Cxcr3

Summary

Gene Symbol: Cxcr3
Description: chemokine (C-X-C motif) receptor 3
Alias: Cd183, Cmkar3, C-X-C chemokine receptor type 3, IP-10 receptor, interferon-inducible protein 10 receptor
Species: mouse
Products:     Cxcr3

Top Publications

  1. Spehlmann M, Dann S, Hruz P, Hanson E, McCole D, Eckmann L. CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching/effacing lesion-forming bacterial pathogen. J Immunol. 2009;183:3332-43 pubmed publisher
    ..CXC chemokines, particularly CXCL1/2/5 and CXCL9/10, which are ligands for the chemokine receptors CXCR2 and CXCR3, respectively...
  2. Kohlmeier J, Cookenham T, Miller S, Roberts A, Christensen J, Thomsen A, et al. CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection. J Immunol. 2009;183:4378-84 pubmed publisher
    ..Although it was previously reported that the chemokine receptors CCR5 and CXCR3 affect trafficking of respiratory virus-specific CD8+ T cells, it is unclear whether these receptors govern ..
  3. Nakanishi Y, Lu B, Gerard C, Iwasaki A. CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help. Nature. 2009;462:510-3 pubmed publisher
    ..Our results reveal a previously unappreciated role of CD4 help in mobilizing effector CTL to the peripheral sites of infection where they help to eliminate infected cells...
  4. Campanella G, Tager A, El Khoury J, Thomas S, Abrazinski T, Manice L, et al. Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. Proc Natl Acad Sci U S A. 2008;105:4814-9 pubmed publisher
    ..Chemokines have been implicated in the development of cerebral malaria, and the IFN-inducible CXCR3 chemokine ligand IP-10 (CXCL10) was recently found to be the only serum biomarker that predicted cerebral malaria ..
  5. Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas C, et al. Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse. J Immunol. 2013;190:2229-40 pubmed publisher
    b>CXCR3, expressed mainly on activated T and NK cells, is implicated in a host of immunological conditions and can contribute either to disease resolution or pathology...
  6. Thapa M, Carr D. CXCR3 deficiency increases susceptibility to genital herpes simplex virus type 2 infection: Uncoupling of CD8+ T-cell effector function but not migration. J Virol. 2009;83:9486-501 pubmed publisher
    b>CXCR3 is a G-protein-coupled receptor preferentially expressed by activated T cells, NK cells, and dendritic cells...
  7. Miu J, Mitchell A, Müller M, Carter S, Manders P, McQuillan J, et al. Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. J Immunol. 2008;180:1217-30 pubmed
    ..murine models of malaria, we found much greater up-regulation of a number of chemokine mRNAs, including those for CXCR3 and its ligands, in the brain during fatal murine CM (FMCM) than in a model of non-CM...
  8. Van Den Steen P, Deroost K, Van Aelst I, Geurts N, Martens E, Struyf S, et al. CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines. Eur J Immunol. 2008;38:1082-95 pubmed publisher
    ..The strain-dependent susceptibility to develop CM is more related to the expression of CXCR3 in circulating leukocytes than to the chemokine expression levels in the brain.
  9. Kohler R, Comerford I, Townley S, Haylock Jacobs S, Clark Lewis I, McColl S. Antagonism of the chemokine receptors CXCR3 and CXCR4 reduces the pathology of experimental autoimmune encephalomyelitis. Brain Pathol. 2008;18:504-16 pubmed publisher
    ..In this study, we have investigated the role of CXCR3 and CXCR4 in the activation of T lymphocytes and their migration to the central nervous system (CNS) using novel ..

More Information

Publications69

  1. Kohlmeier J, Miller S, Smith J, Lu B, Gerard C, Cookenham T, et al. The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections. Immunity. 2008;29:101-13 pubmed publisher
    ..These data highlight the critical importance of early memory T cell recruitment for the efficacy of cellular immunity in the lung. ..
  2. Rosas L, Barbi J, Lu B, Fujiwara Y, Gerard C, Sanders V, et al. CXCR3-/- mice mount an efficient Th1 response but fail to control Leishmania major infection. Eur J Immunol. 2005;35:515-23 pubmed
    ..We analyzed the role of CXC chemokine receptor 3 (CXCR3) in the control of cutaneous leishmaniasis using CXCR3-/- C57BL/6 mice...
  3. MartIn Fontecha A, Thomsen L, Brett S, Gerard C, Lipp M, Lanzavecchia A, et al. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol. 2004;5:1260-5 pubmed
    ..killer (NK) cells, which are normally excluded from lymph nodes, are rapidly recruited in a CCR7-independent, CXCR3-dependent manner to lymph nodes on stimulation by the injection of mature DCs...
  4. Bodnar R, Yates C, Rodgers M, Du X, Wells A. IP-10 induces dissociation of newly formed blood vessels. J Cell Sci. 2009;122:2064-77 pubmed publisher
    ..We demonstrate that activation of CXC chemokine receptor 3 (CXCR3) mediates the regression of newly formed blood vessels...
  5. Nie L, Xiang R, Liu Y, Zhou W, Jiang L, Lu B, et al. Acute pulmonary inflammation is inhibited in CXCR3 knockout mice after short-term cigarette smoke exposure. Acta Pharmacol Sin. 2008;29:1432-9 pubmed publisher
    b>CXCR3, via binding its specific ligand CXCL10, plays an important role in cigarette smoke (CS)-induced pulmonary inflammation. CXCR3 is preferentially expressed in activated T cells (chiefly CD8+ T cells)...
  6. Krug A, Uppaluri R, Facchetti F, Dorner B, Sheehan K, Schreiber R, et al. IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation. J Immunol. 2002;169:6079-83 pubmed
    ..Although L-selectin, CXCR4, and CCR7 are recognized as critical IPC homing mediators, the role of CXCR3 is unclear, since IPC do not respond to CXCR3 ligands in vitro...
  7. Frigerio S, Junt T, Lu B, Gerard C, Zumsteg U, Hollander G, et al. Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat Med. 2002;8:1414-20 pubmed
    ..Thus, in the absence of known etiological agents, CXC receptor 3 represents a novel target for therapeutic interference early in type 1 diabetes. ..
  8. Rappert A, Bechmann I, Pivneva T, Mahlo J, Biber K, Nolte C, et al. CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion. J Neurosci. 2004;24:8500-9 pubmed
    ..We recently identified CXCR3, the corresponding receptor for CXCL10, in microglia and demonstrated that this receptor system controls ..
  9. Mohan K, Cordeiro E, Vaci M, McMaster C, Issekutz T. CXCR3 is required for migration to dermal inflammation by normal and in vivo activated T cells: differential requirements by CD4 and CD8 memory subsets. Eur J Immunol. 2005;35:1702-11 pubmed
    ..The relative importance of these receptors for migration in inflammation is unclear. The role of CXCR3 in T cell subset migration was examined using monoclonal antibodies developed to rat CXCR3...
  10. Lalor S, Segal B. Th1-mediated experimental autoimmune encephalomyelitis is CXCR3 independent. Eur J Immunol. 2013;43:2866-74 pubmed publisher
    ..In this context, chemokines and their receptors are attractive therapeutic targets. CXCR3, a Th1-associated chemokine receptor, is preferentially expressed on T cells that accumulate in MS lesions and ..
  11. Hancock W, Lu B, Gao W, Csizmadia V, Faia K, King J, et al. Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med. 2000;192:1515-20 pubmed
    ..chemoattractant (I-TAC), and by infiltration of activated T cells bearing the corresponding chemokine receptor, CXCR3. We used three in vivo models to demonstrate a role for CXCR3 in the development of transplant rejection...
  12. Nie L, Xiang R, Zhou W, Lu B, Cheng D, Gao J. Attenuation of acute lung inflammation induced by cigarette smoke in CXCR3 knockout mice. Respir Res. 2008;9:82 pubmed publisher
    ..together with CXCL11/ITAC (IFN-inducible T-cell alpha chemoattractant) are ligands for the chemokine receptor CXCR3 which is preferentially expressed chiefly in activated CD8+ T cells...
  13. Schulthess F, Paroni F, Sauter N, Shu L, Ribaux P, Haataja L, et al. CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell Metab. 2009;9:125-39 pubmed publisher
    ..These effects were not mediated by the commonly known CXCL10 receptor CXCR3 but through TLR4...
  14. Suzaki Y, Hamada K, Nomi T, Ito T, Sho M, Kai Y, et al. A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation. Eur Respir J. 2008;31:783-9 pubmed
    ..The aim of the present study was to investigate the role of CCR5 and CXCR3 in allergen-induced acute asthma and to determine whether a novel small-molecule compound, TAK-779, targeting CCR5 ..
  15. Yates C, Whaley D, Kulasekeran P, Hancock W, Lu B, Bodnar R, et al. Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor. Am J Pathol. 2007;171:484-95 pubmed
    ..The signals that direct this "stop and return" process have yet to be deciphered. CXCR3 chemokine receptor and its ligand CXCL11/IP-9/I-TAC are expressed by basal keratinocytes and CXCL10/IP-10 by ..
  16. van Weering H, Boddeke H, Vinet J, Brouwer N, de Haas A, Van Rooijen N, et al. CXCL10/CXCR3 signaling in glia cells differentially affects NMDA-induced cell death in CA and DG neurons of the mouse hippocampus. Hippocampus. 2011;21:220-32 pubmed publisher
    The chemokine CXCL10 and its receptor CXCR3 are implicated in various CNS pathologies since interference with CXCL10/CXCR3 signaling alters the onset and progression in various CNS disease models...
  17. Widney D, Hu Y, Foreman Wykert A, Bui K, Nguyen T, Lu B, et al. CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung. Infect Immun. 2005;73:485-93 pubmed
    ..evaluated the roles of the chemokines MIG (CXCL9), IP-10 (CXCL10), and I-TAC (CXCL11) and their common receptor, CXCR3. Following bacterial inoculation, message expression of interleukin-1 (IL-1), IL-6, and the neutrophil-attracting ..
  18. Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, et al. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol. 2009;10:514-23 pubmed publisher
    ..Our results identify distinct molecular requirements and ports of lymphocyte entry into uninflamed versus inflamed CNS and suggest that the CCR6-CCL20 axis in the choroid plexus controls immune surveillance of the CNS. ..
  19. de Lemos C, Christensen J, Nansen A, Moos T, Lu B, Gerard C, et al. Opposing effects of CXCR3 and CCR5 deficiency on CD8+ T cell-mediated inflammation in the central nervous system of virus-infected mice. J Immunol. 2005;175:1767-75 pubmed
    ..To study the redundancy of the chemokine receptors CXCR3 and CCR5 in regulating virus-induced CD8+ T cell-mediated inflammation in the brain, CXCR3/CCR5 double-deficient ..
  20. Lindell D, Lane T, Lukacs N. CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy. Eur J Immunol. 2008;38:2168-79 pubmed publisher
    ..The present studies investigated the role of the chemokine CXCL10 and its specific receptor, CXCR3, in the host response to pulmonary respiratory syncytial virus (RSV) infection...
  21. Zhang B, Chan Y, Lu B, Diamond M, Klein R. CXCR3 mediates region-specific antiviral T cell trafficking within the central nervous system during West Nile virus encephalitis. J Immunol. 2008;180:2641-9 pubmed
    ..In the current study we used mice deficient for the CXCL10 receptor, CXCR3, to evaluate its role in leukocyte-mediated viral clearance of WNV infection within various CNS compartments...
  22. Riemer C, Schultz J, Burwinkel M, Schwarz A, Mok S, Gültner S, et al. Accelerated prion replication in, but prolonged survival times of, prion-infected CXCR3-/- mice. J Virol. 2008;82:12464-71 pubmed publisher
    ..Among the chemokines upregulated highly and early upregulated during scrapie infections are ligands of CXCR3. To gain more insight into the role of CXCR3 in a prion model, CXCR3-deficient (CXCR3(-/-)) mice were infected ..
  23. Waeckel L, Mallat Z, Potteaux S, Combadiere C, Clergue M, Duriez M, et al. Impairment in postischemic neovascularization in mice lacking the CXC chemokine receptor 3. Circ Res. 2005;96:576-82 pubmed
    ..We hypothesized that the CXC chemokine receptor 3 (CXCR3) may contribute to leukocyte accumulation and subsequently to blood vessel growth in the ischemic area...
  24. Mohan K, Issekutz T. Blockade of chemokine receptor CXCR3 inhibits T cell recruitment to inflamed joints and decreases the severity of adjuvant arthritis. J Immunol. 2007;179:8463-9 pubmed
    T lymphocytes expressing the chemokine receptors, CCR2, CCR5, CXCR3, and CXCR6 are increased in inflamed tissues in rheumatoid arthritis. The role of CXCR3 in autoimmune arthritis induced in Lewis rats was investigated...
  25. Cohen S, Maurer K, Egan C, Oghumu S, Satoskar A, Denkers E. CXCR3-dependent CD4? T cells are required to activate inflammatory monocytes for defense against intestinal infection. PLoS Pathog. 2013;9:e1003706 pubmed publisher
    ..Chemokine receptor CXCR3 is associated with Th1 responses, and here we use bicistronic CXCR3-eGFP knock-in reporter mice to demonstrate ..
  26. Christen U, McGavern D, Luster A, Von Herrath M, Oldstone M. Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease. J Immunol. 2003;171:6838-45 pubmed
    ..Infection of the pancreas with lymphocytic choriomeningitis virus results in rapid and differential expression among CXCR3 chemokines...
  27. Meiser A, Mueller A, Wise E, McDonagh E, Petit S, Saran N, et al. The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor. J Immunol. 2008;180:6713-24 pubmed
    The chemokine receptor CXCR3 is expressed on the surface of both resting and activated T lymphocytes. We describe in this study the endocytosis of CXCR3 using T lymphocytes and CXCR3 transfectants...
  28. Yamada Y, Okubo Y, Shimada A, Oikawa Y, Yamada S, Narumi S, et al. Acceleration of diabetes development in CXC chemokine receptor 3 (CXCR3)-deficient NOD mice. Diabetologia. 2012;55:2238-45 pubmed publisher
    The aim of this study was to understand the role of CXC chemokine receptor 3 (CXCR3), a T-helper 1(Th1) type chemokine receptor, in the pathogenesis of type 1 diabetes...
  29. Marques C, Kapil P, Hinton D, Hindinger C, Nutt S, Ransohoff R, et al. CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis. J Virol. 2011;85:6136-47 pubmed publisher
    ..This study demonstrates that CXCR3 mediates CNS accumulation of ASC during neurotropic coronavirus-induced encephalomyelitis...
  30. Hansen D, Bernard N, Nie C, Schofield L. NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malaria. J Immunol. 2007;178:5779-88 pubmed
    ..berghei-infected animals. NK cell-depleted mice displayed down-regulation of CXCR3 expression and a significant reduction of T cells migrating in response to IFN-gamma-inducible protein 10, ..
  31. Kastenmüller W, Brandes M, Wang Z, Herz J, Egen J, Germain R. Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node. Immunity. 2013;38:502-13 pubmed publisher
    ..These data reveal the distinct localization and dynamic behavior of naive versus memory T cells within LNs and how these differences contribute to host defense. ..
  32. Lu B, Humbles A, Bota D, Gerard C, Moser B, Soler D, et al. Structure and function of the murine chemokine receptor CXCR3. Eur J Immunol. 1999;29:3804-12 pubmed
    The gene encoding the murine homologue of human CXCR3 exists in a single copy consisting of two exons with an intron interrupting the coding sequence between nucleotides 10 and 11...
  33. Hildebrandt G, Corrion L, Olkiewicz K, Lu B, Lowler K, Duffner U, et al. Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. J Immunol. 2004;173:2050-9 pubmed
    ..b>CXCR3 is a chemokine receptor that is expressed on activated Th1/Tc1 T cell subsets and the expression of its ligands ..
  34. MANICONE A, Burkhart K, Lu B, Clark J. CXCR3 ligands contribute to Th1-induced inflammation but not to homing of Th1 cells into the lung. Exp Lung Res. 2008;34:391-407 pubmed publisher
    ..In response to Th1-mediated immune injury, CXCR3 ligands IP10 and MIG are markedly induced...
  35. Veillard N, Steffens S, Pelli G, Lu B, Kwak B, Gerard C, et al. Differential influence of chemokine receptors CCR2 and CXCR3 in development of atherosclerosis in vivo. Circulation. 2005;112:870-8 pubmed
    ..The chemokine receptor CXCR3 is a marker of activated T helper type 1 lymphocytes, the principal T lymphocyte type detected within atheroma...
  36. Chakravarty S, Xu J, Lu B, Gerard C, Flynn J, Chan J. The chemokine receptor CXCR3 attenuates the control of chronic Mycobacterium tuberculosis infection in BALB/c mice. J Immunol. 2007;178:1723-35 pubmed
    The chemokine receptor CXCR3 plays a significant role in regulating the migration of Th1 cells...
  37. Hofer M, Carter S, Müller M, Campbell I. Unaltered neurological disease and mortality in CXCR3-deficient mice infected intracranially with lymphocytic choriomeningitis virus-Armstrong. Viral Immunol. 2008;21:425-33 pubmed publisher
    ..Previous studies have implicated the chemokine receptor CXCR3 and its ligand CXCL10 in CD8(+) T cell trafficking in the brain and in the lethal disease following intracranial ..
  38. Soto H, Wang W, Strieter R, Copeland N, Gilbert D, Jenkins N, et al. The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3. Proc Natl Acad Sci U S A. 1998;95:8205-10 pubmed
    We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X...
  39. Xie J, Nomura N, Lu M, Chen S, Koch G, Weng Y, et al. Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation. J Leukoc Biol. 2003;73:771-80 pubmed
    ..Human studies have shown that CXCR3 is one of the chemokine receptors that is induced during T cell activation...
  40. Groom J, Richmond J, Murooka T, Sorensen E, Sung J, Bankert K, et al. CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. Immunity. 2012;37:1091-103 pubmed publisher
    ..Here we have shown that the CXCR3 chemokine receptor was required for optimal generation of interferon-? (IFN-?)-secreting Th1 cells in vivo...
  41. Steinmetz O, Turner J, Paust H, Lindner M, Peters A, Heiss K, et al. CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. J Immunol. 2009;183:4693-704 pubmed publisher
    ..The chemokine receptor CXCR3 is highly expressed on Th1 cells and is supposed to be crucial for their trafficking into inflamed tissues...
  42. Barbi J, Oghumu S, Rosas L, Carlson T, Lu B, Gerard C, et al. Lack of CXCR3 delays the development of hepatic inflammation but does not impair resistance to Leishmania donovani. J Infect Dis. 2007;195:1713-7 pubmed
    CXC chemokine receptor 3 (CXCR3) ligands CXCL9 and CXCL10 are produced at high levels in mice and humans infected with Leishmania donovani, but their contribution to host resistance against L. donovani is not clear...
  43. Guarda G, Hons M, Soriano S, Huang A, Polley R, MartIn Fontecha A, et al. L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nat Immunol. 2007;8:743-52 pubmed
    ..This recruitment required CXCR3 expression on T cells and occurred through high endothelial venules in concert with lumenal expression of the ..
  44. Müller M, Carter S, Hofer M, Manders P, Getts D, Getts M, et al. CXCR3 signaling reduces the severity of experimental autoimmune encephalomyelitis by controlling the parenchymal distribution of effector and regulatory T cells in the central nervous system. J Immunol. 2007;179:2774-86 pubmed
    The chemokine receptor CXCR3 promotes the trafficking of activated T and NK cells in response to three ligands, CXCL9, CXCL10, and CXCL11...
  45. Fadel S, Bromley S, Medoff B, Luster A. CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortality. Eur J Immunol. 2008;38:3376-87 pubmed publisher
    ..Here we found that CXCR3-deficiency rescued CCR5-deficient (CCR5(-/-)) mice from influenza-induced mortality...
  46. Alanio C, Barreira da Silva R, Michonneau D, Bousso P, Ingersoll M, Albert M. CXCR3/CXCL10 Axis Shapes Tissue Distribution of Memory Phenotype CD8+ T Cells in Nonimmunized Mice. J Immunol. 2018;200:139-146 pubmed publisher
    ..a monospecific TCR, we discovered increased numbers of MP CD8+ T cells circulating in nonimmunized Cxcr3-/- and Cxcl10-/- mice compared with wild-type animals...
  47. Srivastava R, Khan A, Chilukuri S, Syed S, Tran T, Furness J, et al. CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8+ TEM and CD8+ TRM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease. J Virol. 2017;91: pubmed publisher
    ..The CXC chemokine ligand 10 (CXCL10)/CXC chemokine receptor 3 (CXCR3) chemokine pathway promotes T cell immunity to many viral pathogens, but its importance in CD8+ T cell ..
  48. Mony J, Khorooshi R, Owens T. MOG extracellular domain (p1-125) triggers elevated frequency of CXCR3+ CD4+ Th1 cells in the CNS of mice and induces greater incidence of severe EAE. Mult Scler. 2014;20:1312-21 pubmed publisher
    ..EAE in MOG(Igd)-immunized mice was characterized by an increased percentage of CXCR3+ interferon-?-producing CD4+ T cells in CNS. The CD8+ T-cell response to both immunogens was similar...
  49. Hsu H, Duning K, Meyer H, Stölting M, Weide T, Kreusser S, et al. Hypertension in mice lacking the CXCR3 chemokine receptor. Am J Physiol Renal Physiol. 2009;296:F780-9 pubmed publisher
    The CXC chemokine receptor 3 (CXCR3) has been linked to autoimmune and inflammatory disease, allograft rejection, and ischemic nephropathy. CXCR3 is expressed on endothelial and smooth muscle cells...
  50. Schmitz K, Pickert G, Wijnvoord N, Häussler A, Tegeder I. Dichotomy of CCL21 and CXCR3 in nerve injury-evoked and autoimmunity-evoked hyperalgesia. Brain Behav Immun. 2013;32:186-200 pubmed publisher
    The chemokine CCL21 is released from injured neurons and acts as a ligand of the chemokine receptor, CXCR3, which likely contributes to pro-inflammatory adaptations and secondary neuronal damage...
  51. Xanthou G, Williams T, Pease J. Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi-step model of ligand binding and receptor activation. Eur J Immunol. 2003;33:2927-36 pubmed
    b>CXCR3 is a chemokine receptor predominantly expressed on T lymphocytes, and binds the chemokines CXCL9 (Mig), CXCL10 (IP-10) and CXCL11 (I-TAC)...
  52. Pak Wittel M, Yang L, Sojka D, Rivenbark J, Yokoyama W. Interferon-? mediates chemokine-dependent recruitment of natural killer cells during viral infection. Proc Natl Acad Sci U S A. 2013;110:E50-9 pubmed publisher
    ..mRNA expression in the draining LN following infection suggested the selective involvement of CCR2, CCR5, and/or CXCR3. Mice deficient for CCR2 or CCR5 had normal NK-cell recruitment, whereas CXCR3-deficient mice displayed a major ..
  53. Olive A, Gondek D, Starnbach M. CXCR3 and CCR5 are both required for T cell-mediated protection against C. trachomatis infection in the murine genital mucosa. Mucosal Immunol. 2011;4:208-16 pubmed publisher
    ..In this study we identify that the chemokine receptors CXCR3 (chemokine (C-X-C motif) receptor 3) and CCR5 (chemokine (C-C motif) receptor 5) are pivotal for T-lymphocyte ..
  54. Wuest T, Carr D. Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection. J Immunol. 2008;181:7985-93 pubmed
    ..mobilization was also compared between WT, CXCL10(-/-), and mice deficient in the only known receptor for CXCL10, CXCR3 (CXCR3 (-/-))...
  55. Ha Y, Liu H, Zhu S, Yi P, Liu W, Nathanson J, et al. Critical Role of the CXCL10/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush. Am J Pathol. 2017;187:352-365 pubmed publisher
    ..The levels of CXCL10 and CXCR3 were markedly elevated in TON, and up-regulation of CXCL10 was mediated by STAT1/3...
  56. Wickham S, Lu B, Ash J, Carr D. Chemokine receptor deficiency is associated with increased chemokine expression in the peripheral and central nervous systems and increased resistance to herpetic encephalitis. J Neuroimmunol. 2005;162:51-9 pubmed
    ..the role of the receptor for CXCL9 and CXCL10 in the host response to HSV-1 infection using mice deficient in CXCR3 expression (CXCR3-/-)...
  57. Al Banna N, Vaci M, Slauenwhite D, Johnston B, Issekutz T. CCR4 and CXCR3 play different roles in the migration of T cells to inflammation in skin, arthritic joints, and lymph nodes. Eur J Immunol. 2014;44:1633-43 pubmed publisher
    CCR4 and CXCR3 are expressed on several T-cell subsets in inflamed tissues, yet their role in tissue-specific recruitment is unclear...
  58. Liu Z, Chen H, Chen X, Gao J, Guo Z. Characteristics of Allergic Pulmonary Inflammation in CXCR3Knockout Mice Sensitized and Challenged with House Dust Mite Protein. PLoS ONE. 2016;11:e0162905 pubmed publisher
    Chemokine C-X-C motif receptor 3 (CXCR3) is a chemokine receptor that is mainly expressed by activated T lymphocytes...
  59. Jiang B, He L, Wu X, Shi H, Zhang W, Zhang Z, et al. Promoted Interaction of C/EBP? with Demethylated Cxcr3 Gene Promoter Contributes to Neuropathic Pain in Mice. J Neurosci. 2017;37:685-700 pubmed publisher
    ..Here we investigated how chemokine receptor CXCR3 is regulated by DNA methylation and how it contributes to neuropathic pain induced by spinal nerve ligation (SNL) ..
  60. Zhang W, Fei Y, Gao J, Liu B, Zhang F. The role of CXCR3 in the induction of primary biliary cirrhosis. Clin Dev Immunol. 2011;2011:564062 pubmed publisher
    Investigate whether CXCR3 and its ligands were involved in the pathogenesis of primary biliary cirrhosis (PBC) in an autoimmune cholangitis animal model...