, Mineo C, et al. The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. Cell Metab. 2014;20:172-82 pubmed publisher
    ..27-hydroxycholesterol (27HC) is an abundant oxysterol metabolized by CYP7B1. How 27HC impacts vascular health is unknown...
  15. Molyneaux B, Goff L, Brettler A, Chen H, Hrvatin S, Rinn J, et al. DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Neuron. 2015;85:275-288 pubmed publisher
    ..This multifaceted study generates a powerful resource and informs understanding of the transcriptional regulation underlying pyramidal neuron diversity in the neocortex. ..