Cybb

Summary

Gene Symbol: Cybb
Description: cytochrome b-245, beta polypeptide
Alias: C88302, CGD91-phox, Cgd, Cyd, Nox2, gp91-1, gp91phox, cytochrome b-245 heavy chain, NADPH oxidase 2, cytochrome b558 subunit beta, heme-binding membrane glycoprotein gp91phox, neutrophil cytochrome b 91 kDa polypeptide, p22 phagocyte B-cytochrome
Species: mouse
Products:     Cybb

Top Publications

  1. Urao N, Inomata H, Razvi M, Kim H, Wary K, McKinney R, et al. Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia. Circ Res. 2008;103:212-20 pubmed publisher
    ..Reactive oxygen species (ROS) derived from Nox2-based NADPH oxidase play an important role in postnatal neovascularization; however, their role in BM and EPC ..
  2. Wu D, Ré D, Nagai M, Ischiropoulos H, Przedborski S. The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. Proc Natl Acad Sci U S A. 2006;103:12132-7 pubmed
    ..These findings suggest a non-cell-autonomous mechanism through which inflammation could hasten motor neuron death and contribute to the selective motor neuronal degeneration in ALS. ..
  3. Sonati T, Reimann R, Falsig J, Baral P, O CONNOR T, Hornemann S, et al. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature. 2013;501:102-6 pubmed publisher
    ..Furthermore, genetic ablation of the superoxide-producing enzyme NOX2 (also known as CYBB) protected mice from globular domain ligand toxicity...
  4. Mutunga M, Graham S, De Hormaeche R, Musson J, Robinson J, Mastroeni P, et al. Attenuated Salmonella typhimurium htrA mutants cause fatal infections in mice deficient in NADPH oxidase and destroy NADPH oxidase-deficient macrophage monolayers. Vaccine. 2004;22:4124-31 pubmed
    ..In contrast, they were found to be lethal for gene targeted gp91phox-/- mice deficient in NADPH oxidase, as was a S. typhimurium SPI-2 mutant known to be virulent in gp9lphox-/- mice...
  5. Segal B, Han W, Bushey J, Joo M, Bhatti Z, Feminella J, et al. NADPH oxidase limits innate immune responses in the lungs in mice. PLoS ONE. 2010;5:e9631 pubmed publisher
    Chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase in which phagocytes are defective in generating superoxide anion and downstream reactive oxidant intermediates (ROIs), is characterized by recurrent ..
  6. Chen H, Song Y, Chan P. Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion. J Cereb Blood Flow Metab. 2009;29:1262-72 pubmed publisher
    ..This study suggests that NOX plays a role in oxidative stress and inflammation, thus contributing to ischemic brain injury. ..
  7. Corzo C, Cotter M, Cheng P, Cheng F, Kusmartsev S, Sotomayor E, et al. Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. J Immunol. 2009;182:5693-701 pubmed publisher
    ..The increased ROS production by MDSC is mediated by up-regulated activity of NADPH oxidase (NOX2)...
  8. Cheng P, Corzo C, Luetteke N, Yu B, Nagaraj S, Bui M, et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med. 2008;205:2235-49 pubmed publisher
    ..This study demonstrates that tumor-induced up-regulation of S100A9 protein is critically important for accumulation of MDSCs and reveals a novel molecular mechanism of immunological abnormalities in cancer. ..
  9. Miller A, Drummond G, De Silva T, Mast A, Hickey H, Williams J, et al. NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2. Am J Physiol Heart Circ Physiol. 2009;296:H220-5 pubmed publisher
    ..e., mouse, rabbit, and pig. Second, using Nox2-deficient mice, we evaluated the involvement of Nox2-containing NADPH oxidases in any such regional differences...
  10. Pizzolla A, Hultqvist M, Nilson B, Grimm M, Eneljung T, Jonsson I, et al. Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections. J Immunol. 2012;188:5003-11 pubmed publisher
    ..from defective production of reactive oxygen species by phagocytes caused by mutations in genes encoding the NADPH oxidase 2 (NOX2) complex subunits...

Detail Information

Publications66

  1. Urao N, Inomata H, Razvi M, Kim H, Wary K, McKinney R, et al. Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia. Circ Res. 2008;103:212-20 pubmed publisher
    ..Reactive oxygen species (ROS) derived from Nox2-based NADPH oxidase play an important role in postnatal neovascularization; however, their role in BM and EPC ..
  2. Wu D, Ré D, Nagai M, Ischiropoulos H, Przedborski S. The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. Proc Natl Acad Sci U S A. 2006;103:12132-7 pubmed
    ..These findings suggest a non-cell-autonomous mechanism through which inflammation could hasten motor neuron death and contribute to the selective motor neuronal degeneration in ALS. ..
  3. Sonati T, Reimann R, Falsig J, Baral P, O CONNOR T, Hornemann S, et al. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature. 2013;501:102-6 pubmed publisher
    ..Furthermore, genetic ablation of the superoxide-producing enzyme NOX2 (also known as CYBB) protected mice from globular domain ligand toxicity...
  4. Mutunga M, Graham S, De Hormaeche R, Musson J, Robinson J, Mastroeni P, et al. Attenuated Salmonella typhimurium htrA mutants cause fatal infections in mice deficient in NADPH oxidase and destroy NADPH oxidase-deficient macrophage monolayers. Vaccine. 2004;22:4124-31 pubmed
    ..In contrast, they were found to be lethal for gene targeted gp91phox-/- mice deficient in NADPH oxidase, as was a S. typhimurium SPI-2 mutant known to be virulent in gp9lphox-/- mice...
  5. Segal B, Han W, Bushey J, Joo M, Bhatti Z, Feminella J, et al. NADPH oxidase limits innate immune responses in the lungs in mice. PLoS ONE. 2010;5:e9631 pubmed publisher
    Chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase in which phagocytes are defective in generating superoxide anion and downstream reactive oxidant intermediates (ROIs), is characterized by recurrent ..
  6. Chen H, Song Y, Chan P. Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion. J Cereb Blood Flow Metab. 2009;29:1262-72 pubmed publisher
    ..This study suggests that NOX plays a role in oxidative stress and inflammation, thus contributing to ischemic brain injury. ..
  7. Corzo C, Cotter M, Cheng P, Cheng F, Kusmartsev S, Sotomayor E, et al. Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. J Immunol. 2009;182:5693-701 pubmed publisher
    ..The increased ROS production by MDSC is mediated by up-regulated activity of NADPH oxidase (NOX2)...
  8. Cheng P, Corzo C, Luetteke N, Yu B, Nagaraj S, Bui M, et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med. 2008;205:2235-49 pubmed publisher
    ..This study demonstrates that tumor-induced up-regulation of S100A9 protein is critically important for accumulation of MDSCs and reveals a novel molecular mechanism of immunological abnormalities in cancer. ..
  9. Miller A, Drummond G, De Silva T, Mast A, Hickey H, Williams J, et al. NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2. Am J Physiol Heart Circ Physiol. 2009;296:H220-5 pubmed publisher
    ..e., mouse, rabbit, and pig. Second, using Nox2-deficient mice, we evaluated the involvement of Nox2-containing NADPH oxidases in any such regional differences...
  10. Pizzolla A, Hultqvist M, Nilson B, Grimm M, Eneljung T, Jonsson I, et al. Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections. J Immunol. 2012;188:5003-11 pubmed publisher
    ..from defective production of reactive oxygen species by phagocytes caused by mutations in genes encoding the NADPH oxidase 2 (NOX2) complex subunits...
  11. Nair D, Dayyat E, Zhang S, Wang Y, Gozal D. Intermittent hypoxia-induced cognitive deficits are mediated by NADPH oxidase activity in a murine model of sleep apnea. PLoS ONE. 2011;6:e19847 pubmed publisher
    ..Excessive NADPH oxidase activity may play a role in IH-induced CNS dysfunction...
  12. Bao S, Carr E, Xu Y, Hunt N. Gp91(phox) contributes to the development of experimental inflammatory bowel disease. Immunol Cell Biol. 2011;89:853-60 pubmed publisher
    ..in innate immunity via the oxidative burst, using the p47phox- and gp91(phox)-containing NAD(P)H oxidase known as Nox2. In dextran sulphate sodium (DSS)-induced colitis, no significant difference in inflammation between p47(phox-/-) ..
  13. Fernandez Boyanapalli R, McPhillips K, Frasch S, Janssen W, Dinauer M, Riches D, et al. Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-? in a nitric oxide-dependent manner. J Immunol. 2010;185:4030-41 pubmed publisher
    Immunodeficiency in chronic granulomatous disease (CGD) is well characterized. Less understood are exaggerated sterile inflammation and autoimmunity associated with CGD...
  14. Xiang F, Lu X, Strutt B, Hill D, Feng Q. NOX2 deficiency protects against streptozotocin-induced beta-cell destruction and development of diabetes in mice. Diabetes. 2010;59:2603-11 pubmed publisher
    The role of NOX2-containing NADPH oxidase in the development of diabetes is not fully understood...
  15. Behrens M, Ali S, Dao D, Lucero J, Shekhtman G, Quick K, et al. Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase. Science. 2007;318:1645-7 pubmed
    ..These results suggest that NADPH oxidase may represent a novel target for the treatment of ketamine-induced psychosis. ..
  16. Peng T, Lu X, Feng Q. Pivotal role of gp91phox-containing NADH oxidase in lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression. Circulation. 2005;111:1637-44 pubmed
    ..The aim of this study was to investigate the role of gp91phox-containing NADH oxidase signaling in cardiomyocyte TNF-alpha expression and myocardial dysfunction induced by LPS...
  17. Brait V, Jackman K, Walduck A, Selemidis S, Diep H, Mast A, et al. Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide. J Cereb Blood Flow Metab. 2010;30:1306-17 pubmed publisher
    ..male mice is associated with increased expression of proinflammatory proteins, including cyclooxygenase-2 (Cox-2), Nox2, and vascular cell adhesion molecule-1 (VCAM-1), and infiltration of Nox2-containing T lymphocytes into the ..
  18. Carnesecchi S, Deffert C, Pagano A, Garrido Urbani S, Métrailler Ruchonnet I, Schappi M, et al. NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Am J Respir Crit Care Med. 2009;180:972-81 pubmed publisher
    ..Although NOX1 and NOX2 are expressed in the lungs, their precise function has not been determined until now...
  19. Li J, Fan L, George V, Brooks G. Nox2 regulates endothelial cell cycle arrest and apoptosis via p21cip1 and p53. Free Radic Biol Med. 2007;43:976-86 pubmed
    Endothelial cells (EC) express constitutively two major isoforms (Nox2 and Nox4) of the catalytic subunit of NADPH oxidase, which is a major source of endothelial reactive oxygen species...
  20. Miller A, De Silva T, Judkins C, Diep H, Drummond G, Sobey C. Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia. Stroke. 2010;41:784-9 pubmed publisher
    We tested the hypothesis that elevated superoxide production by Nox2-NADPH oxidase occurs in cerebral arteries during hypercholesterolemia and causes decreased nitric oxide function.
  21. Casbon A, Allen L, Dunn K, Dinauer M. Macrophage NADPH oxidase flavocytochrome B localizes to the plasma membrane and Rab11-positive recycling endosomes. J Immunol. 2009;182:2325-39 pubmed publisher
    ..Flavocytochrome b is a membrane heterodimer consisting of a large subunit gp91(phox) (NOX2) and a smaller subunit, p22(phox)...
  22. Fernandez Boyanapalli R, Frasch S, McPhillips K, Vandivier R, Harry B, Riches D, et al. Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4. Blood. 2009;113:2047-55 pubmed publisher
    Chronic granulomatous disease (CGD) is characterized by overexuberant inflammation and autoimmunity that are attributed to deficient anti-inflammatory signaling...
  23. George Chandy A, Nordström I, Nygren E, Jonsson I, Postigo J, Collins L, et al. Th17 development and autoimmune arthritis in the absence of reactive oxygen species. Eur J Immunol. 2008;38:1118-26 pubmed publisher
    ..These data suggest that ROS act as immunomodulators in DC-driven T cell activation and perhaps also in T cell-dependent immunopathology. ..
  24. Murdoch C, Alom Ruiz S, Wang M, Zhang M, Walker S, Yu B, et al. Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction. Basic Res Cardiol. 2011;106:527-38 pubmed publisher
    ..Several Nox isoforms are expressed in the vessel wall, among which Nox2 is especially abundant in the endothelium...
  25. Kazama K, Anrather J, Zhou P, Girouard H, Frys K, Milner T, et al. Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ Res. 2004;95:1019-26 pubmed
    ..antagonist losartan and by ROS scavenger superoxide dismutase or tiron and was not observed in mice lacking the gp91phox subunit of NADPH oxidase or in wild-type mice treated with the NADPH oxidase peptide inhibitor gp91ds-tat...
  26. Tojo T, Ushio Fukai M, Yamaoka Tojo M, Ikeda S, Patrushev N, Alexander R. Role of gp91phox (Nox2)-containing NAD(P)H oxidase in angiogenesis in response to hindlimb ischemia. Circulation. 2005;111:2347-55 pubmed
    ..We reported that reactive oxygen species (ROS) derived from gp91phox (Nox2)-containing NAD(P)H oxidase are involved in angiogenesis in mouse sponge models as well as in vascular ..
  27. Vlahos R, Stambas J, Bozinovski S, Broughton B, Drummond G, Selemidis S. Inhibition of Nox2 oxidase activity ameliorates influenza A virus-induced lung inflammation. PLoS Pathog. 2011;7:e1001271 pubmed publisher
    ..We investigated whether the primary enzymatic source of inflammatory cell ROS (reactive oxygen species), Nox2-containing NADPH oxidase, is a novel pharmacological target against the lung inflammation caused by influenza A ..
  28. Kishida K, Hoeffer C, Hu D, Pao M, Holland S, Klann E. Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease. Mol Cell Biol. 2006;26:5908-20 pubmed
    ..oxidase proteins gp91(phox) and p47(phox), both of which are mouse models of human chronic granulomatous disease (CGD), also lack LTP...
  29. Sareila O, Jaakkola N, Olofsson P, Kelkka T, Holmdahl R. Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation. J Leukoc Biol. 2013;93:427-35 pubmed publisher
    A point mutation in the mouse Ncf1(m1J) gene decreases production of ROS by the phagocytic NOX2 complex...
  30. Park L, Zhou P, Pitstick R, Capone C, Anrather J, Norris E, et al. Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc Natl Acad Sci U S A. 2008;105:1347-52 pubmed publisher
    ..We found that 12- to 15-month-old Tg2576 mice lacking the catalytic subunit Nox2 of NADPH oxidase do not develop oxidative stress, cerebrovascular dysfunction, or behavioral deficits...
  31. Anilkumar N, Weber R, Zhang M, Brewer A, Shah A. Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation. Arterioscler Thromb Vasc Biol. 2008;28:1347-54 pubmed publisher
    The NADPH oxidase isoforms Nox2 and Nox4 are coexpressed in many cell types and are implicated in agonist-stimulated redox-sensitive signal transduction...
  32. Ostanin D, Barlow S, Shukla D, Grisham M. NADPH oxidase but not myeloperoxidase protects lymphopenic mice from spontaneous infections. Biochem Biophys Res Commun. 2007;355:801-6 pubmed
  33. Savina A, Jancic C, Hugues S, Guermonprez P, Vargas P, Moura I, et al. NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell. 2006;126:205-18 pubmed
    ..The NADPH oxidase NOX2 is recruited to the DC's early phagosomes and mediates the sustained production of low levels of reactive oxygen ..
  34. Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, et al. NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J Neurosci. 2005;25:1769-77 pubmed
    ..oxidase peptide inhibitor gp91ds-tat and are not observed in mice lacking the catalytic subunit of NADPH oxidase (gp91phox)...
  35. Gandhirajan R, Meng S, Chandramoorthy H, Mallilankaraman K, Mancarella S, Gao H, et al. Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J Clin Invest. 2013;123:887-902 pubmed publisher
    ..Here we report that LPS-mediated Ca2+ oscillations are ablated in ECs deficient in Nox2, Stim1, and type II inositol triphosphate receptor (Itpr2)...
  36. Behrens M, Ali S, Dugan L. Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia. J Neurosci. 2008;28:13957-66 pubmed publisher
  37. Yuan H, Zhang X, Huang X, Lu Y, Tang W, Man Y, et al. NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of ?-cells via JNK, p38 MAPK and p53 pathways. PLoS ONE. 2010;5:e15726 pubmed publisher
    ..In the present study, we test the hypothesis that NOX2-derived ROS may play a critical role in dysfunction and apoptosis of ?-cells induced by FFA...
  38. Chen H, Kim G, Okami N, Narasimhan P, Chan P. NADPH oxidase is involved in post-ischemic brain inflammation. Neurobiol Dis. 2011;42:341-8 pubmed publisher
    ..Post-ischemic inflammation also causes progressive brain injury. In this study we investigated the role of NOX2 in post-ischemic cerebral inflammation using a transient middle cerebral artery occlusion model in mice...
  39. Chaubey S, Jones G, Shah A, Cave A, Wells C. Nox2 is required for macrophage chemotaxis towards CSF-1. PLoS ONE. 2013;8:e54869 pubmed publisher
    ..the redox modulation of the migratory process in macrophages and in particular that from the NADPH oxidase-2 (Nox2) dependent ROS has not been established...
  40. Heidari Y, Shah A, Gove C. NOX-2S is a new member of the NOX family of NADPH oxidases. Gene. 2004;335:133-40 pubmed
    ..The sequence identity between mouse and human NOX-2S strongly implies conservation in function and possibly a role for NOX-2S in the regulation of NADPH oxidase activity. ..
  41. Judkins C, Diep H, Broughton B, Mast A, Hooker E, Miller A, et al. Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice. Am J Physiol Heart Circ Physiol. 2010;298:H24-32 pubmed publisher
    ..However, no studies have examined which Nox isoform(s) are involved. Here we investigated the role of the Nox2-containing NADPH oxidase in atherogenesis in apolipoprotein E-null (ApoE(-/-)) mice...
  42. Elsen S, Doussiere J, Villiers C, Faure M, Berthier R, Papaioannou A, et al. Cryptic O2- -generating NADPH oxidase in dendritic cells. J Cell Sci. 2004;117:2215-26 pubmed
  43. Martinon F, Chen X, Lee A, Glimcher L. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol. 2010;11:411-8 pubmed publisher
    ..Our findings identify an unsuspected critical function for XBP1 in mammalian host defenses. ..
  44. Sokolovska A, Becker C, Ip W, Rathinam V, Brudner M, Paquette N, et al. Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function. Nat Immunol. 2013;14:543-53 pubmed publisher
    ..caspase-1 accumulates on phagosomes and acts locally to control the pH by modulating buffering by the NADPH oxidase NOX2. These data provide insight into a mechanism by which innate immune signals can modify cellular defenses and ..
  45. Lee K, Won H, Bae M, Hong J, Hwang E. Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells. Proc Natl Acad Sci U S A. 2011;108:9548-53 pubmed publisher
    ..In this study, we investigated the functions of NOX2 and ROS in immune modulation using NOX2 knockout (KO) mice...
  46. Johar S, Cave A, Narayanapanicker A, Grieve D, Shah A. Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB J. 2006;20:1546-8 pubmed
    ..We investigated the potential role of a Nox2-containing NADPH oxidase in aldosterone-induced fibrosis and the involvement of this mechanism in AngII-induced ..
  47. Lo W, Bravo T, Jadhav V, Titova E, Zhang J, Tang J. NADPH oxidase inhibition improves neurological outcomes in surgically-induced brain injury. Neurosci Lett. 2007;414:228-32 pubmed
    ..oxidase, an important reactive oxygen species producing enzyme, is involved in SBI using transgenic mice lacking gp91phox subunit of NADPH oxidase (gp91phox KO) and apocynin, a specific inhibitor of NADPH oxidase...
  48. Zhao W, Zhao D, Yan R, Sun Y. Cardiac oxidative stress and remodeling following infarction: role of NADPH oxidase. Cardiovasc Pathol. 2009;18:156-66 pubmed publisher
    ..Our findings indicate that during NADPH oxidase deficiency, superoxide production can be compensated by other sources, which leads to cardiac oxidative stress and its related molecular/cellular events in the infarcted heart. ..
  49. McCrann D, Eliades A, Makitalo M, Matsuno K, Ravid K. Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy. Blood. 2009;114:1243-9 pubmed publisher
    ..marrow (BM) cultures indicated high expression of Nox1, a weak expression of Nox4, and no significant expression of Nox2. Immunofluorescence of freshly isolated MKs confirmed strong expression of Nox1 in one-third of MKs, whereas Nox1 ..
  50. White J, Mastroeni P, Popoff J, Evans C, Blackwell J. Slc11a1-mediated resistance to Salmonella enterica serovar Typhimurium and Leishmania donovani infections does not require functional inducible nitric oxide synthase or phagocyte oxidase activity. J Leukoc Biol. 2005;77:311-20 pubmed
    ..By intercrossing mice with gene disruptions at Nos2A and Cybb (encoding gp91phox, the heavy chain subunit of cytochrome b-245 and an essential component of phagocyte NADPH oxidase) onto ..
  51. Jung O, Schreiber J, Geiger H, Pedrazzini T, Busse R, Brandes R. gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension. Circulation. 2004;109:1795-801 pubmed
    ..We hypothesized that the endothelial gp91phox-containing NADPH oxidase is predominant in generating the O2- to scavenge endothelial NO and thus is responsible ..
  52. Rothfork J, Timmins G, Harris M, Chen X, Lusis A, Otto M, et al. Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense. Proc Natl Acad Sci U S A. 2004;101:13867-72 pubmed
    ..Thus, oxidant-mediated inactivation of an autoinducing peptide from S. aureus is a critical innate defense mechanism against infection with this pathogen. ..
  53. De Silva T, Broughton B, Drummond G, Sobey C, Miller A. Gender influences cerebral vascular responses to angiotensin II through Nox2-derived reactive oxygen species. Stroke. 2009;40:1091-7 pubmed publisher
    We tested whether gender influences cerebrovascular responses to angiotensin II (AngII) and the role(s) of Nox2. AngII-stimulated superoxide (O(2)(-)) production by cerebral arteries from male and female wild-type (WT) and Nox2(-/-) mice ..
  54. Liu S, Tang J, Ostrowski R, Titova E, Monroe C, Chen W, et al. Oxidative stress after subarachnoid hemorrhage in gp91phox knockout mice. Can J Neurol Sci. 2007;34:356-61 pubmed
    ..Using gp91phox knockout (ko) and wild-type (wt) mice, we studied early brain injury in the endovascular perforation model of SAH...
  55. Kim S, Lee J, Cho W, Cho K, Sakong J, Kim J, et al. Role of NADPH oxidase-2 in lipopolysaccharide-induced matrix metalloproteinase expression and cell migration. Immunol Cell Biol. 2010;88:197-204 pubmed publisher
    This study examined the hypothesis that the control of NADPH oxidase-2 (Nox2)-mediated reactive oxygen species (ROS) regulates the expression of matrix metalloproteinases (MMPs) and the migration of macrophages...
  56. Deffert C, Carnesecchi S, Yuan H, Rougemont A, Kelkka T, Holmdahl R, et al. Hyperinflammation of chronic granulomatous disease is abolished by NOX2 reconstitution in macrophages and dendritic cells. J Pathol. 2012;228:341-50 pubmed publisher
    ..disease (CGD), caused by a lack of reactive oxygen species (ROS) generation by the phagocyte NADPH oxidase NOX2, leads to massively increased inflammatory responses...
  57. Al Shabrawey M, Rojas M, Sanders T, Behzadian A, El Remessy A, Bartoli M, et al. Role of NADPH oxidase in retinal vascular inflammation. Invest Ophthalmol Vis Sci. 2008;49:3239-44 pubmed publisher
    ..ROS, VEGF expression, and vascular permeability are accompanied by increases in the NADPH oxidase catalytic subunit NOX2 within the retinal vessels...
  58. Yao H, Edirisinghe I, Yang S, Rajendrasozhan S, Kode A, Caito S, et al. Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice. Am J Pathol. 2008;172:1222-37 pubmed publisher
    ..Thus, these data suggest that genetic ablation of components of NADPH oxidase enhances susceptibility to the proinflammatory effects of CS leading to airspace enlargement and alveolar damage. ..
  59. Girouard H, Wang G, Gallo E, Anrather J, Zhou P, Pickel V, et al. NMDA receptor activation increases free radical production through nitric oxide and NOX2. J Neurosci. 2009;29:2545-52 pubmed publisher
    ..In mice lacking the NADPH oxidase subunit NOX2, the ROS increase was not observed, but the CBF increase was still present...
  60. Schäppi M, Deffert C, Fiette L, Gavazzi G, Herrmann F, Belli D, et al. Branched fungal beta-glucan causes hyperinflammation and necrosis in phagocyte NADPH oxidase-deficient mice. J Pathol. 2008;214:434-44 pubmed
    Chronic granulomatous disease (CGD), a genetic disorder characterized by the absence of a functional phagocyte NADPH oxidase, is a severe immune deficiency. However, non-infectious hyperinflammation is a second hallmark of the disease...
  61. Sakai J, Li J, Subramanian K, Mondal S, Bajrami B, Hattori H, et al. Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils. Immunity. 2012;37:1037-49 pubmed publisher
    ..Together, these results present a physiological role for glutaredoxin and ROS- induced reversible actin glutathionylation in regulation of actin dynamics in neutrophils. ..
  62. Touyz R, Mercure C, He Y, Javeshghani D, Yao G, Callera G, et al. Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase. Hypertension. 2005;45:530-7 pubmed
    The gp91phox-containing NADPH oxidase is the major source of reactive oxygen species (ROS) in the cardiovascular system and inactivation of gp91phox has been reported to blunt hypertension and cardiac hypertrophy seen in angiotensin (Ang) ..
  63. Abramov A, Jacobson J, Wientjes F, Hothersall J, Canevari L, Duchen M. Expression and modulation of an NADPH oxidase in mammalian astrocytes. J Neurosci. 2005;25:9176-84 pubmed
    ..Responses were absent in transgenic mice lacking gp91phox. Expression of gp91phox and p67phox was increased in reactive astrocytes, which showed increased rates of both ..
  64. Cheret C, Gervais A, Lelli A, Colin C, Amar L, Ravassard P, et al. Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J Neurosci. 2008;28:12039-51 pubmed publisher
    ..CNS macrophages, are prominent sources of ROS through expression of the phagocyte oxidase which catalytic subunit Nox2 generates superoxide ion (O2(.-))...
  65. Looi Y, Grieve D, Siva A, Walker S, Anilkumar N, Cave A, et al. Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction. Hypertension. 2008;51:319-25 pubmed publisher
    ..We investigated the role of Nox2-containing reduced nicotinamide-adenine dinucleotide phosphate oxidase in the development of cardiac remodeling ..
  66. Zhang W, Baban B, Rojas M, Tofigh S, Virmani S, Patel C, et al. Arginase activity mediates retinal inflammation in endotoxin-induced uveitis. Am J Pathol. 2009;175:891-902 pubmed publisher
    ..In conclusion, these studies suggest that LPS-induced retinal inflammation in endotoxin-induced uveitis is mediated by NADPH oxidase-dependent increases in arginase activity. ..