cyclin T1


Gene Symbol: cyclin T1
Description: cyclin T1
Alias: 2810478G24Rik, AI115585, CycT1, cyclin-T1, cyclin-T
Species: mouse
Products:     cyclin T1

Top Publications

  1. Napolitano G, Licciardo P, Carbone R, Majello B, Lania L. CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization. J Cell Physiol. 2002;192:209-15 pubmed
    ..Here we report subcellular distribution of P-TEFb in terms of localization of CDK9 and cyclin T1. We found that cyclin T1 is exclusively nuclear and it is present in nuclear-speckled structures...
  2. Yang Z, He N, Zhou Q. Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression. Mol Cell Biol. 2008;28:967-76 pubmed
    ..It also functions as an associated factor and positive regulator of P-TEFb, a Cdk9-cyclin T1 heterodimer that stimulates transcriptional elongation by phosphorylating RNA polymerase II...
  3. Bieniasz P, Grdina T, Bogerd H, Cullen B. Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat. EMBO J. 1998;17:7056-65 pubmed
    Human cyclin T1 (hCycT1), a major subunit of the essential elongation factor P-TEFb, has been proposed to act as a cofactor for human immunodeficiency virus type 1 (HIV-1) Tat...
  4. Dai Q, Lei T, Zhao C, Zhong J, Tang Y, Chen B, et al. Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells. J Biol Chem. 2012;287:25344-52 pubmed publisher
    ..Importantly, knockdown of either kinase resulted in differentiation. Thus, our studies have uncovered two novel protein kinase complexes that maintain self-renewal in embryonic stem cells. ..
  5. Kwak Y, Ivanov D, Guo J, Nee E, Gaynor R. Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation. J Mol Biol. 1999;288:57-69 pubmed
    Human cyclin T1 markedly stimulates tat-activation in rodent cells which are normally poorly responsive to the effects of Tat...
  6. Espinoza Derout J, Wagner M, Shahmiri K, Mascareno E, Chaqour B, Siddiqui M. Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy. Cardiovasc Res. 2007;75:129-38 pubmed
    ..We performed immunoblot and immunofluorescence analysis of CLP-1 and the P-TEFb components cdk9 and cyclin T in fetal mouse heart and 2 day post-natal mouse cardiomyocytes to determine if they are co-localized...
  7. Hoque M, Young T, Lee C, Serrero G, Mathews M, PE ERY T. The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Mol Cell Biol. 2003;23:1688-702 pubmed
    b>Cyclin T1, together with the kinase CDK9, is a component of the transcription elongation factor P-TEFb which binds the human immunodeficiency virus type 1 (HIV-1) transactivator Tat...
  8. Mata X, Besnard N, Le Roux K, Tilly G, Andreoletti O, Hudrisier M, et al. Unexpected high testis-specific transcriptional activity of the cyclin T1 promoter in transgenic mice. FEBS Lett. 2003;549:163-6 pubmed
    The ubiquitously expressed cyclin T1 gene encodes for a protein involved in human immunodeficiency virus type 1 (HIV-1) transcription activation...
  9. Oqani R, Lin T, Lee J, Kim S, Sa S, Woo J, et al. Inhibition of P-TEFb disrupts global transcription, oocyte maturation, and embryo development in the mouse. Genesis. 2016;54:470-82 pubmed publisher
    ..In this study, using immunocytochemical analyses, we find that the P-TEFb components, Cyclin T1, CDK9, and its T-loop phosphorylated form, are localized to nuclear speckles, as well as in nucleoli in mouse ..

More Information


  1. Oven I, Brdicková N, Kohoutek J, Vaupotic T, Narat M, Peterlin B. AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells. Mol Cell Biol. 2007;27:8815-23 pubmed
    ..Moreover, the genetic inactivation of cyclin T1 from P-TEFb abolished the transcription of AIRE-responsive genes and led to lymphocytic infiltration of lacrimal ..
  2. Fujinaga K, Taube R, Wimmer J, Cujec T, Peterlin B. Interactions between human cyclin T, Tat, and the transactivation response element (TAR) are disrupted by a cysteine to tyrosine substitution found in mouse cyclin T. Proc Natl Acad Sci U S A. 1999;96:1285-90 pubmed
    ..Human cyclin T supports these interactions between Tat and TAR...
  3. Eberhardy S, Farnham P. Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter. J Biol Chem. 2002;277:40156-62 pubmed
    ..We have found that cyclin T1 binding to Myc localizes to the highly conserved Myc Box I, whereas cdk8 binding localizes to the amino-terminal ..
  4. Rollman E, Lund L, Sjöstrand D, Leitner T, Wahren B. A unique amino acid deletion in the chimpanzee Cyclin T1 does not affect Tat trans-activation of HIV. AIDS. 2002;16:2335-7 pubmed
    We have cloned and sequenced the chimpanzee (Pan troglodytes) cyclin T1 cDNA and performed functional HIV-1 Tat trans-activation studies...
  5. Jiang H, Peterlin B. Differential chromatin looping regulates CD4 expression in immature thymocytes. Mol Cell Biol. 2008;28:907-12 pubmed
    ..Moreover, the knockdown of CycT1 from P-TEFb abolishes both of these chromatin loops...
  6. Gaucher J, Boussouar F, Montellier E, Curtet S, Buchou T, Bertrand S, et al. Bromodomain-dependent stage-specific male genome programming by Brdt. EMBO J. 2012;31:3809-20 pubmed publisher
  7. Oqani R, Kim H, Diao Y, Park C, Jin D. The CDK9/cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: a possible role in embryonic genome activation. BMC Dev Biol. 2011;11:33 pubmed publisher
    ..Here, we show that the CDK9 and cyclin T1 subunits of P-TEFb are present in mouse oocytes and preimplantation embryos...
  8. Galatioto J, Mascareno E, Siddiqui M. CLP-1 associates with MyoD and HDAC to restore skeletal muscle cell regeneration. J Cell Sci. 2010;123:3789-95 pubmed publisher
    ..These findings suggest a novel transcriptional paradigm whereby CLP-1, in conjunction with MyoD and HDAC, acts to inhibit growth-related gene expression, a requirement for myoblasts to exit the cell cycle and transit to myotubes. ..
  9. Moiola C, De Luca P, Gardner K, Vazquez E, De Siervi A. Cyclin T1 overexpression induces malignant transformation and tumor growth. Cell Cycle. 2010;9:3119-26 pubmed publisher
    ..In this study we found that several head and neck tumor cell lines overexpress PTE Fb. We also established that Cyclin T1 is able to induce transformation in vitro, as we determined by foci and colony formation assays. Nu/nu mice s.c...
  10. Rahl P, Lin C, Seila A, Flynn R, McCuine S, Burge C, et al. c-Myc regulates transcriptional pause release. Cell. 2010;141:432-45 pubmed publisher
    ..We discuss the implications of these results for the role of c-Myc amplification in human cancer. ..
  11. Mueller D, Garcia Cuellar M, Bach C, Buhl S, Maethner E, Slany R. Misguided transcriptional elongation causes mixed lineage leukemia. PLoS Biol. 2009;7:e1000249 pubmed publisher
    ..In summary, we show aberrant transcriptional elongation as a novel mechanism for oncogenic transformation. ..
  12. Garber M, Wei P, Kewalramani V, Mayall T, Herrmann C, Rice A, et al. The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. Genes Dev. 1998;12:3512-27 pubmed
    HIV-1 Tat activates transcription through binding to human cyclin T1, a regulatory subunit of the TAK/P-TEFb CTD kinase complex...
  13. Biswas D, Milne T, Basrur V, Kim J, Elenitoba Johnson K, Allis C, et al. Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes. Proc Natl Acad Sci U S A. 2011;108:15751-6 pubmed publisher
    ..Thus, our study provides direct mechanistic insight into the role of fusion partners in MLL fusion-mediated leukemogenesis. ..
  14. Barrôco R, De Veylder L, Magyar Z, Engler G, Inze D, Mironov V. Novel complexes of cyclin-dependent kinases and a cyclin-like protein from Arabidopsis thaliana with a function unrelated to cell division. Cell Mol Life Sci. 2003;60:401-12 pubmed
    ..screens and immunoprecipitation assays identified CDKC-interacting proteins with homology to the animal cyclin T/cyclin K group...
  15. Espinoza Derout J, Wagner M, Salciccioli L, Lazar J, Bhaduri S, Mascareno E, et al. Positive transcription elongation factor b activity in compensatory myocardial hypertrophy is regulated by cardiac lineage protein-1. Circ Res. 2009;104:1347-54 pubmed publisher
    ..We also generated bigenic mice (MHC-cyclin T1/CLP-1(+/-)) by crossing MHC-cyclin T1 transgenic mice with CLP-1 heterozygote...
  16. He N, Pezda A, Zhou Q. Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation. Mol Cell Biol. 2006;26:7068-76 pubmed
    ..Concurrently, the P-TEFb equilibrium was shifted overwhelmingly toward the 7SK snRNP side. Together, these data link the P-TEFb equilibrium to the intracellular transcriptional demand and proliferative/differentiated states of cells. ..
  17. Song S, Kim A, Ragoczy T, Bender M, Groudine M, Dean A. Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation. Blood. 2010;116:2356-64 pubmed publisher
    ..Ldb1 contributes these critical functions at both embryonic and adult stages of globin gene expression. These results implicate Ldb1 as a factor that facilitates nuclear relocation for transcription activation. ..
  18. Kohoutek J, Li Q, Blazek D, Luo Z, Jiang H, Peterlin B. Cyclin T2 is essential for mouse embryogenesis. Mol Cell Biol. 2009;29:3280-5 pubmed publisher
    ..In mammals, it contains predominantly the C-type cyclin cyclin T1 (CycT1) or CycT2 and cyclin-dependent kinase 9 (Cdk9)...
  19. Nojima M, Huang Y, Tyagi M, Kao H, Fujinaga K. The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2. J Mol Biol. 2008;382:275-87 pubmed publisher
    The positive transcription elongation factor b (P-TEFb), composed of cyclin-dependent kinase 9 and cyclin T1, stimulates the elongation of transcription by hyperphosphorylating the C-terminal region of RNA polymerase II...
  20. Yedavalli V, Benkirane M, Jeang K. Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1. J Biol Chem. 2003;278:6404-10 pubmed
    P-TEFb, cyclin T1 + CDK9, is needed for the expression of cellular promoters and primate lentiviral long terminal repeats (LTRs)...
  21. Jiang H, Zhang F, Kurosu T, Peterlin B. Runx1 binds positive transcription elongation factor b and represses transcriptional elongation by RNA polymerase II: possible mechanism of CD4 silencing. Mol Cell Biol. 2005;25:10675-83 pubmed
    ..In this study, we found that Runx1 inhibits P-TEFb, which contains CycT1, CycT2, or CycK and Cdk9 and stimulates transcriptional elongation by RNA polymerase II (RNAPII) in eukaryotic ..