Cyp2a5

Summary

Gene Symbol: Cyp2a5
Description: cytochrome P450, family 2, subfamily a, polypeptide 5
Alias: CYPIIA5, Coh, Cyp15a2, cytochrome P450 2A5, coumarin 7-hydroxylase, cytochrome P450, 2a5, cytochrome P450-15-COH, cytochrome P450-IIA3.2
Species: mouse
Products:     Cyp2a5

Top Publications

  1. Lush I, Andrews K. Genetic variation between mice in their metabolism of coumarin and its derivatives. Genet Res. 1978;31:177-86 pubmed
  2. Lindberg R, Negishi M. Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue. Nature. 1989;339:632-4 pubmed
  3. Geneste O, Raffalli F, Lang M. Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization. Biochem J. 1996;313 ( Pt 3):1029-37 pubmed
    Stabilization of mRNA is important in the regulation of CYP2a5 expression but the factors involved in the process are not known [Aida and Negishi (1991) Biochemistry 30, 8041-8045]...
  4. Kirby G, Nichols K, Antenos M. CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis. Curr Drug Metab. 2011;12:186-97 pubmed
    Unlike most cytochrome P450 (CYP) enzymes, murine hepatic CYP2A5 is induced during pathological conditions that result in liver injury including hepatotoxicity mediated by xenobiotics, hepatitis caused by various microbial agents and ..
  5. Nichols K, Kirby G. Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress. Biochem Pharmacol. 2008;75:1230-9 pubmed
    Murine hepatic cytochrome P450 2A5 (CYP2A5), unlike most CYP enzymes, is upregulated during hepatitis and hepatotoxic conditions, but the common stimulus for its induction remains unknown...
  6. Cui Y, Wang Q, Li X, Zhang X. Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation. Redox Biol. 2013;1:433-40 pubmed publisher
    Mouse cytochrome P450 2A5 (CYP2A5) is upregulated in various liver diseases and a putative common feature for all of these conditions is altered cellular redox status...
  7. Lu Y, Zhang X, Cederbaum A. Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicol Sci. 2012;128:427-38 pubmed publisher
    Chronic ethanol consumption was previously shown to induce CYP2A5 in mice, and this induction of CYP2A5 by ethanol was CYP2E1 dependent. In this study, the mechanisms of CYP2E1-dependent ethanol induction of CYP2A5 were investigated...
  8. Gilmore W, Hartmann G, Piquette Miller M, Marriott J, Kirby G. Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression. Toxicology. 2003;184:211-26 pubmed
    Murine hepatic cytochrome P450 2a5 (Cyp2a5) is induced during hepatotoxicity and hepatitis, however, the specific regulatory mechanisms have not been determined...
  9. Arpiainen S, Järvenpää S, Manninen A, Viitala P, Lang M, Pelkonen O, et al. Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes. Toxicol Appl Pharmacol. 2008;232:135-41 pubmed publisher
    ..In the present study, we were able to show that cAMP causes a coordinated induction of PGC-1alpha and CYP2A5 mRNAs in murine primary hepatocytes...

More Information

Publications65

  1. Abu Bakar A, Hakkola J, Juvonen R, Rahnasto Rilla M, Raunio H, Lang M. Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver. Curr Drug Metab. 2013;14:137-50 pubmed
    ..Uniquely, CYP2A5 and CYP2A6 are induced during pathological conditions associated with liver injury when the function of most other ..
  2. Abu Bakar A, Moore M, Lang M. Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5. Biochem Pharmacol. 2005;70:1527-35 pubmed
    ..In this paper, we present evidence for a major role of the hepatic cytochrome P450 2A5 (Cyp2a5) in BR degradation during cadmium intoxication, where the BR levels are elevated following ..
  3. Hahnemann B, Salonpää P, Pasanen M, Maenpaa J, Honkakoski P, Juvonen R, et al. Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression. Biochem J. 1992;286 ( Pt 1):289-94 pubmed
    Pyrazole, cobalt and phenobarbital increase the activity of coumarin 7-hydroxylase (COH) in mouse liver...
  4. Abu Bakar A, Lämsä V, Arpiainen S, Moore M, Lang M, Hakkola J. Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2. Drug Metab Dispos. 2007;35:787-94 pubmed
    We have previously shown that cadmium, a metal that alters cellular redox status, induces CYP2A5 expression in nuclear factor (erythroid-derived 2)-like 2 wild-type (Nrf2+/+) mice but not in the knockout (Nrf2-/-) mice...
  5. Salonpää P, Krause K, Pelkonen O, Raunio H. Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver. Naunyn Schmiedebergs Arch Pharmacol. 1995;351:446-52 pubmed
    Coumarin 7-hydroxylase (COH) activity is catalyzed by the Cyp2a-5 gene product (CYP2A5 enzyme) in mice. Mouse hepatic CYP2A5 expression is often increased in conditions in which other P450 forms are repressed, e.g...
  6. Lavery D, Lopez Molina L, Margueron R, Fleury Olela F, Conquet F, Schibler U, et al. Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP. Mol Cell Biol. 1999;19:6488-99 pubmed
    ..of CYP2A4 mRNA in mouse liver displays circadian kinetics indistinguishable from those of the highly related CYP2A5 gene...
  7. Burkhart B, Harada N, Negishi M. Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation. J Biol Chem. 1985;260:15357-61 pubmed
    ..Sexual dimorphism in hepatic testosterone 15 alpha-hydroxylase activity is shown to result from differential mRNA regulation in females and males. ..
  8. Salonpää P, Iscan M, Pasanen M, Arvela P, Pelkonen O, Raunio H. Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice. Biochem Pharmacol. 1992;44:1269-74 pubmed
    ..and Cyp2a-5 genes encode P450 isoforms catalysing testosterone 15 alpha-hydroxylase and coumarin 7-hydroxylase (COH) activities, respectively. Two days after the administration of a hepatotoxic dose of cerium chloride (2 mg/kg i.v...
  9. Lindberg R, Burkhart B, Ichikawa T, Negishi M. The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene. J Biol Chem. 1989;264:6465-71 pubmed
    ..The results indicated that Type I was the major steroid 15 alpha-hydroxylase. The differential 15 alpha OH-1 expression, therefore, determined the sexual dimorphism of the tissue-specific 15 alpha-hydroxylase activity in mice. ..
  10. Ueng Y, Chen C, Chung Y, Liu T, Chang Y, Lo W, et al. Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo. Br J Pharmacol. 2011;163:1250-62 pubmed publisher
    ..Formation of an epoxide could be a key step in this inactivation. 'Poor metabolizers' carrying CYP2A6*7 or *10 may be less susceptible to inhibition by chalepensin. Given in vivo, chalepensin decreased CYP2A activity in mice. ..
  11. Miles J, Moss J, Meehan R, Wolf C. Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7. Genomics. 1990;7:445-8 pubmed
    The cytochrome P450IIB gene subfamily (Cyp2b) has previously been mapped close to the Coh locus encoding a cytochrome P450 with coumarin 7-hydroxylase (COH) activity on mouse chromosome 7...
  12. Squires E, Negishi M. Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene. J Biol Chem. 1988;263:4166-71 pubmed
    ..Both Types I and II were repressed in male liver, which results in decreased levels of P-450(15 alpha). Androgen was responsible for the repression and expression of Type I in liver and kidney, but not Type II. ..
  13. Dlouhy S, Taylor B, Karn R. The genes for mouse salivary androgen-binding protein (ABP) subunits alpha and gamma are located on chromosome 7. Genetics. 1987;115:535-43 pubmed
    ..The results of cell-free translation studies in which the pre-ABP subunits are identified specifically by immunoprecipitation with anti-ABP antibody supports the idea that independent mRNAs code for the Alpha, Beta and Gamma subunits. ..
  14. Jover R, Hoffmann F, Scheffler Koch V, Lindberg R. Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital. Eur J Biochem. 2000;267:7128-37 pubmed
    ..This inhibitory effect is isoenzyme-specific, being significant for cyp2a5. The activity and mRNA level of this particular cytochrome P450 are significantly lower in the phenobarbital-..
  15. Baur J, Pearson K, Price N, Jamieson H, Lerin C, Kalra A, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444:337-42 pubmed
    ..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing. ..
  16. Arpiainen S, Lämsä V, Pelkonen O, Yim S, Gonzalez F, Hakkola J. Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site. J Mol Biol. 2007;369:640-52 pubmed
    ..in the 5' regulatory region of the murine cytochrome P450 (Cyp) 2a5 gene that was found to be important for Cyp2a5 transcription in primary hepatocytes, and was found by chromatin immunoprecipitation assays to interact with ARNT...
  17. Tilloy Ellul A, Raffalli Mathieu F, Lang M. Analysis of RNA-protein interactions of mouse liver cytochrome P4502A5 mRNA. Biochem J. 1999;339 ( Pt 3):695-703 pubmed
    In our previous studies we have identified a 37/39 kDa, pyrazole-inducible, cytochrome P4502A5 (CYP2A5) mRNA binding protein and provided evidence that it may play a role in the stabilization and processing of the RNA [Geneste, Rafalli ..
  18. Aida K, Moore R, Negishi M. Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily. Genomics. 1994;19:564-6 pubmed
    ..Evolutionarily, therefore, Cyp2a-5 is ancestral to Cyp2a-4. Moreover, the line to Cyp2a-4 descended as recently as 3 million years ago in an ancestral mouse. This evidence implies a rapid evolution of the P450 gene superfamily. ..
  19. Walsh J, Jenkins R, Wong M, Olayanju A, Powell H, Copple I, et al. Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications. J Proteomics. 2014;108:171-87 pubmed publisher
    ..at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 regulation: cytochrome P4502A5 (CYP2A5; 17.2-fold), glutathione-S-transferase-Mu 3 (GSTM3; 6.4-fold), glutathione-S-transferase Mu 1 (GSTM1; 5...
  20. Zhou X, Zhuo X, Xie F, Kluetzman K, Shu Y, Humphreys W, et al. Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model. J Pharmacol Exp Ther. 2010;332:578-87 pubmed publisher
    b>CYP2A5, a mouse cytochrome P450 monooxygenase that shows high similarities to human CYP2A6 and CYP2A13 in protein sequence and substrate specificity, is expressed in multiple tissues, including the liver, kidney, lung, and nasal mucosa...
  21. Zhou X, D Agostino J, Li L, Moore C, Yost G, Ding X. Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models. Drug Metab Dispos. 2012;40:642-7 pubmed publisher
    The aim of this study was to determine whether mouse CYP2A5 and CYP2F2 play critical roles in the bioactivation of 3-methylindole (3MI), a tissue-selective toxicant, in the target tissues, the nasal olfactory mucosa (OM) and lung...
  22. Wei Y, Li L, Zhou X, Zhang Q, Dunbar A, Liu F, et al. Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model. Drug Metab Dispos. 2013;41:132-40 pubmed publisher
    ..2-megabase pair genomic fragment containing nine Cyp genes in mouse chromosome 7 (including, sequentially, Cyp2a5, 2g1, 2b19, 2b23, 2a4, 2b9, 2b13, 2b10, and 2s1) are deleted, through Cre-mediated recombination in vivo...
  23. Ashino T, Ohkubo Morita H, Yamamoto M, Yoshida T, Numazawa S. Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5. Redox Biol. 2014;2:284-8 pubmed publisher
    ..2-related factor 2 (Nrf2)-deficient (Nrf2(-?-)) mice to investigate the involvement of Nrf2 in Cyp2b10 and Cyp2a5 gene expression...
  24. Hong F, Liu X, Ward S, Xiong H, Cederbaum A, Lu Y. Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice. Dig Liver Dis. 2015;47:470-7 pubmed publisher
    ..Recently, we found that in addition to P450 2E1 also cytochrome P450 2A5, another isoform of cytochrome P450, can be induced by ethanol, and that ethanol induction of cytochrome ..
  25. Juvonen R, Iwasaki M, Sueyoshi T, Negishi M. Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity. Biochem J. 1993;294 ( Pt 1):31-4 pubmed
  26. Simmons D, Lalley P, Kasper C. Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes. J Biol Chem. 1985;260:515-21 pubmed
    ..Our data support the proposition that the region of the Coh locus on chromosome 7 is the site of the cytochrome P-450PB gene family...
  27. Kent R, Fallows D, Geissler E, Glaser T, Emanuel J, Lalley P, et al. Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse. Proc Natl Acad Sci U S A. 1987;84:5369-73 pubmed
    ..The dispersion of Na,K-ATPase genes suggests that their expression is not likely to be controlled by a common cis-acting regulatory element. ..
  28. Wang H, Donley K, Keeney D, Hoffman S. Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster. Environ Health Perspect. 2003;111:1835-42 pubmed
  29. Burkhart B, Skow L, Negishi M. Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice. Gene. 1990;87:205-11 pubmed
    ..Analysis of a restriction fragment length polymorphism in recombinant inbred mice shows a close linkage of 15 alpha oh-1 and 15 alpha oh-2 with the Coh locus.
  30. Creasy K, Jiang J, Ren H, Peterson M, Spear B. Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver. Gene Expr. 2016;17:7-17 pubmed publisher
    ..These data indicate that Zhx2 is a novel regulator of sex-biased Cyp gene expression in the normal and diseased liver. ..
  31. Zhou X, Wei Y, Xie F, Laukaitis C, Karn R, Kluetzman K, et al. A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression. Mol Pharmacol. 2011;79:710-23 pubmed publisher
    ..increases in resistance to acetaminophen (APAP) toxicity in the lateral nasal gland (LNG) of the male Cyp2g1-null/Cyp2a5-low mouse...
  32. Hu J, Sheng L, Li L, Zhou X, Xie F, D Agostino J, et al. Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene. Drug Metab Dispos. 2014;42:23-7 pubmed publisher
    ..The aim of this study was to determine whether mouse CYP2A5, abundantly expressed in nasal olfactory mucosa (OM) and the liver, but less in the lung, plays a major role in ..
  33. Lang M, Juvonen R, Jarvinen P, Honkakoski P, Raunio H. Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes. Arch Biochem Biophys. 1989;271:139-48 pubmed
    ..This may suggest that P450Coh has a closer association to the steroid 15 alpha-hydroxylase gene family than to the P450IIB subfamily of phenobarbital-inducible isoenzymes. ..
  34. Chen X, Ward S, Cederbaum A, Xiong H, Lu Y. Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis. Toxicology. 2017;379:12-21 pubmed publisher
    b>Cytochrome P450 2A5 (CYP2A5) is induced by ethanol, and the ethanol induction of CYP2A5 is regulated by nuclear factor-erythroid 2-related factor 2 (NRF2)...
  35. Elliott R, Berger F. DNA sequence polymorphism in an androgen-regulated gene is associated with alteration in the encoded RNAs. Proc Natl Acad Sci U S A. 1983;80:501-4 pubmed
    ..Thus, associated with polymorphism at RP2 is a change in the molecular size pattern of encoded transcripts. ..
  36. Lindberg R, Juvonen R, Negishi M. Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh. Pharmacogenetics. 1992;2:32-7 pubmed
    ..Since P450coh activity is regulated by the Coh locus, we characterized P450coh cDNAs in strains having high coumarin 7-hydroxylase activity (CohH homozygote) ..
  37. Yoshioka H, Lindberg R, Wong G, Ichikawa T, Itakura T, Burkhart B, et al. Characterization and regulation of sex-specific mouse steroid hydroxylase genes. Can J Physiol Pharmacol. 1990;68:754-61 pubmed
    ..It appears, therefore, that the mouse P-450 gene families evolved through gene duplication and selective mutation to create new P-450s structurally as well as to establish novel regulatory elements for the gene expressions. ..
  38. Kanemoto K, Fukuta K, Kawai N, Tozawa K, Ochiai M, Okamoto K, et al. Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype. PLoS ONE. 2016;11:e0167374 pubmed publisher
    ..Cyp2a22 and Cyp2a5 genes but not Cyp2g1, Cyp2a12, and Rab4b genes on mouse chromosome 7qA3 were amplified in invasive bladder cancers...
  39. Denny P, Ashworth A. Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7. Mamm Genome. 1994;5:643-5 pubmed
  40. Endell W, Seidel G. Coumarin toxicity in different strains of mice. Agents Actions. 1978;8:299-302 pubmed
    ..These results are discussed in the context of a strain-specific coumarin metabolism and indicate the need for suitable animal models to assess the toxicity of a given substance in man. ..
  41. Simmons D, Kasper C. Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice. J Biol Chem. 1983;258:9585-8 pubmed
    ..Using the BXD recombinant inbred strains, five of these polymorphisms were mapped to the Coh (coumarin hydroxylase) locus on chromosome 7 of the mouse...
  42. Ventura C, Higdon R, Kolker E, Skerrett S, Rubens C. Host airway proteins interact with Staphylococcus aureus during early pneumonia. Infect Immun. 2008;76:888-98 pubmed publisher
    ..aureus in vivo. The data presented here provide novel insights into the host-pathogen interactions that occur when S. aureus enters the airway. ..
  43. Symington F, Subbarao B, Mosier D, Sprent J. Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody. Immunogenetics. 1982;16:381-91 pubmed
    ..The expression of Lyb-8.2 is controlled by a locus on chromosome 7 that is closely linked to Gpi-1 and RP-2. Added Lyb-8.2-specific antibody did not measurably impair B lymphocyte function in several in vitro systems studied. ..
  44. Xie F, Zhou X, Behr M, Fang C, Horii Y, Gu J, et al. Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation. Toxicol Appl Pharmacol. 2010;249:101-6 pubmed publisher
    ..b>CYP2A5, expressed abundantly in both liver and OM, was previously found to be one of the P450 enzymes active in DCBN ..
  45. Muhsain S, Lang M, Abu Bakar A. Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress. Toxicol Appl Pharmacol. 2015;282:77-89 pubmed publisher
    ..BR regulation by two microsomal enzymes: heme oxygenase 1 (HMOX1), essential for BR production and cytochrome P450 2A5 (CYP2A5), a BR oxidase...
  46. Pelkonen P, Honkakoski P, Geneste O, Bartsch H, Lang M. Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes. Biochem Pharmacol. 1993;46:1681-7 pubmed
    ..In the microsomal fractions, anti-mouse CYP2A5 antibody recognised three bands of about 48, 49 and 52 kDa, suggesting the presence of at least three proteins ..
  47. Megaraj V, Zhou X, Xie F, Liu Z, Yang W, Ding X. Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model. Carcinogenesis. 2014;35:131-7 pubmed publisher
    ..of NNK bioactivation in vitro and incidence of NNK-induced lung tumors in vivo were determined for wild-type, Cyp2a5-null and CYP2A13-humanized (CYP2A13-transgenic/Cyp2a5-null) mice...
  48. De Oliveira A, Poça K, Totino P, Paumgartten F. Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship. PLoS ONE. 2015;10:e0117842 pubmed publisher
    ..2-related factor) 2 (Nrf2) transcription factor activation have been hypothesised to mediate up-regulation of CYP2A5 expression in the murine liver...
  49. Noshiro M, Lakso M, Kawajiri K, Negishi M. Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA. Biochemistry. 1988;27:6434-43 pubmed
    ..It was found that the genotypes of this locus exhibited concordance with that of the coumarin hydroxylase locus (Coh locus) in eight out of nine 9 X A recombinant inbred strains, suggesting the localization of this sex-limited locus ..
  50. Negishi M, Lindberg R, Burkhart B, Ichikawa T, Honkakoski P, Lang M. Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase. Biochemistry. 1989;28:4169-72 pubmed
    ..as the P-450 specific to coumarin 7-hydroxylase activity and characterization of its cDNA and gene, therefore, were significant advances toward understanding the basis of genetic regulation of this activity in mice (known as Coh locus).
  51. Li L, Jia K, Zhou X, McCallum S, Hough L, Ding X. Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse. J Pharmacol Exp Ther. 2013;347:746-54 pubmed publisher
    ..Further comparisons of nicotine metabolism between Cyp2a(4/5)bgs-null and Cyp2a5-null mice revealed significant roles of both CYP2A5 and CYP2B enzymes in nicotine clearance...
  52. Hong F, Si C, Gao P, Cederbaum A, Xiong H, Lu Y. The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:33-43 pubmed publisher
    ..b>CYP2A5 can be induced by TAA but not by CCL4...
  53. Lewis D, Lake B. Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions. Xenobiotica. 2002;32:547-61 pubmed
    ..2. The metabolism of coumarin via 7-hydroxylation in the human (CYP2A6) and mouse (CYP2A5) enzymes is explained in terms of molecular modelling of the active site interactions, whereas the rat orthologue (..
  54. Wood A, Taylor B. Genetic regulation of coumarin hydroxylase activity in mice. Evidence for single locus control on chromosome. J Biol Chem. 1979;254:5647-51 pubmed
  55. Poça K, Parente T, Chagas L, Leal B, Leal H, Paumgartten F, et al. Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver. BMC Res Notes. 2017;10:125 pubmed publisher
    b>Cytochrome P450 2A5 (Cyp2a5), a mouse enzyme orthologous of human CYP2A6, catalyzes a number of toxicologically important reactions, including the metabolism of nicotine, aflatoxin B1, and several other xeno- and endobiotics...
  56. Zhou X, D Agostino J, Xie F, Ding X. Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice. J Pharmacol Exp Ther. 2012;341:233-41 pubmed publisher
    ..The present study was designed to test the hypothesis that mouse CYP2A5 plays an essential role in NNK bioactivation in mouse lung...