Cyp3a11

Summary

Gene Symbol: Cyp3a11
Description: cytochrome P450, family 3, subfamily a, polypeptide 11
Alias: AI256190, Cyp3a, IIIAm1, Pcn, cytochrome P450 3A11, CYPIIIA11, cytochrome P-450IIIAM1, cytochrome P-450UT, cytochrome P450, steroid inducible 3a11, steroid inducible
Species: mouse
Products:     Cyp3a11

Top Publications

  1. Yanagimoto T, Itoh S, Sawada M, Kamataki T. Mouse cytochrome P450 (Cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1. Arch Biochem Biophys. 1997;340:215-8 pubmed
    S1 mapping analysis for the expression of Cyp3a11 and Cyp3a13 indicated that Cyp3a11 mRNA is predominantly expressed in mouse liver, compared with that of Cyp3a13...
  2. Liu X, Lu Y, Guan X, Dong B, Chavan H, Wang J, et al. Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism. Biochem Pharmacol. 2015;97:111-21 pubmed publisher
    ..Using recombinant CYP450 isoforms, CYP3A4 inhibitor, and S9 from Cyp3a-null mice, we confirmed CYP3A is the major enzyme contributing to the formation of aldehydes, GSH adducts, and ..
  3. Yanagimoto T, Itoh S, Muller Enoch D, Kamataki T. Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone. Biochim Biophys Acta. 1992;1130:329-32 pubmed
    ..RNA blot analysis showed that mRNA content of hepatic P-450IIIAM1 was remarkably increased by treatment of mice with dexamethasone. ..
  4. Lee C, Ding X, Riddick D. Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism. Drug Metab Dispos. 2013;41:1782-6 pubmed publisher
    ..that MC treatment triggers a pronounced downregulation, particularly at the protein level, of mouse hepatic Cyp3a11, a counterpart of the key human drug-metabolizing enzyme CYP3A4...
  5. Fisher C, Jackson J, Lickteig A, Augustine L, Cherrington N. Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis. Arch Toxicol. 2008;82:959-64 pubmed publisher
    ..the xenobiotic activation of these transcription factors and induction of downstream DME targets Cyp1A1, Cyp2B10, Cyp3A11, Cyp4A14 and NAD(P)H:quinone oxidoreductase 1 (Nqo1), respectively...
  6. Perloff M, von Moltke L, Cotreau M, Greenblatt D. Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr(-/-) mouse liver microsomes. Biochem Pharmacol. 1999;57:1227-32 pubmed
    P-Glycoprotein (P-gp) and cytochrome P450 3A (CYP3A) share common substrates and expression properties, but the relationship of mdrl deficiency to CYP3A-mediated metabolism and protein expression is not established...
  7. Yanagida A, Chikada H, Ito K, Umino A, Kato Itoh M, Yamazaki Y, et al. Liver maturation deficiency in p57(Kip2)-/- mice occurs in a hepatocytic p57(Kip2) expression-independent manner. Dev Biol. 2015;407:331-43 pubmed publisher
    ..Furthermore, p57(Kip2)-/- hepatoblasts could differentiate into mature hepatocytes in p57(Kip2)-/- and WT chimeric mice, suggesting that the intrinsic activity of p57(Kip2) does not simply regulate hepatoblast maturation. ..
  8. Mitsui T, Nemoto T, Miyake T, Nagao S, Ogawa K, Kato M, et al. A useful model capable of predicting the clearance of cytochrome 3A4 (CYP3A4) substrates in humans: validity of CYP3A4 transgenic mice lacking their own Cyp3a enzymes. Drug Metab Dispos. 2014;42:1540-7 pubmed publisher
    ..the validity of the in vivo model using transgenic mice carrying the human CYP3A4 gene and lacking their own Cyp3a genes (CYP3A4-Tg mice)...
  9. Gonzalez F. CYP3A4 and pregnane X receptor humanized mice. J Biochem Mol Toxicol. 2007;21:158-62 pubmed

More Information

Publications37

  1. Itoh S, Satoh M, Abe Y, Hashimoto H, Yanagimoto T, Kamataki T. A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA cloning and expression in fetal liver. Eur J Biochem. 1994;226:877-82 pubmed
    A complementary DNA clone coding for a novel form of cytochrome P450, Cyp3a-16, in mouse fetal livers was isolated and completely sequenced. This clone encoded a polypeptide of 504 deduced amino acids and showed 87.3% and 66...
  2. Bornheim L, Everhart E, Li J, Correia M. Induction and genetic regulation of mouse hepatic cytochrome P450 by cannabidiol. Biochem Pharmacol. 1994;48:161-71 pubmed
    ..The mechanism of CBD-mediated P450 induction remains to be elucidated but does not appear to be related to CBD-mediated P450 inactivation. ..
  3. Tolliver B, Belknap J, Woods W, Carney J. Genetic analysis of sensitization and tolerance to cocaine. J Pharmacol Exp Ther. 1994;270:1230-8 pubmed
    ..The current results demonstrate that genotype-dependent variation exists in behavioral responsiveness to cocaine in mice and suggest that the acute and long-term responses to cocaine may be under the control of separate sets of genes. ..
  4. Jiang Y, Fan X, Wang Y, Chen P, Zeng H, Tan H, et al. Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. Toxicol Sci. 2015;143:107-15 pubmed publisher
    ..SolB also dramatically altered APAP metabolic activation by inhibiting the activities of CYP2E1 and CYP3A11, which was evidenced by significant inhibition of the formation of the oxidized APAP metabolite NAPQI-GSH...
  5. Li Y, Cui Y, Hart S, Klaassen C, Zhong X. Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation. Mol Pharmacol. 2009;75:1171-9 pubmed publisher
    ..Mice also exhibit a developmental switch between Cyp3a16 (neonatal isoform) and Cyp3a11 (adult isoform) and may serve as a model to study the mechanisms controlling the developmental switch...
  6. Wang Y, Hu H, Pang H, Zhou X, Yu L, Wang L, et al. Lentiviral transgenic microRNA-based shRNA suppressed mouse cytochromosome P450 3A (CYP3A) expression in a dose-dependent and inheritable manner. PLoS ONE. 2012;7:e30560 pubmed publisher
    ..we designed a microRNA-based shRNA (miR-shRNA) simultaneously targeting four members of mouse CYP3A subfamily (CYP3A11, CYP3A16, CYP3A41 and CYP3A44), and transgenic mice expressing the designed miR-shRNA were generated by ..
  7. Hendrikx J, Lagas J, Rosing H, Schellens J, Beijnen J, Schinkel A. P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel. Int J Cancer. 2013;132:2439-47 pubmed publisher
    ..by CYP3A4 and its oral bioavailability can be enhanced in mice and humans by coadministration of the potent CYP3A inhibitor ritonavir. Unexpectedly, ritonavir also enhances the oral bioavailability of paclitaxel in humans...
  8. Gnerre C, Schuster G, Roth A, Handschin C, Johansson L, Looser R, et al. LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. J Lipid Res. 2005;46:1633-42 pubmed
    ..Our data expose differential regulatory patterns for Cyp2b10 and Cyp3a11 dependent on the expression of LXR isoforms and on challenge of cholesterol homeostasis by excess dietary ..
  9. Jugert F, Agarwal R, Kuhn A, Bickers D, Merk H, Mukhtar H. Multiple cytochrome P450 isozymes in murine skin: induction of P450 1A, 2B, 2E, and 3A by dexamethasone. J Invest Dermatol. 1994;102:970-5 pubmed
  10. Hashimoto M, Kobayashi K, Watanabe M, Kazuki Y, Takehara S, Inaba A, et al. Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver. J Lipid Res. 2013;54:2060-8 pubmed publisher
    ..P450 (CYP)3A deficiency on the mRNA expression of genes encoding regulators of hepatic cholesterol levels using Cyp3a-knockout (Cyp3a(-/-)) mice...
  11. Pilipenko N, Ropstad E, Halsne R, Zamaratskaia G. Effect of Naringenin, Quercetin, and Sesamin on Xenobiotica-Metabolizing CYP1A and CYP3A in Mice Offspring after Maternal Exposure to Persistent Organic Pollutants. Biomed Res Int. 2017;2017:8472312 pubmed publisher
    ..phytochemicals naringenin, quercetin, and sesamin on the activities of ethoxy- (EROD; CYP1A) and benzyloxy- (BROD; CYP3A) resorufin O-dealkylases after the exposure to the cocktail of persistent organic pollutants (POPs)...
  12. Bochkis I, Schug J, Ye D, Kurinna S, Stratton S, Barton M, et al. Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. PLoS Genet. 2012;8:e1002770 pubmed publisher
    ..Thus, Foxa1 and Foxa2, while redundant during development, have evolved divergent roles in the adult liver, ensuring the maintenance of both genes during evolution. ..
  13. Meyer R, Gehlhaus M, Schwab R, Bürck C, Knoth R, Hagemeyer C. Concordant up-regulation of cytochrome P450 Cyp3a11, testosterone oxidation and androgen receptor expression in mouse brain after xenobiotic treatment. J Neurochem. 2009;109:670-81 pubmed publisher
    ..ketoconazole and nifedipine as well as antibodies against CYP3A- and 2B-isoforms pointed to major role of Cyp3a11 and an only minor function of Cyp2b9/10 in mouse brain...
  14. Abbott B, Wood C, Watkins A, Tatum Gibbs K, Das K, Lau C. Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues. Reprod Toxicol. 2012;33:491-505 pubmed publisher
    ..The metabolic disruption produced by PFOA may contribute to poor postnatal survival and persistent weight deficits of CD-1 mouse neonates. ..
  15. Li F, Lu J, Wang L, Ma X. CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism. Drug Metab Dispos. 2011;39:394-401 pubmed publisher
    ..These potential reactive metabolites were primarily generated by CYP3A. Our results provide a clue for studies on ATV-related adverse effects from the aspect of metabolic activation...
  16. Tamasi V, Fülöp A, Hegyi K, Monostory K, Falus A. Upregulation of CYP2e1 and CYP3a activities in histamine-deficient histidine decarboxylase gene targeted mice. Cell Biol Int. 2003;27:1011-5 pubmed
    ..activity of CYP2B, chlorzoxazone 6-hydroxylase activity of CYP2E1 and ethylmorphine N-demethylase activity of CYP3A. The results indicate a significant elevation of CYP2E1 and CYP3A activities, however, no change in CYP1A and ..
  17. Xie W, Barwick J, Downes M, Blumberg B, Simon C, Nelson M, et al. Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature. 2000;406:435-9 pubmed
    The cytochrome CYP3A gene products, expressed in mammalian liver, are essential for the metabolism of lipophilic substrates, including endogenous steroid hormones and prescription drugs...
  18. Bornheim L, Correia M. Selective inactivation of mouse liver cytochrome P-450IIIA by cannabidiol. Mol Pharmacol. 1990;38:319-26 pubmed
    ..Thus, CBD appears to inactivate the P-450IIIA isozymes that are constitutively present in hepatic microsomes of untreated mice and/or inducible by phenobarbital pretreatment but not those that are steroid inducible.
  19. Tajima M, Ikarashi N, Igeta S, Toda T, Ishii M, Tanaka Y, et al. Different diets cause alterations in the enteric environment and trigger changes in the expression of hepatic cytochrome P450 3A, a drug-metabolizing enzyme. Biol Pharm Bull. 2013;36:624-34 pubmed
    ..The purpose of this study was to determine whether the expression of CYP3A is affected by a high-fat diet...
  20. Hagemeyer C, Rosenbrock H, Ditter M, Knoth R, Volk B. Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain. Neuroscience. 2003;117:521-9 pubmed
    ..a series of publications about brain P450 isoforms, we now present evidence for the expression of cytochrome P450 3A11 and 3A13 in mouse brain...
  21. Shi R, Wu J, Meng C, Ma B, Wang T, Li Y, et al. Cyp3a11-mediated testosterone-6?-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus. Biopharm Drug Dispos. 2016;37:433-443 pubmed publisher
    ..The data suggest that, in db/db mice, the activity of Cyp3a11, catalysing testosterone-6?-hydroxylation, decreased, while the activity of UGT1a9, catalysing propofol O-..
  22. Park Y, Lee E, Lee Y, Park D, Jang H, Moore D. Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice. Toxicol Appl Pharmacol. 2012;263:131-7 pubmed publisher
    ..15% propylthiouracil. Expression of Cyp3a11 was suppressed in hypothyroid C57BL/6 wild type (WT) mice and a further decrement was observed in hypothyroid CAR-..
  23. Chen S, Lu W, Yueh M, Rettenmeier E, Liu M, Paszek M, et al. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017;114:E1432-E1440 pubmed publisher
    ..These findings provide a mechanism of NCoR1 in intestinal homeostasis during development and provide a key link to those events that control developmental repression of UGT1A1 and hyperbilirubinemia. ..
  24. Inoue S, Yoshinari K, Sugawara M, Yamazoe Y. Activated sterol regulatory element-binding protein-2 suppresses hepatocyte nuclear factor-4-mediated Cyp3a11 expression in mouse liver. Mol Pharmacol. 2011;79:148-56 pubmed publisher
    ..In the present study, we have investigated a possible involvement of SREBP-2 in hepatic Cyp3a11 expression...
  25. van Waterschoot R, van Herwaarden A, Lagas J, Sparidans R, Wagenaar E, van der Kruijssen C, et al. Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes. Mol Pharmacol. 2008;73:1029-36 pubmed
    The cytochrome P450 3A (CYP3A) enzymes represent one of the most important drug-metabolizing systems in humans. Recently, our group has generated cytochrome P450 3A knockout mice to study this drug-handling system in vivo...
  26. Zaphiropoulos P. A map of the mouse Cyp3a locus. DNA Seq. 2003;14:155-62 pubmed
    ..Five out of the six known Cyp3a genes, Cyp3a11, Cyp3a13, Cyp3a16, Cyp3a25, Cyp3a41 and Cyp3a44 were found to be linked to each other, however, Cyp3a13, possibly ..
  27. Simmons D, Lalley P, Kasper C. Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes. J Biol Chem. 1985;260:515-21 pubmed
    ..Corroboratory data are presented to show that the Eph-1 locus on chromosome 1 is the site of at least one microsomal epoxide hydratase gene. ..
  28. Hashimoto M, Kobayashi K, Yamazaki M, Kazuki Y, Takehara S, Oshimura M, et al. Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate. J Steroid Biochem Mol Biol. 2016;163:121-8 pubmed publisher
    ..Because testosterone is inactivated to 6?-hydroxytestosterone by cytochrome P450 3A (CYP3A), we examined the effects of Cyp3a deficiency on circulating testosterone levels and its effects on activation of ..