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Genomes and Genes
| CyldSummaryGene Symbol: Cyld Description: cylindromatosis (turban tumor syndrome) Alias: 2010013M14Rik, 2900009M21Rik, C130039D01Rik, CDMT, CYLD1, EAC, mKIAA0849, deubiquitinating enzyme CYLD, ubiquitin carboxyl-terminal hydrolase CYLD, ubiquitin thioesterase CYLD, ubiquitin thiolesterase CYLD, ubiquitin-specific-processing protease CYLD Species: mouse Top Publications
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Publications
Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activationJiabin An
Department of Medicine, VA Greater Los Angeles Healthcare System West Los Angeles, Los Angeles, CA 90095, USA
Cancer Cell 14:394-407. 2008..The molecular target of E6 in the NF-kappaB pathway is the CYLD lysine 63 (K63) deubiquitinase, a negative regulator of the NF-kappaB pathway...
CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumoniaJae Hyang Lim
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Cell Microbiol 10:2247-56. 2008..The deubiquitinating enzyme CYLD has been identified as a key negative regulator for NF-kappaB...
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infectionsJae Hyang Lim
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Immunity 27:349-60. 2007..Despite recent studies that identify deubiquitinating enzyme cylindromatosis (CYLD) as a key regulator for T cell development, tumor cell proliferation, and NF-kappaB transcription factor signaling, ..- Thymocyte-specific truncation of the deubiquitinating domain of CYLD impairs positive selection in a NF-kappaB essential modulator-dependent mannerAgeliki Tsagaratou
School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece
J Immunol 185:2032-43. 2010The cylindromatosis tumor suppressor gene (Cyld) encodes a deubiquitinating enzyme (CYLD) with immunoregulatory function... - Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturationEirini Trompouki
Institute of Immunology, Biomedical Sciences Research Center Al Fleming, 34 Al Fleming Str, Vari 16672, Greece
Neoplasia 11:469-76. 2009b>Cyld encodes a 956-amino acid deubiquitinating enzyme (CYLD), which is a negative regulator of nuclear factor kappaB and mitogen-activated protein kinase pathways... - Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cellsWei Jin
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 282:15884-93. 2007..Here we provide genetic evidence that CYLD, a recently identified DUB, plays a crucial role in regulating the peripheral development and activation of B cells... - Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responsesWilliam W Reiley
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Exp Med 204:1475-85. 2007The deubiquitinating enzyme CYLD has recently been implicated in the regulation of signal transduction, but its physiological function and mechanism of action are still elusive... - Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signalingTomoaki Koga
Department of Microbiology and Immunology and Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 283:12546-54. 2008..Interestingly, we found for the first time that tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for S... - NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathwayHirofumi Jono
Gonda Department of Cell and Molecular Biology, House Ear Institute, and Department of Otolaryngology, University of Southern California, Los Angeles, CA 90057, USA
J Biol Chem 279:36171-4. 2004..Recent studies have identified the tumor suppressor CYLD, loss of which causes a benign human syndrome called cylindromatosis, as a key negative regulator for NF-kappaB .. - Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteinsMarie W Wooten
Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
J Biol Chem 283:6783-9. 2008..activity of the TRAF6-interacting the Lys63-deubiquitinating enzyme (DUB), cylindromatosis tumor suppressor (CYLD)... - Regulation of T cell development by the deubiquitinating enzyme CYLDWilliam W Reiley
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Nat Immunol 7:411-7. 2006..Here we identify the deubiquitinating enzyme CYLD as a positive regulator of proximal T cell receptor signaling in thymocytes... - Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signalingRamin Massoumi
Department of Molecular Medicine, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
Cell 125:665-77. 2006Mutations in the CYLD gene cause tumors of hair-follicle keratinocytes. The CYLD gene encodes a deubiquitinase that removes lysine 63-linked ubiquitin chains from TRAF2 and inhibits p65/p50 NF-kappaB activation... - Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient miceJun Zhang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 116:3042-9. 2006Cylindromatosis (CYLD) is a deubiquitinating enzyme that is altered in patients with familial cylindromatosis, a condition characterized by numerous benign adnexal tumors. However, the regulatory function of CYLD remains unsettled... - The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemiaLluis Espinosa
Cancer Research Program, Institut Municipal d Investigacions Mediques, IMIM, Hospital del Mar, 08003 Barcelona, Spain
Cancer Cell 18:268-81. 2010..Hes1 exerts its effects by repressing the deubiquitinase CYLD, a negative IKK complex regulator. CYLD expression was found to be significantly suppressed in primary T-ALL... - Mutated cylindromatosis gene affects the functional state of dendritic cellsMatthias Bros
Clinical Research Unit Allergology, Department of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
Eur J Immunol 40:2848-57. 2010Cylindromatosis gene (CYLD) is a ubiquitously expressed deubiquitinating enzyme, which interacts with members of the NF-κB signaling pathway and attenuates NF-κB and JNK signaling... - Truncation of the deubiquitinating domain of CYLD in myelomonocytic cells attenuates inflammatory responsesAgeliki Tsagaratou
School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Macedonia, Greece
PLoS ONE 6:e16397. 2011The cylindromatosis tumor suppressor (CYLD) is a deubiquitinating enzyme that has been implicated in various aspects of adaptive and innate immune responses... - Differential requirement of IKK2 for CYLD-dependent representation of thymic and peripheral T-cell populationsAgeliki Tsagaratou
School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Eur J Immunol 41:3054-62. 2011The cylindromatosis tumor suppressor gene (Cyld) encodes an enzyme (CYLD) with deubiquitinating activity that has been implicated in the regulation of thymocyte selection in an NF-κB-essential-modulator (NEMO)-dependent manner... - The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammationMarion C Bonnet
Institute for Genetics, Center for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, Zülpicher Str 47a, 50674 Cologne, Germany
Immunity 35:572-82. 2011..necrosis (termed necroptosis) of FADD-deficient keratinocytes, which was partly dependent on the deubiquitinating enzyme CYLD and tumor necrosis factor (TNF)-TNF receptor 1 signaling... - Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemiaTeresa D'Altri
Parc Recerca Biomèdica de Barcelona Barcelona, Spain
Cell Cycle 10:1031-6. 2011..We have recently shown that the Notch-Hes1-CYLD-NFkB axis is crucial in the maintenance of T-ALL, but detailed evaluation of the contribution of each one of these .. - Serum response factor controls CYLD expression via MAPK signaling pathwayGang Liang
Department of Laboratory Medicine, Lund University, UMAS, Malmo, Sweden
PLoS ONE 6:e19613. 2011Tumor suppressor gene CYLD is a deubiquitinating enzyme which negatively regulates various signaling pathways by removing the lysine 63-linked polyubiquitin chains from several specific substrates... - Mutant p62P392L stimulation of osteoclast differentiation in Paget's disease of boneKumaran Sundaram
Charles P Darby Children s Research Institute, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
Endocrinology 152:4180-9. 2011..Deubiquitinating enzyme cylindromatosis (CYLD) has been shown to negatively regulate RANK ligand-RANK signaling essential for OCL differentiation... - FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammationPatrick Simon Welz
Institute for Genetics, Centre for Molecular Medicine, University of Cologne, Zülpicher Str 47a, 50674 Cologne, Germany
Nature 477:330-4. 2011..Epithelial-specific inhibition of CYLD, a deubiquitinase that regulates cellular necrosis, prevented colitis development in FADD(IEC-KO) but not in NEMO(.. - Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase 2AJiHoon Chang
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 107:8340-5. 2010..Unlike PP2A, MAP kinase phosphatase-1 or CYLD did not show an effect on IL-23 production supporting the specificity of PP2A... - CARMA1 regulation of regulatory T cell development involves modulation of interleukin-2 receptor signalingAndrew Joon Lee
Department of Immunology, The University of Texas MD Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
J Biol Chem 285:15696-703. 2010T cell receptor-stimulated NF-kappaB activation requires CARMA1 and is negatively regulated by the deubiquitinase CYLD. Recent studies suggest that CARMA1 regulates regulatory T cell (Treg) development, although the role of NF-kappaB in .. - The bacterium, nontypeable Haemophilus influenzae, enhances host antiviral response by inducing Toll-like receptor 7 expression: evidence for negative regulation of host anti-viral response by CYLDAkihiro Sakai
Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642, USA
FEBS J 274:3655-68. 2007..Interestingly, CYLD, a novel deubiquitinase, acts as a negative regulator of TLR7 induction by NTHi... - Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLDNadine Hövelmeyer
I Medical Department, Johannes Gutenberg University Mainz, Verfügungsgebäude, 55131 Mainz, Germany
J Exp Med 204:2615-27. 2007..We describe a novel mouse strain that expresses solely and excessively a naturally occurring splice variant of CYLD (CYLD(ex7/8) mice), which is a deubiquitinating enzyme that is integral to NF-kappaB signaling... - Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of miceJae Hyang Lim
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS ONE 2:e1032. 2007..The deubiquitinating enzyme cylindromatosis (CYLD), loss of which was originally reported to cause a benign human syndrome called cylindromatosis, has been .. - Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLDAto Wright
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Dev Cell 13:705-16. 2007..Here we show that genetic deficiency of Cyld, a recently identified deubiquitinating enzyme, attenuates the early wave of germ cell apoptosis and causes .. - Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in miceWei Jin
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Clin Invest 118:1858-66. 2008..We therefore investigated the role of the recently identified deubiquitinating enzyme CYLD in osteoclastogenesis and found that mice with a genetic deficiency of CYLD had aberrant osteoclast .. - Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLDMinying Zhang
Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 283:18621-6. 2008..However, how these kinases are negatively regulated remains unclear. We show here that the tumor suppressor CYLD has an essential role in preventing aberrant activation of IKKepsilon/TBK1... - Naturally occurring short splice variant of CYLD positively regulates dendritic cell functionCathy Cecilia Srokowski
Institute for Immunology, Johannes Gutenberg University, Mainz, Germany
Blood 113:5891-5. 2009Deubiquitination of NF-kappaB members by CYLD is crucial in controlling the magnitude and nature of cell activation... - Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclast-like cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha signaling cascadesEstabelle Ang
Molecular Orthopaedic Laboratory, Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Nedlands, Western Australia, Australia
J Cell Physiol 220:450-9. 2009..pathway using selective inhibitors (MG-132, MG-115, and epoxomicin) resulted in the accumulation of p62 and CYLD, and altered the subcellular targeting and distribution of p62 and TRAF6 in osteoclast-like cells... - CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulinSara A Wickström
Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
EMBO J 29:131-44. 2010b>CYLD is a tumour-suppressor gene that is mutated in a benign skin tumour syndrome called cylindromatosis... - Regulation of natural killer T-cell development by deubiquitinase CYLDAndrew J Lee
Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
EMBO J 29:1600-12. 2010..We show here that CYLD, a tumour suppressor with deubiquitinase function, has a pivotal and cell-intrinsic function in NKT cell .. - The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammationNeesar Ahmed
Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA
Nat Immunol 12:1176-83. 2011..Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction through 'WW-PPXY' motifs...