Cyp19a1

Summary

Gene Symbol: Cyp19a1
Description: cytochrome P450, family 19, subfamily a, polypeptide 1
Alias: ArKO, Cyp19, Int-5, Int5, p450arom, aromatase, CYPXIX, cytochrome P-450AROM, cytochrome P450 19A1, cytochrome P450, 19, aromatase, estrogen synthase
Species: mouse

Top Publications

  1. ncbi Effect of estrogen deficiency in the male: the ArKO mouse model
    Y Murata
    Prince Henry s Institute of Medical Research, 246 Clayton Road, Clayton, VIC 3168, Australia
    Mol Cell Endocrinol 193:7-12. 2002
  2. ncbi Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene
    S Honda
    Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
    Biochem Biophys Res Commun 252:445-9. 1998
  3. pmc Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells
    Stefania Catalano
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Italy
    J Biol Chem 285:5581-93. 2010
  4. ncbi The formation of estrogens by central neuroendocrine tissues
    F Naftolin
    Recent Prog Horm Res 31:295-319. 1975
  5. pmc Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
    D B Lubahn
    Department of Pathology, University of North Carolina, Chapel Hill 27599
    Proc Natl Acad Sci U S A 90:11162-6. 1993
  6. ncbi The alternative exons 1 of the mouse aromatase cytochrome P-450 gene
    S Honda
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, School of Medicine, Fujita Health University, Aichi, Japan
    Biochim Biophys Acta 1305:145-50. 1996
  7. pmc Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene
    C R Fisher
    Cecil H and Ida Green Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9051, USA
    Proc Natl Acad Sci U S A 95:6965-70. 1998
  8. ncbi Developmental expression and regulation of aromatase- and 5alpha-reductase type I mRNA in the male and female mouse hypothalamus
    M Karolczak
    Abteilung Anatomie und Zellbiologie, Universitat Ulm, Germany
    J Neuroendocrinol 10:267-74. 1998
  9. pmc Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene
    K M Robertson
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Proc Natl Acad Sci U S A 96:7986-91. 1999
  10. ncbi Upregulation of estrogen receptors in the forebrain of aromatase knockout (ArKO) mice
    V R Agarwal
    Department of Ob Gyn and Biochemistry, Green Center for Reproductive Biological Sciences, University of Texas Southwestern Medical Center, Dallas 75235 9051, USA
    Mol Cell Endocrinol 162:9-16. 2000

Research Grants

  1. Int5/Aromatase Effect of Breast Estrogen in Neoplasia
    RAJESHWAR TEKMAL; Fiscal Year: 2005
  2. CSF-1 and c-fms and the Early Endometriotic Lesion
    Rajeshwar Rao Tekmal; Fiscal Year: 2010
  3. REDUCTASE INTERACTIONS GOVERNING AROMATASE ACTIVITIES
    Alan Conley; Fiscal Year: 2001
  4. PREHAB VS REHAB FOR REDUCING BEDREST EFFECTS WITH AGING
    Marybeth Brown; Fiscal Year: 2002
  5. THE ROLE OF ESTROGEN IN BONE METABOLISM
    ORHAN OZ; Fiscal Year: 2004
  6. EXERCISE SPECIFICITY FOR PHYSICAL FRAILTY
    Marybeth Brown; Fiscal Year: 2004
  7. New Paradigms of P450-mediated Steroids Metabolism
    Alan Conley; Fiscal Year: 2006
  8. Estradiol Production by Prostaglandin F2alpha
    Carlos Stocco; Fiscal Year: 2006
  9. COX-2 Inhibitors, APC and Colon Cancer Prevention
    Kotha Subbaramaiah; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications112 found, 100 shown here

  1. ncbi Effect of estrogen deficiency in the male: the ArKO mouse model
    Y Murata
    Prince Henry s Institute of Medical Research, 246 Clayton Road, Clayton, VIC 3168, Australia
    Mol Cell Endocrinol 193:7-12. 2002
    b>Aromatase, the enzyme responsible for the conversion of androgens to estrogens, is present in the mouse gonads, brain, adipose tissue and bone...
  2. ncbi Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene
    S Honda
    Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
    Biochem Biophys Res Commun 252:445-9. 1998
    b>Aromatase is known to be involved in the control of morphological, neuroendocrine, and behavioral sex differences in the brain...
  3. pmc Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells
    Stefania Catalano
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Italy
    J Biol Chem 285:5581-93. 2010
    ..Recently, FXR was identified as a negative modulator of the androgen-estrogen-converting aromatase enzyme in human breast cancer cells...
  4. ncbi The formation of estrogens by central neuroendocrine tissues
    F Naftolin
    Recent Prog Horm Res 31:295-319. 1975
  5. pmc Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
    D B Lubahn
    Department of Pathology, University of North Carolina, Chapel Hill 27599
    Proc Natl Acad Sci U S A 90:11162-6. 1993
    ..Prenatal male and female reproductive tract development can therefore occur in the absence of estradiol receptor-mediated responsiveness...
  6. ncbi The alternative exons 1 of the mouse aromatase cytochrome P-450 gene
    S Honda
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, School of Medicine, Fujita Health University, Aichi, Japan
    Biochim Biophys Acta 1305:145-50. 1996
    b>Aromatase cDNA clones were isolated from cDNA libraries of mouse hypothalamus, amygdala and ovary...
  7. pmc Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene
    C R Fisher
    Cecil H and Ida Green Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9051, USA
    Proc Natl Acad Sci U S A 95:6965-70. 1998
    The formation of estrogens from C19 steroids is catalyzed by aromatase cytochrome P450 (P450arom), the product of the cyp19 gene...
  8. ncbi Developmental expression and regulation of aromatase- and 5alpha-reductase type I mRNA in the male and female mouse hypothalamus
    M Karolczak
    Abteilung Anatomie und Zellbiologie, Universitat Ulm, Germany
    J Neuroendocrinol 10:267-74. 1998
    Androgen metabolites synthesized by neural aromatase and 5alpha-reductase are implicated in many aspects of mammalian brain development and, in particular, in the masculinization of distinct central nervous system structures and brain ..
  9. pmc Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene
    K M Robertson
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Proc Natl Acad Sci U S A 96:7986-91. 1999
    ..A., Korach, K. S., and Lubahn, D. B. (1997) Nature (London) 390, 509-512]. Despite the demonstration of the aromatase enzyme, which converts androgens to estrogens, and estrogen receptors within the rodent seminiferous epithelium, ..
  10. ncbi Upregulation of estrogen receptors in the forebrain of aromatase knockout (ArKO) mice
    V R Agarwal
    Department of Ob Gyn and Biochemistry, Green Center for Reproductive Biological Sciences, University of Texas Southwestern Medical Center, Dallas 75235 9051, USA
    Mol Cell Endocrinol 162:9-16. 2000
    ..in which estrogen synthesis is completely eliminated by homologous recombination to delete the gene encoding aromatase cytochrome P450 (P450(arom))...
  11. pmc Altered expression of fatty acid-metabolizing enzymes in aromatase-deficient mice
    Y Nemoto
    Department of Medicine, Kochi Medical School, Nankoku, Japan
    J Clin Invest 105:1819-25. 2000
    ..In addition, hepatic steatosis became evident spontaneously in the aromatase-deficient (ArKO) mouse, which lacks intrinsic estrogen production...
  12. ncbi Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17beta-oestradiol
    K Toda
    Department of Medical Chemistry, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    J Endocrinol 170:99-111. 2001
    b>Aromatase P450 (CYP19) is an enzyme catalysing the conversion of androgens into oestrogens...
  13. ncbi Characterization of the fertility of male aromatase knockout mice
    K M Robertson
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
    J Androl 22:825-30. 2001
    Previous studies employing the male aromatase knockout (ArKO) mouse have indicated that local expression of estrogens appears to be important for the progression of spermatogenesis...
  14. ncbi Aromatase-deficient (ArKO) mice accumulate excess adipose tissue
    M E Jones
    Prince Henry s Institute of Medical Research, P O Box 5152, VIC 3168, Clayton, Australia
    J Steroid Biochem Mol Biol 79:3-9. 2001
    b>Aromatase is the enzyme which catalyses the conversion of C19 steroids into C18 estrogens...
  15. ncbi Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency
    K Takeda
    Department of Clinical Laboratory Medicine, Kochi Medical School, Kohasu, Okocho, Nankoku City, Kochi 783 8505, Japan
    J Endocrinol 176:237-46. 2003
    b>Aromatase (CYP19) is a cytochrome P450 enzyme that catalyzes the formation of aromatic C18 estrogens from C19 androgens. It is expressed in various tissues and contributes to sex-specific differences in cellular metabolism...
  16. ncbi Three different promoters control expression of the aromatase cytochrome p450 gene (cyp19) in mouse gonads and brain
    Konstantin Golovine
    Research Unit Molecular Biology, Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
    Biol Reprod 68:978-84. 2003
    b>Aromatase cytochrome P450, the key enzyme of estrogen biosynthesis, is encoded by Cyp19...
  17. ncbi Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse
    Kylie N Hewitt
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Endocrinology 145:1842-8. 2004
    The aromatase knockout (ArKO) mouse cannot synthesize endogenous estrogens due to a disruption to the Cyp19 gene...
  18. ncbi Relationships between aromatase activity in the brain and gonads and behavioural deficits in homozygous and heterozygous aromatase knockout mice
    J Bakker
    Centre for Cellular and Molecular Neurobiology, Research Group in Behavioural Neuroendocrinology, University of Liege, Liege, Belgium
    J Neuroendocrinol 16:483-90. 2004
    The present study was carried out to determine whether aromatase knockout (ArKO) mice are completely devoid of aromatase activity in their brain and gonads and to compare aromatase activity in wild-type and ArKO mice, as well as in ..
  19. doi Alternative 5'-untranslated first exons of the mouse Cyp19A1 (aromatase) gene
    Jenny D Y Chow
    Prince Henry s Institute, Clayton, VIC 3168, Australia
    J Steroid Biochem Mol Biol 115:115-25. 2009
    The human aromatase gene (CYP19A1) has eleven tissue-specific untranslated first exons, while only three have been described in the mouse Cyp19A1 namely brain-, ovary- and testis-specific exons 1...
  20. pmc Estrogen masculinizes neural pathways and sex-specific behaviors
    Melody V Wu
    Program in Neuroscience, University of California San Francisco, San Francisco, CA 94158, USA
    Cell 139:61-72. 2009
    ..testosterone activates the androgen receptor (AR) and is also converted into estrogen in the brain via aromatase. We demonstrate extensive sexual dimorphism in the number and projections of aromatase-expressing neurons...
  21. pmc The androgen receptor governs the execution, but not programming, of male sexual and territorial behaviors
    Scott A Juntti
    Graduate Program in Neuroscience, University of California, San Francisco, MC2722, San Francisco, CA 94158, USA
    Neuron 66:260-72. 2010
    ....
  22. doi The two kisspeptin neuronal populations are differentially organized and activated by estradiol in mice
    Olivier Brock
    Netherlands Institute for Neuroscience, 1105 BA Amsterdam, The Netherlands
    Endocrinology 154:2739-49. 2013
    ..By using wild-type (WT) and aromatase knockout (ArKO) mice (which cannot convert testosterone into estradiol) and immunohistochemistry, we observed ..
  23. pmc Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice
    Cedric Le May
    Division of Diabetes, Endocrinology and Metabolism, Department of, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:9232-7. 2006
    ..we have used mice that were rendered estradiol-deficient or estradiol-resistant by targeted disruption of aromatase (ArKO) or ERalpha (alphaERKO) respectively...
  24. ncbi Ontogeny of aromatase messenger ribonucleic acid in mouse brain: fluorometrical quantitation by polymerase chain reaction
    N Harada
    Division of Molecular Genetics, Fujita Health University, Aichi, Japan
    Endocrinology 131:2306-12. 1992
    A sensitive method was developed for the determination of trace amounts of aromatase mRNA in various tissues...
  25. ncbi Isolation of a full-length cDNA encoding mouse aromatase P450
    M Terashima
    Department of Medical Chemistry, Kochi Medical School, Japan
    Arch Biochem Biophys 285:231-7. 1991
    A full-length cDNA clone for aromatase P450 has been isolated from a pregnant mouse ovarian cDNA library...
  26. ncbi Development of cytochrome P450 aromatase mRNA levels and enzyme activity in ovaries of normal and hypogonadal (hpg) mice
    S A Gray
    Department of Veterinary Physiology, University of Glasgow Veterinary School, UK
    J Mol Endocrinol 14:295-301. 1995
    The cytochrome P450 aromatase (P450arom) enzyme is required for bioconversion of androgen to oestrogen...
  27. ncbi Regulation of aromatase expression in the ovary and placenta: a comparison between two species
    M M Hinshelwood
    Cecil H and Ida Green Center for Reproductive Biology Sciences, and the Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas 75235 9051, U S A
    J Steroid Biochem Mol Biol 61:399-405. 1997
    The conversion of C19 steroids to estrogens is catalysed by aromatase P450 (P450arom; product of the CYP19 gene)...
  28. ncbi Oestrogen at the neonatal stage is critical for the reproductive ability of male mice as revealed by supplementation with 17beta-oestradiol to aromatase gene (Cyp19) knockout mice
    K Toda
    Department of Medical Chemistry, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    J Endocrinol 168:455-63. 2001
    b>Aromatase P450 (CYP19) is an enzyme responsible for the conversion of androgens to oestrogens. We generated CYP19 knockout (ArKO) mice by targeted disruption of Cyp19 and studied the role of oestrogens in male reproductive ability...
  29. ncbi Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development
    R N Freiman
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720 3204, USA
    Science 293:2084-7. 2001
    ....
  30. ncbi Estrogen-dependent regulation of the expression of hepatic Cyp2b and 3a isoforms: assessment using aromatase-deficient mice
    Hideyuki Yamada
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Toxicol Appl Pharmacol 180:1-10. 2002
    ..the expression and induction of hepatic Cyp2b and Cyp3a isoforms was studied using mice [Ar (-/-) mice] lacking aromatase, a key enzyme for estrogen biosynthesis...
  31. ncbi Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue
    Zongjuan Fang
    Department of Obstetrics and Gynecology, University of Illinois, 820 South Wood Street, M C 808, Chicago, IL 60612, USA
    J Clin Endocrinol Metab 87:3460-6. 2002
    b>Aromatase P450 (P450arom) is the key enzyme for the biosynthesis of estrogen that is essential for the growth of human endometriosis, a pathology characterized by endometrium-like tissue on the peritoneal surfaces of abdominal organs ..
  32. ncbi Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse
    Marie L Misso
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Endocrinology 144:1474-80. 2003
    Estrogen deficiency in the aromatase knockout (ArKO) mouse leads to the development of obesity by as early as 3 months of age, which is characterized by a marked increase in the weights of gonadal and infrarenal fat pads...
  33. ncbi Alteration in sex-specific behaviors in male mice lacking the aromatase gene
    Takahiro Matsumoto
    Department of Biochemistry, Fujita Health University School of Medicine, Aichi, Japan
    Neuroendocrinology 77:416-24. 2003
    Brain aromatase (P450arom) is a key enzyme in estrogen biosynthesis from testicular androgens...
  34. ncbi Oestrogen-deficient female aromatase knockout (ArKO) mice exhibit depressive-like symptomatology
    C Dalla
    Centre for Cellular and Molecular Neurobiology, University of Liege, Liege, Belgium
    Eur J Neurosci 20:217-28. 2004
    We recently found that female aromatase knockout (ArKO) mice that are deficient in oestradiol due to a targeted mutation in the aromatase gene show deficits in sexual behaviour that cannot be corrected by adult treatment with oestrogens...
  35. ncbi The effect of low estrogen state on serotonin transporter function in mouse hippocampus: a behavioral and electrochemical study
    Paul P Bertrand
    Department of Physiology, University of Melbourne, Parkville VIC 3010, Australia
    Brain Res 1064:10-20. 2005
    ..We compared control mice, ovariectomized (OVX) C57BL/6J mice and aromatase knockout (ArKO) mice that are unable to produce estrogen...
  36. ncbi EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    J Biol Chem 283:3433-44. 2008
    Cytochrome P450 aromatase (aromatase), a product of the CYP19 gene, catalyzes the synthesis of estrogens from androgens...
  37. doi Preserved tissue structure of efferent ductules in aromatase-deficient mice
    Katsumi Toda
    Department of Biochemistry, School of Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    J Endocrinol 199:137-46. 2008
    ..This study was aimed to clarify whether disruption of the gene for aromatase (Ar), an enzyme responsible for estrogen biosynthesis, results in morphological and transcriptional alterations ..
  38. doi Comparative assessment of estrogenic responses with relevance to the metabolic syndrome and to menopausal symptoms in wild-type and aromatase-knockout mice
    Manuela I Bader
    Institute of Zoology, Technische Universitat Dresden, 01062 Dresden, Germany
    J Steroid Biochem Mol Biol 127:428-34. 2011
    Knockout of the Cyp-19 gene (aromatase) renders mice to have insufficient endogenous estrogen production and contributes to the development of symptoms related the metabolic syndrome, including excess adiposity and insulin resistance...
  39. doi Generation and characterization of a mouse model of the metabolic syndrome: apolipoprotein E and aromatase double knockout mice
    Nicola J A Scott
    Dept of Medicine, Univ of Otago Christchurch, Christchurch, NZ
    Am J Physiol Endocrinol Metab 302:E576-84. 2012
    The aim of this study was to create a comprehensive mouse model of the metabolic syndrome by crossing aromatase-deficient (ArKO) mice with apolipoprotein E-deficient (ApoE(-/-)) mice...
  40. pmc The aromatase gene CYP19A1: several genetic and functional lines of evidence supporting a role in reading, speech and language
    Heidi Anthoni
    Department of Medical Genetics, Biomedicum, University of Helsinki, 00014, Helsinki, Finland
    Behav Genet 42:509-27. 2012
    ..The aromatase enzyme is a member of the cytochrome P450 super family, and it serves several key functions: it catalyzes the ..
  41. pmc Estrogens mediate cardiac hypertrophy in a stimulus-dependent manner
    Christopher D Haines
    Department of Molecular, Cellular, and Developmental Biology and Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80309 0347, USA
    Endocrinology 153:4480-90. 2012
    ..We exposed aromatase knockout (ArKO) mice, which produce no estrogens, to both pathologic and physiologic stimuli...
  42. doi Seminal vesicles and urinary bladder as sites of aromatization of androgens in men, evidenced by a CYP19A1-driven luciferase reporter mouse and human tissue specimens
    Leena Strauss
    Department of Physiology, University of Turku, Turku, Finland
    FASEB J 27:1342-50. 2013
    ..Accordingly, CYP19A1 gene and P450arom protein expression was detected in those human tissues...
  43. doi Estradiol responsiveness of synaptopodin in hippocampal neurons is mediated by estrogen receptor β
    Lars Fester
    Institute of Neuroanatomy, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Steroid Biochem Mol Biol 138:455-61. 2013
    ..In this study, we show, unexpectedly, that synaptopodin is downregulated in the hippocampus of aromatase knock-out mice and that inhibition of neuronal estradiol synthesis using the aromatase inhibitor letrozole also ..
  44. doi Aromatase-null mice expressing enhanced green fluorescent protein in germ cells provide a model system to assess estrogen-dependent ovulatory responses
    Katsumi Toda
    Department of Biochemistry, School of Medicine, Kochi University, Nankoku, Kochi, 783 8505, Japan
    Transgenic Res 23:293-302. 2014
    ..By exploiting these features, we evaluated ovulatory responses of aromatase-gene (Cyp19a) knockout mouse expressing the EGFP transgene, which is totally anovulatory due to 17β-estradiol (..
  45. pmc Hepatic glucose intolerance precedes hepatic steatosis in the male aromatase knockout (ArKO) mouse
    Michelle L Van Sinderen
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 9:e87230. 2014
    Estrogens are known to play a role in modulating metabolic processes within the body. The Aromatase knockout (ArKO) mice have been shown to harbor factors of Metabolic syndrome with central adiposity, hyperinsulinemia and male-specific ..
  46. pmc Aromatase is required for female abdominal aortic aneurysm protection
    William F Johnston
    Division of Vascular and Endovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, VA
    J Vasc Surg 61:1565-74.e1-4. 2015
    ..Estrogen synthesis is dependent on the enzyme aromatase, which is located both centrally in the ovaries and peripherally in adipose tissue, bone, and vascular smooth ..
  47. pmc Characterization of aromatase expression in the adult male and female mouse brain. I. Coexistence with oestrogen receptors α and β, and androgen receptors
    Davor Stanic
    Systems Neurophysiology, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia Department of Florey Neuroscience, University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 9:e90451. 2014
    b>Aromatase catalyses the last step of oestrogen synthesis. There is growing evidence that local oestrogens influence many brain regions to modulate brain development and behaviour...
  48. doi Co-administration of insulin with a gonadotropin partly improves ovulatory responses of estrogen-deficient mice
    Katsumi Toda
    Department of Biochemistry, Kochi University School of Medicine, Nankoku, Kochi 783 8505, Japan Electronic address
    Mol Cell Endocrinol 411:177-86. 2015
    ..mare serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG) can induce ovulation in estrogen-deficient (ArKO) mice; nevertheless, ovulatory efficiency and rate are low...
  49. doi Sex chromosome complement determines sex differences in aromatase expression and regulation in the stria terminalis and anterior amygdala of the developing mouse brain
    Carla D Cisternas
    Instituto de Investigacion Medica Mercedes y Martin Ferreyra, INIMEC CONICET Universidad Nacional de Córdoba, Cordoba, Argentina Departamento de Biología Bucal, Facultad de Odontología Universidad Nacional de Córdoba, Cordoba, Argentina
    Mol Cell Endocrinol 414:99-110. 2015
    b>Aromatase, which converts testosterone in estradiol, is involved in the generation of brain sex dimorphisms...
  50. doi Characterization of Ovarian Responses to Equine Chorionic Gonadotropin of Aromatase-Deficient Mice With or Without 17β-Estradiol Supplementation
    Katsumi Toda
    Departments of Biochemistry K T, Pathology Y H, and Gastroenterology and Hepatology M O, T S, Kochi University School of Medicine, Nankoku, Kochi 783 8505, Japan
    Endocrinology 157:2093-103. 2016
    b>Aromatase is an enzyme catalyzing the final step of 17β-estradiol (E2) biosynthesis. Aromatase-deficient (ArKO) mice displayed vital roles of E2 at various tissue sites, including ovary...
  51. doi Pituitary Aromatase P450 May Be Involved in Maintenance of the Population of Luteinizing Hormone-Positive Pituitary Cells in Mice
    Jose Carretero
    Department of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, Salamanca, Spain
    Cells Tissues Organs 201:390-8. 2016
    As aromatase P450 is located in several pituitary cells, testosterone can be transformed into 17β-estradiol in the gland by the enzyme...
  52. doi Estradiol-induced neurogenesis in the female accessory olfactory bulb is required for the learning of the male odor
    Maïna Brus
    Laboratory of Neuroendocrinology, Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA Neurosciences, University of Liege, Liege, Belgium
    J Neurochem 138:457-68. 2016
    ..determine the role of estradiol in learning the odors of sexual partners and in the adult neurogenesis of female aromatase knockout mice (ArKO), unable to produce estradiol...
  53. doi Estradiol deficiency during development modulates the expression of circadian and daily rhythms in male and female aromatase knockout mice
    Rebecca Brockman
    University of Illinois, Department of Comparative Biosciences, Urbana, IL 61802, USA
    Horm Behav 60:439-47. 2011
    ..daily patterns of activity, circadian free running period and behavioral responses to light pulses using aromatase deficient (ArKO) mice. These animals lack the enzyme necessary to produce estradiol...
  54. doi Alteration in expression of estrogen receptor isoforms alpha and beta, and aromatase in the testis and its relation with changes in nitric oxide during aging in mice
    Arnab Banerjee
    Department of Zoology, Banaras Hindu University, Varanasi 221005, UP, India
    Steroids 77:609-20. 2012
    The aim of present study was to investigate the changes in the testicular expression of aromatase, ER alpha, ER beta and iNOS protein and correlate these with serum testosterone and nitric oxide levels, to elucidate the role of estrogen ..
  55. ncbi Localisation of aromatase activity in androgen target areas of the mouse brain
    A Wozniak
    MRC Neuroendocrine Development and Behaviour Group, Institute of Animal Physiology and Genetics Research, Babraham Cambridge, UK
    Neurosci Lett 146:191-4. 1992
    Oestrogens are formed from androgens in the mouse brain, but the localization of aromatase activity is unresolved. Immunocytochemistry has not detected aromatase in expected key androgen target areas such as the medial preoptic area...
  56. ncbi The structural genes encoding P450scc and P450arom are closely linked on mouse chromosome 9
    G L Youngblood
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0278
    Endocrinology 125:2784-6. 1989
    ..the two genes that encode the cytochrome P450 enzymes, P450SCC (cholesterol side-chain cleavage) and P450arom (aromatase), was identified in the mouse...
  57. ncbi A common mouse mammary tumor virus integration site in chemically induced precancerous mammary hyperplasias
    D A Gray
    Virology 148:360-8. 1986
    ..We propose that mouse mammary tumor virus integration at this site is responsible for a specific abnormality in differentiation associated with the preneoplastic phenotype...
  58. ncbi Normal onset, but prolonged expression, of Sry gene in the B6.YDOM sex-reversed mouse gonad
    C H Lee
    Urology Research Laboratory, Royal Victoria Hospital, Montreal, Canada
    Dev Biol 165:442-52. 1994
    ..YDOM ovotestis and completely absent in the B6.YDOM ovary. P450 aromatase (P450arom), which converts androgens to estrogens, was transcribed in both control XX and XY gonads at the onset ..
  59. ncbi Ontogeny of expression of the genes for steroidogenic enzymes P450 side-chain cleavage, 3 beta-hydroxysteroid dehydrogenase, P450 17 alpha-hydroxylase/C17-20 lyase, and P450 aromatase in fetal mouse gonads
    T L Greco
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor 48109 0278
    Endocrinology 135:262-8. 1994
    ..dehydrogenase/delta 5-delta 4-isomerase (3 beta HSD), P450 17 alpha-hydroxylase/C17-20 lyase (P450c17), and P450 aromatase (P450arom) was determined before ovaries and testes were distinguishable (13 days postconception) and during ..
  60. ncbi Aromatase-immunoreactivity is localised specifically in neurones in the developing mouse hypothalamus and cortex
    C Beyer
    MRC Neuroendocrine Development and Behaviour Group, Babraham Institute, Cambridge, UK
    Brain Res 638:203-10. 1994
    Local formation of oestrogens from androgens by aromatase cytochrome P-450 within brain cells is crucial for the sexual differentiation of the mammalian CNS...
  61. ncbi Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities
    R R Tekmal
    Department of Gynecology and Obstetrics and Winship Cancer Center, Emory University School of Medicine, Atlanta, Georgia 30322 4710, USA
    Cancer Res 56:3180-5. 1996
    ..have shown that the cellular gene at the mouse mammary tumor virus integration site in the int-5 locus is aromatase. To study the role of int-5/aromatase in normal mammary development and mammary neoplasia, we have generated ..
  62. ncbi Rapid sequencing of rabbit aromatase cDNA using RACE PCR
    B Delarue
    Laboratoire de Biochimie, CHU, Caen, France
    C R Acad Sci III 319:663-70. 1996
    The sequencing of aromatase cDNA from rabbit granulosa cells was obtained by RACE PCR. This cDNA is 2.9 kb long. The first 119 nucleotides correspond to the first untranslated exon...
  63. ncbi Expression of aromatase in the embryonic and postnatal mouse striatum
    E Kuppers
    Abteilung Anatomie und Zellbiologie, Universitat Ulm, D 89069, Ulm, Germany
    Brain Res Mol Brain Res 63:184-8. 1998
    ..This study is concerned with the ontogenetic and postnatal expression of aromatase in the mouse striatum...
  64. ncbi Identification of cis-acting elements in the proximal promoter region for brain-specific exon 1 of the mouse aromatase gene
    S Honda
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Brain Res Mol Brain Res 66:122-32. 1999
    Among multiple exons 1 of the mouse aromatase gene, brain-specific exon 1 is only utilized in the hypothalamus and amygdala regions...
  65. ncbi Ontogenetic expression and sex differences of aromatase and estrogen receptor-alpha/beta mRNA in the mouse hippocampus
    T Ivanova
    Abteilung Anatomie und Zellbiologie, Universitat Ulm, Germany
    Cell Tissue Res 300:231-7. 2000
    ..The present study is concerned with the developmental expression of mRNAs for the estrogen-synthesizing enzyme aromatase and the two known nuclear estrogen receptors (alpha/beta) in the male and female mouse hippocampus...
  66. pmc Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity
    M E Jones
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Proc Natl Acad Sci U S A 97:12735-40. 2000
    The aromatase-knockout (ArKO) mouse provides a useful model to examine the role that estrogens play in development and homeostasis in mammals...
  67. ncbi A loss of aggressive behaviour and its reinstatement by oestrogen in mice lacking the aromatase gene (Cyp19)
    K Toda
    Department of Medical Chemistry, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    J Endocrinol 168:217-20. 2001
    b>Aromatase P450 (CYP19) is an enzyme responsible for conversion of androgens to oestrogens...
  68. ncbi Expression of mRNA for the LH and FSH receptors in mouse oocytes and preimplantation embryos
    E Patsoula
    First Department of Obstetrics and Gynaecology, Athens University Medical School, IVF Unit, Alexandra Maternity Hospital, Athens, Greece
    Reproduction 121:455-61. 2001
    ....
  69. ncbi Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland
    S J McPherson
    Center for Urological Research, Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    Endocrinology 142:2458-67. 2001
    ..This study describes the effects of estrogen deficiency using aromatase knockout mice (ArKO) with targeted disruption of the cyp19 gene...
  70. ncbi Mammalian aromatases
    A Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Reproduction 121:685-95. 2001
    b>Aromatase is the enzyme complex that catalyses the synthesis of oestrogens from androgens, and therefore it has unique potential to influence the physiological balance between the sex steroid hormones...
  71. ncbi The effects of aromatase overexpression on mammary growth and gene expression in the aromatase x transforming growth factor alpha double transgenic mice
    N Kirma
    Department of Gynecology and Obstetrics, Winship Cancer Center, Emory University School of Medicine, 4217 WMB, 1639 Pierce Drive, Atlanta, GA 30322 4710, USA
    J Steroid Biochem Mol Biol 78:419-26. 2001
    ..In the aromatase transgenic mice, the mammary glands exhibit preneoplastic developments but do not form frank tumors...
  72. ncbi The ovarian phenotype of the aromatase knockout (ArKO) mouse
    K L Britt
    Prince Henry s Institute of Medical Research, P O Box 5152, VIC 3168, Clayton, Australia
    J Steroid Biochem Mol Biol 79:181-5. 2001
    Targeted disruption of exon 9 of the cyp19 gene gives rise to a non-functional aromatase enzyme incapable of converting androgens to oestrogens...
  73. ncbi Characterization and purification of a protein binding to the cis-acting element for brain-specific exon 1 of the mouse aromatase gene
    S I Honda
    Department of Biochemistry, School of Medicine, Fujita Health University, Kutsukake cho, Toyoake, 470 1192, Aichi, Japan
    J Steroid Biochem Mol Biol 79:255-60. 2001
    ..Androgen exerts its action on the brain after conversion to estrogen by brain aromatase. The aromatase appears in some neural nuclei such as in the hypothalamus and amygdala, and has been indicated to ..
  74. ncbi The aromatase knock-out mouse provides new evidence that estradiol is required during development in the female for the expression of sociosexual behaviors in adulthood
    Julie Bakker
    Center for Cellular and Molecular Neurobiology, Research Group in Behavioral Neuroendocrinology, University of Liege, B 4020 Liege, Belgium
    J Neurosci 22:9104-12. 2002
    We used estrogen-deficient aromatase knock-out (ArKO) mice to determine whether estrogens contribute to the development of the brain and behavior in females. Female mice of three different genotypes [i.e...
  75. ncbi Induction of Fos in the accessory olfactory system by male odors persists in female mice with a null mutation of the aromatase (cyp19) gene
    Y E Lau
    Department of Biology, Boston University, Cummington St, Boston, MA 02215, USA
    Brain Res Bull 60:143-50. 2003
    ..with a homozygous null mutation of the cyp19 gene (ArKO) which encodes the estrogen biosynthetic P450 enzyme, aromatase. However, a significant odor-induced activation of Fos-IR was seen in other segments of the VNO-projection ..
  76. ncbi Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice
    Tetsu Egawa
    Department of Medicine, Kochi Medical School, Nankoku, 783 8505 Japan
    Lipids 38:519-23. 2003
    ..study we tried to restore impaired hepatic FA beta-oxidation by administering a novel statin, pitavastatin, to aromatase-deficient (Ar-/-) mice defective in intrinsic estrogen synthesis...
  77. ncbi The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis
    Kylie N Hewitt
    Prince Henry s Institute of Medical Research and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Endocrinology 144:3895-903. 2003
    The aromatase knockout (ArKO) mouse cannot synthesize endogenous estrogens due to disruption of the Cyp19 gene...
  78. ncbi Impaired spatial reference memory in aromatase-deficient (ArKO) mice
    Sally Martin
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia
    Neuroreport 14:1979-82. 2003
    Previous studies indicate an important role for estrogen in memory and learning. Aromatase-knockout (ArKO) mice are unable to produce estrogen because they lack a functional Cyp 19 gene that encodes for aromatase, the enzyme that ..
  79. ncbi Functional modification of pituitary somatotropes in the aromatase knockout mouse and the effect of estrogen replacement
    Ming Yan
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Endocrinology 145:604-12. 2004
    ..In this study we investigated gene expression implicated in GH secretion in somatotropes derived from female aromatase knockout (ArKO) mice...
  80. ncbi Phenotype characteristics of transgenic male mice expressing human aromatase under ubiquitin C promoter
    Xiangdong Li
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    J Steroid Biochem Mol Biol 86:469-76. 2003
    ..concentration for the male reproductive functions, we have generated transgenic mice expressing human P450 aromatase under a promoter providing ubiquitous and permanent transgene expression (AROM+ mice)...
  81. ncbi Aromatase-knockout mouse carrying an estrogen-inducible enhanced green fluorescent protein gene facilitates detection of estrogen actions in vivo
    Katsumi Toda
    Department of Molecular Genetics, Kochi Medical School, Nankoku, Japan
    Endocrinology 145:1880-8. 2004
    b>Aromatase is an enzyme that converts androgen to estrogen in the gonads and also at extragonadal sites, including the brain...
  82. ncbi Estrogen is not directly required for oocyte developmental competence
    Kim Huynh
    Department of Anatomy, Monash University, Clayton, Victoria 3800, Australia
    Biol Reprod 70:1263-9. 2004
    ..understand the role of estrogen in maintaining developmental competence of mammalian oocytes, we studied the Aromatase knockout (ArKO) mouse, which has been genetically engineered to be incapable of synthesizing endogenous estrogen...
  83. ncbi Estrogen actions on follicle formation and early follicle development
    Kara L Britt
    Prince Henry s Institute of Medical Research, Monash Medical Centre Clayton, Block E, Level 4, Clayton, VIC 3168, Australia
    Biol Reprod 71:1712-23. 2004
    ..To test this hypothesis we compared numbers of primordial and primary follicles in wild-type and E(2)-deficient, aromatase knockout (ArKO) mice, and the immunohistochemical staining or mRNA expression of Mullerian inhibiting substance (..
  84. ncbi Attraction thresholds and sex discrimination of urinary odorants in male and female aromatase knockout (ArKO) mice
    Sylvie Pierman
    Center for Cellular and Molecular Neurobiology, University of Liege, Belgium
    Horm Behav 49:96-104. 2006
    We previously found that both male and female aromatase knockout (ArKO) mice, which cannot synthesize estrogens due to a targeted mutation of the aromatase gene, showed less investigation of volatile body odors from anesthetized ..
  85. ncbi Temporal and spatial expression of liver receptor homologue-1 (LRH-1) during embryogenesis suggests a potential role in gonadal development
    Margaret M Hinshelwood
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Dev Dyn 234:159-68. 2005
    ..and contrasting LRH and SF-1 expression with the two tissue-specific steroidogenic markers, cytochromes P450 aromatase and P450 17alpha-hydroxylase/17,20 lyase, we provide evidence for a potential role for LRH-1 in gonadal ..
  86. ncbi Transgenic mice expressing p450 aromatase as a model for male infertility associated with chronic inflammation in the testis
    Xiangdong Li
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Endocrinology 147:1271-7. 2006
    Our previous studies have shown that transgenic male mice expressing human P450 aromatase (AROM+) are infertile. In the present study, we followed the testis phenotype up to 15 months of age in these mice...
  87. ncbi Effects of estradiol on spatial learning, hippocampal cytochrome P450 19, and estrogen alpha and beta mRNA levels in ovariectomized female mice
    S Iivonen
    Department of Neuroscience and Neurology, University Hospital and University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    Neuroscience 137:1143-52. 2006
    ..estrogen but it also has its own steroid biosynthesis producing estrogen from testosterone catalyzed by the aromatase enzyme...
  88. ncbi Estrogen deficient male mice develop compulsive behavior
    Rachel A Hill
    Prince Henry s Institute of Medical Research, Monash University, Clayton, Australia
    Biol Psychiatry 61:359-66. 2007
    b>Aromatase converts androgen to estrogen. Thus, the aromatase knockout (ArKO) mouse is estrogen deficient...
  89. pmc Transient neonatal estrogen exposure to estrogen-deficient mice (aromatase knockout) reduces prostate weight and induces inflammation in late life
    Joseph John Bianco
    Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
    Am J Pathol 168:1869-78. 2006
    ..We have addressed this question using aromatase-knockout (ArKO) mice that are estrogen-deficient during their lifespan but have elevated androgen levels and ..
  90. ncbi Fas/FasL-mediated apoptosis in the arcuate nucleus and medial preoptic area of male ArKO mice is ameliorated by selective estrogen receptor alpha and estrogen receptor beta agonist treatment, respectively
    Rachel A Hill
    Prince Henry s Institute, Clayton 3168, Vic, Australia
    Mol Cell Neurosci 36:146-57. 2007
    The aromatase (ArKO) knockout mouse is estrogen deficient. Our previous analysis revealed apoptosis of dopaminergic neurons in the arcuate nucleus (Arc) and medial preoptic area (MPO) of 1-year-old male ArKO mice...
  91. ncbi The characteristics of aromatase deficient hairless mice indicate important roles of extragonadal estrogen in the skin
    Kazue Tsukahara
    Biological Science Laboratories, Kao Corporation, Ichikai, Haga, Tochigi, Japan
    J Steroid Biochem Mol Biol 108:82-90. 2008
    ..We examined the skin phenotypes of aromatase-knockout hairless (ArKO) mice and wild-type hairless (WT) mice, both of which were obtained through ..
  92. ncbi The effects of targeted deletion of the aromatase enzyme on prostatic contractile responses to noradrenaline in mice
    Katherine T Gray
    Prostate Research Co operative, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia
    J Endocrinol 195:495-502. 2007
    ..Isolated organ bath studies using prostates from aromatase knockout (ArKO) mice which were homozygous (ArKO-/-) and heterozygous (ArKO+/-) for the disrupted aromatase ..
  93. ncbi Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signaling
    William A Ricke
    Department of Urology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    FASEB J 22:1512-20. 2008
    ..To determine whether local in situ production of E2 affected incidence of PRCA, aromatase-knockout (ArKO) mice were evaluated...
  94. pmc Activational effects of estradiol and dihydrotestosterone on social recognition and the arginine-vasopressin immunoreactive system in male mice lacking a functional aromatase gene
    S Pierman
    Centre for Cellular and Molecular Neurobiology, University of Liege, Avenue de l Hopital 1 B36, 4000 Liege, Belgium
    Horm Behav 54:98-106. 2008
    ..We demonstrate here that gonadally intact male aromatase knockout (ArKO) mice, which cannot aromatize androgens into estrogens due to a targeted mutation in the ..
  95. pmc Aromatase is phosphorylated in situ at serine-118
    Todd W Miller
    Department of Medicine, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Steroid Biochem Mol Biol 112:95-101. 2008
    Phosphorylation of the cytochrome P450 aromatase has been proposed as a switch to rapidly modulate enzymatic activity and estrogen biosynthesis...
  96. pmc Estrogen receptor-alpha and -beta and aromatase knockout effects on lower limb muscle mass and contractile function in female mice
    Marybeth Brown
    Department of Biomedical Sciences, SHP Physical Therapy Program, University of Missouri Columbia, 106 Lewis Hall, Columbia, MO 65211, USA
    Am J Physiol Endocrinol Metab 296:E854-61. 2009
    ..To determine E2 elimination effects on muscle, we also used aromatase (Ar) knockout (KO) and wild-type (WT) mice...
  97. pmc A novel promoter controls Cyp19a1 gene expression in mouse adipose tissue
    Hong Zhao
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Reprod Biol Endocrinol 7:37. 2009
    b>Aromatase, the key enzyme in estrogen biosynthesis, is encoded by the Cyp19a1 gene...
  98. doi Increased litter size and super-ovulation rate in congenic C57BL mice carrying a polymorphic fragment of NFR/N origin at the Fecq4 locus of chromosome 9
    Maria Liljander
    Lund Transgenic Core Facility, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Genet Res (Camb) 91:259-65. 2009
    ..Genes of the cytochrome P450 family (1, 11 and 19), such as Cyp19a1, are assumed to be particularly interesting, since they are known to exhibit female-associated reproductive ..
  99. doi Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones
    Julie Bakker
    GIGA Neurosciences, University of Liege, B36 1st floor Avenue de l Hopital, 1 4000, Liege, Belgium
    Horm Behav 57:390-5. 2010
    ..Furthermore, we analyzed the effects of aromatase mutation (ArKO) and thus the role of estradiol on RP3V kisspeptin neuronal numbers and on the response of these ..
  100. pmc Transactivation of the epidermal growth factor receptor is involved in the lutropin receptor-mediated down-regulation of ovarian aromatase expression in vivo
    Nebojsa Andric
    Department of Pharmacology, 2 319B BSB, 51 Newton Road, The University of Iowa, Iowa City, Iowa 52242, USA
    Mol Endocrinol 24:552-60. 2010
    Ovarian follicular development and differentiation is characterized by dramatic changes in aromatase (Cyp19a1) expression...
  101. pmc Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated
    Stephen J McPherson
    Prostate and Breast Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 107:3123-8. 2010
    ..apoptosis in prostatic stromal, luminal and castrate-resistant basal epithelial cells of estrogen-deficient aromatase knock-out mice...

Research Grants10

  1. Int5/Aromatase Effect of Breast Estrogen in Neoplasia
    RAJESHWAR TEKMAL; Fiscal Year: 2005
    A number of studies have shown that the levels of aromatase are higher in breast tumors compared to normal tissue, indicating that the in situ aromatase/breast estrogen may play a role in breast cancer...
  2. CSF-1 and c-fms and the Early Endometriotic Lesion
    Rajeshwar Rao Tekmal; Fiscal Year: 2010
    ....
  3. REDUCTASE INTERACTIONS GOVERNING AROMATASE ACTIVITIES
    Alan Conley; Fiscal Year: 2001
    b>Aromatase cytochrome P450 (P450arom), a membrane-associated enzyme is expressed in diverse microsomal environments which include NADPH- cytochrome P450 reductase (reductase), an essential microsomal component of the active enzyme complex ..
  4. PREHAB VS REHAB FOR REDUCING BEDREST EFFECTS WITH AGING
    Marybeth Brown; Fiscal Year: 2002
    ..If preliminary findings are confirmed, it would provide support for appropriate human studies, and for expansion of habilitation services to older adults to include both pre-habilitation and rehabilitation. ..
  5. THE ROLE OF ESTROGEN IN BONE METABOLISM
    ORHAN OZ; Fiscal Year: 2004
    ..The enzyme aromatase synthesizes estrogen from its androgen precursors...
  6. EXERCISE SPECIFICITY FOR PHYSICAL FRAILTY
    Marybeth Brown; Fiscal Year: 2004
    ..3. Determine if the gains from each exercise program can be sustained for 3 months. ..
  7. New Paradigms of P450-mediated Steroids Metabolism
    Alan Conley; Fiscal Year: 2006
    ..abstract_text> ..
  8. Estradiol Production by Prostaglandin F2alpha
    Carlos Stocco; Fiscal Year: 2006
    The goal of this proposal is to elucidate the molecular and cellular mechanisms that regulate P450 aromatase (P450arom) expression in the rat corpus luteum (CL)...
  9. COX-2 Inhibitors, APC and Colon Cancer Prevention
    Kotha Subbaramaiah; Fiscal Year: 2009
    ..These studies will enhance our understanding of the mechanistic link between COX-2 and colorectal cancer and potentially assist us in optimizing the use of selective COX-2 inhibitors as therapy. ..