Gene Symbol: Cxcr2
Description: chemokine (C-X-C motif) receptor 2
Alias: CD128, CDw128, Cmkar2, Gpcr16, IL-8Rh, IL-8rb, IL8RA, Il8rb, mIL-8RH, C-X-C chemokine receptor type 2, CXC-R2, CXCR-2, GRO/MGSA receptor, IL-8 receptor alpha chain, IL-8R B, chemokine (C-X-C) receptor 2, high affinity interleukin-8 receptor B, interleukin 8 receptor, beta, interleukin-8 receptor type B
Species: mouse
Products:     Cxcr2

Top Publications

  1. Wareing M, Shea A, Inglis C, Dias P, Sarawar S. CXCR2 is required for neutrophil recruitment to the lung during influenza virus infection, but is not essential for viral clearance. Viral Immunol. 2007;20:369-78 pubmed
    ..In the present study, we used CXCR2(/) mice to investigate the role of the chemokine receptor CXCR2 in neutrophil recruitment to the lungs during ..
  2. Frendeus B, Godaly G, Hang L, Karpman D, Lundstedt A, Svanborg C. Interleukin 8 receptor deficiency confers susceptibility to acute experimental pyelonephritis and may have a human counterpart. J Exp Med. 2000;192:881-90 pubmed
    ..The results provide a first molecular clue to disease susceptibility of patients prone to acute pyelonephritis. ..
  3. Singh U, Singh S, Boyaka P, McGhee J, Lillard J. Granulocyte chemotactic protein-2 mediates adaptive immunity in part through IL-8Rbeta interactions. J Leukoc Biol. 2004;76:1240-7 pubmed
    ..In contrast, cytokine and costimulatory molecule enhancement by GCP-2 was not induced by lymphocytes from IL-8Rbeta-/- mice, suggesting that GCP-2 modulates cellular immunity in part through IL-8Rbeta interactions. ..
  4. Spörri R, Joller N, Albers U, Hilbi H, Oxenius A. MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infection. J Immunol. 2006;176:6162-71 pubmed
  5. Wislez M, Fujimoto N, Izzo J, Hanna A, Cody D, Langley R, et al. High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer Res. 2006;66:4198-207 pubmed
    CXCL8, a ligand for the chemokine receptor CXCR2, was recently reported to be a transcriptional target of Ras signaling, but its role in Ras-induced tumorigenesis has not been fully defined...
  6. Abromson Leeman S, Bronson R, Luo Y, Berman M, Leeman R, Leeman J, et al. T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis. Am J Pathol. 2004;165:1519-33 pubmed
    ..Furthermore, studies using CXCR2 knockout recipients, unable to recruit neutrophils to inflammatory sites, show that although neutrophils are ..
  7. Padovani Claudio D, Liu L, Ransohoff R, Miller R. Alterations in the oligodendrocyte lineage, myelin, and white matter in adult mice lacking the chemokine receptor CXCR2. Glia. 2006;54:471-83 pubmed
    ..Previous studies showed that localized expression of the chemokine CXCL1 signals through the receptor CXCR2 to inhibit the migration and enhance the proliferation of spinal cord OPCs during development...
  8. Smith M, Olson T, Ley K. CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo. J Exp Med. 2004;200:935-9 pubmed
    ..investigated neutrophil adhesion in inflamed cremaster muscle venules in tumor necrosis factor (TNF)-alpha-treated CXCR2(-/-) or wild-type (WT) mice injected with E-selectin blocking monoclonal antibody (mAb) 9A9...
  9. Galioto A, Hess J, Nolan T, Schad G, Lee J, Abraham D. Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval strongyloides stercoralis in mice. Infect Immun. 2006;74:5730-8 pubmed
    ..approach used was to treat mice with an anti-CCR3 monoclonal antibody to eliminate eosinophils or to use CXCR2-/- mice, which have a severe neutrophil recruitment defect, and then determine the effect of the reduction or ..

More Information


  1. Goncalves A, Appelberg R. The involvement of the chemokine receptor CXCR2 in neutrophil recruitment in LPS-induced inflammation and in Mycobacterium avium infection. Scand J Immunol. 2002;55:585-91 pubmed
    Knockout mice for CXC receptor 2 (CXCR2) chemokine receptor were used to study the recruitment of neutrophils during acute and chronic inflammatory responses...
  2. Reutershan J, Morris M, Burcin T, Smith D, Chang D, Saprito M, et al. Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung. J Clin Invest. 2006;116:695-702 pubmed
    In models of acute lung injury, CXC chemokine receptor 2 (CXCR2) mediates migration of polymorphonuclear leukocytes (PMNs) into the lung...
  3. Hosking M, Liu L, Ransohoff R, Lane T. A protective role for ELR+ chemokines during acute viral encephalomyelitis. PLoS Pathog. 2009;5:e1000648 pubmed publisher
    ..central nervous system (CNS) of mice resulted in the rapid mobilization of PMNs expressing the chemokine receptor CXCR2 into the blood...
  4. Chintakuntlawar A, Chodosh J. Chemokine CXCL1/KC and its receptor CXCR2 are responsible for neutrophil chemotaxis in adenoviral keratitis. J Interferon Cytokine Res. 2009;29:657-66 pubmed publisher
    ..Here, we have characterized the role of chemokine CXCL1/KC and receptor CXCR2 in adenoviral keratitis using a novel mouse model...
  5. Boisvert W, Rose D, Johnson K, Fuentes M, Lira S, Curtiss L, et al. Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression. Am J Pathol. 2006;168:1385-95 pubmed
    ..We have determined previously that the CXC chemokine receptor CXCR2 is involved in advanced atherosclerosis...
  6. Shaftel S, Carlson T, Olschowka J, Kyrkanides S, Matousek S, O Banion M. Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. J Neurosci. 2007;27:9301-9 pubmed
    ..Knock-out of their sole receptor CXCR2 abrogated neutrophil infiltration but failed to reduce leakage of the blood-brain barrier.
  7. Svensson M, Irjala H, Alm P, Holmqvist B, Lundstedt A, Svanborg C. Natural history of renal scarring in susceptible mIL-8Rh-/- mice. Kidney Int. 2005;67:103-10 pubmed
    ..The tissue damage resembles human disease, and these mice offer a model system to study the molecular mechanisms of renal scarring. ..
  8. Van Sweringen H, Sakai N, Quillin R, Bailey J, Schuster R, Blanchard J, et al. Roles of hepatocyte and myeloid CXC chemokine receptor-2 in liver recovery and regeneration after ischemia/reperfusion in mice. Hepatology. 2013;57:331-8 pubmed publisher
    Previous studies have demonstrated the significance of signaling through the CXC chemokine receptor-2 (CXCR2) receptor in the process of recovery and regeneration of functional liver mass after hepatic ischemia/reperfusion (I/R)...
  9. Hall L, Diaconu E, Patel R, Pearlman E. CXC chemokine receptor 2 but not C-C chemokine receptor 1 expression is essential for neutrophil recruitment to the cornea in helminth-mediated keratitis (river blindness). J Immunol. 2001;166:4035-41 pubmed
    ..b>CXCR2(-/-) and CCR1(-/-) mice were immunized s.c...
  10. Hang L, Frendeus B, Godaly G, Svanborg C. Interleukin-8 receptor knockout mice have subepithelial neutrophil entrapment and renal scarring following acute pyelonephritis. J Infect Dis. 2000;182:1738-48 pubmed
    ..In their absence, the neutrophils are trapped, and the tissues are destroyed. This molecular deficiency may determine the progression from acute pyelonephritis to renal scarring. ..
  11. Sugimoto N, Rui T, Yang M, Bharwani S, Handa O, Yoshida N, et al. Points of control exerted along the macrophage-endothelial cell-polymorphonuclear neutrophil axis by PECAM-1 in the innate immune response of acute colonic inflammation. J Immunol. 2008;181:2145-54 pubmed
    ..Further, as compared with PECAM-1(+/+) PMN, PECAM-1(-/-) PMN were less effective in orientating their CXCR2 receptors (polarization) in the direction of a chemotactic gradient...
  12. Kuboki S, Shin T, Huber N, Eismann T, Galloway E, Schuster R, et al. Hepatocyte signaling through CXC chemokine receptor-2 is detrimental to liver recovery after ischemia/reperfusion in mice. Hepatology. 2008;48:1213-23 pubmed publisher
    CXC chemokines and their receptor, CXC chemokine receptor-2 (CXCR2), are important components of the hepatic inflammatory response to ischemia/reperfusion (I/R)...
  13. Belperio J, Keane M, Burdick M, Londhe V, Xue Y, Li K, et al. Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury. J Clin Invest. 2002;110:1703-16 pubmed
    ..Because the murine CXC chemokines KC/CXCL1 and MIP-2/CXCL2/3, via CXCR2, are potent neutrophil chemoattractants, we investigated their role in a murine model of VILI...
  14. Citro A, Cantarelli E, Maffi P, Nano R, Melzi R, Mercalli A, et al. CXCR1/2 inhibition enhances pancreatic islet survival after transplantation. J Clin Invest. 2012;122:3647-51 pubmed publisher
    ..These findings indicate that the CXCR1/2-mediated pathway is a regulator of islet damage and should be a target for intervention to improve the efficacy of transplantation. ..
  15. Fan X, Patera A, Pong Kennedy A, Deno G, Gonsiorek W, Manfra D, et al. Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8. J Biol Chem. 2007;282:11658-66 pubmed
    Functional interleuin-8 (IL-8) receptors (IL-8RA and IL-8RB: CXCR1 and CXCR2, respectively) have been described in human, monkey, dog, rabbit, and guinea pig...
  16. Liu L, Belkadi A, Darnall L, Hu T, Drescher C, Cotleur A, et al. CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis. Nat Neurosci. 2010;13:319-26 pubmed publisher
    ..We found that mice lacking the type 2 CXC chemokine receptor (CXCR2) were relatively resistant to cuprizone-induced demyelination and that circulating CXCR2-positive neutrophils were ..
  17. Stefanovic L, Brenner D, Stefanovic B. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Exp Biol Med (Maywood). 2005;230:573-86 pubmed
    ..Hepatic stellate cells constitutively express the KC receptor, CXCR2. Addition of recombinant KC to HSCs undergoing activation in culture increases secretion and processing of Type I ..
  18. Tsai H, Frost E, To V, Robinson S, Ffrench Constant C, Geertman R, et al. The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. Cell. 2002;110:373-83 pubmed
    ..Here we demonstrate a role for the chemokine CXCL1 and its receptor CXCR2 in patterning the developing spinal cord...
  19. Keane M, Belperio J, Xue Y, Burdick M, Strieter R. Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer. J Immunol. 2004;172:2853-60 pubmed
    ..ELR(+) CXC chemokines share a common chemokine receptor, CXCR2. We hypothesized that CXCR2 mediates the proangiogenic effects of ELR(+) CXC chemokines during tumorigenesis...
  20. Carlson T, Kroenke M, Rao P, Lane T, Segal B. The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease. J Exp Med. 2008;205:811-23 pubmed publisher
    ..Blockade or genetic silencing of CXCR2, a major receptor for these chemokines in mice, abrogates blood-brain barrier (BBB) breakdown, CNS infiltration by ..
  21. Del Rio L, Bennouna S, Salinas J, Denkers E. CXCR2 deficiency confers impaired neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection. J Immunol. 2001;167:6503-9 pubmed
    ..In this work, mice deficient in expression of the chemokine receptor CXCR2 were infected with Toxoplasma gondii and the outcome was monitored...
  22. Godaly G, Hang L, Frendeus B, Svanborg C. Transepithelial neutrophil migration is CXCR1 dependent in vitro and is defective in IL-8 receptor knockout mice. J Immunol. 2000;165:5287-94 pubmed
    ..Uroepithelial CXCR1 and CXCR2 expression was detected in human urinary tract biopsies, and in vitro infection of human uroepithelial cell lines ..
  23. Devalaraja R, Nanney L, Du J, Qian Q, Yu Y, Devalaraja M, et al. Delayed wound healing in CXCR2 knockout mice. J Invest Dermatol. 2000;115:234-44 pubmed
    Previous studies demonstrated that the CXC chemokine, MGSA/GRO-alpha and its receptor, CXCR2, are expressed during wound healing by keratinocytes and endothelial cells at areas where epithelialization and neovascularization occur...
  24. Cacalano G, Lee J, Kikly K, Ryan A, Pitts Meek S, Hultgren B, et al. Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science. 1994;265:682-4 pubmed
    ..This receptor was the major mediator of neutrophil migration to sites of inflammation and may provide a potential therapeutic target in inflammatory disease. ..
  25. Lee J, Cacalano G, Camerato T, Toy K, Moore M, Wood W. Chemokine binding and activities mediated by the mouse IL-8 receptor. J Immunol. 1995;155:2158-64 pubmed
    ..These results show that macrophage inflammatory protein 2 and KC potently activate mouse neutrophils via a unique IL-8R, and these proteins may function as the major proinflammatory alpha chemokines in mice. ..
  26. Eash K, Greenbaum A, Gopalan P, Link D. CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. J Clin Invest. 2010;120:2423-31 pubmed publisher
    ..We investigated the role of CXCR2-binding ELR+ chemokines in neutrophil trafficking using mouse mixed bone marrow chimeras reconstituted with Cxcr2(-..
  27. Chou R, Kim N, Sadik C, Seung E, Lan Y, Byrne M, et al. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity. 2010;33:266-78 pubmed publisher
    ..CCR1 and CXCR2, two neutrophil chemokine receptors, operate nonredundantly to sequentially control the later phase of neutrophil ..
  28. Moepps B, Nuesseler E, Braun M, Gierschik P. A homolog of the human chemokine receptor CXCR1 is expressed in the mouse. Mol Immunol. 2006;43:897-914 pubmed
    ..that is highly similar to the cDNAs of hCXCR1 and hCXCR2, but is clearly distinct from the cDNA encoding mouse CXCR2 (mCXCR2)...
  29. Balish E, Wagner R, Vazquez Torres A, Jones Carson J, Pierson C, Warner T. Mucosal and systemic candidiasis in IL-8Rh-/- BALB/c mice. J Leukoc Biol. 1999;66:144-50 pubmed
    ..These results suggest a role for the IL-8Rh in murine resistance to gastric and acute systemic candidiasis, but not in resistance to systemic candidiasis of endogenous origin. ..
  30. Acosta J, O Loghlen A, Banito A, Guijarro M, Augert A, Raguz S, et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell. 2008;133:1006-18 pubmed publisher
    ..Here, we report that knocking down the chemokine receptor CXCR2 (IL8RB) alleviates both replicative and oncogene-induced senescence (OIS) and diminishes the DNA-damage response...
  31. Deberge M, Ely K, Cheng G, Enelow R. ADAM17-mediated processing of TNF-? expressed by antiviral effector CD8+ T cells is required for severe T-cell-mediated lung injury. PLoS ONE. 2013;8:e79340 pubmed publisher
    ..expression in acute lung injury by transferring influenza-specific CD8(+) T cells into transgenic mice lacking CXCR2. These mice exhibited reduced airway infiltration, attenuated lung injury, and enhanced survival...
  32. Jacobs J, Ortiz Lopez A, Campbell J, Gerard C, Mathis D, Benoist C. Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model. Arthritis Rheum. 2010;62:1921-32 pubmed publisher
    ..relevance of chemokine induction was assessed by transferring serum into mice deficient in CCR1-7, CCR9, CXCR2, CXCR3, CXCR5, CX(3)CR1, CCL2, or CCL3...
  33. Moore K, Swing D, Copeland N, Jenkins N. The murine dilute suppressor gene encodes a cell autonomous suppressor. Genetics. 1994;138:491-7 pubmed
    ..In addition, we have further refined the map location of dsu in order to examine a number of possible dsu candidate genes mapping in the region and to provide a genetic basis for the positional cloning of dsu. ..
  34. Connolly M, Mallen St Clair J, Bedrosian A, Malhotra A, Vera V, Ibrahim J, et al. Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor. J Leukoc Biol. 2010;87:713-25 pubmed publisher
    ..These findings may explain the propensity of patients with intra-abdominal cancers to develop liver metastases and suggest a promising target for experimental therapeutics. ..
  35. Kim H, ALONZO E, Dorothee G, Pollard J, Sant Angelo D. Selective depletion of eosinophils or neutrophils in mice impacts the efficiency of apoptotic cell clearance in the thymus. PLoS ONE. 2010;5:e11439 pubmed publisher
    ..These results suggested that there is crosstalk between cells of the innate immune system that is necessary for maximizing the efficiency of apoptotic cell removal. ..
  36. Zarpelon A, Pinto L, Cunha T, Vieira S, Carregaro V, Souza G, et al. Endothelin-1 induces neutrophil recruitment in adaptive inflammation via TNF? and CXCL1/CXCR2 in mice. Can J Physiol Pharmacol. 2012;90:187-99 pubmed publisher
    ..recruitment were reduced in TNFR1 deficient mice, and by treatments targeting CXCL1 or CXC chemokine receptor 2 (CXCR2); further, treatment with bosentan, BQ-123, or BQ-788 inhibited ET-1- and antigen-induced production of TNF? and ..
  37. Buanne P, Di Carlo E, Caputi L, Brandolini L, Mosca M, Cattani F, et al. Crucial pathophysiological role of CXCR2 in experimental ulcerative colitis in mice. J Leukoc Biol. 2007;82:1239-46 pubmed
    ..To investigate the pathophysiological role played by CXCR2 in experimental UC, we induced chronic experimental colitis in WT and CXCR2(-/-) mice by two consecutive cycles of ..
  38. Zhao M, Wimmer A, Trieu K, DiScipio R, Schraufstatter I. Arrestin regulates MAPK activation and prevents NADPH oxidase-dependent death of cells expressing CXCR2. J Biol Chem. 2004;279:49259-67 pubmed
    Activation of CXCR2 IL-8 receptor leads to activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and rapid receptor endocytosis...
  39. Londhe V, Maisonet T, Lopez B, Jeng J, Xiao J, Li C, et al. Conditional deletion of epithelial IKK? impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis. Respir Res. 2011;12:134 pubmed publisher
    ..The purpose of this study was to test our hypothesis that targeted deletion of NF-?B signaling in lung epithelium would impair alveolar formation...
  40. Schuh J, Blease K, Hogaboam C. CXCR2 is necessary for the development and persistence of chronic fungal asthma in mice. J Immunol. 2002;168:1447-56 pubmed
    ..Therefore, the present study addressed the role of CXCR2 during Aspergillus fumigatus-induced asthma...
  41. Hsieh C, Chen C, Lin Y, Yeh T, Tsai T, Hong M, et al. Macrophage migration inhibitory factor triggers chemotaxis of CD74+CXCR2+ NKT cells in chemically induced IFN-γ-mediated skin inflammation. J Immunol. 2014;193:3693-703 pubmed publisher
    ..MIF specifically triggered the chemotaxis of NKT cells via CD74 and CXCR2, and the resulting depletion of NKT cells abolished TPA-induced skin inflammation...
  42. Wilson G, Kuboki S, Freeman C, Nojima H, Schuster R, Edwards M, et al. CXC chemokines function as a rheostat for hepatocyte proliferation and liver regeneration. PLoS ONE. 2015;10:e0120092 pubmed publisher
    Our previous in vitro studies have demonstrated dose-dependent effects of CXCR2 ligands on hepatocyte cell death and proliferation...
  43. Yu J, Ruddy M, Wong G, Sfintescu C, Baker P, Smith J, et al. An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. Blood. 2007;109:3794-802 pubmed
    ..Consistently, CXCR2(KO) mice were highly susceptible to alveolar bone loss; interestingly, these mice also suggested a role for ..
  44. Jones C, Pitchford S, Lloyd C, Rankin S. CXCR2 mediates the recruitment of endothelial progenitor cells during allergic airways remodeling. Stem Cells. 2009;27:3074-81 pubmed publisher
    ..The influx in EPCs was associated with a significant increase in the proangiogenic factors VEGF-A and the CXCR2 ligands, CXCL1 and CXCL2...
  45. Kumar V, Donthireddy L, Marvel D, Condamine T, Wang F, Lavilla Alonso S, et al. Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. Cancer Cell. 2017;32:654-668.e5 pubmed publisher
    ..Combining CSF1R inhibitor with a CXCR2 antagonist blocked granulocyte infiltration of tumors and showed strong anti-tumor effects.
  46. Gong L, Cumpian A, Caetano M, Ochoa C, De la Garza M, Lapid D, et al. Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase. Mol Cancer. 2013;12:154 pubmed publisher
    ..We further selectively inhibited the main receptor for neutrophil chemo-attractant KC, CXCR2. Similarly, this resulted in suppression of neutrophil recruitment into the lung of CC-LR mice followed by ..
  47. Bajrami B, Zhu H, Kwak H, Mondal S, Hou Q, Geng G, et al. G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling. J Exp Med. 2016;213:1999-2018 pubmed publisher
    ..In this study, we report that CXCR2 ligands are responsible for rapid neutrophil mobilization during early-stage acute inflammation...
  48. Marazioti A, Lilis I, Vreka M, Apostolopoulou H, Kalogeropoulou A, Giopanou I, et al. Myeloid-derived interleukin-1? drives oncogenic KRAS-NF-?? addiction in malignant pleural effusion. Nat Commun. 2018;9:672 pubmed publisher
    ..Hence we show that mutant KRAS facilitates IKK?-mediated responsiveness of tumor cells to host IL-1?, thereby establishing a host-to-tumor signaling circuit that culminates in inflammatory MPE development and drug resistance. ..
  49. Mestas J, Burdick M, Reckamp K, Pantuck A, Figlin R, Strieter R. The role of CXCR2/CXCR2 ligand biological axis in renal cell carcinoma. J Immunol. 2005;175:5351-7 pubmed
    ..We hypothesized that the CXCR2/CXCR2 ligand biological axis represents a mechanism by which RCC cells promote angiogenesis and facilitate tumor ..
  50. Kesteman N, Vansanten G, Pajak B, Goyert S, Moser M. Injection of lipopolysaccharide induces the migration of splenic neutrophils to the T cell area of the white pulp: role of CD14 and CXC chemokines. J Leukoc Biol. 2008;83:640-7 pubmed further suggest the involvement of the chemokine MIP-2 and keratinocyte-derived chemokine and their receptor CXCR2. We conclude that neutrophils may interact with naïve T cells upon infection/inflammation and that the migration ..
  51. Gavard J, Hou X, Qu Y, Masedunskas A, Martin D, Weigert R, et al. A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability. Mol Cell Biol. 2009;29:2469-80 pubmed publisher
    ..Rac1 through Src-related kinases, IL-8 specifically signals to Rac1 through its cognate G protein-linked receptor, CXCR2, and the stimulation of the phosphatidylinositol 3-kinase gamma (PI3Kgamma) catalytic isoform, thereby providing a ..
  52. Panopoulos A, Zhang L, Snow J, Jones D, Smith A, El Kasmi K, et al. STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood. 2006;108:3682-90 pubmed
    ..STAT3 also controls neutrophil chemotactic responses to natural ligands for CXCR2 and regulates the magnitude of chemoattractant-induced actin polymerization...
  53. Gelderblom M, Weymar A, Bernreuther C, Velden J, Arunachalam P, Steinbach K, et al. Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke. Blood. 2012;120:3793-802 pubmed publisher
    ..We propose that selective targeting of IL-17A signaling might provide a new therapeutic option for the treatment of stroke. ..
  54. Mei J, Liu Y, Dai N, Hoffmann C, Hudock K, Zhang P, et al. Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice. J Clin Invest. 2012;122:974-86 pubmed publisher
    ..Neutrophil homeostasis is therefore tightly regulated. Cxcr2 plays a critical role in neutrophil homeostasis, as Cxcr2(-/-) mice demonstrate mild neutrophilia and severe ..
  55. Suzuki H, Prado G, Wilkinson N, Navarro J. The N terminus of interleukin-8 (IL-8) receptor confers high affinity binding to human IL-8. J Biol Chem. 1994;269:18263-6 pubmed
    ..To identify the domain(s) conferring high affinity binding to IL-8, we constructed rabbit/mouse receptor chimeras.(ABSTRACT TRUNCATED AT 400 WORDS) ..
  56. Harada A, Kuno K, Nomura H, Mukaida N, Murakami S, Matsushima K. Cloning of a cDNA encoding a mouse homolog of the interleukin-8 receptor. Gene. 1994;142:297-300 pubmed
  57. Lee P, Kumagai Y, Xu Y, Li Y, Barker T, Liu C, et al. IL-1? modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil. J Immunol. 2011;186:1747-54 pubmed publisher
    ..IL-1? and IL-1R signaling promote the migration of neutrophils to the peritoneal cavity in a CXCR2-dependent manner...
  58. Neel N, Barzik M, Raman D, Sobolik Delmaire T, Sai J, Ham A, et al. VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis. J Cell Sci. 2009;122:1882-94 pubmed publisher
    ..b>CXCR2 is a major chemokine receptor expressed on neutrophils...
  59. Raghuwanshi S, Su Y, Singh V, Haynes K, Richmond A, Richardson R. The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions. J Immunol. 2012;189:2824-32 pubmed publisher
    The chemokine receptors, CXCR1 and CXCR2, couple to G?i to induce leukocyte recruitment and activation at sites of inflammation. Upon activation by CXCL8, these receptors become phosphorylated, desensitized, and internalized...
  60. Amura C, Brodsky K, Gitomer B, McFann K, Lazennec G, Nichols M, et al. CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation. Am J Physiol Cell Physiol. 2008;294:C786-96 pubmed publisher
    ..Comparative analyses of human kidney and liver cyst fluids revealed disparate cytokine/growth factor profiles. CXCR2 agonists, including IL-8, epithelial neutrophil-activating peptide (ENA-78), growth-related oncogene-alpha (GRO-..
  61. Del Prete A, Martínez Muñoz L, Mazzon C, Toffali L, Sozio F, Za L, et al. The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage. Blood. 2017;130:1223-1234 pubmed publisher
    ..In vitro, CCRL2 was found to constitutively form homodimers and heterodimers with CXCR2, a main neutrophil chemotactic receptor...
  62. Cao D, Qian B, Zhang Z, Gao Y, Wu X. Chemokine receptor CXCR2 in dorsal root ganglion contributes to the maintenance of inflammatory pain. Brain Res Bull. 2016;127:219-225 pubmed publisher
    ..Recent studies showed that chemokine (C-X-C motif) ligand 1 (CXCL1) and its major receptor CXCR2 are respectively expressed in astrocytes and neurons in the spinal cord and are involved in the maintenance of ..
  63. Moutsopoulos N, Konkel J, Sarmadi M, Eskan M, Wild T, Dutzan N, et al. Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss. Sci Transl Med. 2014;6:229ra40 pubmed publisher
    ..Therefore, our findings support an IL-17-targeted therapy for periodontitis in LAD-I patients. ..
  64. Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft L, et al. CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood. 2016;128:371-83 pubmed publisher
    ..In human CD34(+) hematopoietic cells, knockdown of CXCL4 or pharmacologic inhibition of the chemokine receptor CXCR2, significantly decreased cell viability and colony forming cell (CFC) potential...
  65. De Buck M, Berghmans N, Pörtner N, Vanbrabant L, Cockx M, Struyf S, et al. Serum amyloid A1α induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils. J Leukoc Biol. 2015;98:1049-60 pubmed publisher
    ..g., lipopolysaccharide) inflammatory mediators induce primary chemoattractants such as serum amyloid A that synergize in an autocrine (monocyte) or a paracrine (neutrophil) fashion with secondary chemokines induced in stromal cells. ..
  66. Miller A, Strieter R, Gruber A, Ho S, Lukacs N. CXCR2 regulates respiratory syncytial virus-induced airway hyperreactivity and mucus overproduction. J Immunol. 2003;170:3348-56 pubmed
    ..chemokine receptors responsible for mediating the pathophysiological response to RSV infection, we found that CXCR2 mRNA was induced at 4 days after RSV infection...
  67. Flannigan K, Ngo V, Geem D, Harusato A, Hirota S, Parkos C, et al. IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria. Mucosal Immunol. 2017;10:673-684 pubmed publisher
    ..Here we report that colonization of mice with SFB-containing microbiota induced IL-17A- and CXCR2-dependent recruitment of neutrophils to the ileum...
  68. McGrath K, Koniski A, Maltby K, McGann J, Palis J. Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. Dev Biol. 1999;213:442-56 pubmed
    ..5 and E8.5). Other chemokine receptor messages (CCR1, CCR4, CCR5, CCR2, and CXCR2) were found in E12.5 tissues concordant temporally and spatially with definitive (adult-like) hematopoiesis...
  69. Mishra H, Long C, Bahaie N, Walcheck B. Regulation of CXCR2 expression and function by a disintegrin and metalloprotease-17 (ADAM17). J Leukoc Biol. 2015;97:447-54 pubmed publisher
    The chemokine receptor CXCR2 is expressed at high levels on circulating neutrophils and is critical for directing their migration to sites of inflammation...
  70. Lefebvre S, Fliniaux I, Schneider P, Mikkola M. Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012;132:1094-102 pubmed publisher
    ..Deficiency in cxcR3 resulted in decreased primary hair follicle density but otherwise normal hair development, indicating that chemokine signaling influences the patterning of primary hair placodes only. ..
  71. Sue R, Belperio J, Burdick M, Murray L, Xue Y, Dy M, et al. CXCR2 is critical to hyperoxia-induced lung injury. J Immunol. 2004;172:3860-8 pubmed
    ..Because CXCL1 and CXCL2/3, acting through CXCR2, are potent neutrophil chemoattractants, we investigated their role in mediating hyperoxia-induced lung injury...
  72. Shen H, Schuster R, Lu B, Waltz S, Lentsch A. Critical and opposing roles of the chemokine receptors CXCR2 and CXCR3 in prostate tumor growth. Prostate. 2006;66:1721-8 pubmed
    Angiogenic and angiostatic CXC chemokines mediate their effects via the receptors, CXCR2 and CXCR3, respectively. The current study sought to determine whether the presence of these receptors alters prostate tumor growth...
  73. Oh S, Woo J, Lim D, Moon S. ERK2-dependent activation of c-Jun is required for nontypeable Haemophilus influenzae-induced CXCL2 upregulation in inner ear fibrocytes. J Immunol. 2012;188:3496-505 pubmed publisher
    ..influenzae-activated c-Jun than that of the distal one. Our results will enable us better to understand the molecular pathogenesis of middle ear infection-induced inner ear inflammation...
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    ..Although IL-8 has previously been implicated in cell adhesion, video imaging in vivo demonstrated that deletion of the IL-8 receptor homologue had minimal effect on rolling or arrest in this model of inflammation. ..
  75. Baluk P, Hogmalm A, Bry M, Alitalo K, Bry K, McDonald D. Transgenic overexpression of interleukin-1? induces persistent lymphangiogenesis but not angiogenesis in mouse airways. Am J Pathol. 2013;182:1434-47 pubmed publisher
    ..Triple-transgenic CCSP/IL-1?/CXCR2(-/-) mice had the usual IL-1?-mediated lymphangiogenesis but no neutrophil recruitment, suggesting that ..