Cyp2b9

Summary

Gene Symbol: Cyp2b9
Description: cytochrome P450, family 2, subfamily b, polypeptide 9
Alias: Cyp2b, cytochrome P450 2B9, 16alphaoh-a, CYPIIB9, cytochrome P450 clone PF26, cytochrome P450, 2b9, phenobarbitol inducible, type a, cytochrome P450-16-alpha, phenobarbitol inducible, type a, testosterone 16-alpha hydroxylase
Species: mouse

Top Publications

  1. ncbi Genetic regulation of estrogen-dependent repression of female-specific testosterone 16 alpha-hydroxylase (I-P-450(16 alpha) in male mouse liver: murine Ripr locus
    M Noshiro
    Laboratory of Cellular and Molecular Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Biochemistry 27:6444-8. 1988
  2. ncbi Suppression of female-specific murine Cyp2b9 gene expression by growth or glucocorticoid hormones
    Tsutomu Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Biochem Biophys Res Commun 323:776-81. 2004
  3. doi Role of multiple microRNAs in the sexually dimorphic expression of Cyp2b9 in mouse liver
    Xiaofeng Xie
    Center for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, X X, L M, J Y, C F, C L, M G, M L, L G, X Q, J R, Laboratory of Neural Signal Transduction, Institute of Neuroscience, Chinese Academy of Sciences Y W, Shanghai, China
    Drug Metab Dispos 41:1732-7. 2013
  4. pmc Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
  5. doi Bimodal action of miroestrol and deoxymiroestrol, phytoestrogens from Pueraria candollei var. mirifica, on hepatic CYP2B9 and CYP1A2 expressions and antilipid peroxidation in mice
    Latiporn Udomsuk
    Academic Office for Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
    Nutr Res 32:45-51. 2012
  6. pmc Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function
    Basma Damiri
    Environmental Toxicology Program, Clemson University, Clemson, South Carolina 29634, USA
    Toxicol Sci 125:368-81. 2012
  7. ncbi Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver
    Magnus Lundgren
    Toxicology Division, National Food Administration, Uppsala, Sweden
    Toxicology 242:100-8. 2007
  8. ncbi Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6
    P W Chiang
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor 48109, USA
    Genomics 47:426-8. 1998
  9. doi Forkhead box A2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene
    Tadahiro Hashita
    Department of Toxicology, Graduate School of Medical and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Drug Metab Dispos 36:1080-7. 2008
  10. pmc Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster
    Haoyi Wang
    Department of Zoology, Miami University, 700 East High Street, Oxford, OH 45056, USA
    Environ Health Perspect 111:1835-42. 2003

Scientific Experts

  • Kanokwan Jarukamjorn
  • P W Chiang
  • Magnus Lundgren
  • T Sakuma
  • Xiaofeng Xie
  • Latiporn Udomsuk
  • Basma Damiri
  • Tadahiro Hashita
  • Joseph A Baur
  • Haoyi Wang
  • Chenggang Li
  • Likun Gong
  • Man Gao
  • Chenchen Feng
  • Xinming Qi
  • Lingling Miao
  • Mingxia Liu
  • Jin Ren
  • Yizheng Wang
  • Jun Yao
  • Xianzhong Yu
  • Eric Holle
  • Thaweesak Juengwatanatrakul
  • William S Baldwin
  • Waraporn Putalun
  • N Nemoto
  • Hidekazu Takesako
  • Mami Akada
  • Nobuo Nemoto
  • Sumiyo Ito
  • Asuka Nakajima
  • Hirofumi Yamahara
  • Sharan Ramaswamy
  • Kevin J Pearson
  • Kaitlyn Lewis
  • Paul J Pistell
  • Vinayakumar V Prabhu
  • Olivier Boss
  • Richard G Spencer
  • Carles Lerin
  • Suresh Poosala
  • Placido Navas
  • Dana Gwinn
  • Reuben J Shaw
  • David Le Couteur
  • Kevin G Becker
  • Edward G Lakatta
  • Rafael De Cabo
  • Kenneth W Fishbein
  • Mingyi Wang
  • Pere Puigserver
  • Avash Kalra
  • Donald K Ingram
  • David A Sinclair
  • Nathan L Price
  • Joanne S Allard
  • Guillermo Lopez-Lluch
  • Hamish A Jamieson
  • Diane S Keeney
  • Kyle M Donley
  • Susan M G Hoffman
  • M Damon
  • M R Bösl
  • J Sakurai
  • A Guillouzo
  • L Corcos
  • A Fautrel
  • S Nishimura
  • M Noshiro
  • M Taketo
  • M F Seldin
  • Y Funae
  • F Rudert
  • P Honkakoski
  • M Lakso
  • M Negishi
  • J A Thompson
  • A Kojo
  • W Zimmermann
  • S Rebstock
  • J S Miles
  • A M Saunders
  • M A Lang
  • C R Wolf
  • R R Meehan
  • K Kawajiri
  • J E Moss
  • R Masaki

Detail Information

Publications20

  1. ncbi Genetic regulation of estrogen-dependent repression of female-specific testosterone 16 alpha-hydroxylase (I-P-450(16 alpha) in male mouse liver: murine Ripr locus
    M Noshiro
    Laboratory of Cellular and Molecular Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Biochemistry 27:6444-8. 1988
    ..The results suggested that estrogen rather than androgen is a repressor of I-P-450(16 alpha) in livers of male mice.(ABSTRACT TRUNCATED AT 250 WORDS)..
  2. ncbi Suppression of female-specific murine Cyp2b9 gene expression by growth or glucocorticoid hormones
    Tsutomu Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Biochem Biophys Res Commun 323:776-81. 2004
    b>CYP2B9 is a constitutively and female-specifically expressed P450 isoform in mouse livers. Hypophysectomy-induced CYP2B9 mRNA expression in males to a level similar to that in females, while the operation did not affect females...
  3. doi Role of multiple microRNAs in the sexually dimorphic expression of Cyp2b9 in mouse liver
    Xiaofeng Xie
    Center for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, X X, L M, J Y, C F, C L, M G, M L, L G, X Q, J R, Laboratory of Neural Signal Transduction, Institute of Neuroscience, Chinese Academy of Sciences Y W, Shanghai, China
    Drug Metab Dispos 41:1732-7. 2013
    Mouse cytochrome P450 2b9 (Cyp2b9) is a testosterone 16α-hydroxylase enzyme showing female-specific expression in many inbred mouse strains, including C57BL/6J...
  4. pmc Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
    ..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing...
  5. doi Bimodal action of miroestrol and deoxymiroestrol, phytoestrogens from Pueraria candollei var. mirifica, on hepatic CYP2B9 and CYP1A2 expressions and antilipid peroxidation in mice
    Latiporn Udomsuk
    Academic Office for Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
    Nutr Res 32:45-51. 2012
    ..We hypothesized that miroestrol and deoxymiroestrol would induce CYP2B9 expression, whereas CYP1A2 expression would be suppressed compared with estradiol...
  6. pmc Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function
    Basma Damiri
    Environmental Toxicology Program, Clemson University, Clemson, South Carolina 29634, USA
    Toxicol Sci 125:368-81. 2012
    ..mouse using lentiviral-promoted short hairpin RNA (shRNA) homologous to all five murine Cyp2b subfamily members (Cyp2b9, 2b10, 2b13, 2b19, and 2b23)...
  7. ncbi Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver
    Magnus Lundgren
    Toxicology Division, National Food Administration, Uppsala, Sweden
    Toxicology 242:100-8. 2007
    ..B3 (CVB3) adapted to Balb/c mice was used to examine whether infection affects xenobiotic-metabolising CYP1A1 and CYP2B gene expression (measured by RT-PCR) and the corresponding enzyme activities of ethoxyresorufin-O-deethylase (EROD)..
  8. ncbi Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6
    P W Chiang
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor 48109, USA
    Genomics 47:426-8. 1998
  9. doi Forkhead box A2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene
    Tadahiro Hashita
    Department of Toxicology, Graduate School of Medical and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Drug Metab Dispos 36:1080-7. 2008
    The regulation mechanism of female-predominant expression of the mouse Cyp2b9 gene was investigated in vivo and in vitro...
  10. pmc Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster
    Haoyi Wang
    Department of Zoology, Miami University, 700 East High Street, Oxford, OH 45056, USA
    Environ Health Perspect 111:1835-42. 2003
    ..The mouse cluster includes 22 loci from the same six CYP2 subfamilies--Cyp2a, Cyp2b, Cyp2f, Cyp2g, Cyp2s, Cyp2t--that are found in the human cluster...
  11. ncbi Sexual dimorphic expression of mouse hepatic CYP2B: alterations during development or after hypophysectomy
    Kanokwan Jarukamjorn
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Japan
    Biochem Pharmacol 63:2037-41. 2002
    The constitutive expression of CYP2B mRNA in the livers of mice in the prepubertal stage was sex-independent, with CYP2B9 as the principal isoform...
  12. pmc Regulation of the mouse liver cytochrome P450 2B subfamily by sex hormones and phenobarbital
    P Honkakoski
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    Biochem J 285:979-83. 1992
    ..The fact that P4502b-9 does not respond to phenobarbital, while P4502b-10 is regulated by both phenobarbital and sex hormones, demonstrates the complexity of P450 expression even within one subfamily...
  13. pmc Genetic analysis of the phenobarbital regulation of the cytochrome P-450 2b-9 and aldehyde dehydrogenase type 2 mRNAs in mouse liver
    M Damon
    Faculte de Pharmacie, Universite de Rennes I, France
    Biochem J 317:481-6. 1996
    ..This study suggests that the genetic basis for phenobarbital induction in mice depends on the target gene, and that more than one regulatory step would by involved in this response pathway...
  14. ncbi Maintenance of phenobarbital-inducible Cyp2b gene expression in C57BL/6 mouse hepatocytes in primary culture as spheroids
    N Nemoto
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Arch Biochem Biophys 316:362-9. 1995
    Expression of the Cyp2b-9 and Cyp2b-10 genes was investigated in primary cultured adult C57BL/6NCrj mouse hepatocytes in monolayers or during the formation of spheroids (multicellular aggregates)...
  15. ncbi Glucocorticoid and sex hormones as activating or modulating factors for expression of Cyp2b-9 and Cyp2b-10 in the mouse liver and hepatocytes
    N Nemoto
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Arch Biochem Biophys 319:286-92. 1995
    The effects of male and female hormones as well as glucocorticoid upon the expression of Cyp2b-9 and Cyp2b-10 were investigated in C57BL/6 mouse liver and hepatocytes in primary culture...
  16. ncbi Cloning, structural analysis and mapping of the mouse selenocysteine tRNA([Ser]Sec) gene (Trsp)
    M R Bösl
    Banyu Tsukuba Research Institute, Merck, Japan
    Mol Gen Genet 248:247-52. 1995
    ....
  17. ncbi Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA
    M Noshiro
    Laboratory of Cellular and Molecular Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Biochemistry 27:6434-43. 1988
    ..abstract truncated at 400 words)..
  18. ncbi Structures and characterization of sex-specific mouse cytochrome P-450 genes as members within a large family. Duplication boundary and evolution
    M Lakso
    Pharmacogenetics Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Eur J Biochem 195:477-86. 1991
    ..All genes in that class contain the long ATTT repeat sequences in intron 1, which may have triggered a rapid gene conversion and/or stabilize the duplicated genes...
  19. ncbi Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7
    J S Miles
    Laboratory of Molecular Pharmacology, University Department of Biochemistry, Edinburgh, United Kingdom
    Genomics 7:445-8. 1990
    The cytochrome P450IIB gene subfamily (Cyp2b) has previously been mapped close to the Coh locus encoding a cytochrome P450 with coumarin 7-hydroxylase (COH) activity on mouse chromosome 7...
  20. ncbi Characterization of murine carcinoembryonic antigen gene family members
    F Rudert
    Institut fur Immunbiologie, Universitat Freiburg, FRG
    Mamm Genome 3:262-73. 1992
    ..The more distantly related Cea-5 seems to be ubiquitously expressed. The putative promoter region of Cea-2 lacks typical TATA- or CAAT-boxes, but contains other conserved motifs that could play a role in the initiation of transcription...