Gene Symbol: Cyp26b1
Description: cytochrome P450, family 26, subfamily b, polypeptide 1
Alias: CP26, P450RAI-2, cytochrome P450 26B1, cytochrome P450 retinoic acid-inactivating 2, cytochrome P450, 26, retinoic acid B1, cytochrome P450RAI-2, retinoic acid B1, retinoic acid hydroxylase
Species: mouse
Products:     Cyp26b1

Top Publications

  1. Vezina C, Allgeier S, Fritz W, Moore R, Strerath M, Bushman W, et al. Retinoic acid induces prostatic bud formation. Dev Dyn. 2008;237:1321-33 pubmed publisher
    ..These observations suggest that reciprocal changes in hedgehog and BMP signaling by RA may regulate bud initiation. ..
  2. Sato Y, Heuckeroth R. Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro. Dev Biol. 2008;320:185-98 pubmed publisher
    ..Collectively these data demonstrate diverse effects of RA on ENS precursor development and suggest that altered fetal retinoid availability or metabolism could contribute to intestinal motility disorders. ..
  3. Li H, MacLean G, Cameron D, Clagett Dame M, Petkovich M. Cyp26b1 expression in murine Sertoli cells is required to maintain male germ cells in an undifferentiated state during embryogenesis. PLoS ONE. 2009;4:e7501 pubmed publisher germ cells, as meiosis in male embryonic germ cells is blocked by the activity of a RA-catabolizing enzyme, CYP26B1. However, the mechanisms regulating mitotic arrest in male germ cells are not well understood...
  4. Suzuki A, Saga Y. Nanos2 suppresses meiosis and promotes male germ cell differentiation. Genes Dev. 2008;22:430-5 pubmed publisher
    ..acid (RA) induces meiosis in the female germ cells, whereas the male germ cells never enter meiosis due to Cyp26b1-mediated RA metabolism. We show here that Nanos2 plays critical roles in the differentiation of male germ cells...
  5. Bowles J, Feng C, Spiller C, Davidson T, Jackson A, Koopman P. FGF9 suppresses meiosis and promotes male germ cell fate in mice. Dev Cell. 2010;19:440-9 pubmed publisher
    ..ovarian germ cells to enter meiosis and thereby commit to oogenesis, whereas in the developing testis, the enzyme CYP26B1 degrades RA and germ cells are not induced to enter meiosis...
  6. Gregoire E, Lavery R, Chassot A, Akiyama H, Treier M, Behringer R, et al. Transient development of ovotestes in XX Sox9 transgenic mice. Dev Biol. 2011;349:65-77 pubmed publisher
    ..Finally, ovarian cells of the XX Wt1:Sox9 ovotestis undergo apoptosis during late embryogenesis leading to complete female-to-male sex reversal of the transgenic mice at birth...
  7. Koubova J, Menke D, Zhou Q, Capel B, Griswold M, Page D. Retinoic acid regulates sex-specific timing of meiotic initiation in mice. Proc Natl Acad Sci U S A. 2006;103:2474-9 pubmed
    ..Because RA signaling regulates Stra8 expression in both embryonic ovaries and adult testes, this portion of the meiotic initiation pathway may be identical in both sexes. ..
  8. MacLean G, Dolle P, Petkovich M. Genetic disruption of CYP26B1 severely affects development of neural crest derived head structures, but does not compromise hindbrain patterning. Dev Dyn. 2009;238:732-45 pubmed publisher
    b>Cyp26b1 encodes a cytochrome-P450 enzyme that catabolizes retinoic acid (RA), a vitamin A derived signaling molecule...
  9. Chassot A, Ranc F, Gregoire E, Roepers Gajadien H, Taketo M, Camerino G, et al. Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary. Hum Mol Genet. 2008;17:1264-77 pubmed publisher
    ..Thus, a balance between Sox9 and beta-catenin activation determines the fate of the gonad, with Rspo1 acting as a crucial regulator of canonical beta-catenin signaling required for female development. ..

More Information


  1. MacLean G, Li H, Metzger D, Chambon P, Petkovich M. Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice. Endocrinology. 2007;148:4560-7 pubmed
    b>Cyp26b1 encodes a retinoic acid (RA) metabolizing cytochrome P450 enzyme that is expressed in embryonic tissues undergoing morphogenesis, including the testes...
  2. Bowles J, Knight D, Smith C, Wilhelm D, Richman J, Mamiya S, et al. Retinoid signaling determines germ cell fate in mice. Science. 2006;312:596-600 pubmed
    ..Meiosis is retarded in the fetal testis by the action of the retinoid-degrading enzyme CYP26B1, ultimately leading to spermatogenesis...
  3. Takeuchi H, Yokota A, Ohoka Y, Iwata M. Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-?. PLoS ONE. 2011;6:e16089 pubmed publisher
    ..Antigen-experienced CD44+ T cells in gut-related lymphoid organs selectively expressed Cyp26b1, a member of the cytochrome P450 family 26...
  4. Chassot A, Gregoire E, Lavery R, Taketo M, de Rooij D, Adams I, et al. RSPO1/?-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. PLoS ONE. 2011;6:e25641 pubmed publisher
    ..Our results demonstrate that RSPO1/?-catenin signaling is involved in meiosis in fetal germ cells and contributes to the cellular decision of germ cells to differentiate into oocyte or sperm...
  5. Tahayato A, Dolle P, Petkovich M. Cyp26C1 encodes a novel retinoic acid-metabolizing enzyme expressed in the hindbrain, inner ear, first branchial arch and tooth buds during murine development. Gene Expr Patterns. 2003;3:449-54 pubmed
    ..This pattern of expression suggests that mCYP26C1 may play an important role in protecting the hindbrain, first branchial arch, otocyst and tooth buds against RA exposure during embryonic development. ..
  6. Yashiro K, Zhao X, Uehara M, Yamashita K, Nishijima M, Nishino J, et al. Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb. Dev Cell. 2004;6:411-22 pubmed
    ..We have studied the role of RA in mouse limb development by focusing on CYP26B1, a cytochrome P450 enzyme that inactivates RA...
  7. Wu J, Wang R, Guo Q, Xu C. Expression of the retinoic acid-metabolizing enzymes RALDH2 and CYP26b1 during mouse postnatal testis development. Asian J Androl. 2008;10:569-76 pubmed publisher
    To study the expression pattern of the retinoic acid metabolizing enzymes RALDH2 and CYP26b1 during mouse postnatal testis development at both mRNA and protein levels...
  8. Saba R, Wu Q, Saga Y. CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways. Dev Biol. 2014;389:173-81 pubmed publisher
    Germ cell sex is defined by factors derived from somatic cells. CYP26B1 is known to be a male sex-promoting factor that inactivates retinoic acid (RA) in somatic cells...
  9. Bowles J, Koopman P. Retinoic acid, meiosis and germ cell fate in mammals. Development. 2007;134:3401-11 pubmed
    ..Although this knowledge clarifies a long-standing mystery in reproductive biology, it also poses many new questions, which we discuss in this review. ..
  10. MacLean G, Abu Abed S, Dolle P, Tahayato A, Chambon P, Petkovich M. Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development. Mech Dev. 2001;107:195-201 pubmed
    ..The RA-metabolizing enzymes Cyp26A1 and Cyp26B1 are believed to play important roles in protecting certain embryonic tissues from inappropriate RA signaling...
  11. Hogarth C, Evans E, Onken J, Kent T, Mitchell D, Petkovich M, et al. CYP26 Enzymes Are Necessary Within the Postnatal Seminiferous Epithelium for Normal Murine Spermatogenesis. Biol Reprod. 2015;93:19 pubmed publisher
    ..One previous study alluded to a requirement for one of the RA degrading enzymes, CYP26B1, in Sertoli cells but no data exist to determine whether germ cells possess the ability to degrade RA...
  12. Bénazet J, Pignatti E, Nugent A, Unal E, Laurent F, Zeller R. Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds. Development. 2012;139:4250-60 pubmed publisher
    ..In summary, our analysis reveals that SMAD4 is required to initiate: (1) formation of the Sox9-positive digit ray primordia; and (2) aggregation and chondrogenic differentiation of all limb skeletal elements...
  13. Yakushiji Kaminatsui N, Kondo T, Endo T, Koseki Y, Kondo K, Ohara O, et al. RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression. Development. 2016;143:276-85 pubmed publisher
    ..We suggest that the RING1-MEIS1/2 axis is regulated by early PD signals and contributes to the initiation or maintenance of the distal signal circuitry. ..
  14. Lee L, Leung M, Kwok R, Leung Y, Wang C, McCaffery P, et al. Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes. Diabetes. 2017;66:1041-1051 pubmed publisher
  15. Kashimada K, Svingen T, Feng C, Pelosi E, Bagheri Fam S, Harley V, et al. Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. FASEB J. 2011;25:3561-9 pubmed publisher
    ..and the degradation of RA achieved by the testis-specific expression of the catabolic cytochrome P450 enzyme, CYP26B1. Therefore, identification of factors regulating the expression of the Cyp26b1 gene is an important goal in ..
  16. Tiboni G, Marotta F, Carletti E. Fluconazole alters CYP26 gene expression in mouse embryos. Reprod Toxicol. 2009;27:199-202 pubmed publisher
    ..chain reaction (quantitative real-time RT-PCR) assay was used to quantify the mRNA expression of CYP26a1, CYP26b1 and CYP26c1 in embryos...
  17. Uehara M, Yashiro K, Takaoka K, Yamamoto M, Hamada H. Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning. Genes Dev. 2009;23:1689-98 pubmed publisher
    ..These observations suggest that maternal RA must be removed by embryonic CYP26 for correct Nodal expression during embryonic patterning. ..
  18. Spoorendonk K, Peterson Maduro J, Renn J, Trowe T, Kranenbarg S, Winkler C, et al. Retinoic acid and Cyp26b1 are critical regulators of osteogenesis in the axial skeleton. Development. 2008;135:3765-74 pubmed publisher
    ..stocksteif encodes cyp26b1, a cytochrome P450 member that metabolizes RA...
  19. Bowles J, Secker G, Nguyen C, Kazenwadel J, Truong V, Frampton E, et al. Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Dev Biol. 2014;386:25-33 pubmed publisher
    ..Here we identify a novel function for CYP26B1, an enzyme known to play a role in tissue morphogenesis by fine-tuning retinoic acid (RA) concentration, in ..
  20. Bagheri Fam S, Sim H, Bernard P, Jayakody I, Taketo M, Scherer G, et al. Loss of Fgfr2 leads to partial XY sex reversal. Dev Biol. 2008;314:71-83 pubmed
    ..In summary, we provide evidence that FGFR2 is important for male sex determination in mice, thereby rendering human FGFR2 a candidate gene for unsolved DSD cases such as 10q26 deletions. ..
  21. Naillat F, Prunskaite Hyyryläinen R, Pietilä I, Sormunen R, Jokela T, Shan J, et al. Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development. Hum Mol Genet. 2010;19:1539-50 pubmed publisher
    ..In addition, we find that Stra8 expression is downregulated and the Cyp26b1 gene is expressed ectopically in the partially masculinized Wnt-4-deficient ovary...
  22. Sakai Y, Luo T, McCaffery P, Hamada H, DRAGER U. CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development. Dev Biol. 2004;276:143-57 pubmed
    ..The safeguard of the RA-poor stripe by two distinct enzymes during later development points to a role in maturation of a significant functional feature like an area of higher visual acuity that develops at its location. ..
  23. Adams M, Belyaeva O, Wu L, Kedishvili N. The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis. J Biol Chem. 2014;289:14868-80 pubmed publisher
    ..The mutually activating interaction between the two related proteins may represent a highly sensitive and conserved mechanism for precise control over the rate of retinoic acid biosynthesis. ..
  24. Lavery R, Chassot A, Pauper E, Gregoire E, Klopfenstein M, de Rooij D, et al. Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals. PLoS Genet. 2012;8:e1003170 pubmed publisher
    ..The dogma that considers female differentiation as a default pathway therefore needs to be definitively revised. ..
  25. Laue K, Janicke M, Plaster N, Sonntag C, Hammerschmidt M. Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development. Development. 2008;135:3775-87 pubmed publisher
    ..based on the positional cloning of the dolphin mutation, we have studied the role of the RA-oxidizing enzyme Cyp26b1 during cartilage and bone development in zebrafish...
  26. Lee L, Leung C, Tang W, Choi H, Leung Y, McCaffery P, et al. A paradoxical teratogenic mechanism for retinoic acid. Proc Natl Acad Sci U S A. 2012;109:13668-73 pubmed publisher
    ..levels of Raldh transcripts encoding retinoic acid-synthesizing enzymes and increased levels of Cyp26a1 and Cyp26b1 mRNAs encoding enzymes that catabolize retinoic acid...
  27. Le Bouffant R, Souquet B, Duval N, Duquenne C, Hervé R, Frydman N, et al. Msx1 and Msx2 promote meiosis initiation. Development. 2011;138:5393-402 pubmed publisher
    ..Collectively, our data demonstrate for the first time that some homeobox genes are required for meiosis initiation in the female germ line. ..
  28. Combes A, Bowles J, Feng C, Chiu H, Khoo P, Jackson A, et al. Expression and functional analysis of Dkk1 during early gonadal development. Sex Dev. 2011;5:124-30 pubmed publisher
    ..Nor did we find significant differences in expression of key markers of testis and ovarian development. We propose that DKK1 may play a protective role that is not unmasked by loss-of-function in the absence of other stressors. ..
  29. Hägglund M, Berghard A, Strotmann J, Bohm S. Retinoic acid receptor-dependent survival of olfactory sensory neurons in postnatal and adult mice. J Neurosci. 2006;26:3281-91 pubmed
    ..we find that nuclear retinoid signaling is required for the expression of a retinoic acid-degrading enzyme, Cyp26B1, in a small fraction of mature neurons...
  30. Cook M, Munger S, Nadeau J, Capel B. Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. Development. 2011;138:23-32 pubmed publisher
  31. Login H, Butowt R, Bohm S. Activity-dependent and graded BACE1 expression in the olfactory epithelium is mediated by the retinoic acid metabolizing enzyme CYP26B1. Brain Struct Funct. 2015;220:2143-57 pubmed publisher
    ..We show that expression of BACE1 and the all-trans retinoic acid (RA)-degrading enzyme Cyp26B1 form DM-VL counter gradients in the olfactory epithelium...
  32. Roberts C, Ivins S, Cook A, Baldini A, Scambler P. Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick. Hum Mol Genet. 2006;15:3394-410 pubmed
    ..Using real-time PCR and in situ hybridization analysis of Cyp26a1 and its two functionally related family members Cyp26b1 and c1, we demonstrate reduced and/or altered expression for all three genes in pharyngeal tissues of Tbx1 null ..
  33. Bowles J, Feng C, Miles K, Ineson J, Spiller C, Koopman P. ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries. Nat Commun. 2016;7:10845 pubmed publisher
    ..Stra8 and enter meiosis, and that these effects are prevented in the fetal testis by the RA-degrading P450 enzyme CYP26B1. Nonetheless, the role of RA has been disputed principally because germ cells in embryos lacking two major RA-..
  34. El Shahawy M, Reibring C, Neben C, Hallberg K, Marangoni P, Harfe B, et al. Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017;13:e1006914 pubmed publisher
    ..These findings reveal key functions for SHH and RA in cell fate specification in the lingual epithelium and aid in deciphering the molecular mechanisms that assign cell identity. ..
  35. Makita T, Duncan S, Sucov H. Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol. 2005;280:59-72 pubmed
    ..5 onward is enhancer-independent, and is driven instead by basal promoter elements that provide a sufficient level of expression to support further erythropoietic differentiation. ..
  36. Uehara M, Yashiro K, Mamiya S, Nishino J, Chambon P, Dolle P, et al. CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse. Dev Biol. 2007;302:399-411 pubmed
  37. Okano J, Lichti U, Mamiya S, Aronova M, Zhang G, Yuspa S, et al. Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development. J Cell Sci. 2012;125:1827-36 pubmed publisher
    ..Absence of cytochrome P450, family 26, subfamily b, polypeptide 1 (Cyp26b1), a retinoic-acid-degrading enzyme, results in aberrant epidermal differentiation and filaggrin expression, ..
  38. Chambers D, Wilson L, Alfonsi F, Hunter E, Saxena U, Blanc E, et al. Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain. Neural Dev. 2009;4:6 pubmed publisher
    ..These findings give the first genome-wide insight into the complexity of gene expression during patterning of the developing hindbrain. ..
  39. Chenery A, Burrows K, Antignano F, Underhill T, Petkovich M, Zaph C. The retinoic acid-metabolizing enzyme Cyp26b1 regulates CD4 T cell differentiation and function. PLoS ONE. 2013;8:e72308 pubmed publisher
    ..Catabolism of RA is mediated by the Cyp26 family of cytochrome P450 oxidases. We examined the role of Cyp26b1, the T cell-specific family member, in CD4(+) T cells...
  40. Okano J, Levy C, Lichti U, Sun H, Yuspa S, Sakai Y, et al. Cutaneous retinoic acid levels determine hair follicle development and downgrowth. J Biol Chem. 2012;287:39304-15 pubmed publisher
    ..In the present study, we demonstrate that specific levels of RA, regulated by Cyp26b1, one of the RA-degrading enzymes, are required for hair follicle (hf) morphogenesis...
  41. Kataoka K, Matsushima T, Ito Y, Sato T, Yokoyama S, Asahara H. Bhlha9 regulates apical ectodermal ridge formation during limb development. J Bone Miner Metab. 2018;36:64-72 pubmed publisher
  42. Okano J, Kimura W, Papaionnou V, Miura N, Yamada G, Shiota K, et al. The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves. Dev Dyn. 2012;241:1744-56 pubmed publisher
    ..In the present study, we deleted Cyp26b1, one of the RA-degrading enzymes, to further study the effects of excess RA in the normal developing palate and ..
  43. Wu R, Zeng Y, Chen Y, Lanz R, Wu M. Temporal-Spatial Establishment of Initial Niche for the Primary Spermatogonial Stem Cell Formation Is Determined by an ARID4B Regulatory Network. Stem Cells. 2017;35:1554-1565 pubmed publisher
    ..Stem Cells 2017;35:1554-1565. ..
  44. Sheth R, Bastida M, Kmita M, Ros M. "Self-regulation," a new facet of Hox genes' function. Dev Dyn. 2014;243:182-91 pubmed publisher
    ..e., HOX controlling the establishment of the ultimate HOX code. ..
  45. Zaremba K, Reeder A, Kowalkowski A, Girma E, Nichol P. Utility and limits of Hprt-Cre technology in generating mutant mouse embryos. J Surg Res. 2014;187:386-93 pubmed publisher
    ..Null mutants for Cyp26b1, Pitx2, and Shh were generated with Hprt-Cre from conditional alleles as were double and triple allelic ..
  46. Billings S, Pierzchalski K, Butler Tjaden N, Pang X, Trainor P, KANE M, et al. The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB J. 2013;27:4877-89 pubmed publisher
    ..These data demonstrate that the reduction of retinaldehyde by DHRS3 is critical for preventing formation of excess ATRA during embryonic development...
  47. Abu Abed S, MacLean G, Fraulob V, Chambon P, Petkovich M, Dolle P. Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis. Mech Dev. 2002;110:173-7 pubmed
    We recently cloned the murine homologue of Cyp26B1, a novel retinoic acid (RA)-metabolizing enzyme and showed that its gene expression pattern is unique from that of Cyp26A1 during early embryogenesis...
  48. Cho K, Kwon H, Shin J, Lee J, Cho S, Tickle C, et al. Retinoic acid signaling and the initiation of mammary gland development. Dev Biol. 2012;365:259-66 pubmed publisher
    ..the expression of gene-encoding enzymes that produce retinoic acid (Raldh2) and enzymes that degrade it (Cyp26a1, Cyp26b1). We also analyzed the expression of RAR-?, a direct transcriptional target of retinoic acid signaling...
  49. Probst S, Kraemer C, Demougin P, Sheth R, Martin G, Shiratori H, et al. SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling. Development. 2011;138:1913-23 pubmed publisher
    ..retinoic acid (RA) target genes were upregulated proximally, while the expression of the RA-inactivating Cyp26b1 enzyme was downregulated distally, pointing to increased RA activity in Shh-deficient mouse limb buds...
  50. Schmidt K, Hughes C, Chudek J, Goodyear S, Aspden R, Talbot R, et al. Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb. Mol Cell Biol. 2009;29:2716-29 pubmed publisher
    ..Thus, cellular POR-dependent cholesterol synthesis is essential during limb and skeletal development. Modulation of P450 activity could contribute to susceptibility of the embryo and developing organs to teratogenesis. ..
  51. Alfano G, Conte I, Caramico T, Avellino R, Arnò B, Pizzo M, et al. Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye. Development. 2011;138:261-71 pubmed publisher
    ..These data demonstrate for the first time that Vax2 is both necessary and sufficient for the control of intraretinal RA metabolism, which in turn contributes to the appropriate expression of cone opsins in the vertebrate eye. ..
  52. Koubova J, Hu Y, Bhattacharyya T, Soh Y, Gill M, Goodheart M, et al. Retinoic acid activates two pathways required for meiosis in mice. PLoS Genet. 2014;10:e1004541 pubmed publisher
    ..Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function. ..
  53. Minegishi Y, Sakai Y, Yahara Y, Akiyama H, Yoshikawa H, Hosokawa K, et al. Cyp26b1 within the growth plate regulates bone growth in juvenile mice. Biochem Biophys Res Commun. 2014;454:12-8 pubmed publisher the diaphyseal portion of the growth plate cartilage were associated with the specific expression of Cyp26b1 in the epiphyseal portion in juvenile mice...
  54. Garcia T, Farmaha J, Kow S, Hofmann M. RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche. Development. 2014;141:4468-78 pubmed publisher
    ..Several Sertoli cell-expressed genes, such as Gdnf and Cyp26b1, have been identified as being indispensable for the proper maintenance of SSCs in their niche, but the pathways ..
  55. Li B, MATTESON P, Ababon M, Nato A, Lin Y, Nanda V, et al. The orphan GPCR, Gpr161, regulates the retinoic acid and canonical Wnt pathways during neurulation. Dev Biol. 2015;402:17-31 pubmed publisher
    ..These results establish the RA and canonical Wnt as pathways downstream of Gpr161 during neurulation, and suggest that Modvl5(MOLF) bypasses the Gpr161(vl) mutation by restoring the activity of these pathways. ..
  56. Guris D, Duester G, Papaioannou V, Imamoto A. Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome. Dev Cell. 2006;10:81-92 pubmed
    ..Thus, we suggest that del22q11 is a contiguous gene syndrome involving dose-sensitive interaction of CRKL and TBX1 and locally aberrant RA signaling. ..
  57. Lenti E, Farinello D, Yokoyama K, Penkov D, Castagnaro L, Lavorgna G, et al. Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development. J Clin Invest. 2016;126:2452-64 pubmed publisher
    ..Finally, spleen growth was impaired in mice lacking either cytochrome P450 26B1 (Cyp26b1), which results in excess RA, or retinol dehydrogenase 10 (Rdh10), which results in RA deficiency...
  58. Kipp J, Golebiowski A, Rodriguez G, Demczuk M, Kilen S, Mayo K. Gene expression profiling reveals Cyp26b1 to be an activin regulated gene involved in ovarian granulosa cell proliferation. Endocrinology. 2011;152:303-12 pubmed publisher
    ..The gene most strongly inhibited by activin was Cyp26b1, which encodes a P450 cytochrome enzyme that degrades retinoic acid (RA)...
  59. Li Y, Zhang L, Hu Y, Han F, Qin Y, Chen M, et al. β-Catenin directs the transformation of testis Sertoli cells to ovarian granulosa-like cells by inducing Foxl2 expression. J Biol Chem. 2017;292:17577-17586 pubmed publisher
    ..Our study provides a new mechanism for Sertoli cell lineage maintenance during gonad development. ..
  60. Zhang J, Smith D, Yamamoto M, Ma L, McCaffery P. The meninges is a source of retinoic acid for the late-developing hindbrain. J Neurosci. 2003;23:7610-20 pubmed
    ..Further regulation of RA signaling is provided by the presence of a RA sink in the form of the CYP26B1 RA catabolic enzyme expressed in deeper regions of the brain...
  61. Guerquin M, Duquenne C, Lahaye J, Tourpin S, Habert R, Livera G. New testicular mechanisms involved in the prevention of fetal meiotic initiation in mice. Dev Biol. 2010;346:320-30 pubmed publisher
    ..5 dpc whereas in the male, germ cells undergo mitotic arrest. Recent findings indicate that Cyp26b1, a RA-degrading enzyme, is a key factor preventing initiation of meiosis in the fetal testis...
  62. Kuerbitz J, Arnett M, Ehrman S, Williams M, Vorhees C, Fisher S, et al. Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes. J Neurosci. 2018;38:1160-1177 pubmed publisher
  63. Pennimpede T, Cameron D, Maclean G, Petkovich M. Analysis of Cyp26b1/Rarg compound-null mice reveals two genetically separable effects of retinoic acid on limb outgrowth. Dev Biol. 2010;339:179-86 pubmed publisher
    ..similarly, changes in the endogenous distribution of RA following genetic ablation of the RA-metabolizing enzyme, CYP26B1, result in phocomelia accompanied by changes in expression of proximo-distal (P-D) patterning genes, increased ..
  64. Li P, Pashmforoush M, Sucov H. Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation. Dev Cell. 2010;18:480-5 pubmed publisher
    ..This may be a common pathogenic pathway when second heart field and septation defects are coupled. ..
  65. Login H, HÃ¥glin S, Berghard A, Bohm S. The Stimulus-Dependent Gradient of Cyp26B1+ Olfactory Sensory Neurons Is Necessary for the Functional Integrity of the Olfactory Sensory Map. J Neurosci. 2015;35:13807-18 pubmed publisher
    Stimulus-dependent expression of the retinoic acid-inactivating enzyme Cyp26B1 in olfactory sensory neurons (OSNs) forms a dorsomedial (DM)-ventrolateral (VL) gradient in the mouse olfactory epithelium...
  66. Fujimoto Y, Tanaka S, Yamaguchi Y, Kobayashi H, Kuroki S, Tachibana M, et al. Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev Cell. 2013;26:416-30 pubmed publisher
    ..The regulation of Fog2 induces Sry expression in male sex determination, and the regulation of Nr5a1 in gonadal precursor formation determines gonadal size. ..
  67. Shou S, Carlson H, Perez W, Stadler H. HOXA13 regulates Aldh1a2 expression in the autopod to facilitate interdigital programmed cell death. Dev Dyn. 2013;242:687-98 pubmed publisher
    ..These findings provide new insights into the transcriptional regulation of RA signaling necessary for limb morphogenesis. ..