Cyp2b10

Summary

Gene Symbol: Cyp2b10
Description: cytochrome P450, family 2, subfamily b, polypeptide 10
Alias: Cyp2b, Cyp2b20, p16, cytochrome P450 2B10, CYPIIB10, CYPIIB20, P24, cytochrome P450 2B20, cytochrome P450 clone PF3/46, cytochrome P450, 2b10, phenobarbitol inducible, type b, cytochrome P450, 2b20, cytochrome P450, family 2, subfamily b, polypeptide 20, cytochrome P450-16-alpha, phenobarbitol inducible, type b, testosterone 16-alpha hydroxylase
Species: mouse

Top Publications

  1. pmc Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy
    Takayuki Koga
    From the Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania 16802
    J Biol Chem 291:25255-25263. 2016
  2. pmc The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers
    Marumi Ohno
    Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 9:e115663. 2014
  3. pmc Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5
    Takashi Ashino
    Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Redox Biol 2:284-8. 2014
  4. doi Old dance with a new partner: EGF receptor as the phenobarbital receptor mediating Cyp2B expression
    Sharon A Meyer
    Department of Toxicology, College of Pharmacy, University of Louisiana, Monroe, LA 71201, USA
    Sci Signal 6:pe16. 2013
  5. ncbi Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver
    Magnus Lundgren
    Toxicology Division, National Food Administration, Uppsala, Sweden
    Toxicology 242:100-8. 2007
  6. pmc Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function
    Basma Damiri
    Environmental Toxicology Program, Clemson University, Clemson, South Carolina 29634, USA
    Toxicol Sci 125:368-81. 2012
  7. doi Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues
    Barbara D Abbott
    Developmental Toxicology Branch, Toxicity Assessment Division MD 67, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 33:491-505. 2012
  8. pmc Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice
    Young Joo Park
    Department of Internal Medicine, Seoul National University College of Medicine, Republic of Korea
    Toxicol Appl Pharmacol 263:131-7. 2012
  9. doi Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver
    Antoine Amaury Lachaud
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec, CHUQ, Quebec, Canada
    Biochem Pharmacol 79:463-70. 2010
  10. pmc Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors
    Xingguo Cheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 106:29-36. 2008

Scientific Experts

  • M Katoh
  • Kanokwan Jarukamjorn
  • P W Chiang
  • D S Keeney
  • Sharon A Meyer
  • Barbara D Abbott
  • Magnus Lundgren
  • Craig D Fisher
  • Takayuki Koga
  • Marumi Ohno
  • Takashi Ashino
  • Young Joo Park
  • Basma Damiri
  • Antoine Amaury Lachaud
  • Rick Moore
  • Masahiko Negishi
  • Xingguo Cheng
  • P Honkakoski
  • Johannes Lengler
  • Frederic Gachon
  • Carmela Gnerre
  • Iain A Murray
  • Jeffrey M Peters
  • Maryam Goudarzi
  • Ilia Rivera-Rivera
  • Gayathri Balandaram
  • Frank J Gonzalez
  • Pei Li Yao
  • Kouichi Yoshinari
  • Albert J Fornace
  • Haoyi Wang
  • Gary H Perdew
  • Haruyo Ohkubo-Morita
  • N Marc
  • Satoshi Numazawa
  • Manas Ray
  • Tomohiko Kanayama
  • Masayuki Yamamoto
  • Takemi Yoshida
  • William S Baldwin
  • Yoon Kwang Lee
  • Eric Holle
  • Eun Kyung Lee
  • Xianzhong Yu
  • Do Joon Park
  • Hak Chul Jang
  • David D Moore
  • M Damon
  • N Nemoto
  • C Handschin
  • Michel Lebel
  • Laurent Massip
  • Sacha Auclair-Vincent
  • Alan Anderson
  • Etienne Audet-Walsh
  • Curtis D Klaassen
  • M Negishi
  • Brian Salmons
  • Fabienne Fleury Olela
  • Matthias Renner
  • Ueli Schibler
  • Harry Holzmüller
  • Wolfgang Gregor
  • Walter H Gunzburg
  • Markus Omann
  • Patrick Descombes
  • Dana Düvier
  • Olivier Schaad
  • Renate Looser
  • Paolo Parini
  • Gertrud U Schuster
  • Adrian Roth
  • Kirsten Robertsson
  • A Fautrel
  • Lisen Johansson
  • L Corcos
  • Urs A Meyer
  • Jan Ake Gustafsson
  • Christoph Handschin
  • Michael Podvinec
  • A Guillouzo
  • Takeshi Kawamoto
  • Kyle M Donley
  • Susan M G Hoffman
  • Kaoru Kobayashi
  • Byron Kemper
  • Jongsook Kim
  • U A Meyer
  • M R Bösl
  • J Sakurai

Detail Information

Publications44

  1. pmc Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy
    Takayuki Koga
    From the Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania 16802
    J Biol Chem 291:25255-25263. 2016
    ..Chronic ethanol treatment causes increased hepatic CYP2B10 expression inPparβ/δ+/+ mice but not in Pparβ/δ-/- mice...
  2. pmc The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers
    Marumi Ohno
    Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 9:e115663. 2014
    ..Despite this accumulation, phenobarbital-induced activation of the Cyp2b10 gene was significantly attenuated...
  3. pmc Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5
    Takashi Ashino
    Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Redox Biol 2:284-8. 2014
    ..factor erythroid 2-related factor 2 (Nrf2)-deficient (Nrf2(-⧸-)) mice to investigate the involvement of Nrf2 in Cyp2b10 and Cyp2a5 gene expression...
  4. doi Old dance with a new partner: EGF receptor as the phenobarbital receptor mediating Cyp2B expression
    Sharon A Meyer
    Department of Toxicology, College of Pharmacy, University of Louisiana, Monroe, LA 71201, USA
    Sci Signal 6:pe16. 2013
    The decades-long quest for the phenobarbital (PhB) receptor that mediates activation of Cyp2B would appear fulfilled with the discovery by Mutoh et al...
  5. ncbi Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver
    Magnus Lundgren
    Toxicology Division, National Food Administration, Uppsala, Sweden
    Toxicology 242:100-8. 2007
    ..B3 (CVB3) adapted to Balb/c mice was used to examine whether infection affects xenobiotic-metabolising CYP1A1 and CYP2B gene expression (measured by RT-PCR) and the corresponding enzyme activities of ethoxyresorufin-O-deethylase (EROD)..
  6. pmc Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function
    Basma Damiri
    Environmental Toxicology Program, Clemson University, Clemson, South Carolina 29634, USA
    Toxicol Sci 125:368-81. 2012
    ..activator, 1,4-Bis[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP), was used to determine if shRNA-mediated Cyp2b10 repression could be outcompeted by Cyp2b10 induction...
  7. doi Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues
    Barbara D Abbott
    Developmental Toxicology Branch, Toxicity Assessment Division MD 67, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 33:491-505. 2012
    ..The metabolic disruption produced by PFOA may contribute to poor postnatal survival and persistent weight deficits of CD-1 mouse neonates...
  8. pmc Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice
    Young Joo Park
    Department of Internal Medicine, Seoul National University College of Medicine, Republic of Korea
    Toxicol Appl Pharmacol 263:131-7. 2012
    ..In contrast, expression of Cyp2b10 was induced in both WT and PXR-/- hypothyroid mice, and this induction was abolished in CAR-/- mice and in and ..
  9. doi Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver
    Antoine Amaury Lachaud
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec, CHUQ, Quebec, Canada
    Biochem Pharmacol 79:463-70. 2010
    ..The rat CYP2B2 gene and its closely related mouse homolog, Cyp2b10, are both strongly induced in liver by phenobarbital...
  10. pmc Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors
    Xingguo Cheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 106:29-36. 2008
    ..50 mg/kg) of perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) increased mRNA expression of Cyp2B10 (20-fold), 3A11 (two-fold), and 4A14 (32-fold), but not Cyp1A1/2 in mouse livers...
  11. pmc Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis
    Craig D Fisher
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel, Tucson, AZ 85721, USA
    Arch Toxicol 82:959-64. 2008
    ..alters the xenobiotic activation of these transcription factors and induction of downstream DME targets Cyp1A1, Cyp2B10, Cyp3A11, Cyp4A14 and NAD(P)H:quinone oxidoreductase 1 (Nqo1), respectively...
  12. ncbi Differentiating keratinocytes express a novel cytochrome P450 enzyme, CYP2B19, having arachidonate monooxygenase activity
    D S Keeney
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    J Biol Chem 273:32071-9. 1998
    ....
  13. ncbi Cytochrome P450 reductase dependent inhibition of cytochrome P450 2B1 activity: Implications for gene directed enzyme prodrug therapy
    Johannes Lengler
    Austrianova Biotechnology GmbH, Veterinarplatz 1, A 1210 Vienna, Austria
    Biochem Pharmacol 72:893-901. 2006
    ....
  14. ncbi The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification
    Frederic Gachon
    Department of Molecular Biology, National Center of Competence in Research Frontiers in Genetics, Sciences III, University of Geneva, 1211 Geneva 4, Switzerland
    Cell Metab 4:25-36. 2006
    ..Indeed, PAR bZip triple knockout mice are hypersensitive to xenobiotic compounds, and the deficiency in detoxification may contribute to their early aging...
  15. ncbi LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver
    Carmela Gnerre
    Division of Pharmacology Neurobiology, Biozentrum of the University of Basel, CH 4056 Basel, Switzerland
    J Lipid Res 46:1633-42. 2005
    ..Our data expose differential regulatory patterns for Cyp2b10 and Cyp3a11 dependent on the expression of LXR isoforms and on challenge of cholesterol homeostasis by excess ..
  16. pmc Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster
    Haoyi Wang
    Department of Zoology, Miami University, 700 East High Street, Oxford, OH 45056, USA
    Environ Health Perspect 111:1835-42. 2003
    ..The mouse cluster includes 22 loci from the same six CYP2 subfamilies--Cyp2a, Cyp2b, Cyp2f, Cyp2g, Cyp2s, Cyp2t--that are found in the human cluster...
  17. ncbi Identification and characterization of human FNBP3 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:651-6. 2003
    ..On the other hand, FNBP3 with nuclear localization signals and two tyrosine phosphorylation sites might transduce extracellular signals to the nucleus. This is the first report on comprehensive characterization of human FNBP3 gene...
  18. ncbi Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital
    Kouichi Yoshinari
    Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    FEBS Lett 548:17-20. 2003
    ..This recruitment may lead CAR to translocate into the nucleus, consistent with the inhibitions of nuclear CAR accumulation in PB-induced mouse primary hepatocytes by okadaic acid as well as by geldanamycin...
  19. ncbi Transcriptional analysis in vivo of the hepatic genes, Cyp2b9 and Cyp2b10, by intravenous administration of plasmid DNA in mice
    Ilia Rivera-Rivera
    Department of Molecular and Integrative Physiology and College of Medicine at Urbana Champaign, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochim Biophys Acta 1619:254-62. 2003
    ..In this assay PB treatment increased transactivation by the Cyp2b10 PBRU about 100-fold, which is similar to the increase in the expression of the endogenous gene while the Cyp2b9 ..
  20. ncbi Sexual dimorphic expression of mouse hepatic CYP2B: alterations during development or after hypophysectomy
    Kanokwan Jarukamjorn
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Japan
    Biochem Pharmacol 63:2037-41. 2002
    ..During the maturation stage, CYP2B10 was expressed in both sexes, whereas CYP2B9 was diminished markedly in the males, resulting in a sexually ..
  21. ncbi A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line
    C Handschin
    Department of Pharmacology Neurobiology, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 275:13362-9. 2000
    ..phenobarbital response elements in the flanking regions of three phenobarbital-inducible genes, rat CYP2B2, mouse Cyp2b10, and human CYP2B6...
  22. ncbi Isolation of a cyp2b10-like cDNA and of a clone derived from a cyp2b10-like pseudogene
    N Marc
    Faculte de Pharmacie, INSERM U456, 2, avenue Léon Bernard, Rennes Cedex, 35043, France
    Biochem Biophys Res Commun 258:11-6. 1999
    By screening Balb/c male mouse liver cDNA library with a rat CYP2B1 cDNA probe, we have isolated a 1795 bp cyp2b10-like clone, referred to as P16...
  23. ncbi Cloning, structural analysis and mapping of the mouse selenocysteine tRNA([Ser]Sec) gene (Trsp)
    M R Bösl
    Banyu Tsukuba Research Institute, Merck, Japan
    Mol Gen Genet 248:247-52. 1995
    ....
  24. ncbi Mouse minor satellite DNA genetically maps to the centromere and is physically linked to the proximal telomere
    D Kipling
    MRC Human Genetics Unit, Western General Hospital, Edinburg, United Kingdom
    Genomics 11:235-41. 1991
    ..The apparent lack of any sizable amount of nonsatellite DNA between the minor satellite and the terminal repeat arrays indicates that many mouse chromosomes are truly telocentric...
  25. ncbi Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice
    B A Burkhart
    Pharmacogenetics Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Gene 87:205-11. 1990
    ..Analysis of a restriction fragment length polymorphism in recombinant inbred mice shows a close linkage of 15 alpha oh-1 and 15 alpha oh-2 with the Coh locus...
  26. ncbi Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7
    J S Miles
    Laboratory of Molecular Pharmacology, University Department of Biochemistry, Edinburgh, United Kingdom
    Genomics 7:445-8. 1990
    The cytochrome P450IIB gene subfamily (Cyp2b) has previously been mapped close to the Coh locus encoding a cytochrome P450 with coumarin 7-hydroxylase (COH) activity on mouse chromosome 7...
  27. ncbi The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q
    A M Saunders
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 6:324-32. 1990
    ..Their order from the centromere was Prkcg, [Apoe, Atpa-2, Ckmm, D19S19h, Ercc-2], Cyp2b, Mag, Lhb. Two other murine loci, D7Rp2 and Ngfg, were also positioned within this interval...
  28. ncbi Mouse liver phenobarbital-inducible P450 system: purification, characterization, and differential inducibility of four cytochrome P450 isozymes from D2 mouse
    P Honkakoski
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    Arch Biochem Biophys 273:42-57. 1989
    ..This mouse PB-inducible P450 model may be valuable in further studies on the induction mechanisms of PB and TCPOBOP...
  29. ncbi Purification and characterization of a mouse liver cytochrome P-450 induced by cannabidiol
    L M Bornheim
    Department of Pharmacology, University of California, San Francisco 94143
    Mol Pharmacol 36:377-83. 1989
    ..Thus, CBD exposure results in the induction of an isozyme that is refractory to CBD-mediated inactivation, thereby apparently altering the cytochrome P-450 isozymal composition of mouse hepatic microsomes...
  30. ncbi Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA
    M Noshiro
    Laboratory of Cellular and Molecular Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Biochemistry 27:6434-43. 1988
    ..abstract truncated at 400 words)..
  31. ncbi Genetic regulation of estrogen-dependent repression of female-specific testosterone 16 alpha-hydroxylase (I-P-450(16 alpha) in male mouse liver: murine Ripr locus
    M Noshiro
    Laboratory of Cellular and Molecular Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Biochemistry 27:6444-8. 1988
    ..The results suggested that estrogen rather than androgen is a repressor of I-P-450(16 alpha) in livers of male mice.(ABSTRACT TRUNCATED AT 250 WORDS)..
  32. ncbi Cloning of DNA complementary to rat liver NADPH-cytochrome c (P-450) oxidoreductase and cytochrome P-450b mRNAs. Evidence that phenobarbital augments transcription of specific genes
    F J Gonzalez
    J Biol Chem 257:5962-8. 1982
  33. ncbi Genetic differences in phenytoin pharmacokinetics. In vivo clearance and in vitro metabolism among inbred strains of mice
    S A Atlas
    Dev Pharmacol Ther 1:281-304. 1980
    ....
  34. pmc Regulation of the mouse liver cytochrome P450 2B subfamily by sex hormones and phenobarbital
    P Honkakoski
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    Biochem J 285:979-83. 1992
    ..The fact that P4502b-9 does not respond to phenobarbital, while P4502b-10 is regulated by both phenobarbital and sex hormones, demonstrates the complexity of P450 expression even within one subfamily...
  35. ncbi Regulation of cytochrome P-450 isozymes CYP1A1, CYP1A2 and CYP2B10 by three benzodioxole compounds
    D Y Ryu
    Department of Toxicology, North Carolina State University, Raleigh 27695, USA
    Chem Biol Interact 96:235-47. 1995
    ..used to investigate the structural requirement for regulation of the cytochrome P450 isozymes, CYP1A1, CYP1A2 and CYP2B10, in mouse liver...
  36. ncbi Glucocorticoid and sex hormones as activating or modulating factors for expression of Cyp2b-9 and Cyp2b-10 in the mouse liver and hepatocytes
    N Nemoto
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Arch Biochem Biophys 319:286-92. 1995
    The effects of male and female hormones as well as glucocorticoid upon the expression of Cyp2b-9 and Cyp2b-10 were investigated in C57BL/6 mouse liver and hepatocytes in primary culture...
  37. ncbi Maintenance of phenobarbital-inducible Cyp2b gene expression in C57BL/6 mouse hepatocytes in primary culture as spheroids
    N Nemoto
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Arch Biochem Biophys 316:362-9. 1995
    Expression of the Cyp2b-9 and Cyp2b-10 genes was investigated in primary cultured adult C57BL/6NCrj mouse hepatocytes in monolayers or during the formation of spheroids (multicellular aggregates)...
  38. ncbi Multiple cytochrome P450 isozymes in murine skin: induction of P450 1A, 2B, 2E, and 3A by dexamethasone
    F K Jugert
    Department of Dermatology, University of Cologne, Germany
    J Invest Dermatol 102:970-5. 1994
    ....
  39. ncbi Induction and genetic regulation of mouse hepatic cytochrome P450 by cannabidiol
    L M Bornheim
    Department of Pharmacology, University of California, San Francisco 94143 0450
    Biochem Pharmacol 48:161-71. 1994
    ..The mechanism of CBD-mediated P450 induction remains to be elucidated but does not appear to be related to CBD-mediated P450 inactivation...
  40. ncbi Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes
    P Honkakoski
    Pharmacogenectics Section, Laboratory of Reproductive and Development Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 271:9746-53. 1996
    The mouse phenobarbital (PB)-inducible Cyp2b10 gene promoter has been isolated and sequenced, and control of its expression has been characterized...
  41. ncbi Isolation of a new mouse cDNA clone: hybrid form of cytochrome P450 2b10 and NADPH-cytochrome P450 oxidoreductase
    M Damon
    Groupe Détoxication et Réparation Tissulaire, Faculte de Pharmacie, Universite de Rennes I, France
    Biochem Biophys Res Commun 226:900-5. 1996
    ..consists of an open reading frame containing no stop codon of 1348 bp which share 98% similarity with the cytochrome P450 2b10 followed by 95 nucleotides sharing 88% identity with the mouse NADPH cytochrome P450 oxidoreductase...
  42. ncbi Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6
    P W Chiang
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor 48109, USA
    Genomics 47:426-8. 1998
  43. pmc Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes
    P Honkakoski
    Department of Pharmaceutics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biochem J 330:889-95. 1998
    Using a primary hepatocyte culture in which the mouse Cyp2b10 gene transcription is activated by phenobarbital (PB)-type inducers, we examined the cellular signalling mechanisms associated with PB induction...
  44. ncbi The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal chromosome 7 in the mouse, near a cluster of Cyp2 family genes
    D S Keeney
    Department of Biochemistry and Department of Medicine Dermatology, Vanderbilt University, Nashville, Tennessee, 37232, USA
    Genomics 53:417-9. 1998