Cyp1b1

Summary

Gene Symbol: Cyp1b1
Description: cytochrome P450, family 1, subfamily b, polypeptide 1
Alias: CP1B, P4501b1, cytochrome P450 1B1, CYPIB1, benz[a]anthracene inducible, cytochrome P450, 1b1, benz[a]anthracene inducible, cytochrome P450CMEF, cytochrome P450EF
Species: mouse
Products:     Cyp1b1

Top Publications

  1. Choudhary D, Jansson I, Stoilov I, Sarfarazi M, Schenkman J. Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues. Arch Biochem Biophys. 2005;436:50-61 pubmed
    ..Highest expression of the individual CYPs in the different late term human fetal tissues was: thymus, CYP1B1 and CYP2U1; liver, CYP2E1; brain, CYP2R1, CYP1A1 and CYP4X1; and lung, CYP4B1 and CYP2W1...
  2. Vasiliou V, Gonzalez F. Role of CYP1B1 in glaucoma. Annu Rev Pharmacol Toxicol. 2008;48:333-58 pubmed
    ..Genetic linkage analysis and mutation studies have identified CYP1B1 as a causative gene in PCG, as a modifier gene in POAG, and, on rare occasions, as causative gene in POAG as well ..
  3. White K, Johansen A, Nilsen M, Ciuclan L, Wallace E, Paton L, et al. Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension. Circulation. 2012;126:1087-98 pubmed publisher
    ..Curiously, heightened expression of the estrogen-metabolizing enzyme cytochrome P450 1B1 (CYP1B1) is reported in idiopathic PAH and murine models of PAH...
  4. Buters J, Sakai S, Richter T, Pineau T, Alexander D, Savas U, et al. Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas. Proc Natl Acad Sci U S A. 1999;96:1977-82 pubmed
    b>CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype, thus establishing that CYP1B1 is not required for mouse development...
  5. Jennings B, Sahan Firat S, Estes A, Das K, Farjana N, Fang X, et al. Cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology. Hypertension. 2010;56:667-74 pubmed publisher
    ..Our recent study showing that angiotensin II-induced vascular smooth muscle cell growth depends on cytochrome P450 1B1 led us to investigate its contribution to hypertension caused by this peptide...
  6. Zheng W, Tong T, Lee J, Liu X, Marcus C, Jefcoate C. Stimulation of mouse Cyp1b1 during adipogenesis: characterization of promoter activation by the transcription factor Pax6. Arch Biochem Biophys. 2013;532:1-14 pubmed publisher
    Cytochrome P4501B1 (Cyp1b1) is expressed specifically in certain neural crest (NC) cells during embryogenesis. Mesenchymal progenitor cells that develop from NC cells are modeled here by mouse C3H10T1/2 and 3T3-L1 cells...
  7. White K, Loughlin L, Maqbool Z, Nilsen M, McClure J, Dempsie Y, et al. Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH. Physiol Genomics. 2011;43:417-37 pubmed publisher
    ..In relevant groups, immunoblotting was performed for genes of interest (CEBP?, CYP1B1, and FOS)...
  8. Choudhary D, Jansson I, Stoilov I, Sarfarazi M, Schenkman J. Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004;32:840-7 pubmed
    ..For example, mouse Cyp1b1 was originally identified as the enzyme responsible for oxidative metabolism of 7,12-dimethylbenz(alpha)anthracene ..
  9. Palenski T, Gurel Z, Sorenson C, Hankenson K, Sheibani N. Cyp1B1 expression promotes angiogenesis by suppressing NF-?B activity. Am J Physiol Cell Physiol. 2013;305:C1170-84 pubmed publisher
    ..We recently demonstrated that cytochrome P-450 1B1 (Cyp1B1) deficiency in endothelial cells (EC) and pericytes (PC) results in increased oxidative stress, alterations in ..

More Information

Publications78

  1. Savas U, Carstens C, Jefcoate C. Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B1. Arch Biochem Biophys. 1997;347:181-92 pubmed
    Orthologs of a previously identified CYP1B subfamily designated CYP1B1, which are constitutively expressed in mammary, uterine, and embryonic cells, have previously been functionally linked to 7,12-dimethylbenz-a-anthracene (DMBA) ..
  2. Jennings B, Moore J, Pingili A, Estes A, Fang X, Kanu A, et al. Disruption of the cytochrome P-450 1B1 gene exacerbates renal dysfunction and damage associated with angiotensin II-induced hypertension in female mice. Am J Physiol Renal Physiol. 2015;308:F981-92 pubmed publisher
    ..The present study was conducted to determine if Cyp1b1 gene disruption ameliorates renal dysfunction and organ damage associated with ANG II-induced hypertension in ..
  3. Pingili A, Kara M, Khan N, Estes A, Lin Z, Li W, et al. 6β-hydroxytestosterone, a cytochrome P450 1B1 metabolite of testosterone, contributes to angiotensin II-induced hypertension and its pathogenesis in male mice. Hypertension. 2015;65:1279-87 pubmed publisher
    ..This study was conducted to test the hypothesis that cytochrome P450 1B1-generated metabolites of testosterone, 6β-hydroxytestosterone and 16α-hydroxytestosterone, contribute ..
  4. Smerdová L, Šmerdová J, Kabátková M, Kohoutek J, Blažek D, Machala M, et al. Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway. Carcinogenesis. 2014;35:2534-43 pubmed publisher
    b>Cytochrome P450 1B1 (CYP1B1) is an enzyme that has a unique tumor-specific pattern of expression and is capable of bioactivating a wide range of carcinogenic compounds...
  5. Kerzee J, Ramos K. Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells: role of the Ahr bHLH/PAS transcription factor. Circ Res. 2001;89:573-82 pubmed
    ..The present studies were conducted to examine constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells (VSMCs) from Ahr(+/+) and Ahr(-/-) mice...
  6. Jennings B, Anderson L, Estes A, Yaghini F, Fang X, Porter J, et al. Cytochrome P450 1B1 contributes to renal dysfunction and damage caused by angiotensin II in mice. Hypertension. 2012;59:348-54 pubmed publisher
    b>Cytochrome P450 1B1 contributes to the development of angiotensin II-induced hypertension and associated cardiovascular pathophysiology...
  7. Jiang F, Cui L, Liu X. [Structural observation of the anterior chamber angle in CYP1B1-null mice]. Zhonghua Yan Ke Za Zhi. 2008;44:418-22 pubmed
    To determine the effects of CYP1B1 gene on the structure of anterior chamber angle in mice. It is experimental study. Adult CYP1B1-null mice were used, in comparison C57BL/6J mice was used as control...
  8. Madeen E, Löhr C, You H, Siddens L, Krueger S, Dashwood R, et al. Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. Mol Carcinog. 2017;56:163-171 pubmed publisher
    ..Utilizing a mouse model, null for Cyp1b1 and expressing human CYP1B1, we tested the hypothesis that hCYP1B1 is important for dibenzo[def,p]chrysene (DBC) ..
  9. Peng J, Xu X, Mace B, Vanderveer L, Workman L, Slifker M, et al. Estrogen metabolism within the lung and its modulation by tobacco smoke. Carcinogenesis. 2013;34:909-15 pubmed publisher
    ..Levels of 4-OHEs, carcinogenic derivatives produced primarily by cytochrome P450 1B1 (Cyp1b1), were 2-fold higher in females than males...
  10. Choudhary D, Jansson I, Rezaul K, Han D, Sarfarazi M, Schenkman J. Cyp1b1 protein in the mouse eye during development: an immunohistochemical study. Drug Metab Dispos. 2007;35:987-94 pubmed
    We show, for the first time, the spatiotemporal appearance of Cyp1b1 protein during mouse eye ontogeny...
  11. Bushkofsky J, Maguire M, Larsen M, Fong Y, Jefcoate C. Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4α and PPARα. Arch Biochem Biophys. 2016;597:30-47 pubmed publisher
    b>Cytochrome P450 1b1 (Cyp1b1) is expressed in endothelia, stellate cells and pre-adipocytes, but not hepatocytes. Deletion alters liver fatty acid metabolism and prevents obesity and hepatic steatosis...
  12. Sarfarazi M, Stoilov I, Schenkman J. Genetics and biochemistry of primary congenital glaucoma. Ophthalmol Clin North Am. 2003;16:543-54, vi pubmed
    ..of PCG was confirmed by genetic linkage studies conducted in the 1990s when the authors determined that CYP1B1 is the congenital glaucoma gene at the GLC3A locus...
  13. Jennings B, Estes A, Anderson L, Fang X, Yaghini F, Fan Z, et al. Cytochrome P450 1B1 gene disruption minimizes deoxycorticosterone acetate-salt-induced hypertension and associated cardiac dysfunction and renal damage in mice. Hypertension. 2012;60:1510-6 pubmed publisher
    Previously, we showed that the cytochrome P450 1B1 inhibitor 2,3',4,5'-tetramethoxystilbene reversed deoxycorticosterone acetate (DOCA)-salt-induced hypertension and minimized endothelial and renal dysfunction in the rat...
  14. Uno S, Dragin N, Miller M, Dalton T, Gonzalez F, Nebert D. Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract. Free Radic Biol Med. 2008;44:570-83 pubmed
    The CYP1A1, CYP1A2, and CYP1B1 enzymes are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); metabolism of BaP by these enzymes leads to electrophilic intermediates and genotoxicity...
  15. Shen Z, Liu J, Wells R, Elkind M. cDNA cloning, sequence analysis, and induction by aryl hydrocarbons of a murine cytochrome P450 gene, Cyp1b1. DNA Cell Biol. 1994;13:763-9 pubmed
    ..Accordingly, the Committee on Standardized Cytochrome P450 Nomenclature designated the gene Cyp1b1. Exposure to various aryl hydrocarbons (2...
  16. Song C, Ghafoor K, Ghafoor H, Khan N, Thirunavukkarasu S, Jennings B, et al. Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice. Hypertension. 2016;67:206-13 pubmed publisher
    ..This study was conducted to determine the contribution of CYP1B1 to the development of atherosclerosis and hypertension and associated pathogenesis in 8-week-old male ..
  17. Hwang D, Chae K, Shin D, Hwang J, Lim C, Kim Y, et al. Xenobiotic response in humanized double transgenic mice expressing tetracycline-controlled transactivator and human CYP1B1. Arch Biochem Biophys. 2001;395:32-40 pubmed
    ..In this study, we used the tetracycline-regulated (tet) promoter system to increase the expression of the human CYP1B1 (hCYP1B1) gene in the tissues of transgenic mice...
  18. Ociepa Zawal M, Rubis B, Filas V, Breborowicz J, Trzeciak W. Studies on CYP1A1, CYP1B1 and CYP3A4 gene polymorphisms in breast cancer patients. Ginekol Pol. 2009;80:819-23 pubmed
    The role of CYP1A1, CYP1B1 and CYP3A4 polymorphism in pathogenesis of breast cancer has not been fully elucidated...
  19. Savas U, Bhattacharyya K, Christou M, Alexander D, Jefcoate C. Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression. J Biol Chem. 1994;269:14905-11 pubmed
    ..These sequence relationships suggest that P450EF is a member of a new CYP1B subfamily (mouse CYP1B1)...
  20. Chambers D, Wilson L, Alfonsi F, Hunter E, Saxena U, Blanc E, et al. Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain. Neural Dev. 2009;4:6 pubmed publisher
    ..These findings give the first genome-wide insight into the complexity of gene expression during patterning of the developing hindbrain. ..
  21. Ward J, Nikolov N, Tschetter J, Kopp J, Gonzalez F, Kimura S, et al. Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice. Toxicol Pathol. 2004;32:710-8 pubmed
    The cytochrome P450 CYP1B1 enzyme metabolically activates polycyclic aromatic hydrocarbons and is a major P450 isoenzyme in human monocytes and macrophages...
  22. Galvez Peralta M, Shi Z, Chen J, Miller M, Nebert D. Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct. Int J Cancer. 2013;132:2065-75 pubmed publisher
    ..Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates involved in mutagenesis and tumor ..
  23. Nebert D, Dalton T, Okey A, Gonzalez F. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem. 2004;279:23847-50 pubmed
    The mammalian CYP1A1, CYP1A2, and CYP1B1 genes (encoding cytochromes P450 1A1, 1A2, and 1B1, respectively) are regulated by the aromatic hydrocarbon receptor (AHR)...
  24. Chatuphonprasert W, Jarukamjorn K, Putalun W. Regulation of cancer-related genes - Cyp1a1, Cyp1b1, Cyp19, Nqo1 and Comt - expression in β-naphthoflavone-treated mice by miroestrol. J Pharm Pharmacol. 2016;68:475-84 pubmed publisher
    ..The expression of cancer-related genes including cytochrome P450 1A (Cyp1a), cytochrome P450 1B1 (Cyp1b1), aromatase P450 (Cyp19), NAD(P)H: quinone oxidoreductase 1 (Nqo1) and catechol-O-methyltransferase ..
  25. Gonzalez F, Kimura S. Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis. Cancer Lett. 1999;143:199-204 pubmed
    ..Mouse lines having disruption of genes encoding P450s CYP1A2, CYP2E1, and CYP1B1 were developed by use of gene disruption in empbryonic stem cells...
  26. Pottenger L, Christou M, Jefcoate C. Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells. Arch Biochem Biophys. 1991;286:488-97 pubmed
    ..P450-EF is probably distantly related to the P450IIA subfamily and may belong to a new P450 subfamily. ..
  27. Maguire M, Larsen M, Foong Y, Tanumihardjo S, Jefcoate C. Cyp1b1 deletion and retinol deficiency coordinately suppress mouse liver lipogenic genes and hepcidin expression during post-natal development. Mol Cell Endocrinol. 2017;454:50-68 pubmed publisher
    b>Cyp1b1 deletion and gestational vitamin A deficiency (GVAD) redirect adult liver gene expression...
  28. Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate C, et al. Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury. Biochem Biophys Res Commun. 2016;476:346-351 pubmed publisher
    ..The role of CYP1B1 in oxygen-mediated pulmonary toxicity has not been studied...
  29. Castro D, Baird W, Pereira C, Giovanini J, LOHR C, Fischer K, et al. Fetal mouse Cyp1b1 and transplacental carcinogenesis from maternal exposure to dibenzo(a,l)pyrene. Cancer Prev Res (Phila). 2008;1:128-34 pubmed publisher
    ..Targeted disruption of the cyp1b1 gene protects against most DBP-dependent cancers...
  30. Uno S, Dalton T, Dragin N, Curran C, Derkenne S, Miller M, et al. Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. Mol Pharmacol. 2006;69:1103-14 pubmed
    CYP1A1 and CYP1B1 metabolically activate many polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene, to reactive intermediates associated with toxicity, mutagenesis, and carcinogenesis...
  31. Shin S, Wakabayashi N, Misra V, Biswal S, Lee G, Agoston E, et al. NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Mol Cell Biol. 2007;27:7188-97 pubmed
    ..of the AHR signaling cascade, including (i) transcriptional control of the xenobiotic metabolism genes Cyp1a1 and Cyp1b1 and (ii) inhibition of adipogenesis in mouse embryonic fibroblasts (MEFs)...
  32. Stoilov I, Rezaie T, Jansson I, Schenkman J, Sarfarazi M. Expression of cytochrome P4501b1 (Cyp1b1) during early murine development. Mol Vis. 2004;10:629-36 pubmed
    To examine the embryonic expression of cytochrome P4501b1 (Cyp1b1) gene by whole mount in situ hybridization. FVB/NcrlBR mouse embryos staged at 9.5, 10.5, and 11.5 dpc were obtained by timed breeding experiments...
  33. Xu M, Miller M. Determination of murine fetal Cyp1a1 and 1b1 expression by real-time fluorescence reverse transcription-polymerase chain reaction. Toxicol Appl Pharmacol. 2004;201:295-302 pubmed
    ..In addition, we demonstrate for the first time the induction of Cyp1b1 RNA expression in fetal lung and liver tissues following in utero exposure to 3-methylcholanthrene (MC), a ..
  34. Zhao Y, Wang S, Sorenson C, Teixeira L, Dubielzig R, Peters D, et al. Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress. Mol Cell Biol. 2013;33:4225-40 pubmed publisher
    Mutation in CYP1B1 has been reported for patients with congenital glaucoma. However, the underlying mechanisms remain unknown. Here we show increased diurnal intraocular pressure (IOP) in Cyp1b1-deficient (Cyp1b1(-/-)) mice...
  35. Kumar M, Jain M, Sehgal A, Sharma V. Modulation of CYP1A1, CYP1B1 and DNA adducts level by green and white tea in Balb/c mice. Food Chem Toxicol. 2012;50:4375-81 pubmed publisher
    ..WT elucidate greater efficacy in ameliorating BaP toxicity, but further long term studies are required to validate white tea as a cancer chemopreventive agent. ..
  36. Harel I, Maezawa Y, Avraham R, Rinon A, Ma H, Cross J, et al. Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci U S A. 2012;109:18839-44 pubmed publisher
    ..We suggest that PM-derived cardiogenesis and myogenesis are network properties rather than properties specific to individual PM members. These findings shed new light on the developmental underpinnings of congenital defects. ..
  37. Siddens L, Bunde K, Harper T, McQuistan T, LOHR C, Bramer L, et al. Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. Toxicol Appl Pharmacol. 2015;287:149-160 pubmed publisher
    ..These results document that Cyp 1b1 plays a significant role in bioactivation and carcinogenesis of DBC in a two-stage mouse skin tumor model and that loss of Cyp 1b1 has little impact on tumor response with BaP or CTE as initiators. ..
  38. Hushka L, Williams J, Greenlee W. Characterization of 2,3,7,8-tetrachlorodibenzofuran-dependent suppression and AH receptor pathway gene expression in the developing mouse mammary gland. Toxicol Appl Pharmacol. 1998;152:200-10 pubmed
    ..nuclear translocator (ARNT; the heterodimerization partner of AHR), and two AHR-regulated genes, Cyp1A1 and Cyp1B1, were similar and not altered by treatment of mammary glands in organ culture with TCDF...
  39. Behesti H, Papaioannou V, Sowden J. Loss of Tbx2 delays optic vesicle invagination leading to small optic cups. Dev Biol. 2009;333:360-72 pubmed publisher
    ..Dorsal expression of potential regulators of retinal growth, Cyp1b1 and Cx43, and the topographic guidance molecule ephrinB2, was increased, and intraretinal axons were disorganised ..
  40. Palenski T, Sorenson C, Jefcoate C, Sheibani N. Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells. Lab Invest. 2013;93:646-62 pubmed publisher
    ..We recently showed that a Cyp1B1 deficiency in mice results in the attenuation of angiogenesis in vivo and the pro-angiogenic activity of ..
  41. Dragin N, Dalton T, Miller M, Shertzer H, Nebert D. For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential. J Biol Chem. 2006;281:18591-600 pubmed
    ..The Cyp1a1, Cyp1a2, and Cyp1b1 genes are up-regulated by the aryl hydrocarbon receptor...
  42. Gao J, Lauer F, Dunaway S, Burchiel S. Cytochrome P450 1B1 is required for 7,12-dimethylbenz(a)-anthracene (DMBA) induced spleen cell immunotoxicity. Toxicol Sci. 2005;86:68-74 pubmed
    ..Previous studies have shown that CYP1B1 is required for bone marrow toxicity produced by DMBA in mice...
  43. Harper T, Morré J, Lauer F, McQuistan T, Hummel J, Burchiel S, et al. Analysis of dibenzo[def,p]chrysene-deoxyadenosine adducts in wild-type and cytochrome P450 1b1 knockout mice using stable-isotope dilution UHPLC-MS/MS. Mutat Res Genet Toxicol Environ Mutagen. 2015;782:51-6 pubmed publisher
    ..this study was designed to identify DBCDE-DNA adduct formation in the spleen and thymus of wild-type and cytochrome P450 1b1 (Cyp1b1) knockout (KO) mice using a highly sensitive stable-isotope dilution UHPLC-MS/MS method...
  44. LU J, Izvolsky K, Qian J, Cardoso W. Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis. J Biol Chem. 2005;280:4834-41 pubmed
    ..Our approach identifies Fgf10 targets that are common to multiple biological processes and provides insights into potential mechanisms by which Fgf signaling regulates epithelial cell behavior. ..
  45. Dempsie Y, MacRitchie N, White K, Morecroft I, Wright A, Nilsen M, et al. Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension. Cardiovasc Res. 2013;99:24-34 pubmed publisher
    ..Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH...
  46. Dragin N, Uno S, Wang B, Dalton T, Nebert D. Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line. Biochem Biophys Res Commun. 2007;359:635-42 pubmed
    ..8% C57BL/6J genetic background-having both human genes replacing the mouse orthologs. This line will be valuable for human risk assessment studies involving any environmental toxicant or drug that is a substrate for CYP1A1 or CYP1A2. ..
  47. Gonzalez F, Kimura S. Study of P450 function using gene knockout and transgenic mice. Arch Biochem Biophys. 2003;409:153-8 pubmed
    ..The P450s chosen for study, CYP1A1, CYP1B1, CYP1A2, and CYP2E1, are conserved in mammals and are known to metabolize most toxicants and chemical carcinogens...
  48. Vezina C, ALLGEIER S, Moore R, Lin T, Bemis J, Hardin H, et al. Dioxin causes ventral prostate agenesis by disrupting dorsoventral patterning in developing mouse prostate. Toxicol Sci. 2008;106:488-96 pubmed publisher
    ..Disrupted axial patterning provides a new paradigm for understanding how in utero TCDD exposure causes ventral prostate agenesis and may shed light on how TCDD impairs development of other organs. ..
  49. Shertzer H, Genter M, Talaska G, Curran C, Nebert D, Dalton T. 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis. 2007;28:1371-8 pubmed
    ..Using knockout mice for Cyp1a1, Cyp1a2 and Cyp1b1, we showed that the major CYP1 enzymes that metabolize DBC are CYP1A1 in beta-naphthoflavone (BNF)-induced liver, ..
  50. MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson J, Matthews J. 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acids Res. 2013;41:1604-21 pubmed publisher
    ..TiPARP in T-47D breast cancer and HuH-7 hepatoma cells increased TCDD-dependent cytochrome P450 1A1 (CYP1A1) and CYP1B1 messenger RNA (mRNA) expression levels and recruitment of AHR to both genes...
  51. Deb S, Tai J, Leung G, Chang T, Bandiera S. Estradiol-mediated suppression of CYP1B1 expression in mouse MA-10 Leydig cells is independent of protein kinase A and estrogen receptor. Mol Cell Biochem. 2011;358:387-95 pubmed publisher
    ..In the present study, we focused on estradiol as a potential regulator of testicular cytochrome P450 1B1 (CYP1B1) expression and investigated the possible mechanisms involved in the estradiol-mediated suppression...
  52. Li F, Jiang C, Larsen M, Bushkofsky J, Krausz K, Wang T, et al. Lipidomics reveals a link between CYP1B1 and SCD1 in promoting obesity. J Proteome Res. 2014;13:2679-87 pubmed publisher
    b>Cytochrome P450 1B1 (CYP1B1) is involved in the metabolism of xenobiotic compounds and endogenous metabolites...
  53. Lewis J, Bürgler C, Fraser J, Liao H, Golubets K, Kucher C, et al. Mechanisms of chemical cooperative carcinogenesis by epidermal Langerhans cells. J Invest Dermatol. 2015;135:1405-1414 pubmed publisher
    ..LC expression of p450 enzyme CYP1B1 is required for maximal rapid induction of DNA-damage within adjacent keratinocytes and their efficient neoplastic ..
  54. Shen Z, Wells R, Liu J, Elkind M. Identification of a cytochrome P450 gene by reverse transcription--PCR using degenerate primers containing inosine. Proc Natl Acad Sci U S A. 1993;90:11483-7 pubmed
    ..This method should be useful in identifying additional P450 genes and genes in other gene families. ..
  55. Divanovic S, Dalli J, Jorge Nebert L, Flick L, Galvez Peralta M, Boespflug N, et al. Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways. J Immunol. 2013;191:3347-57 pubmed publisher
    ..Together, these results demonstrate novel contributions of CYP1 enzymes to the local metabolite profile of lipid mediators that regulate neutrophilic inflammation. ..
  56. Alexander D, Eltom S, Jefcoate C. Ah receptor regulation of CYP1B1 expression in primary mouse embryo-derived cells. Cancer Res. 1997;57:4498-506 pubmed
    Cytochrome P4501B1 is highly active in the bioactivation of polycyclic aromatic hydrocarbons (PAHs) to mutagenic metabolites...
  57. Bansal S, Leu A, Gonzalez F, Guengerich F, Chowdhury A, Anandatheerthavarada H, et al. Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction. J Biol Chem. 2014;289:9936-51 pubmed publisher
    We report that polycyclic aromatic hydrocarbon (PAH)-inducible CYP1B1 is targeted to mitochondria by sequence-specific cleavage at the N terminus by a cytosolic Ser protease (polyserase 1) to activate the cryptic internal signal...
  58. Iqbal J, Sun L, Cao J, Yuen T, Lu P, Bab I, et al. Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes. Proc Natl Acad Sci U S A. 2013;110:11115-20 pubmed publisher
    ..Finally, deletion of the Cyp1a1, Cyp1a2, and Cyp1b1 in triple knockout mice resulted in reduced bone resorption and recapitulated the high bone mass phenotype of Ahr(-..
  59. Dong H, Shertzer H, Genter M, Gonzalez F, Vasiliou V, Jefcoate C, et al. Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. Biochem Biophys Res Commun. 2013;435:727-32 pubmed publisher
    ..enzymes--NAD(P)H: quinone oxidoreductase-1 (NQO1) and three cytochromes P450 (CYP1A1, CYP1A2 & CYP1B1)--are implicated in both detoxication and metabolic activation of various endobiotics and xenobiotics...
  60. Tang Y, Scheef E, Wang S, Sorenson C, Marcus C, Jefcoate C, et al. CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression. Blood. 2009;113:744-54 pubmed publisher
    ..We show that CYP1B1-deficient (CYP1B1(-/-)) mice fail to elicit a neovascular response during oxygen-induced ischemic retinopathy...
  61. Tang Y, Scheef E, Gurel Z, Sorenson C, Jefcoate C, Sheibani N. CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress. Am J Physiol Cell Physiol. 2010;298:C665-78 pubmed publisher
    We have recently shown that deletion of constitutively expressed CYP1B1 is associated with attenuation of retinal endothelial cell (EC) capillary morphogenesis (CM) in vitro and angiogenesis in vivo...
  62. Du X, Zhou X, Cao R, Xiao P, Teng Y, Ning C, et al. FSH-induced p38-MAPK-mediated dephosphorylation at serine 727 of the signal transducer and activator of transcription 1 decreases Cyp1b1 expression in mouse granulosa cells. Cell Signal. 2015;27:6-14 pubmed publisher
    ..b>Cyp1b1, a member of the cytochrome P450 1 subfamily, is responsible for the metabolism of a wide variety of halogenated ..
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    Crossing the Cyp1a1/1a2(-/-) double-knockout mouse with the Cyp1b1(-/-) single-knockout mouse, we generated the Cyp1a1/1a2/1b1(-/-) triple-knockout mouse...
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    ..From our studies we have identified candidate genes, Cyp1b1, Fkbp51 and MafB as potential androgen targets during mouse GT masculinization.
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    ..We assessed the contribution of CYP1B1 to angiotensin (Ang) II-induced abdominal aortic aneurysm (AAA)...
  66. Maayah Z, Althurwi H, El Sherbeni A, Abdelhamid G, Siraki A, El Kadi A. The role of cytochrome P450 1B1 and its associated mid-chain hydroxyeicosatetraenoic acid metabolites in the development of cardiac hypertrophy induced by isoproterenol. Mol Cell Biochem. 2017;429:151-165 pubmed publisher
    Numerous experimental studies have demonstrated the role of cytochrome P450 1B1 (CYP1B1) and its associated mid-chain hydroxyeicosatetraenoic acids (mid-chain HETEs) metabolite in the pathogenesis of cardiac hypertrophy...
  67. Borland M, Krishnan P, Lee C, Albrecht P, Shan W, Bility M, et al. Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor ?/? (PPAR?/?) in keratinocytes. Carcinogenesis. 2014;35:1602-12 pubmed publisher
    ..Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes...
  68. Nishida C, Everett S, Ortiz de Montellano P. Specificity determinants of CYP1B1 estradiol hydroxylation. Mol Pharmacol. 2013;84:451-8 pubmed publisher
    ..P450 enzymes, including CYP1A1 and CYP1A2, exhibit a high preference for estradiol 2-hydroxylation, but human CYP1B1 greatly favors 4-hydroxylation...
  69. Libby R, Smith R, Savinova O, Zabaleta A, Martin J, Gonzalez F, et al. Modification of ocular defects in mouse developmental glaucoma models by tyrosinase. Science. 2003;299:1578-81 pubmed
    Mutations in the cytochrome P450 family 1, subfamily B, polypeptide 1 (CYP1B1) gene are a common cause of human primary congenital glaucoma (PCG)...