Gene Symbol: Cxcr6
Description: chemokine (C-X-C motif) receptor 6
Alias: BB217514, BONZO, STRL33, C-X-C chemokine receptor type 6, CXC-R6, CXCR-6
Species: mouse
Products:     Cxcr6

Top Publications

  1. Matloubian M, David A, Engel S, Ryan J, Cyster J. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol. 2000;1:298-304 pubmed
    ..By expression cloning, Bonzo (also known as STRL33 and TYMSTR) was identified as a CXCL16 receptor...
  2. Unutmaz D, Xiang W, Sunshine M, Campbell J, Butcher E, Littman D. The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse. J Immunol. 2000;165:3284-92 pubmed
    ..Here we show that the expression pattern of Bonzo/STRL33, an orphan SIV/HIV coreceptor, is highly restricted to the memory subset of T cells and is up-regulated upon ..
  3. Paust S, Gill H, Wang B, Flynn M, Moseman E, Senman B, et al. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol. 2010;11:1127-35 pubmed publisher
    ..NK cell memory of haptens and viruses depended on CXCR6, a chemokine receptor on hepatic NK cells that was required for the persistence of memory NK cells but not for ..
  4. Riedel J, Paust H, Turner J, Tittel A, Krebs C, Disteldorf E, et al. Immature renal dendritic cells recruit regulatory CXCR6(+) invariant natural killer T cells to attenuate crescentic GN. J Am Soc Nephrol. 2012;23:1987-2000 pubmed publisher
    ..More than 90% of renal iNKT cells expressed the chemokine receptor CXCR6, and renal DCs produced high amounts of the cognate ligand CXCL16 early after induction of nephritis, suggesting ..
  5. Matsumura S, Wang B, Kawashima N, Braunstein S, Badura M, Cameron T, et al. Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol. 2008;181:3099-107 pubmed
    ..IR markedly enhanced the secretion by mouse and human breast cancer cells of CXCL16, a chemokine that binds to CXCR6 on Th1 and activated CD8 effector T cells, and plays an important role in their recruitment to sites of ..
  6. Geissmann F, Cameron T, Sidobre S, Manlongat N, Kronenberg M, Briskin M, et al. Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol. 2005;3:e113 pubmed
    ..of mice in which a green fluorescent protein cDNA was used to replace the gene encoding the chemokine receptor CXCR6. NKT cells, which account for most CXCR6(+) cells in liver, were found to crawl within hepatic sinusoids at 10-20 ..
  7. Sato T, Thorlacius H, Johnston B, Staton T, Xiang W, Littman D, et al. Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver. J Immunol. 2005;174:277-83 pubmed
    ..The present study examines the role of the chemokine receptor CXCR6, which is highly expressed by liver-infiltrating CD8 T cells...
  8. Johnston B, Kim C, Soler D, Emoto M, Butcher E. Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsets. J Immunol. 2003;171:2960-9 pubmed
    ..CXCR3, while >90% of Valpha14i-positive and approximately 50% of Valpha14i-negative NKT cells expressed CXCR6 via an enhanced green fluorescent protein reporter construct...
  9. Petit S, Chayen N, Pease J. Site-directed mutagenesis of the chemokine receptor CXCR6 suggests a novel paradigm for interactions with the ligand CXCL16. Eur J Immunol. 2008;38:2337-50 pubmed publisher
    Chemokine receptor CXCR6 mediates the chemotaxis and adhesion of leukocytes to soluble and membrane-anchored forms of CXCL16, and is an HIV-1 co-receptor...

More Information


  1. Taghizadeh R, Noh M, Huh Y, Ciusani E, Sigalotti L, Maio M, et al. CXCR6, a newly defined biomarker of tissue-specific stem cell asymmetric self-renewal, identifies more aggressive human melanoma cancer stem cells. PLoS ONE. 2010;5:e15183 pubmed publisher
    ..phenotypic evidence to support the origin of melanoma cancer stem cells (CSCs) from mutated tissue-specific stem cells; and the second one is the identification of a more aggressive subpopulation of CSCs in melanoma that are CXCR6+.
  2. Kim J, Jiang N, Tadokoro C, Liu L, Ransohoff R, Lafaille J, et al. Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites. J Immunol Methods. 2010;352:89-100 pubmed publisher
    ..We next demonstrate a distinct rostrocaudal migration of GFP(+) immune cells in the spinal cord of CXCR6(gfp/+) mice during active experimental autoimmune encephalomyelitis (EAE)...
  3. Cullen R, Germanov E, Shimaoka T, Johnston B. Enhanced tumor metastasis in response to blockade of the chemokine receptor CXCR6 is overcome by NKT cell activation. J Immunol. 2009;183:5807-15 pubmed publisher
    ..However, the mechanisms that regulate the effects of iNKT cells are unclear. The chemokine receptor CXCR6, and its ligand CXCL16, have been shown to play critical roles in iNKT cell homeostasis and activation...
  4. Postea O, Koenen R, Hristov M, Weber C, Ludwig A. Homocysteine up-regulates vascular transmembrane chemokine CXCL16 and induces CXCR6+ lymphocyte recruitment in vitro and in vivo. J Cell Mol Med. 2008;12:1700-9 pubmed publisher
    ..The CXC-chemokine CXCL16 functions as an adhesion molecule by interacting with its receptor (CXCR6) and also as a scavenger for oxidized low density lipoprotein (oxLDL)...
  5. Velazquez P, Cameron T, Kinjo Y, Nagarajan N, Kronenberg M, Dustin M. Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids. J Immunol. 2008;180:2024-8 pubmed
    ..Interestingly, NKT cell arrest also results from IL-12 and IL-18 synergistic activation. Thus, innate cytokines and natural microbial TCR agonists trigger sinusoidal NKT cell arrest and an effector response. ..
  6. Possot C, Schmutz S, Chea S, Boucontet L, Louise A, Cumano A, et al. Notch signaling is necessary for adult, but not fetal, development of ROR?t(+) innate lymphoid cells. Nat Immunol. 2011;12:949-58 pubmed publisher
    ..Here we identify the chemokine receptor CXCR6 as an additional marker of the development of ILCs and show that common lymphoid progenitors lost B cell and T ..
  7. Xia Y, Jin X, Yan J, Entman M, Wang Y. CXCR6 plays a critical role in angiotensin II-induced renal injury and fibrosis. Arterioscler Thromb Vasc Biol. 2014;34:1422-8 pubmed publisher
    ..However, the signaling mechanisms are poorly understood. In this study, we investigated the role of CXCR6 in Ang II-induced renal injury and fibrosis...
  8. Galkina E, Harry B, Ludwig A, Liehn E, Sanders J, Bruce A, et al. CXCR6 promotes atherosclerosis by supporting T-cell homing, interferon-gamma production, and macrophage accumulation in the aortic wall. Circulation. 2007;116:1801-11 pubmed
    ..In this study we tested the hypothesis that CXCR6, a chemokine receptor that is expressed on a subset of CD4+ T helper 1 cells and natural killer T cells, is ..
  9. Satoh Takayama N, Serafini N, Verrier T, Rekiki A, Renauld J, Frankel G, et al. The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells. Immunity. 2014;41:776-88 pubmed publisher
    ..We show that the CXCL16-CXCR6 chemokine-chemokine receptor axis regulated group 3 innate lymphoid cell (ILC3) diversity and function...
  10. Borst O, Münzer P, Gatidis S, Schmidt E, Schonberger T, Schmid E, et al. The inflammatory chemokine CXC motif ligand 16 triggers platelet activation and adhesion via CXC motif receptor 6-dependent phosphatidylinositide 3-kinase/Akt signaling. Circ Res. 2012;111:1297-307 pubmed publisher
  11. Thanabalasuriar A, Neupane A, Wang J, Krummel M, Kubes P. iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation. Cell Rep. 2016;16:3260-3272 pubmed publisher
    ..Moreover, impairing iNKT cell recruitment by blocking CCL17 increased susceptibility to S. pneumoniae infection, suggesting a critical role for the influx of iNKT cells in host defense. ..
  12. O Connor R, Li X, Blumerman S, Anderton S, Noelle R, Dalton D. Adjuvant immunotherapy of experimental autoimmune encephalomyelitis: immature myeloid cells expressing CXCL10 and CXCL16 attract CXCR3+CXCR6+ and myelin-specific T cells to the draining lymph nodes rather than the central nervous system. J Immunol. 2012;188:2093-101 pubmed publisher
    ..Subsequently, CD4(+) T cells coexpressing the cognate chemokine receptors CXCR3 and CXCR6 and myelin oligodendrocyte glycoprotein (MOG)-specific CD4(+) T cells accumulated within the chemokine-expressing ..
  13. Zhao G, Wang S, Wang Z, Sun A, Yang X, Qiu Z, et al. CXCR6 deficiency ameliorated myocardial ischemia/reperfusion injury by inhibiting infiltration of monocytes and IFN-?-dependent autophagy. Int J Cardiol. 2013;168:853-62 pubmed publisher
    ..b>CXCR6, the receptor for CXCL16, is also critically involved...
  14. Xia Y, Yan J, Jin X, Entman M, Wang Y. The chemokine receptor CXCR6 contributes to recruitment of bone marrow-derived fibroblast precursors in renal fibrosis. Kidney Int. 2014;86:327-37 pubmed publisher
    ..hematopoietic origin, and they proliferate, differentiate into myofibroblasts, and express the chemokine receptor CXCR6. As chemokines mediate the trafficking of circulating cells to sites of injury, we studied the role of CXCR6 in ..
  15. Lynch L, Michelet X, Zhang S, Brennan P, Moseman A, Lester C, et al. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nat Immunol. 2015;16:85-95 pubmed publisher
    ..Thus, iNKT cells in adipose tissue are unique regulators of immunological homeostasis in this tissue. ..
  16. Wong C, Jenne C, Lee W, Leger C, Kubes P. Functional innervation of hepatic iNKT cells is immunosuppressive following stroke. Science. 2011;334:101-5 pubmed publisher
  17. Kastenmüller W, Torabi Parizi P, Subramanian N, Lämmermann T, Germain R. A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell. 2012;150:1235-48 pubmed publisher
  18. Li C, Zhao J, Sun L, Yao Z, Liu R, Huang J, et al. RANKL downregulates cell surface CXCR6 expression through JAK2/STAT3 signaling pathway during osteoclastogenesis. Biochem Biophys Res Commun. 2012;429:156-62 pubmed publisher
    ..and their receptors have recently been shown to play critical roles in osteoclastogenesis, however, whether CXCL16-CXCR6 plays role in RANKL-mediated osteoclastogenesis is unknown...
  19. Kiss H, Darai E, Kiss C, Kost Alimova M, Klein G, Dumanski J, et al. Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3. Mamm Genome. 2002;13:646-55 pubmed
    ..We also recognized a large number of conserved elements that were neither exons, CpG islands, nor repeats. We further identified and characterized five novel orthologous mouse genes (Kiaa0028, Xtrp3s1, Fyco1, Tmem7, and Lrrc2). ..
  20. Fairfax K, Everts B, Smith A, Pearce E. Regulation of the development of the hepatic B cell compartment during Schistosoma mansoni infection. J Immunol. 2013;191:4202-10 pubmed publisher
    ..Expression of the CXCL16 receptor CXCR6 was increased on B cells within the hepatic LNs, but not the mesenteric LNs...
  21. Jiang X, Sun W, Zhu L, Guo D, Jiang H, Ma D, et al. Expression of CXCR6 on CD8(+) T cells was up-regulated in allograft rejection. Transpl Immunol. 2010;22:179-83 pubmed publisher
    ..Its receptor CXCR6 expresses on activated CD8(+) T cells, type 1-polarized CD4(+), and constitutively expresses on NKT cells...
  22. Lefebvre S, Fliniaux I, Schneider P, Mikkola M. Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012;132:1094-102 pubmed publisher
    ..Deficiency in cxcR3 resulted in decreased primary hair follicle density but otherwise normal hair development, indicating that chemokine signaling influences the patterning of primary hair placodes only. ..
  23. Kastenmüller W, Brandes M, Wang Z, Herz J, Egen J, Germain R. Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node. Immunity. 2013;38:502-13 pubmed publisher
    ..These data reveal the distinct localization and dynamic behavior of naive versus memory T cells within LNs and how these differences contribute to host defense. ..
  24. Butcher M, Wu C, Waseem T, Galkina E. CXCR6 regulates the recruitment of pro-inflammatory IL-17A-producing T cells into atherosclerotic aortas. Int Immunol. 2016;28:255-61 pubmed publisher
    ..The chemokine receptor CXCR6 is expressed on several T-cell subsets and plays a pro-atherogenic role in atherosclerosis...
  25. Tong P, Roediger B, Kolesnikoff N, Biro M, Tay S, Jain R, et al. The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy. J Invest Dermatol. 2015;135:84-93 pubmed publisher
    ..These approaches are applicable to assessing immune cell variations and potential functional consequences in the setting of infection, as well as the pathogenesis of inflammatory skin conditions. ..
  26. Wu M, Lin Y, Liao W, Tu C, Chen M, Roffler S, et al. Inhibition of the plasma SCUBE1, a novel platelet adhesive protein, protects mice against thrombosis. Arterioscler Thromb Vasc Biol. 2014;34:1390-8 pubmed publisher
    ..We conclude that plasma SCUBE1 participates in platelet aggregation by bridging adjacent activated platelets in thrombosis. Blockade of soluble SCUBE1 might represent a novel antithrombotic strategy. ..
  27. Wehr A, Baeck C, Heymann F, Niemietz P, Hammerich L, Martin C, et al. Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis. J Immunol. 2013;190:5226-36 pubmed publisher
    ..We hypothesized that chemokine receptor CXCR6 and its ligand CXCL16 control NKT cell migration and functionality in liver fibrosis...
  28. Monticelli L, Yang Y, Knell J, D Cruz L, Cannarile M, Engel I, et al. Transcriptional regulator Id2 controls survival of hepatic NKT cells. Proc Natl Acad Sci U S A. 2009;106:19461-6 pubmed publisher
    ..Id2-deficient iNKT cells exhibited diminished expression of CXCR6, a critical determinant of iNKT cell accumulation in the liver, and of the anti-apoptotic molecules bcl-2 and bcl-..
  29. Hattermann K, Ludwig A, Gieselmann V, Held Feindt J, Mentlein R. The chemokine CXCL16 induces migration and invasion of glial precursor cells via its receptor CXCR6. Mol Cell Neurosci. 2008;39:133-41 pubmed publisher
    ..Its receptor CXCR6 is detected during brain development highest at postnatal day 6, found in glial precursor cells differentiated ..
  30. Jiang X, Shimaoka T, Kojo S, Harada M, Watarai H, Wakao H, et al. Cutting edge: critical role of CXCL16/CXCR6 in NKT cell trafficking in allograft tolerance. J Immunol. 2005;175:2051-5 pubmed
    ..In this study, we demonstrate that blocking of the interaction between the chemokine receptor, CXCR6, highly expressed on V alpha14+ NKT cells and its ligand, CXCL16, resulted in the failure to maintain graft ..
  31. Rosito M, Deflorio C, Limatola C, Trettel F. CXCL16 orchestrates adenosine A3 receptor and MCP-1/CCL2 activity to protect neurons from excitotoxic cell death in the CNS. J Neurosci. 2012;32:3154-63 pubmed publisher
    ..We demonstrate here for the first time that the chemokine CXCL16 and its unique receptor CXCR6 are functionally expressed in the CNS, and induce neuroprotection against excitotoxic damage due to excessive ..
  32. Sasai K, Romer J, Kimura H, Eberhart D, Rice D, Curran T. Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor. Cancer Res. 2007;67:3871-7 pubmed
    ..Here, we report that 3% to 4% of mice lacking either one or both functional copies of Cxcr6 develop medulloblastoma...
  33. Herretes S, Ross D, Duffort S, Barreras H, Yaohong T, Saeed A, et al. Recruitment of Donor T Cells to the Eyes During Ocular GVHD in Recipients of MHC-Matched Allogeneic Hematopoietic Stem Cell Transplants. Invest Ophthalmol Vis Sci. 2015;56:2348-57 pubmed publisher
  34. Zaid A, Mackay L, Rahimpour A, Braun A, Veldhoen M, Carbone F, et al. Persistence of skin-resident memory T cells within an epidermal niche. Proc Natl Acad Sci U S A. 2014;111:5307-12 pubmed publisher
    ..Together, these data suggest that skin tissue-resident memory T cells persist within a tightly regulated epidermal T-cell niche. ..
  35. Wang J, Su F, Wang S, Lu X, Zhang S, Chen D, et al. CXCR6 deficiency attenuates pressure overload-induced monocytes migration and cardiac fibrosis through downregulating TNF-α-dependent MMP9 pathway. Int J Clin Exp Pathol. 2014;7:6514-23 pubmed
    ..Our previous study showed a reduction of TNF-α and attenuated cardiac remodeling in CXCR6 knockout (KO) mice after ischemia/reperfusion injury...
  36. Lee W, Sanz M, Wong C, Hardy P, Salman Dilgimen A, Moriarty T, et al. Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia. Proc Natl Acad Sci U S A. 2014;111:13936-41 pubmed publisher
    b>CXCR6-GFP(+) cells, which encompass 70% invariant natural killer T cells (iNKT cells), have been found primarily patrolling inside blood vessels in the liver...
  37. Slauenwhite D, Gebremeskel S, Doucette C, Hoskin D, Johnston B. Regulation of cytokine polarization and T cell recruitment to inflamed paws in mouse collagen-induced arthritis by the chemokine receptor CXCR6. Arthritis Rheumatol. 2014;66:3001-12 pubmed publisher
    The chemokine receptor CXCR6 is highly expressed on lymphocytes isolated from the synovium of patients with rheumatoid arthritis, psoriatic arthritis, or juvenile idiopathic arthritis, suggesting that CXCR6 regulates immune cell ..
  38. Tse S, Radtke A, Espinosa D, Cockburn I, Zavala F. The chemokine receptor CXCR6 is required for the maintenance of liver memory CD8? T cells specific for infectious pathogens. J Infect Dis. 2014;210:1508-16 pubmed publisher
    ..induced by immunization with parasites undergo a unique differentiation program and have enhanced expression of CXCR6. Following immunization with malaria parasites, CXCR6-deficient memory CD8(+) T cells recovered from the liver ..
  39. Hägglöf T, Sedimbi S, Yates J, Parsa R, Salas B, Harris R, et al. Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses. Nat Immunol. 2016;17:1407-1414 pubmed publisher
    ..Neutrophils can thus license iNKT cells to regulate potentially harmful autoreactive B cell responses during inflammasome-driven inflammation. ..
  40. Shimaoka T, Nakayama T, Fukumoto N, Kume N, Takahashi S, Yamaguchi J, et al. Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells. J Leukoc Biol. 2004;75:267-74 pubmed
    ..low-density lipoprotein and also the chemokine ligand for a G protein-coupled receptor CXC chemokine receptor 6 (CXCR6), expressed on activated T cells and NKT cells...
  41. Germanov E, Veinotte L, Cullen R, Chamberlain E, Butcher E, Johnston B. Critical role for the chemokine receptor CXCR6 in homeostasis and activation of CD1d-restricted NKT cells. J Immunol. 2008;181:81-91 pubmed
    ..Thymic NKT cells up-regulated the chemokine receptor CXCR6 following positive selection and migrated toward CXCL16 in vitro...
  42. Liew P, Lee W, Kubes P. iNKT Cells Orchestrate a Switch from Inflammation to Resolution of Sterile Liver Injury. Immunity. 2017;47:752-765.e5 pubmed publisher
    ..We have shown that self-antigen-driven iNKT cells function as sensors and orchestrators of the transformation from inflammation to tissue restitution for essential timely wound repair. ..
  43. Chea S, Possot C, Perchet T, Petit M, Cumano A, Golub R. CXCR6 Expression Is Important for Retention and Circulation of ILC Precursors. Mediators Inflamm. 2015;2015:368427 pubmed publisher
    ..Using Rag2(-/-) Cxcr6(Gfp/+) reporter mice, we assessed the expression and role of CXCR6 in the circulation of ILC precursors and their ..
  44. Heesch K, Raczkowski F, Schumacher V, Hünemörder S, Panzer U, Mittrücker H. The function of the chemokine receptor CXCR6 in the T cell response of mice against Listeria monocytogenes. PLoS ONE. 2014;9:e97701 pubmed publisher
    The chemokine receptor CXCR6 is expressed on different T cell subsets and up-regulated following T cell activation...
  45. Gray E, Friend S, Suzuki K, Phan T, Cyster J. Subcapsular sinus macrophage fragmentation and CD169+ bleb acquisition by closely associated IL-17-committed innate-like lymphocytes. PLoS ONE. 2012;7:e38258 pubmed publisher
    ..They also suggest an intimate crosstalk between SSMs and IL-17 committed innate-like lymphocytes that may help provide early protection of the lymph node against lymph-borne invaders. ..