Gene Symbol: Cyp4a14
Description: cytochrome P450, family 4, subfamily a, polypeptide 14
Alias: AI314743, cytochrome P450 4A14, CYPIVA14, cyp4a14, cytochrome P450, 4a14, cytochrome P450-LA-omega 3, lauric acid omega-hydroxylase 3, long-chain fatty acid omega-monooxygenase
Species: mouse
Products:     Cyp4a14

Top Publications

  1. Muller D, Schmidt C, Barbosa Sicard E, Wellner M, Gross V, Hercule H, et al. Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. Biochem J. 2007;403:109-18 pubmed
    ..AA hydroxylase activities were approx. 25-75-fold lower with Cyp4a10 and not detectable with Cyp4a14. Cyp4a12a and Cyp4a12b also efficiently converted EPA (eicosapentaenoic acid) into 19/20-OH- and 17,18-epoxy-EPA...
  2. Cheng X, Klaassen C. Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors. Toxicol Sci. 2008;106:29-36 pubmed publisher
    ..PFDA and PFOA also markedly increased protein expression of Cyp2B (50-fold) and 4A (10-fold). PFDA increased Cyp4A14 mRNA expression at relatively low doses (0...
  3. Quigley R, Chakravarty S, Zhao X, Imig J, Capdevila J. Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice. Nephron Physiol. 2009;113:p23-8 pubmed publisher
    Disrupting the enzyme Cyp4a14 in mice leads to hypertension, which is more severe in the male mice and appears to be due to androgen excess...
  4. Ding Y, Wu C, Garcia V, Dimitrova I, Weidenhammer A, Joseph G, et al. 20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension. Am J Physiol Renal Physiol. 2013;305:F753-63 pubmed publisher
    ..In Cyp4a14(-/-) mice, which display androgen-driven and 20-HETE-dependent hypertension, treatment with the 20-HETE ..
  5. Pandey V, Garcia V, Gilani A, Mishra P, Zhang F, Paudyal M, et al. The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis. J Pharmacol Exp Ther. 2017;363:412-418 pubmed publisher
    ..the effects of 20-HETE blockade on blood pressure, renal hemodynamics, and urinary sodium excretion in Cyp4a14(-/-) male mice, which display androgen-driven 20-HETE-dependent hypertension...
  6. Zhou Y, Yu J, Liu J, Cao R, Su W, Li S, et al. Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice. Biochim Biophys Acta Mol Basis Dis. 2018;1864:860-870 pubmed publisher
    ..the molecular mechanism by which AngII induces renal damage, we found that AngII infusion significantly induced CYP4A14 expression in renal proximal tubule cells (RPTCs) with marked increases in blood pressure and proteinuria...
  7. Cook W, Jain S, Jia Y, Cao W, Yeldandi A, Reddy J, et al. Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice. Exp Cell Res. 2001;268:70-6 pubmed
  8. Abbott B, Wood C, Watkins A, Tatum Gibbs K, Das K, Lau C. Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues. Reprod Toxicol. 2012;33:491-505 pubmed publisher
    ..The metabolic disruption produced by PFOA may contribute to poor postnatal survival and persistent weight deficits of CD-1 mouse neonates. ..
  9. Zhang X, Li S, Zhou Y, Su W, Ruan X, Wang B, et al. Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. Proc Natl Acad Sci U S A. 2017;114:3181-3185 pubmed publisher
    ..Cytochrome P450 omega-hydroxylase 4A14 (CYP4A14) is a homolog of human CYP4A hydroxylase that catalyzes omega-hydroxylation of medium-chain fatty acids and ..

More Information


  1. Fisher C, Jackson J, Lickteig A, Augustine L, Cherrington N. Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis. Arch Toxicol. 2008;82:959-64 pubmed publisher
    ..activation of these transcription factors and induction of downstream DME targets Cyp1A1, Cyp2B10, Cyp3A11, Cyp4A14 and NAD(P)H:quinone oxidoreductase 1 (Nqo1), respectively...
  2. Fidelis P, Wilson L, Thomas K, Villalobos M, Oyekan A. Renal function and vasomotor activity in mice lacking the Cyp4a14 gene. Exp Biol Med (Maywood). 2010;235:1365-74 pubmed publisher
    ..This study evaluated the effect of deletion of the Cyp4a14 gene on blood pressure, renal vascular responses and tubular function...
  3. Hayashi Y, Ito Y, Yanagiba Y, Kamijima M, Naito H, Nakajima T. Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice. Arch Toxicol. 2012;86:563-9 pubmed publisher
    ..two enzyme activities [lipase and uridine 5'-diphosphate-glucuronosyltransferase (UGT)] or expression of cytochrome P450 4A14 (CYP4A14) in dams (on gestational day 18 and postnatal day 2) and their offspring...
  4. Nyagode B, Williams I, Morgan E. Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes. Inflammation. 2014;37:893-907 pubmed publisher
    ..Here, we investigated the roles of Cyp4a10 and Cyp4a14 in the response to infection with C. rodentium...
  5. Heng Y, Kuo C, Jones P, Savory R, Schulz R, Tomlinson S, et al. A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans. Biochem J. 1997;325 ( Pt 3):741-9 pubmed
    ..The novel gene, designated Cyp4a14, has a GC rich sequence immediately 5' of the transcription start site, and is similar to the rat CYP4A2 and ..
  6. Enriquez A, Leclercq I, Farrell G, Robertson G. Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats. Biochem Biophys Res Commun. 1999;255:300-6 pubmed
    ..Further, they implicate leptin receptor signaling as a factor that may modulate expression of CYP gene products involved in fatty acid oxidation. ..
  7. Holla V, Adas F, Imig J, Zhao X, Price E, Olsen N, et al. Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A. 2001;98:5211-6 pubmed