Gene Symbol: Cyp2b19
Description: cytochrome P450, family 2, subfamily b, polypeptide 19
Alias: CYPIIB19, cytochrome P450 2B19, cytochrome P450, 2b19
Keeney D. The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal chromosome 7 in the mouse, near a cluster of Cyp2 family genes. Genomics. 1998;53:417-9 pubmed
Keeney D, Skinner C, Travers J, Capdevila J, Nanney L, King L, et al
. Differentiating keratinocytes express a novel cytochrome P450 enzyme, CYP2B19, having arachidonate monooxygenase activity. J Biol Chem. 1998;273:32071-9 pubmed
The novel cytochrome P450, CYP2B19, is a specific cellular marker of late differentiation in skin keratinocytes...
Ladd P, Du L, Capdevila J, Mernaugh R, Keeney D. Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes. J Biol Chem. 2003;278:35184-92 pubmed
The cytochrome P450 CYP2B19 is a keratinocyte-specific arachidonic acid epoxygenase expressed in the granular cell layer of mouse epidermis...
Wang H, Donley K, Keeney D, Hoffman S. Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster. Environ Health Perspect. 2003;111:1835-42 pubmed
Lundgren M, Darnerud P, Molin Y, Lilienthal H, Blomberg J, Ilback N. Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver. Toxicology. 2007;242:100-8 pubmed
..PBDE exposure can modify these effects. Notably, in the infected mice differences between BDE-99 and Bromkal were observed on CYP2B gene expression and PROD activity. ..
Damiri B, Holle E, Yu X, Baldwin W. Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function. Toxicol Sci. 2012;125:368-81 pubmed publisher
..We foresee that this novel Cyp2b-KD mouse model will significantly improve our understanding of the role of Cyp2b enzymes in chemical sensitivity and drug metabolism. ..
Jaradat S, Ko M, Grossman L. Tissue-specific expression and mapping of the Cox7ah gene in mouse. Genomics. 1998;49:363-70 pubmed
..1. As a result, all three COX heart isoform genes in mouse group to chromosome 7. Interestingly, mapping of the mouse Cox7al to chromosome 9 suggests a new syntenic region between the mouse and the human genomes. ..
Du L, Yermalitsky V, Ladd P, Capdevila J, Mernaugh R, Keeney D. Evidence that cytochrome P450 CYP2B19 is the major source of epoxyeicosatrienoic acids in mouse skin. Arch Biochem Biophys. 2005;435:125-33 pubmed
b>CYP2B19 is an arachidonic acid monooxygenase highly expressed in the outer, differentiated cell layers of mouse epidermis...