Gene Symbol: Cyp2b9
Description: cytochrome P450, family 2, subfamily b, polypeptide 9
Alias: Cyp2b, cytochrome P450 2B9, 16alphaoh-a, CYPIIB9, cytochrome P450 clone PF26, cytochrome P450, 2b9, phenobarbitol inducible, type a, cytochrome P450-16-alpha, phenobarbitol inducible, type a, testosterone 16-alpha hydroxylase
Species: mouse
Products:     Cyp2b9

Top Publications

  1. Noshiro M, Negishi M. Genetic regulation of estrogen-dependent repression of female-specific testosterone 16 alpha-hydroxylase (I-P-450(16 alpha) in male mouse liver: murine Ripr locus. Biochemistry. 1988;27:6444-8 pubmed
    ..The results suggested that estrogen rather than androgen is a repressor of I-P-450(16 alpha) in livers of male mice.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  2. Sakuma T, Kitajima K, Nishiyama M, Mashino M, Hashita T, Nemoto N. Suppression of female-specific murine Cyp2b9 gene expression by growth or glucocorticoid hormones. Biochem Biophys Res Commun. 2004;323:776-81 pubmed
    b>CYP2B9 is a constitutively and female-specifically expressed P450 isoform in mouse livers. Hypophysectomy-induced CYP2B9 mRNA expression in males to a level similar to that in females, while the operation did not affect females...
  3. Creasy K, Jiang J, Ren H, Peterson M, Spear B. Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver. Gene Expr. 2016;17:7-17 pubmed publisher
    ..These data indicate that Zhx2 is a novel regulator of sex-biased Cyp gene expression in the normal and diseased liver. ..
  4. Xie X, Miao L, Yao J, Feng C, Li C, Gao M, et al. Role of multiple microRNAs in the sexually dimorphic expression of Cyp2b9 in mouse liver. Drug Metab Dispos. 2013;41:1732-7 pubmed publisher
    Mouse cytochrome P450 2b9 (Cyp2b9) is a testosterone 16?-hydroxylase enzyme showing female-specific expression in many inbred mouse strains, including C57BL/6J...
  5. Chiang P, Stubbs L, Zhang L, Kurnit D. Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6. Genomics. 1998;47:426-8 pubmed
  6. Lundgren M, Darnerud P, Molin Y, Lilienthal H, Blomberg J, Ilback N. Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver. Toxicology. 2007;242:100-8 pubmed
    ..B3 (CVB3) adapted to Balb/c mice was used to examine whether infection affects xenobiotic-metabolising CYP1A1 and CYP2B gene expression (measured by RT-PCR) and the corresponding enzyme activities of ethoxyresorufin-O-deethylase (EROD)..
  7. Jarukamjorn K, Sakuma T, Nemoto N. Sexual dimorphic expression of mouse hepatic CYP2B: alterations during development or after hypophysectomy. Biochem Pharmacol. 2002;63:2037-41 pubmed
    The constitutive expression of CYP2B mRNA in the livers of mice in the prepubertal stage was sex-independent, with CYP2B9 as the principal isoform...
  8. Nemoto N, Sakurai J. Glucocorticoid and sex hormones as activating or modulating factors for expression of Cyp2b-9 and Cyp2b-10 in the mouse liver and hepatocytes. Arch Biochem Biophys. 1995;319:286-92 pubmed
    The effects of male and female hormones as well as glucocorticoid upon the expression of Cyp2b-9 and Cyp2b-10 were investigated in C57BL/6 mouse liver and hepatocytes in primary culture...
  9. Noshiro M, Lakso M, Kawajiri K, Negishi M. Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA. Biochemistry. 1988;27:6434-43 pubmed
    ..abstract truncated at 400 words) ..

More Information


  1. Lakso M, Masaki R, Noshiro M, Negishi M. Structures and characterization of sex-specific mouse cytochrome P-450 genes as members within a large family. Duplication boundary and evolution. Eur J Biochem. 1991;195:477-86 pubmed
    ..All genes in that class contain the long ATTT repeat sequences in intron 1, which may have triggered a rapid gene conversion and/or stabilize the duplicated genes. ..
  2. Bösl M, Seldin M, Nishimura S, Taketo M. Cloning, structural analysis and mapping of the mouse selenocysteine tRNA([Ser]Sec) gene (Trsp). Mol Gen Genet. 1995;248:247-52 pubmed
  3. Honkakoski P, Kojo A, Lang M. Regulation of the mouse liver cytochrome P450 2B subfamily by sex hormones and phenobarbital. Biochem J. 1992;285 ( Pt 3):979-83 pubmed
    ..The fact that P4502b-9 does not respond to phenobarbital, while P4502b-10 is regulated by both phenobarbital and sex hormones, demonstrates the complexity of P450 expression even within one subfamily. ..
  4. Damiri B, Holle E, Yu X, Baldwin W. Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function. Toxicol Sci. 2012;125:368-81 pubmed publisher
    ..mouse using lentiviral-promoted short hairpin RNA (shRNA) homologous to all five murine Cyp2b subfamily members (Cyp2b9, 2b10, 2b13, 2b19, and 2b23)...
  5. Nemoto N, Sakurai J, Funae Y. Maintenance of phenobarbital-inducible Cyp2b gene expression in C57BL/6 mouse hepatocytes in primary culture as spheroids. Arch Biochem Biophys. 1995;316:362-9 pubmed
    Expression of the Cyp2b-9 and Cyp2b-10 genes was investigated in primary cultured adult C57BL/6NCrj mouse hepatocytes in monolayers or during the formation of spheroids (multicellular aggregates)...
  6. Damon M, Fautrel A, Guillouzo A, Corcos L. Genetic analysis of the phenobarbital regulation of the cytochrome P-450 2b-9 and aldehyde dehydrogenase type 2 mRNAs in mouse liver. Biochem J. 1996;317 ( Pt 2):481-6 pubmed
    ..This study suggests that the genetic basis for phenobarbital induction in mice depends on the target gene, and that more than one regulatory step would by involved in this response pathway. ..
  7. Baur J, Pearson K, Price N, Jamieson H, Lerin C, Kalra A, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444:337-42 pubmed
    ..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing. ..
  8. Hashita T, Sakuma T, Akada M, Nakajima A, Yamahara H, Ito S, et al. Forkhead box A2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene. Drug Metab Dispos. 2008;36:1080-7 pubmed publisher
    The regulation mechanism of female-predominant expression of the mouse Cyp2b9 gene was investigated in vivo and in vitro...
  9. Udomsuk L, Juengwatanatrakul T, Putalun W, Jarukamjorn K. Bimodal action of miroestrol and deoxymiroestrol, phytoestrogens from Pueraria candollei var. mirifica, on hepatic CYP2B9 and CYP1A2 expressions and antilipid peroxidation in mice. Nutr Res. 2012;32:45-51 pubmed publisher
    ..We hypothesized that miroestrol and deoxymiroestrol would induce CYP2B9 expression, whereas CYP1A2 expression would be suppressed compared with estradiol...
  10. Miles J, Moss J, Meehan R, Wolf C. Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7. Genomics. 1990;7:445-8 pubmed
    The cytochrome P450IIB gene subfamily (Cyp2b) has previously been mapped close to the Coh locus encoding a cytochrome P450 with coumarin 7-hydroxylase (COH) activity on mouse chromosome 7...
  11. Rudert F, Saunders A, Rebstock S, Thompson J, Zimmermann W. Characterization of murine carcinoembryonic antigen gene family members. Mamm Genome. 1992;3:262-73 pubmed
    ..The more distantly related Cea-5 seems to be ubiquitously expressed. The putative promoter region of Cea-2 lacks typical TATA- or CAAT-boxes, but contains other conserved motifs that could play a role in the initiation of transcription. ..
  12. Wang H, Donley K, Keeney D, Hoffman S. Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster. Environ Health Perspect. 2003;111:1835-42 pubmed
    ..The mouse cluster includes 22 loci from the same six CYP2 subfamilies--Cyp2a, Cyp2b, Cyp2f, Cyp2g, Cyp2s, Cyp2t--that are found in the human cluster...