Gene Symbol: Cyp1a1
Description: cytochrome P450, family 1, subfamily a, polypeptide 1
Alias: AHH, AHRR, CP11, CYPIA1, P450-1, cytochrome P450 1A1, cytochrome P450 subfamily I, polypeptide 1, cytochrome P450, 1a1, aromatic compound inducible, cytochrome P450-P1
Species: mouse
Products:     Cyp1a1

Top Publications

  1. Salbaum J, Kruger C, Zhang X, Delahaye N, Pavlinkova G, Burk D, et al. Altered gene expression and spongiotrophoblast differentiation in placenta from a mouse model of diabetes in pregnancy. Diabetologia. 2011;54:1909-20 pubmed publisher
  2. Ito S, Chen C, Satoh J, Yim S, Gonzalez F. Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut. J Clin Invest. 2007;117:1940-50 pubmed
    b>Cytochrome P450 1A1 (CYP1A1) is one of the most important detoxification enzymes due to its broad substrate specificity and wide distribution throughout the body...
  3. Shi Z, Dragin N, Galvez Peralta M, Jorge Nebert L, Miller M, Wang B, et al. Organ-specific roles of CYP1A1 during detoxication of dietary benzo[a]pyrene. Mol Pharmacol. 2010;78:46-57 pubmed publisher
    ..This lab has previously shown that Cyp1a1(-/-) global knockout mice treated by oral administration of BaP die at 28 to 32 days with immunosuppression, ..
  4. Uno S, Dragin N, Miller M, Dalton T, Gonzalez F, Nebert D. Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract. Free Radic Biol Med. 2008;44:570-83 pubmed
    The CYP1A1, CYP1A2, and CYP1B1 enzymes are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); metabolism of BaP by these enzymes leads to electrophilic intermediates and genotoxicity...
  5. Nebert D, Dalton T, Okey A, Gonzalez F. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem. 2004;279:23847-50 pubmed
    The mammalian CYP1A1, CYP1A2, and CYP1B1 genes (encoding cytochromes P450 1A1, 1A2, and 1B1, respectively) are regulated by the aromatic hydrocarbon receptor (AHR)...
  6. Wincent E, Bengtsson J, Mohammadi Bardbori A, Alsberg T, Luecke S, Rannug U, et al. Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor. Proc Natl Acad Sci U S A. 2012;109:4479-84 pubmed publisher
    ..FICZ is both the most tightly bound endogenous agonist for the AHR and an ideal substrate for cytochrome CYP1A1/1A2 and 1B1, thereby also participating in an autoregulatory loop that keeps its own steady-state concentration ..
  7. Uno S, Dalton T, Dragin N, Curran C, Derkenne S, Miller M, et al. Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. Mol Pharmacol. 2006;69:1103-14 pubmed
    b>CYP1A1 and CYP1B1 metabolically activate many polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene, to reactive intermediates associated with toxicity, mutagenesis, and carcinogenesis...
  8. Nukaya M, Moran S, Bradfield C. The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology. Proc Natl Acad Sci U S A. 2009;106:4923-8 pubmed publisher
    ..The Cyp1a1 and Cyp1a2 loci represent linked genes thought to play important roles in AHR biology...
  9. Nemoto N, Sakurai J. Differences in regulation of gene expression between Cyp1a-1 and Cyp1a-2 in adult mouse hepatocytes in primary culture. Carcinogenesis. 1992;13:2249-54 pubmed
    ..The expression of 3-methylcholanthrene (MCA)-induced CYP1A1 mRNA remained high during the observation period under both monolayer and spheroid culture conditions...

More Information


  1. Kimura S, Smith H, Hankinson O, Nebert D. Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast. EMBO J. 1987;6:1929-33 pubmed
    ..wild-type (wt) cell line were examined for their lack of P(1)450 [aryl hydrocarbon (benzo[a]pyrene) hydroxylase (AHH)] activity...
  2. Pendurthi U, Okino S, Tukey R. Accumulation of the nuclear dioxin (Ah) receptor and transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes. Arch Biochem Biophys. 1993;306:65-9 pubmed
  3. Youngblood G, Nesbitt M, Payne A. The structural genes encoding P450scc and P450arom are closely linked on mouse chromosome 9. Endocrinology. 1989;125:2784-6 pubmed
    ..The information presented in this report, along with other studies, indicate conservation between homologous human and mouse chromosomal regions and suggest that human P450SCC will be found to be closely linked with human P450arom. ..
  4. Dong H, Shertzer H, Genter M, Gonzalez F, Vasiliou V, Jefcoate C, et al. Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. Biochem Biophys Res Commun. 2013;435:727-32 pubmed publisher
    Four dioxin-inducible enzymes--NAD(P)H: quinone oxidoreductase-1 (NQO1) and three cytochromes P450 (CYP1A1, CYP1A2 & CYP1B1)--are implicated in both detoxication and metabolic activation of various endobiotics and xenobiotics...
  5. Gonzalez F, Mackenzie P, Kimura S, Nebert D. Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450. Gene. 1984;29:281-92 pubmed
    ..The 3' terminal exon of P1-450 is about 500 bp longer than that of P3-450. These data suggest that both P1-450 and P3-450 have diverged from a common ancestral gene. ..
  6. Tuteja N, Gonzalez F, Nebert D. Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes. Dev Biol. 1985;112:177-84 pubmed
  7. Galvez Peralta M, Shi Z, Chen J, Miller M, Nebert D. Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct. Int J Cancer. 2013;132:2065-75 pubmed publisher
    Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH) found in combustion processes. Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates ..
  8. Campbell S, Henderson C, Anthony D, Davidson D, Clark A, Wolf C. The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development. J Biol Chem. 2005;280:5828-35 pubmed
    In adult mice the cytochrome P450 Cyp1a1 gene is not constitutively expressed but is highly inducible by foreign compounds acting through the aryl hydrocarbon (Ah) receptor...
  9. Zhou J, Gasiewicz T. 3'-methoxy-4'-nitroflavone, a reported aryl hydrocarbon receptor antagonist, enhances Cyp1a1 transcription by a dioxin responsive element-dependent mechanism. Arch Biochem Biophys. 2003;416:68-80 pubmed a ligand-activated transcription factor, regulating expression of a group of specific genes including cytochrome P450 1A1 (Cyp1a1)...
  10. Kerzee J, Ramos K. Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells: role of the Ahr bHLH/PAS transcription factor. Circ Res. 2001;89:573-82 pubmed
    ..The present studies were conducted to examine constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells (VSMCs) from Ahr(+/+) and Ahr(-/-) mice...
  11. Shi Z, Chen Y, Dong H, Amos Kroohs R, Nebert D. Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor. Biochem Biophys Res Commun. 2008;376:775-80 pubmed publisher
    Herein, we describe generation of the hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr(d) mouse line, which carries human functional CYP1A1 and CYP1A2 genes in the absence of mouse Cyp1a1 and Cyp1a2 genes, in a (>99...
  12. Ebina M, Shibazaki M, Kudo K, Kasai S, Kikuchi H. Correlation of dysfunction of nonmuscle myosin IIA with increased induction of Cyp1a1 in Hepa-1 cells. Biochim Biophys Acta. 2011;1809:176-83 pubmed publisher
    The aryl hydrocarbon receptor (AhR) is one of the best known ligand-activated transcription factors and it induces Cyp1a1 transcription by binding with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...
  13. Hankinson O. A genetic analysis of processes regulating cytochrome P4501A1 expression. Adv Enzyme Regul. 1994;34:159-71 pubmed
    ..Such motifs have been identified in several transcription factors that bind DNA as heterodimers or homodimers. The roles of the proteins corresponding to the B and D genes are presently under investigation. ..
  14. Gonzalez F, Kimura S. Study of P450 function using gene knockout and transgenic mice. Arch Biochem Biophys. 2003;409:153-8 pubmed
    ..The P450s chosen for study, CYP1A1, CYP1B1, CYP1A2, and CYP2E1, are conserved in mammals and are known to metabolize most toxicants and chemical ..
  15. Uno S, Endo K, Ishida Y, Tateno C, Makishima M, Yoshizato K, et al. CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines. Toxicol Appl Pharmacol. 2009;237:119-26 pubmed publisher
    ..a bacterial-artificial-chromosome-transgenic mouse, carrying the human CYP1A1_CYP1A2 locus and lacking the mouse Cyp1a1 and Cyp1a2 orthologs, was shown to express robustly human dioxin-inducible CYP1A1 and basal versus inducible ..
  16. Ma X, Idle J, Malfatti M, Krausz K, Nebert D, Chen C, et al. Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis. 2007;28:732-7 pubmed
    ..PhIP) carcinogenesis is initiated by N(2)-hydroxylation, mediated by several cytochromes P450, including CYP1A1. However, the role of CYP1A1 in PhIP metabolic activation in vivo is unclear...
  17. Braeuning A, Kohle C, Buchmann A, Schwarz M. Coordinate regulation of cytochrome P450 1a1 expression in mouse liver by the aryl hydrocarbon receptor and the beta-catenin pathway. Toxicol Sci. 2011;122:16-25 pubmed publisher
    ..further analyzed in vitro, and the stimulatory role of ?-catenin was ascribed to a TCF-binding site within the CYP1A1 promoter...
  18. Tsyrlov I, Goldfarb I, Gelboin H. Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expressed, microsomal, and purified CYP1A1 and CYP1A2. Arch Biochem Biophys. 1993;307:259-66 pubmed
    ..EROD) were estimated in microsomes of Hep G2 cells infected with a recombinant vaccinia virus bearing mouse CYP1A1 or CYP1A2 cDNAs...
  19. Shertzer H, Clay C, Genter M, Schneider S, Nebert D, Dalton T. Cyp1a2 protects against reactive oxygen production in mouse liver microsomes. Free Radic Biol Med. 2004;36:605-17 pubmed
    H(2)O(2) production was evaluated in liver microsomes prepared from Cyp1a1/1a2(+/+) wild-type and Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice pretreated with 5 microg dioxin (TCDD)/kg body wt or vehicle alone...
  20. Vezina C, ALLGEIER S, Moore R, Lin T, Bemis J, Hardin H, et al. Dioxin causes ventral prostate agenesis by disrupting dorsoventral patterning in developing mouse prostate. Toxicol Sci. 2008;106:488-96 pubmed publisher
    ..Disrupted axial patterning provides a new paradigm for understanding how in utero TCDD exposure causes ventral prostate agenesis and may shed light on how TCDD impairs development of other organs. ..
  21. Kimura S, Gonzalez F, Nebert D. Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues. Mol Cell Biol. 1986;6:1471-7 pubmed
    ..These data indicate that even though both genes are controlled by the same receptor, striking tissue-specific differences in transcription and mRNA stabilization affect the final mRNA concentrations. ..
  22. Levová K, Moserova M, Nebert D, Phillips D, Frei E, Schmeiser H, et al. NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I. Toxicol Appl Pharmacol. 2012;265:360-7 pubmed publisher
    ..We found that NQO1 levels in liver, kidney and lung of Cyp1a1?/?, Cyp1a2?/? and Cyp1a1/1a2?/? knockout mouse lines, as well as in two CYP1A-humanized mouse lines harboring ..
  23. Goddard A, Yuan J, Fairbairn L, Dexter M, Borrow J, Kozak C, et al. Cloning of the murine homolog of the leukemia-associated PML gene. Mamm Genome. 1995;6:732-7 pubmed
  24. Iqbal J, Sun L, Cao J, Yuen T, Lu P, Bab I, et al. Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes. Proc Natl Acad Sci U S A. 2013;110:11115-20 pubmed publisher
    ..Furthermore, the osteoclastogenesis induced by TCDD was lower in Cyp1a1/1a2(-/-) and Cyp1a1/1a2/1b1(-/-) cultures, indicating that Ahr was upstream of the Cyp enzymes...
  25. Wang L, Lingappan K, Jiang W, Couroucli X, Welty S, Shivanna B, et al. Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury. Free Radic Biol Med. 2015;82:147-59 pubmed publisher
    ..In summary, our results support the hypothesis that hepatic CYP1A2 plays a critical role in the attenuation of hyperoxic lung injury by decreasing lipid peroxidation and oxidative stress in vivo. ..
  26. Xu M, Miller M. Determination of murine fetal Cyp1a1 and 1b1 expression by real-time fluorescence reverse transcription-polymerase chain reaction. Toxicol Appl Pharmacol. 2004;201:295-302 pubmed
    We describe the application of quantitative RT-PCR methodology to study expression of Cyp1a1 and 1b1 in murine fetal tissue...
  27. Peterson T, Gonzalez F, Nebert D. Methylation differences in the murine P1450 and P3450 genes in wild-type and mutant hepatoma cell culture. Biochem Pharmacol. 1986;35:2107-14 pubmed
    ..It is of interest that the same nine bases are found in intron 2 about 80 bp upstream from the 5' end of exon 3 in the homologous P3450 gene. ..
  28. Nebert D, Nelson D, Coon M, Estabrook R, Feyereisen R, Fujii Kuriyama Y, et al. The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol. 1991;10:1-14 pubmed
    ..This system is consistent with our earlier proposed nomenclature for P450 of all eukaryotes and prokaryotes, except that we are discouraging the future use of cumbersome Roman numerals. ..
  29. Fowlis G, Adelman S, Knight A, Simpson E. PCR-analyzed microsatellites of the mouse genome--additional polymorphisms among ten inbred mouse strains. Mamm Genome. 1992;3:192-6 pubmed
    ..This simple approach will, therefore, continue to be useful in genome mapping studies, leading eventually to high-resolution maps of both the mouse and human genomes; this should allow for physical mapping and cloning of specific genes. ..
  30. Szele E, Gombos K, Kovacs A, Ember I. Effects of purified glycerol from biodiesel on Cyp1a1 and Cyp2e1 expressions in CBA/CA mice. In Vivo. 2011;25:237-40 pubmed
    ..After dietary exposure, gene expressions of cytochrome P450, family 1, subfamily a polypeptide 1 (Cyp1a1) and cytochrome P450, family 2, subfamily e, polypeptide 1 (Cyp2e1) were analysed in liver...
  31. Dalton T, Dieter M, Matlib R, Childs N, Shertzer H, Genter M, et al. Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery. Biochem Biophys Res Commun. 2000;267:184-9 pubmed
    Using the Cre-lox system, we have generated a cytochrome P450 1A1 Cyp1a1(-/-) knockout mouse by deletion of the translated portions of the Cyp1a1 gene...
  32. Fisher C, Jackson J, Lickteig A, Augustine L, Cherrington N. Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis. Arch Toxicol. 2008;82:959-64 pubmed publisher
    ..NASH alters the xenobiotic activation of these transcription factors and induction of downstream DME targets Cyp1A1, Cyp2B10, Cyp3A11, Cyp4A14 and NAD(P)H:quinone oxidoreductase 1 (Nqo1), respectively...
  33. Villa M, Gialitakis M, Tolaini M, Ahlfors H, Henderson C, Wolf C, et al. Aryl hydrocarbon receptor is required for optimal B-cell proliferation. EMBO J. 2017;36:116-128 pubmed publisher
    ..a natural ligand of AhR, FICZ, induces AhR translocation to the nucleus and transcription of the AhR target gene Cyp1a1, showing that the AhR pathway is functional in B cells...
  34. Hildebrand C, Gonzalez F, Kozak C, Nebert D. Regional linkage analysis of the dioxin-inducible P-450 gene family on mouse chromosome 9. Biochem Biophys Res Commun. 1985;130:396-406 pubmed
  35. Kumar M, Jain M, Sehgal A, Sharma V. Modulation of CYP1A1, CYP1B1 and DNA adducts level by green and white tea in Balb/c mice. Food Chem Toxicol. 2012;50:4375-81 pubmed publisher
    ..WT elucidate greater efficacy in ameliorating BaP toxicity, but further long term studies are required to validate white tea as a cancer chemopreventive agent. ..
  36. Xu D, Hu J, De Bruyne E, Menu E, Schots R, Vanderkerken K, et al. Dll1/Notch activation contributes to bortezomib resistance by upregulating CYP1A1 in multiple myeloma. Biochem Biophys Res Commun. 2012;428:518-24 pubmed publisher
    ..We describe the upregulation of CYP1A1, a Cytochrome P450 enzyme involved in drug metabolism, as a possible mechanism of Dll1/Notch induced bortezomib ..
  37. Lingappan K, Jiang W, Wang L, Couroucli X, Moorthy B. Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A. Toxicology. 2015;331:14-23 pubmed publisher
    ..display gender-specific differences in HLI, and that this phenomenon will be altered in mice lacking the genes for Cyp1a1 or 1a2...
  38. Ohgiya S, Goda T, Ishizaki K, Kamataki T, Shinriki N. Molecular cloning and sequence analysis of guinea-pig NADPH-cytochrome P-450 oxidoreductase [corrected]. Biochim Biophys Acta. 1992;1171:103-5 pubmed
    ..The high conservation of acidic residues of the enzyme sustained the importance of them to maintain its function [corrected]. ..
  39. Tamaki H, Sakuma T, Uchida Y, Jaruchotikamol A, Nemoto N. Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes. Toxicology. 2005;216:224-31 pubmed
    Expression of CYP1A1 mRNA in mouse hepatocytes in primary culture was investigated. The expression was obvious on day 3 of culture without addition of any known ligands of the aryl hydrocarbon receptor and increased with culture period...
  40. Walsh A, Tullis K, Rice R, Denison M. Identification of a novel cis-acting negative regulatory element affecting expression of the CYP1A1 gene in rat epidermal cells. J Biol Chem. 1996;271:22746-53 pubmed
    ..of a luciferase reporter construct containing -1317 to +256 base pairs of the 5'-flanking region of the murine CYP1A1 gene was TCDD-inducible in low but not high passage cells...
  41. Dasari V, Anandatheerthavarada H, Robin M, Boopathi E, Biswas G, Fang J, et al. Role of protein kinase C-mediated protein phosphorylation in mitochondrial translocation of mouse CYP1A1, which contains a non-canonical targeting signal. J Biol Chem. 2006;281:30834-47 pubmed
    ..Herein, we have studied the mechanism of mouse MT-CYP1A1 targeting to gain insight into the regulatory features and evolutionary conservation of bimodal targeting ..
  42. Chatuphonprasert W, Jarukamjorn K, Putalun W. Regulation of cancer-related genes - Cyp1a1, Cyp1b1, Cyp19, Nqo1 and Comt - expression in β-naphthoflavone-treated mice by miroestrol. J Pharm Pharmacol. 2016;68:475-84 pubmed publisher
    ..In the presence of BNF, MR suppressed hepatic CYP1A1 activity and CYP1A2 activity, expression of CYP1B1 mRNA and expression of CYP1A1/2 and CYP1B1 protein...
  43. Dragin N, Uno S, Wang B, Dalton T, Nebert D. Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line. Biochem Biophys Res Commun. 2007;359:635-42 pubmed
    Human/rodent CYP1A1 and CYP1A2 orthologs are well known to exhibit species-specific differences in substrate preferences and rates of metabolism...
  44. MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson J, Matthews J. 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acids Res. 2013;41:1604-21 pubmed publisher
    ..RNAi-mediated knockdown of TiPARP in T-47D breast cancer and HuH-7 hepatoma cells increased TCDD-dependent cytochrome P450 1A1 (CYP1A1) and CYP1B1 messenger RNA (mRNA) expression levels and recruitment of AHR to both genes...
  45. Ryu D, Levi P, Hodgson E. Regulation of cytochrome P-450 isozymes CYP1A1, CYP1A2 and CYP2B10 by three benzodioxole compounds. Chem Biol Interact. 1995;96:235-47 pubmed
    ..BD) compounds were used to investigate the structural requirement for regulation of the cytochrome P450 isozymes, CYP1A1, CYP1A2 and CYP2B10, in mouse liver...
  46. Gharavi N, El Kadi A. Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide. J Pharm Sci. 2007;96:2795-807 pubmed
    ..and lipopolysaccharide (LPS) downregulate aryl hydrocarbon receptor (AhR)-regulated genes, such as cytochrome P450 1a1 (Cyp1a1) and NADPH: quinone oxidoreductase 1 (Nqo1) gene expression, yet the mechanisms involved remain ..
  47. Abbott B, Schmid J, Brown J, Wood C, White R, Buckalew A, et al. RT-PCR quantification of AHR, ARNT, GR, and CYP1A1 mRNA in craniofacial tissues of embryonic mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and hydrocortisone. Toxicol Sci. 1999;47:76-85 pubmed
    ..The induction of CYP1A1 mRNA was also quantified at 2, 4, 6, 12, 24, and 48 h for control and TCDD-exposed samples...
  48. Korkalainen M, Törrönen A, Karenlampi S. Comparison of expression of aldehyde dehydrogenase 3 and CYP1A1 in dominant and recessive aryl hydrocarbon hydroxylase-deficient mutant mouse hepatoma cells. Chem Biol Interact. 1995;94:121-34 pubmed
    The mouse hepatoma cell line Hepa-1 is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for both CYP1A1 (aryl hydrocarbon hydroxylase, AHH) and class 3 aldehyde dehydrogenase (ALDH3) enzymes...
  49. Komori M, Kikuchi O, Sakuma T, Funaki J, Kitada M, Kamataki T. Molecular cloning of monkey liver cytochrome P-450 cDNAs: similarity of the primary sequences to human cytochromes P-450. Biochim Biophys Acta. 1992;1171:141-6 pubmed
    ..The deduced amino acid sequences of four monkey cytochrome P-450 cDNAs, including P450 1A1 (MKah1) which we isolated previously, were more than 92% identical with those of corresponding human cytochrome P-450 cDNAs. ..
  50. Zhao C, Shichi H. Immunocytochemical study of cytochrome P450 (1A1/1A2) induction in murine ocular tissues. Exp Eye Res. 1995;60:143-52 pubmed
    ..Control animals received an injection of corn oil. The immunoreactivity of cytochrome P450 1A1/1A2 expressed in different ocular tissues and liver was examined with goat anti-P450 antibody (primary ..
  51. Agbor L, Wiest E, Rothe M, Schunck W, Walker M. Role of CYP1A1 in modulating the vascular and blood pressure benefits of omega-3 polyunsaturated fatty acids. J Pharmacol Exp Ther. 2014;351:688-98 pubmed publisher
    ..b>Cytochrome P450 1A1 efficiently metabolizes n-3 PUFAs to potent vasodilators...
  52. Hushka L, Williams J, Greenlee W. Characterization of 2,3,7,8-tetrachlorodibenzofuran-dependent suppression and AH receptor pathway gene expression in the developing mouse mammary gland. Toxicol Appl Pharmacol. 1998;152:200-10 pubmed
    ..aryl hydrocarbon nuclear translocator (ARNT; the heterodimerization partner of AHR), and two AHR-regulated genes, Cyp1A1 and Cyp1B1, were similar and not altered by treatment of mammary glands in organ culture with TCDF...
  53. Cheung C, Loy S, Li G, Liu A, Yang C. Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. Carcinogenesis. 2011;32:233-9 pubmed publisher
    ..Transgenic CYP1A-humanized mice (hCYP1A-mice), which have the human CYP1A1 and CYP1A2 genes but lack the murine orthologs Cyp1a1 and Cyp1a2, provide an excellent opportunity to develop a ..
  54. Cheng K, Park S, Krutzsch H, Grantham P, Gelboin H, Friedman F. Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450. Biochemistry. 1986;25:2397-402 pubmed
    ..This report shows the varying degree of structural relatedness among the isozymes examined and demonstrates the suitability and advantage of immunopurified cytochromes P-450 for sequencing and structural studies. ..
  55. El Gendy M, El Kadi A. Harmine and harmaline downregulate TCDD-induced Cyp1a1 in the livers and lungs of C57BL/6 mice. Biomed Res Int. 2013;2013:258095 pubmed publisher
    ..inhibit the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated induction of the carcinogen-activating enzyme, Cyp1a1, in vitro. However, the effect of both alkaloids on Cyp1a1 in vivo has not been investigated...
  56. Degawa M, Kobayashi K, Miura S, Arai H, Esumi H, Sugimura T, et al. Species difference among experimental rodents in induction of P450IA family enzymes by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res. 1992;83:1047-51 pubmed
    ..In rats, PhIP induced P450IA1, P450IA2 and a new but unspecified P450 isozyme in the liver, and induced P450IA1 in the kidney. However, PhIP induced none of these P450 isozymes in mice, hamsters and guinea pigs. ..
  57. Kakutani H, Aozasa O, Mizuno A, Akiyama E, Nakao T, Ohta S. In vitro and in vivo induction of cytochrome P450 by coplanar polychlorinated/brominated biphenyls (Co-PXBs) providing high TEQ in mother's milk in Japan. Toxicology. 2014;324:68-75 pubmed publisher
    ..Although the TEFs of Co-PXBs are not set, if Co-PXBs are included in these calculations because of their higher toxicity compared to Co-PCBs, exposure to Co-PXBs cannot be neglected when assessing human health risks. ..
  58. Hildebrand C, Stallings R, Gonzalez F, Nebert D. Assignment of dioxin-inducible cytochrome P-450 gene family to Chinese hamster chromosome 4. Somat Cell Mol Genet. 1985;11:391-5 pubmed
    ..0 and 7.4 kb) were assigned to Chinese hamster chromosome 4. These data are consistent with linkage conservation among these two P-450 sequences and four other loci on mouse chromosome 9 that map to hamster chromosome 4. ..
  59. Henderson C, McLaughlin L, Osuna Cabello M, Taylor M, Gilbert I, McLaren A, et al. Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability. Biochem J. 2015;465:479-88 pubmed publisher drug disposition, we have generated a novel mouse line where Cre recombinase is driven off the endogenous Cyp1a1 gene promoter; this line was then crossed on to a floxed POR mouse...
  60. Borland M, Krishnan P, Lee C, Albrecht P, Shan W, Bility M, et al. Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor ?/? (PPAR?/?) in keratinocytes. Carcinogenesis. 2014;35:1602-12 pubmed publisher
    ..Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes...
  61. Jones J, Nebert D. Transcriptional start site in the mouse Cyp1a1 (cytochrome P1450) gene. DNA. 1989;8:527-34 pubmed
    Two transcriptional initiation sites have been described by different laboratories for the mouse Cyp1a1 (cytochrome P1450) gene: start site TI, at the beginning of the nontranslated 87-bp first exon, and start site TII, 635 bp downstream ..
  62. Meyer R, Podvinec M, Meyer U. Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme. Mol Pharmacol. 2002;62:1061-7 pubmed
    Cytochrome P450 CYP1A1 is expressed in most tissues. In brain and kidney, its function remains unclear because its enzymatic activity is barely measurable...
  63. Kondraganti S, Jiang W, Moorthy B. Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene. J Pharmacol Exp Ther. 2002;303:945-51 pubmed
    ..that CYP1A2, a liver-specific P450 isozyme, plays an important role in the mechanisms governing persistent CYP1A1 induction by MC in liver but not in extra-hepatic tissues such as lung, which is devoid of endogenous CYP1A2...
  64. Uno S, Wang B, Shertzer H, Nebert D, Dalton T. Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele. Biochem Biophys Res Commun. 2003;312:494-9 pubmed
    ..available Balancer2-Cre transgenic mouse line to carry out this function from a tri-loxP-site-containing cytochrome p450 1A1 (Cyp1a1) targeted allele...
  65. Kikuchi H, Kato H, Mizuno M, Hossain A, Ikawa S, Miyazaki J, et al. Differences in inducibility of CYP1A1-mRNA by benzimidazole compounds between human and mouse cells: evidences of a human-specific signal transduction pathway for CYP1A1 induction. Arch Biochem Biophys. 1996;334:235-40 pubmed
    ..omeprazole (OP), thiabendazole (TBZ), and lansoprazole (LP), were compared with respect to the induction of CYP1A1-mRNA in human hepatoma cells, HepG2...
  66. Kobayashi E, Tachibana M, Ikadai H, Imamichi T, Kunieda T. Linkage among esterase-6 (Es-6), neural cell adhesion molecule (NCAM), and apolipoprotein C-III (apoc-3) genes on rat chromosome 8. Mamm Genome. 1992;3:656-8 pubmed
  67. Nemoto N, Sakurai J. Altered regulation of Cyp1a-1 gene expression during cultivation of mouse hepatocytes in primary culture. Biochem Pharmacol. 1992;44:51-8 pubmed
    ..The findings do suggest, however, that superinducibility of the gene expression after cycloheximide treatment might be a result of a regulatory mechanism operating after adaptation to culture. ..
  68. Tukey R, Lalley P, Nebert D. Localization of cytochrome P1-450 and P3-450 genes to mouse chromosome 9. Proc Natl Acad Sci U S A. 1984;81:3163-6 pubmed
    ..Chromosome segregation analysis of 12 hybrid clones demonstrated that the structural genes for both P1-450 and P3-450 can be assigned to mouse chromosome 9. ..
  69. Lundgren M, Darnerud P, Molin Y, Lilienthal H, Blomberg J, Ilback N. Coxsackievirus B3 infection and PBDE exposure causes organ-specific effects on CYP-gene expression in the mouse. Toxicology. 2007;242:91-9 pubmed
    ..used to study the combined effects of infection and exposure to pure BDE-99 or the commercial mixture Bromkal on CYP1A1 and CYP2B expression in the lungs and pancreas on day 3 of the infection...
  70. Schnekenburger M, Peng L, Puga A. HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation. Biochim Biophys Acta. 2007;1769:569-78 pubmed
    ..procarcinogen benzo[a]pyrene, is catalyzed by a cytochrome P450 monooxygenase encoded by the substrate-inducible Cyp1a1 gene...
  71. Divanovic S, Dalli J, Jorge Nebert L, Flick L, Galvez Peralta M, Boespflug N, et al. Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways. J Immunol. 2013;191:3347-57 pubmed publisher
    All three cytochrome P450 1 (CYP1) monooxygenases are believed to participate in lipid mediator biosynthesis and/or their local inactivation; however, distinct metabolic steps are unknown...
  72. Uno S, Dalton T, Sinclair P, Gorman N, Wang B, Smith A, et al. Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria. Toxicol Appl Pharmacol. 2004;196:410-21 pubmed
    ..In this study, we asked the question how important is the role of CYP1A1 in causing TCDD toxicity...
  73. Sadek C, Allen Hoffmann B. Suspension-mediated induction of Hepa 1c1c7 Cyp1a-1 expression is dependent on the Ah receptor signal transduction pathway. J Biol Chem. 1994;269:31505-9 pubmed
    ..cells from cell-substratum and/or cell-cell adhesion generates cellular signals that induce the expression of CYP1A1 in the absence of xenobiotic polycyclic aromatic hydrocarbons (Sadek, C. M., and Allen-Hoffmann, B. L. (1994) J...
  74. Bansal S, Leu A, Gonzalez F, Guengerich F, Chowdhury A, Anandatheerthavarada H, et al. Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction. J Biol Chem. 2014;289:9936-51 pubmed publisher
    ..induced similar mitochondrial functional abnormalities and oxidative stress in the lungs of wild-type mice and Cyp1a1/1a2-null mice, but the effects were markedly blunted in Cyp1b1-null mice...
  75. Uno S, Sakurai K, Nebert D, Makishima M. Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta. Toxicology. 2014;316:34-42 pubmed publisher
    ..b>Cytochrome P450 1A1 (CYP1A1) plays a role in both metabolic activation and detoxication of BaP in a context-dependent manner...
  76. Nishizawa H, Imanishi S, Manabe N. Effects of exposure in utero to bisphenol a on the expression of aryl hydrocarbon receptor, related factors, and xenobiotic metabolizing enzymes in murine embryos. J Reprod Dev. 2005;51:593-605 pubmed
    ..receptor repressor (AhRR) and AhR nuclear translocator (Arnt)], xenobiotic metabolizing enzymes [XMEs; cytochrome P450 1A1 (CYP1A1) and UDP-glucuronosyltransferase, and the glutathione S-transferase Ya subunit (GST)], in murine ..
  77. Dragin N, Shi Z, Madan R, Karp C, Sartor M, Chen C, et al. Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse. Mol Pharmacol. 2008;73:1844-56 pubmed publisher
    Crossing the Cyp1a1/1a2(-/-) double-knockout mouse with the Cyp1b1(-/-) single-knockout mouse, we generated the Cyp1a1/1a2/1b1(-/-) triple-knockout mouse...
  78. Van Voorhis M, Knopp S, Julliard W, Fechner J, Zhang X, Schauer J, et al. Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor. PLoS ONE. 2013;8:e82545 pubmed publisher
  79. Friedman J, Schneider B, Barton D, Francke U. Level of expression and chromosome mapping of the mouse cholecystokinin gene: implications for murine models of genetic obesity. Genomics. 1989;5:463-9 pubmed
  80. Shertzer H, Genter M, Talaska G, Curran C, Nebert D, Dalton T. 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis. 2007;28:1371-8 pubmed
    ..Using knockout mice for Cyp1a1, Cyp1a2 and Cyp1b1, we showed that the major CYP1 enzymes that metabolize DBC are CYP1A1 in beta-naphthoflavone (..
  81. Gonzalez F, Kimura S, Nebert D. Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes. J Biol Chem. 1985;260:5040-9 pubmed
    ..It can be shown that these two gene families probably diverged from a common ancestor more than 200 million years ago and that P1-450 and P3-450 split from each other about 65 million years ago. ..
  82. Casley W, Menzies J, Mousseau N, Girard M, Moon T, Whitehouse L. Increased basal expression of hepatic Cyp1a1 and Cyp1a2 genes in inbred mice selected for susceptibility to acetaminophen-induced hepatotoxicity. Pharmacogenetics. 1997;7:283-93 pubmed
    ..Ethoxyresorufin O-deethylase activity, associated with both CYP1A1 and CYP1A2, was also significantly elevated in this group...
  83. Akhmedov N, Piriev N, Chang B, Rapoport A, Hawes N, Nishina P, et al. A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse. Proc Natl Acad Sci U S A. 2000;97:5551-6 pubmed
    ..Our findings demonstrate that mPNR expression is critical for the normal development and function of the photoreceptor cells. ..