Cyp2e1

Summary

Gene Symbol: Cyp2e1
Description: cytochrome P450, family 2, subfamily e, polypeptide 1
Alias: Cyp2e, cytochrome P450 2E1, 4-nitrophenol 2-hydroxylase, CYPIIE1, cytochrome P450, 2e1, ethanol inducible, cytochrome P450-ALC, cytochrome P450-J
Species: mouse
Products:     Cyp2e1

Top Publications

  1. Kathirvel E, Chen P, Morgan K, French S, Morgan T. Oxidative stress and regulation of anti-oxidant enzymes in cytochrome P4502E1 transgenic mouse model of non-alcoholic fatty liver. J Gastroenterol Hepatol. 2010;25:1136-43 pubmed publisher
    Reactive oxygen species produced by cytochrome P4502E1 (CYP2E1) are believed to play a role in pathophysiology of non-alcoholic fatty liver disease (NAFLD)...
  2. Matsunaga N, Ikeda M, Takiguchi T, Koyanagi S, Ohdo S. The molecular mechanism regulating 24-hour rhythm of CYP2E1 expression in the mouse liver. Hepatology. 2008;48:240-51 pubmed publisher
    b>Cytochrome P450 2E1 (CYP2E1) is clinically and toxicologically important and exhibits 24-hour periodicity in its activity...
  3. Abdelmegeed M, Choi Y, Ha S, Song B. Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress. Free Radic Biol Med. 2016;91:188-202 pubmed publisher
    The role of ethanol-inducible cytochrome P450-2E1 (CYP2E1) in promoting aging-dependent hepatic disease is unknown and thus was investigated in this study...
  4. Bailey S, Mantena S, Millender Swain T, Cakir Y, Jhala N, Chhieng D, et al. Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE(-/-) mouse: implications for a "multihit" hypothesis of fatty liver disease. Free Radic Biol Med. 2009;46:928-38 pubmed
    ..Exposure to ethanol + ETS induced the largest increase in CYP2E1 and iNOS protein, as well as increased 3-nitrotyrosine, mtDNA damage, and decreased cytochrome c oxidase protein, ..
  5. Wu D, Cederbaum A. Activation of ASK-1 and downstream MAP kinases in cytochrome P4502E1 potentiated tumor necrosis factor alpha liver injury. Free Radic Biol Med. 2010;49:348-60 pubmed publisher
    Cytochrome P4502E1 (CYP2E1) potentiates TNFalpha toxicity by a mechanism involving increased oxidative stress and activation of JNK and p38 MAPKs...
  6. Shekels L, Lyftogt C, Kieliszewski M, Filie J, Kozak C, Ho S. Mouse gastric mucin: cloning and chromosomal localization. Biochem J. 1995;311 ( Pt 3):775-85 pubmed
    ..Due to sequence similarity and predominant expression in the stomach, the MGM gene may be considered a MUC5AC homologue and named Muc5ac. ..
  7. Sakurai J, Funae Y, Nemoto N. Maintenance and activation of Cyp2e-1 gene expression in mouse hepatocytes in primary culture. Biochim Biophys Acta. 1996;1313:35-40 pubmed
    The expression of Cyp2e-1 mRNA and protein was investigated in the C57BL/6NCrj mouse hepatocytes in primary culture, as well as liver and kidney...
  8. Gonzalez F, Kimura S. Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis. Cancer Lett. 1999;143:199-204 pubmed
    ..Mouse lines having disruption of genes encoding P450s CYP1A2, CYP2E1, and CYP1B1 were developed by use of gene disruption in empbryonic stem cells...
  9. Dey A, Cederbaum A. Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice. Hepatology. 2007;45:1355-65 pubmed
    b>Cytochrome P450 2E1 (CYP2E1) activates several hepatotoxins and contributes to alcoholic liver damage. Obesity is a growing health problem in the United States...

More Information

Publications97

  1. Mikstacka R, Gnojkowski J, Baer Dubowska W. Effect of natural phenols on the catalytic activity of cytochrome P450 2E1. Acta Biochim Pol. 2002;49:917-25 pubmed
    ..These results indicate that trans-resveratrol and tannic acid may modulate cytochrome P450 2E1 and influence the metabolic activation of xenobiotics mediated by this P450 isoform.
  2. Yang L, Wu D, Wang X, Cederbaum A. Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver. Free Radic Biol Med. 2012;53:1170-80 pubmed publisher
    ..Recent studies showed that chronic ethanol-induced fatty liver was, at least in part, CYP2E1 dependent. The mechanism of acute alcohol-induced steatosis and whether CYP2E1 plays any role are still unclear...
  3. Kim Y, Eom S, Ogawa M, Oyama T, Isse T, Kang J, et al. Ethanol-induced oxidative DNA damage and CYP2E1 expression in liver tissue of Aldh2 knockout mice. J Occup Health. 2007;49:363-9 pubmed
    ..The increase in the level of 8-OHdG was associated with hepatic expression of cytochrome P450 2E1 (CYP2E1)...
  4. Zaher H, Buters J, Ward J, Bruno M, Lucas A, Stern S, et al. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. Toxicol Appl Pharmacol. 1998;152:193-9 pubmed
    ..At least two forms of cytochrome P450, CYP2E1 and CYP1A2, have been implicated in this reaction in mice...
  5. Shen S, Li L, Ding X, Zheng J. Metabolism of styrene to styrene oxide and vinylphenols in cytochrome P450 2F2- and P450 2E1-knockout mouse liver and lung microsomes. Chem Res Toxicol. 2014;27:27-33 pubmed publisher
    ..e., styrene oxide and 4-vinylphenol) and pulmonary toxicity of styrene, using Cyp2e1- and Cyp2f2-null mouse models...
  6. Leclercq I, Field J, Enriquez A, Farrell G, Robertson G. Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice. Biochem Biophys Res Commun. 2000;268:337-44 pubmed
    In this study we have analyzed the inducible as well as constitutive hepatic expression of Cyp2e1 in a genetic model of obesity and non-insulin dependent (type II) diabetes, the leptin-deficient ob/ob mouse...
  7. Zhang W, Lu D, Dong W, Zhang L, Zhang X, Quan X, et al. Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice. FEBS J. 2011;278:1484-92 pubmed publisher
    b>Cytochrome P450 2E1 (CYP2E1) is an effective generator of reactive oxygen species. Marked expression of CYP2E1 occurs in the heart and it is known to be regulated in the course of progression of myocardial ischemia and cardiomyopathy...
  8. Cederbaum A. Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction. Redox Biol. 2014;2:1048-54 pubmed publisher
    ..There are many forms of P450. CYP2E1 metabolizes many toxicologically important compounds including ethanol and is active in generating reactive oxygen ..
  9. Tamura T, Kong H, Tunyaplin C, Tsujimura H, Calame K, Ozato K. ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells. Blood. 2003;102:4547-54 pubmed
    ..These results indicate that ICSBP inhibits growth of Bcr/Abl-transformed myeloid progenitor cells by activating several genes that interfere with the c-Myc pathway. ..
  10. Bondoc F, Bao Z, Hu W, Gonzalez F, Wang Y, Yang C, et al. Acetone catabolism by cytochrome P450 2E1: studies with CYP2E1-null mice. Biochem Pharmacol. 1999;58:461-3 pubmed
    Previous experiments in vitro have suggested that cytochrome P450 2E1 (CYP2E1) is involved in acetone catabolism by converting acetone to acetol and then to methylglyoxal, both intermediates in the gluconeogenic pathway...
  11. Tamasi V, Fülöp A, Hegyi K, Monostory K, Falus A. Upregulation of CYP2e1 and CYP3a activities in histamine-deficient histidine decarboxylase gene targeted mice. Cell Biol Int. 2003;27:1011-5 pubmed
    ..activity of CYP1A, pentoxyresorufin O-dealkylase activity of CYP2B, chlorzoxazone 6-hydroxylase activity of CYP2E1 and ethylmorphine N-demethylase activity of CYP3A...
  12. Shi X, Yao D, Chen C. Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis. J Biol Chem. 2012;287:6336-49 pubmed publisher
    The influence of ethanol on the small molecule metabolome and the role of CYP2E1 in ethanol-induced hepatotoxicity were investigated using liquid chromatography-mass spectrometry (LC-MS)-based metabolomics platform and Cyp2e1-null mouse ..
  13. Mikstacka R, Rimando A, Szalaty K, Stasik K, Baer Dubowska W. Effect of natural analogues of trans-resveratrol on cytochromes P4501A2 and 2E1 catalytic activities. Xenobiotica. 2006;36:269-85 pubmed
    ..effect of a series of naturally occurring trans-resveratrol analogues on cytochromes P450, namely CYP1A2 and CYP2E1, in vitro in order to analyse any structure-activity relationships...
  14. Yanagiba Y, Suzuki T, Suda M, Hojo R, Gonzalez F, Nakajima T, et al. Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage. Toxicol Ind Health. 2016;32:1589-97 pubmed publisher
    ..of cancer, we studied the metabolic pathways and the hepatotoxic effect of 1,2-DCP in mice with or without cytochrome P450 2E1 (CYP2E1) activity...
  15. Kang J, Wanibuchi H, Morimura K, Wongpoomchai R, Chusiri Y, Gonzalez F, et al. Role of CYP2E1 in thioacetamide-induced mouse hepatotoxicity. Toxicol Appl Pharmacol. 2008;228:295-300 pubmed publisher
    ..Some experiments suggest that CYP2E1 may be involved in the metabolic activation of TAA...
  16. Keating A, Rajapaksa K, Sipes I, Hoyer P. Effect of CYP2E1 gene deletion in mice on expression of microsomal epoxide hydrolase in response to VCD exposure. Toxicol Sci. 2008;105:351-9 pubmed publisher
    ..The phase I enzyme, cytochrome P450 isoform 2E1 (CYP2E1) is involved in ovarian metabolism of VCM to VCD...
  17. Cederbaum A. Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity. Dig Dis. 2010;28:802-11 pubmed publisher
    ..While some studies support a role for cytochrome P450 2E1 (CYP2E1), others do not...
  18. Abdelmegeed M, Banerjee A, Yoo S, Jang S, Gonzalez F, Song B. Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis. J Hepatol. 2012;57:860-6 pubmed publisher
    Ethanol-inducible cytochrome P450 2E1 (CYP2E1) activity contributes to oxidative stress. However, CYP2E1 may have an important role in the pathogenesis of high-fat mediated non-alcoholic steatohepatitis (NASH)...
  19. Perez M, Cederbaum A. Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells. Hepatology. 2003;37:1395-404 pubmed
    Chronic ethanol consumption causes increased oxidative damage in the liver. Induction of CYP2E1 is one pathway involved in how ethanol produces oxidative stress...
  20. Voliva C, Paigen K. Isolation of the mouse cytochrome P450J (CYP2E1) cDNA and its reciprocal testosterone regulation in kidney and liver. J Mol Endocrinol. 1991;7:155-66 pubmed
    ..mRNA showed strong homology to the rat and human cytochrome P450J and the rabbit cytochrome P450 3a genes (CYP2E1)...
  21. Pan J, Hong J, Yang C. Post-transcriptional regulation of mouse renal cytochrome P450 2E1 by testosterone. Arch Biochem Biophys. 1992;299:110-5 pubmed
    ..in renal metabolism of N-nitrosodimethylamine in C3H/HeJ mouse was due to the sexual dichotomy of cytochrome P450 2E1 (P450 2E1) and that renal P450 2E1 in female mouse was inducible by testosterone...
  22. Matsumoto A, Kawamoto T, Horita M, Takahashi T, Isse T, Oyama T, et al. Single-dose ethanol administration downregulates expression of cytochrome p450 2E1 mRNA in aldehyde dehydrogenase 2 knockout mice. Alcohol. 2007;41:587-9 pubmed
    ..These findings suggest that single-dose ethanol administration downregulates the expression of cytochrome p450 2E1 mRNA in the presence of inactive ALDH2.
  23. Wang X, Cederbaum A. Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways. Free Radic Biol Med. 2007;42:971-84 pubmed
    ..evaluated whether acute ethanol pretreatment potentiates Fas-mediated liver injury and if oxidative stress and CYP2E1 play a role in any enhanced hepatotoxicity...
  24. Seth R, Das S, Dattaroy D, Chandrashekaran V, Alhasson F, Michelotti G, et al. TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity. Free Radic Biol Med. 2017;102:260-273 pubmed publisher
    ..potential calcium-permeable ion channel that responds to the cytotoxic liver environment and negatively regulates CYP2E1, a cytochrome p450 enzyme...
  25. Cheung C, Yu A, Ward J, Krausz K, Akiyama T, Feigenbaum L, et al. The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity. Drug Metab Dispos. 2005;33:449-57 pubmed
    The cytochrome P450 (P450) CYP2E1 enzyme metabolizes and activates a wide array of toxicological substrates, including alcohols, the widely used analgesic acetaminophen, acetone, benzene, halothane, and carcinogens such as azoxymethane ..
  26. Abdelmegeed M, Moon K, Chen C, Gonzalez F, Song B. Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity. Biochem Pharmacol. 2010;79:57-66 pubmed publisher
    ..a hallmark of peroxynitrite production, were colocalized with necrotic hepatic centrilobular regions where cytochrome P450 2E1 (CYP2E1) is highly expressed, suggesting that 3-NT formation may be essential in APAP-mediated toxicity...
  27. Zhou R, Lin J, Wu D. Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis. Biochim Biophys Acta. 2014;1840:209-18 pubmed publisher
    ..b>CYP2E1-generated ROS contributes to the ethanol-induced oxidant stress and inhibition of CYP2E1 activity decreases ..
  28. Wang X, Lu Y, Xie B, Cederbaum A. Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase. Free Radic Biol Med. 2009;47:518-28 pubmed publisher
    ..or acute ethanol potentiated Fas agonistic Jo2 antibody-induced liver injury by a mechanism involving induction of CYP2E1 and elevated oxidative stress...
  29. Wang S, Xue J, Zhou J. [Preliminary effects of alcohol and Curcuma longa upon CYP2E1 and hematotoxicity in benzene-induced mice]. Zhonghua Yi Xue Za Zhi. 2009;89:2429-31 pubmed
    To observe the effects of CYP2E1 enzymatic alteration upon hematotoxicity by benzene poisoning in mice and the interference of alcohol and Curcuma longa.
  30. Evans M, Caldwell J. Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling for in vivo inhalation gas uptake data exposure in female B6C3F1 mice. Toxicol Appl Pharmacol. 2010;244:280-90 pubmed publisher
    ..One hypothesis describes two metabolic pathways: one involving cytochrome P450 2E1 (CYP2E1) and a second glutathione (GSH)...
  31. Vaglini F, Pardini C, Viaggi C, Bartoli C, Dinucci D, Corsini G. Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease. J Neurochem. 2004;91:285-98 pubmed
    ..This study indicates that the occurrence of CYP 2E1 in C57/bl mouse brain is relevant to MPTP toxicity, and suggests that this isozyme may have a detoxificant role related to the efflux transporter of the toxin. ..
  32. Sohn O, Fiala E, Requeijo S, Weisburger J, Gonzalez F. Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol. Cancer Res. 2001;61:8435-40 pubmed
    ..precursor, azoxymethane (AOM), both strong colon carcinogens in rodents, can be metabolically activated by CYP2E1 in vitro...
  33. McKinnon R, Nebert D. Cytochrome P450 knockout mice: new toxicological models. Clin Exp Pharmacol Physiol. 1998;25:783-7 pubmed
    ..4. Also discussed are null mouse lines with targeted mutations in genes encoding receptors having primary roles in Cyp gene regulation. ..
  34. Cheng J, Krausz K, Li F, Ma X, Gonzalez F. CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid. Toxicol Appl Pharmacol. 2013;266:245-53 pubmed publisher
    ..Isoniazid is known to have a biphasic effect on the inhibition-induction of CYP2E1 and is also considered to be involved in isoniazid-induced hepatotoxicity...
  35. Jiang Y, Fan X, Wang Y, Chen P, Zeng H, Tan H, et al. Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. Toxicol Sci. 2015;143:107-15 pubmed publisher
    ..SolB also dramatically altered APAP metabolic activation by inhibiting the activities of CYP2E1 and CYP3A11, which was evidenced by significant inhibition of the formation of the oxidized APAP metabolite NAPQI-..
  36. Das J, Ghosh J, Manna P, Sil P. Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res. 2010;44:340-55 pubmed publisher
    ..Also, incubation of hepatocytes with APAP reduced cell viability, enhanced ROS generation and increased CYP2E1 activity. APAP overdose caused injury in the hepatic tissue and hepatocytes via the upregulation of CYP2E1 and JNK...
  37. El Hadri L, Chanas B, Ghanayem B. Comparative metabolism of methacrylonitrile and acrylonitrile to cyanide using cytochrome P4502E1 and microsomal epoxide hydrolase-null mice. Toxicol Appl Pharmacol. 2005;205:116-25 pubmed
    ..We have recently shown that CYP2E1 is essential for AN epoxidation and subsequent cyanide liberation...
  38. Choudhary D, Jansson I, Stoilov I, Sarfarazi M, Schenkman J. Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues. Arch Biochem Biophys. 2005;436:50-61 pubmed
    ..two of the orthologs to be expressed only in the E7 mouse; Cyp2s1 was expressed in all stages, including E7, while Cyp2e1 appeared only at E17...
  39. Planas Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, et al. The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol. 2016;18:467-79 pubmed publisher
    ..Taken together, our results indicate that the RSPO-LGR4/5-ZNRF3/RNF43 module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration. ..
  40. Ramesh V, Cheng S, Kozak C, Herron B, Shih V, Taylor B, et al. Mapping of ornithine aminotransferase gene sequences to mouse chromosomes 7, X, and 3. Mamm Genome. 1992;3:17-22 pubmed
    ..Progeny of an intersubspecific backcross were used to map the Chr 7 locus between Tyr and Int-2, near Cyp2e-1.
  41. Wong F, Chan W, Lee S. Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression. Toxicol Appl Pharmacol. 1998;153:109-18 pubmed
    b>CYP2E1 knockout mice (cyp2e1-/-) were used to investigate the involvement of CYP2E1 in the development of carbon tetrachloride (CCl4)-induced hepatotoxicity. Male cyp2e1-/- and wild-type (cyp2e1+/+) mice were given a single i.p...
  42. Ryskov A, Ivanov P, Kramerov D, Georgiev G. Mouse ubiquitous B2 repeat in polysomal and cytoplasmic poly(A)+RNAs: uniderectional orientation and 3'-end localization. Nucleic Acids Res. 1983;11:6541-58 pubmed
    ..The conclusion has been drawn that only one its strand can survive the processing. This strand contains promoter-like sequences and AATAAA blocks. The latter can be used in some cases by the cell as mRNA polyadenylation signals. ..
  43. Buchert M, Athineos D, Abud H, Burke Z, Faux M, Samuel M, et al. Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet. 2010;6:e1000816 pubmed publisher
    ..Together, the present genotype-phenotype analysis suggests tissue-specific response levels for the Wnt/beta-catenin pathway that regulate both physiological and pathophysiological conditions. ..
  44. Kang Y, Zhou Z. Zinc prevention and treatment of alcoholic liver disease. Mol Aspects Med. 2005;26:391-404 pubmed
    ..Zn supplementation attenuates ethanol-induced hepatic Zn depletion and suppresses ethanol-elevated cytochrome P450 2E1 (CYP2E1) activity, but increases the activity of alcohol dehydrogenase in the liver; an action that is ..
  45. Sumner S, Fennell T, Moore T, Chanas B, Gonzalez F, Ghanayem B. Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice. Chem Res Toxicol. 1999;12:1110-6 pubmed
    ..mice, WT mice pretreated with aminobenzotriazole (ABT, 50 mg/kg ip, 2 h pre-exposure), and mice devoid of cytochrome P450 2E1 (P450 2E1-null) were treated with 50 mg/kg [(13)C]AM po. WT mice and P450 2E1-null mice were treated with 2...
  46. Seth R, Kumar A, Das S, Kadiiska M, Michelotti G, Diehl A, et al. Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. Toxicol Sci. 2013;134:291-303 pubmed publisher
    ..byproduct of drinking water, causes nonalcoholic steatohepatitis (NASH), mediated by cytochrome P450 isoform CYP2E1 and adipokine leptin...
  47. Wang S, Bott D, Tung A, Sugamori K, Grant D. Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice. Drug Metab Dispos. 2015;43:916-21 pubmed publisher
    ..study, we detected similar reductions in Vmax for ABP N-hydroxylation by liver microsomes from Cyp1a2(-/-) and Cyp2e1(-/-) mice when compared with wild-type mice...
  48. Choi M, Kim Y, Kwon E, Ryoo J, Kim S, Jung U. High-fat diet decreases energy expenditure and expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in the adipose tissue, along with increased expression of extracellular matrix remodelling- and in. Br J Nutr. 2015;113:867-77 pubmed publisher
    ..The top ten up- or down-regulated genes include Acsm3, mt-Nd6, Fam13a, Cyp2e1, Rgs1 and Gpnmb, whose roles in the deterioration of obesity-associated adipose tissue are poorly understood...
  49. Szele E, Gombos K, Kovacs A, Ember I. Effects of purified glycerol from biodiesel on Cyp1a1 and Cyp2e1 expressions in CBA/CA mice. In Vivo. 2011;25:237-40 pubmed
    ..P450, family 1, subfamily a polypeptide 1 (Cyp1a1) and cytochrome P450, family 2, subfamily e, polypeptide 1 (Cyp2e1) were analysed in liver...
  50. Wolf K, Wood S, Allard J, Hunt J, Gorman N, Walton Strong B, et al. Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice. Drug Metab Dispos. 2007;35:1223-31 pubmed
    b>CYP2E1 is widely accepted as the sole form of cytochrome P450 responsible for alcohol-mediated increases in acetaminophen (APAP) hepatotoxicity...
  51. Xu W, Kozak C, Desnick R. Uroporphyrinogen-III synthase: molecular cloning, nucleotide sequence, expression of a mouse full-length cDNA, and its localization on mouse chromosome 7. Genomics. 1995;26:556-62 pubmed
  52. Lu Y, Wu D, Wang X, Ward S, Cederbaum A. Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. Free Radic Biol Med. 2010;49:1406-16 pubmed publisher
    ..Although some studies support a role for cytochrome P450 2E1 (CYP2E1), others do not...
  53. Ghanayem B. Inhibition of urethane-induced carcinogenicity in cyp2e1-/- in comparison to cyp2e1+/+ mice. Toxicol Sci. 2007;95:331-9 pubmed
    ..However, recent studies in this laboratory showed that CYP2E1, and not esterase, is the primary enzyme responsible for urethane oxidation...
  54. Gong P, Cederbaum A. Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity. J Biol Chem. 2006;281:14573-9 pubmed
    ..Arachidonic acid (AA) causes CYP2E1-dependent toxicity in HepG2 cells...
  55. Valentine J, Lee S, Seaton M, Asgharian B, Farris G, Corton J, et al. Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. Toxicol Appl Pharmacol. 1996;141:205-13 pubmed
    Transgenic CYP2E1 knockout mice (cyp2e1-/-) were used to investigate the involvement of CYP2E1 in the in vivo metabolism of benzene and in the development of benzene-induced toxicity...
  56. Dostalek M, Hardy K, Milne G, Morrow J, Chen C, Gonzalez F, et al. Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. J Biol Chem. 2008;283:17147-57 pubmed publisher
    ..These multiple effects on the protective systems are proposed to be more important than P450 induction in oxidative stress and emphasize the importance of studying in vivo models. ..
  57. Garner C, Sloan C, Sumner S, Burgess J, Davis J, Etheridge A, et al. CYP2E1-catalyzed oxidation contributes to the sperm toxicity of 1-bromopropane in mice. Biol Reprod. 2007;76:496-505 pubmed
    ..The contribution of cytochrome P4502E1 (CYP2E1) to both 1-BrP metabolism and the induction of male reproductive toxicity was investigated using wild-type (WT) ..
  58. Lu Y, Cederbaum A. Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. Hepatology. 2006;44:263-74 pubmed
    The mechanisms by which alcohol causes liver injury are still not certain. Either LPS or CYP2E1 are considered independent risk factors involved in alcoholic liver disease, but mutual relationships or interactions between them are unknown...
  59. Wang C, Li H, Meng Q, Du Y, Xiao F, Zhang Q, et al. ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression. J Cell Mol Med. 2014;18:80-90 pubmed publisher
    ..oxidative stress, TG accumulation and expression of cytochrome P450, family 2, subfamily, polypeptide 1 (CYP2E1) are also blocked by knocking down ATF4 expression in the mouse liver...
  60. Leclercq I, Farrell G, Field J, Bell D, Gonzalez F, Robertson G. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest. 2000;105:1067-75 pubmed
    Nonalcoholic steatohepatitis (NASH) and alcoholic liver disease have similar pathological features. Because CYP2E1 plays a key role in alcoholic liver disease with its ability to stimulate lipid peroxidation, we tested the proposal that ..
  61. Cederbaum A. CYP2E1 potentiates toxicity in obesity and after chronic ethanol treatment. Drug Metabol Drug Interact. 2012;27:125-44 pubmed publisher
    b>CYP2E1 activates several hepatotoxins and contributes to alcoholic liver damage. In this report, we review our studies on whether induction of CYP2E1 can potentiate liver injury in obesity...
  62. Qian N, Frank D, O KEEFE D, Dao D, Zhao L, Yuan L, et al. The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis. Hum Mol Genet. 1997;6:2021-9 pubmed
    ..These data expand the repertoire of known imprinted genes and will be helpful in testing the mechanism of genomic imprinting and the role of imprinted genes in growth regulation. ..
  63. Powley M, Carlson G. Hepatic and pulmonary microsomal benzene metabolism in CYP2E1 knockout mice. Toxicology. 2001;169:187-94 pubmed
    ..To exert its toxic effects, benzene must be metabolized via cytochrome P450. CYP2E1 has been identified as the most important cytochrome, P450 isozyme in hepatic benzene metabolism in mice, rats, ..
  64. Robin M, Sauvage I, Grandperret T, Descatoire V, Pessayre D, Fromenty B. Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes. FEBS Lett. 2005;579:6895-902 pubmed
    Enhanced hepatic levels of cytochrome P450 2E1 (CYP2E1) may play a key role in the pathogenesis of some liver diseases because CYP2E1 represents a significant source of reactive oxygen species...
  65. Boadas Vaello P, Jover E, Saldaña Ruíz S, Soler Martín C, Chabbert C, Bayona J, et al. Allylnitrile metabolism by CYP2E1 and other CYPs leads to distinct lethal and vestibulotoxic effects in the mouse. Toxicol Sci. 2009;107:461-72 pubmed publisher
    This study addressed the hypothesis that the vestibular or lethal toxicities of allylnitrile depend on CYP2E1-mediated bioactivation. Wild-type (129S1) and CYP2E1-null male mice were exposed to allylnitrile at doses of 0, 0.5, 0.75, or 1...
  66. Roe A, Howard G, Blouin R, Snawder J. Characterization of cytochrome P450 and glutathione S-transferase activity and expression in male and female ob/ob mice. Int J Obes Relat Metab Disord. 1999;23:48-53 pubmed
    ..b>CYP2E1-dependent, 4-nitrophenol hydroxylase (PNP-OH) and CYP3A-dependent erythromycin N-demethylase (ERY-DM) were also ..
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    Ethanol induces hypoxia and elevates HIF-1? in the liver. CYP2E1 plays a role in the mechanisms by which ethanol generates oxidative stress, fatty liver, and liver injury...
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    ..Gel shift assays revealed higher activation of nuclear factor-kappaB in WT-DB mice after APAP treatment. These findings suggest PPAR-alpha activation as a hepatoprotective adaptive response mediating protection against APAP in diabetes. ..
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    b>Cytochrome P450 2E1 (CYP2E1) is a cytochrome P450 enzyme that catalyzes the metabolism of toxic substrates. CYP2E1 is upregulated in heart disease, including the dilated cardiomyopathy (DCM) mouse model...
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    ..inhibition experiments using liver microsomes from wild-type and genetically modified mice identified CYP2E1 as a major ABP N-hydroxylating enzyme...
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    Environmental toxins induce a novel CYP2E1/leptin signaling axis in liver. This in turn activates a poorly characterized innate immune response that contributes to nonalcoholic steatohepatitis (NASH) progression...
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    Microsomal CYP2E1 metabolizes about 160 hydrophobic exogens, many of which are environmental pollutants...
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    Insulin resistance and increased cytochrome P450 2E1 (CYP2E1) expression are both associated with and mechanistically implicated in the development of nonalcoholic fatty liver disease...
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    ..The objective of the present work was to determine whether CYP2E1 is involved in the oxidative metabolism of MAN as was suggested for AN...