Cxcl9

Summary

Gene Symbol: Cxcl9
Description: chemokine (C-X-C motif) ligand 9
Alias: BB139920, CMK, Mig, MuMIG, Scyb9, crg-10, C-X-C motif chemokine 9, M119, gamma interferon-induced monokine, monokine induced by gamma interferon, monokine induced by interferon-gamma, protein m119, small inducible cytokine B subfamily (Cys-X-Cys), member 9, small-inducible cytokine B9
Species: mouse
Products:     Cxcl9

Top Publications

  1. Drevets D, Schawang J, Dillon M, Lerner M, Bronze M, Brackett D. Innate responses to systemic infection by intracellular bacteria trigger recruitment of Ly-6Chigh monocytes to the brain. J Immunol. 2008;181:529-36 pubmed
    ..IFN-gamma-/- mice showed diminished mRNA expression for monocyte-attracting chemokines, and significantly less CXCL9 and CXCL10 protein in the brain compared with normal mice...
  2. Caso G, Barry C, Patejunas G. Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient mice. J Hematol Oncol. 2009;2:7 pubmed publisher
    ..Expression of the chemokine Mig (CXCL9) was increased 2.8-fold in tumors from knockout mice, but no increase was found in serum levels of Mig...
  3. Rydström A, Wick M. Monocyte and neutrophil recruitment during oral Salmonella infection is driven by MyD88-derived chemokines. Eur J Immunol. 2009;39:3019-30 pubmed publisher
    ..Here, we show that CCL2, CXCL9 and CXCL2 mRNA are up-regulated in PP and MLN coincident with the first arrival of monocytes and neutrophils...
  4. Farber J. A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proc Natl Acad Sci U S A. 1990;87:5238-42 pubmed
    ..It is proposed that the gene encoding this protein be called mig, for monokine induced by gamma interferon.
  5. Schrage A, Wechsung K, Neumann K, Schumann M, Schulzke J, Engelhardt B, et al. Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines. Hepatology. 2008;48:1262-72 pubmed publisher
    ..LSEC significantly enhanced the chemotactic effect of CXC-motif chemokine ligand 12 (CXCL12) and CXCL9, but not of CXCL16 or CCL20, on naive and memory CD4(+) T cells of a T helper 1, T helper 2, or interleukin-10-..
  6. Wasmuth H, Lammert F, Zaldivar M, Weiskirchen R, Hellerbrand C, Scholten D, et al. Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans. Gastroenterology. 2009;137:309-19, 319.e1-3 pubmed publisher
    ..We investigated the roles of the chemokine CXCL9 and its receptor CXCR3 in liver fibrosis...
  7. Groom J, Richmond J, Murooka T, Sorensen E, Sung J, Bankert K, et al. CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. Immunity. 2012;37:1091-103 pubmed publisher
    ..By using a CXCR3 ligand reporter mouse, we found that stromal cells predominately expressed the chemokine ligand CXCL9 whereas hematopoietic cells expressed CXCL10 in LNs...
  8. Setsuda J, Teruya Feldstein J, Harris N, Ferry J, Sorbara L, Gupta G, et al. Interleukin-18, interferon-gamma, IP-10, and Mig expression in Epstein-Barr virus-induced infectious mononucleosis and posttransplant lymphoproliferative disease. Am J Pathol. 1999;155:257-65 pubmed
    ..Here we report that PTLD tissues express significantly lower levels of IL-18, interferon-gamma (IFN-gamma), Mig, and RANTES compared to lymphoid tissues diagnosed with acute EBV-induced infectious mononucleosis, as assessed by ..
  9. Nancy P, Tagliani E, Tay C, Asp P, Levy D, Erlebacher A. Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface. Science. 2012;336:1317-21 pubmed publisher
    ..These findings give insight into mechanisms of fetomaternal immune tolerance, as well as reveal the epigenetic modification of tissue stromal cells as a modality for limiting effector T cell trafficking...

More Information

Publications79

  1. Abe J, Ueha S, Suzuki J, Tokano Y, Matsushima K, Ishikawa S. Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol. 2008;173:1682-92 pubmed publisher
    ..Taken together, we conclude that T(reg) cells in BWF1 mice are not predisposed to functional incompetence but rather are present in a highly activated state. ..
  2. Auerbach M, Shimoda N, Amano H, Rosenblum J, Kish D, Farber J, et al. Monokine induced by interferon-gamma (MIG/CXCL9) is derived from both donor and recipient sources during rejection of class II major histocompatibility complex disparate skin allografts. Am J Pathol. 2009;174:2172-81 pubmed publisher
    Chemokines, including monokine induced by interferon-gamma (Mig/CXCL9), are produced both in allografts and during the direct T-cell infiltration that mediates graft rejection...
  3. Valbuena G, Bradford W, Walker D. Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. Am J Pathol. 2003;163:1357-69 pubmed
    ..The expression of the CXCR3 ligands CXCL9 and CXCL10 was significantly higher than the other chemokines investigated...
  4. Mikhak Z, Fleming C, Medoff B, Thomas S, Tager A, Campanella G, et al. STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells. J Immunol. 2006;176:4959-67 pubmed
    ..STAT1 controls the recruitment of Th1 cells through the induction of CXCL9, CXCL10, CXCL11, and CXCL16, whose expression levels in the lung were markedly decreased in STAT1-/- mice...
  5. Ohneda O, Ohneda K, Nomiyama H, Zheng Z, Gold S, Arai F, et al. WECHE: a novel hematopoietic regulatory factor. Immunity. 2000;12:141-50 pubmed
    ..WECHE hindered the growth of yolk sac-derived endothelial cells. WECHE was also chemotactic for bone marrow cells. Thus, WECHE is a novel chemokine that regulates hematopoietic differentiation. ..
  6. Zhang B, Chan Y, Lu B, Diamond M, Klein R. CXCR3 mediates region-specific antiviral T cell trafficking within the central nervous system during West Nile virus encephalitis. J Immunol. 2008;180:2641-9 pubmed
    ..These results indicate that WNV differentially induces CXCL10 within neuronal populations and suggest a novel model for nonredundancy in chemokine-mediated inflammation among CNS compartments. ..
  7. Giegold O, Ogrissek N, Richter C, Schröder M, Herrero San Juan M, Pfeilschifter J, et al. CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation. J Immunol. 2013;190:3696-705 pubmed publisher
    ..Effects of combined stimulation by murine CXCL9 and CXCL12, ligands of CXCR3 and CXCR4, respectively, were analyzed using a murine central memory Th1 cell clone...
  8. Hildebrandt G, Corrion L, Olkiewicz K, Lu B, Lowler K, Duffner U, et al. Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. J Immunol. 2004;173:2050-9 pubmed
    ..is a chemokine receptor that is expressed on activated Th1/Tc1 T cell subsets and the expression of its ligands CXCL9 (monokine induced by IFN-gamma (Mig)) and CXCL10 (IFN-gamma-inducible protein 10 (IP-10)) can be induced in a ..
  9. Happel K, Rudner X, Quinton L, Movassaghi J, Clark C, Odden A, et al. Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide. Alcohol. 2007;41:325-33 pubmed
    ..t.) LPS challenge for the ELR- CXC chemokines monokine induced by gamma (MIG or CXCL9), interferon-inducible protein 10 (IP-10 or CXCL10), and interferon-inducible T cell alpha chemoattractant (I-TAC ..
  10. Ronchi F, Basso C, Preite S, Reboldi A, Baumjohann D, Perlini L, et al. Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1? production by myeloid cells. Nat Commun. 2016;7:11541 pubmed publisher
  11. Park M, Amichay D, Love P, Wick E, Liao F, Grinberg A, et al. The CXC chemokine murine monokine induced by IFN-gamma (CXC chemokine ligand 9) is made by APCs, targets lymphocytes including activated B cells, and supports antibody responses to a bacterial pathogen in vivo. J Immunol. 2002;169:1433-43 pubmed
    ..as a chemotactic factor for resting memory and activated T cells, both CD4(+) and CD8(+), and responsiveness to MuMig correlated with surface expression of MuCXCR3...
  12. Campanella G, Tager A, El Khoury J, Thomas S, Abrazinski T, Manice L, et al. Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. Proc Natl Acad Sci U S A. 2008;105:4814-9 pubmed publisher
    ..We show that the CXCR3 chemokine ligands IP-10 and Mig (CXCL9) were highly induced in the brains of mice with murine cerebral malaria caused by Plasmodium berghei ANKA...
  13. Liang Y, Luo J, Lu Q, Zhou Y, Wu H, Zheng D, et al. Gene profile of chemokines on hepatic stellate cells of schistosome-infected mice and antifibrotic roles of CXCL9/10 on liver non-parenchymal cells. PLoS ONE. 2012;7:e42490 pubmed publisher
    ..i) when the egg granulomatous response was not obviously evoked in the liver. However, some of them like CXCL9, CXCL10 and CXCL11 were subsequently decreased at 6 weeks p.i when the granulomatous response reached the peak...
  14. Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, et al. Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis. J Immunol. 2015;194:2522-30 pubmed publisher
    ..Further study into the role of testosterone for liver inflammation could lead to novel treatment targets in human autoimmune liver diseases. ..
  15. McPhee C, Duncan F, Silva K, King L, HogenEsch H, Roopenian D, et al. Increased expression of Cxcr3 and its ligands, Cxcl9 and Cxcl10, during the development of alopecia areata in the mouse. J Invest Dermatol. 2012;132:1736-8 pubmed publisher
  16. de Valle E, Grigoriadis G, O Reilly L, Willis S, Maxwell M, Corcoran L, et al. NF?B1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells. J Exp Med. 2016;213:621-41 pubmed publisher
    ..Collectively, our findings identify a previously unrecognized role for NF?B1 in preventing multiorgan autoimmunity through its negative regulation of Il-6 gene expression in Fo B cells. ..
  17. Richmond J, Bangari D, Essien K, Currimbhoy S, Groom J, Pandya A, et al. Keratinocyte-Derived Chemokines Orchestrate T-Cell Positioning in the Epidermis during Vitiligo and May Serve as Biomarkers of Disease. J Invest Dermatol. 2017;137:350-358 pubmed publisher
    ..Analysis of chemokine expression in mouse skin showed that CXCL9 and CXCL10 expression strongly correlate with disease activity, whereas CXCL10 alone correlates with severity, ..
  18. Shinde P, Liu W, Menoret A, Luster A, Vella A. Optimal CD4 T cell priming after LPS-based adjuvanticity with CD134 costimulation relies on CXCL9 production. J Leukoc Biol. 2017;102:57-69 pubmed publisher
    ..IFN?R1 signaling promoted CXCL9 and CXCL10 synthesis, suggesting that these chemokines might be involved in the LPS and CD134 costimulation ..
  19. Yano T, Ohira M, Nakano R, Tanaka Y, Ohdan H. Hepatectomy leads to loss of TRAIL-expressing liver NK cells via downregulation of the CXCL9-CXCR3 axis in mice. PLoS ONE. 2017;12:e0186997 pubmed publisher
    ..TRAIL+ NK cells strongly and exclusively expressed CXCR3, and the expression of its ligand CXCL9 was significantly decreased in the liver after hepatectomy...
  20. Sun H, Jackson M, Kundu N, Fulton A. Interleukin-10 gene transfer activates interferon-gamma and the interferon-gamma-inducible genes Gbp-1/Mag-1 and Mig-1 in mammary tumors. Int J Cancer. 1999;80:624-9 pubmed
    ..The other cDNA corresponds to the chemokine Mig-1 (monokine induced by IFN-gamma)...
  21. Colvin B, Wang Z, Nakano H, Wu W, Kakiuchi T, Fairchild R, et al. CXCL9 antagonism further extends prolonged cardiac allograft survival in CCL19/CCL21-deficient mice. Am J Transplant. 2005;5:2104-13 pubmed
    ..Anti-CXCL9/Mig was administered for 2 weeks post-transplant to determine whether impairment of activated T-cell migration ..
  22. Gorbachev A, Kobayashi H, Kudo D, Tannenbaum C, Finke J, Shu S, et al. CXC chemokine ligand 9/monokine induced by IFN-gamma production by tumor cells is critical for T cell-mediated suppression of cutaneous tumors. J Immunol. 2007;178:2278-86 pubmed
    ..We retrieved an in vivo growing MCA205 fibrosarcoma and isolated tumor cell clones that produce both CXCL9/monokine induced by IFN-gamma (Mig) and CXCL10/IFN-gamma-inducible protein 10 following stimulation with IFN-gamma ..
  23. Medoff B, Wain J, Seung E, Jackobek R, Means T, Ginns L, et al. CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function. J Immunol. 2006;176:7087-95 pubmed
    ..The chemokine receptor CXCR3 and two of its ligands, CXCL9 and CXCL10, have been identified as important mediators of OB...
  24. Horton M, Boodoo S, Powell J. NF-kappa B activation mediates the cross-talk between extracellular matrix and interferon-gamma (IFN-gamma) leading to enhanced monokine induced by IFN-gamma (MIG) expression in macrophages. J Biol Chem. 2002;277:43757-62 pubmed
    ..induce macrophage expression of chemokines, cytokines, and growth factors as well greatly enhance IFN-gamma-induced MIG expression...
  25. Debes G, Dahl M, Mahiny A, Bonhagen K, Campbell D, Siegmund K, et al. Chemotactic responses of IL-4-, IL-10-, and IFN-gamma-producing CD4+ T cells depend on tissue origin and microbial stimulus. J Immunol. 2006;176:557-66 pubmed
    ..IFN-gamma-expressing T cells as well as populations of IL-4+ or IL-10+ T cells migrated to the CXCR3 ligand, CXCL9. All cytokine-producing T cell subsets strongly migrated to the CXCR4 ligand, CXCL12...
  26. Andersson A, Yang S, Huang M, Zhu L, Kar U, Batra R, et al. IL-7 promotes CXCR3 ligand-dependent T cell antitumor reactivity in lung cancer. J Immunol. 2009;182:6951-8 pubmed publisher
    ..Accompanying the antitumor responses were increases in IFN-gamma, CXCL9, CXCL10, and IL-12...
  27. Hiroi M, Ohmori Y. The transcriptional coactivator CREB-binding protein cooperates with STAT1 and NF-kappa B for synergistic transcriptional activation of the CXC ligand 9/monokine induced by interferon-gamma gene. J Biol Chem. 2003;278:651-60 pubmed
    ..CREB-binding protein (CBP) mediated the STAT1/NF-kappaB synergy for transcription of the gene for CXC ligand 9 (CXCL9), an interferon-gamma (IFN-gamma)-inducible chemokine...
  28. Muse M, Kane J, Carr D, Farber J, Lane T. Insertion of the CXC chemokine ligand 9 (CXCL9) into the mouse hepatitis virus genome results in protection from viral-induced encephalitis and hepatitis. Virology. 2008;382:132-44 pubmed publisher
    The role of the CXC chemokine ligand 9 (CXCL9) in host defense following infection with mouse hepatitis virus (MHV) was determined...
  29. Reid Yu S, Tuinema B, Small C, Xing L, Coombes B. CXCL9 contributes to antimicrobial protection of the gut during citrobacter rodentium infection independent of chemokine-receptor signaling. PLoS Pathog. 2015;11:e1004648 pubmed publisher
    ..Here, we show that CXCL9, an ELR- chemokine, exhibits direct antimicrobial activity against Citrobacter rodentium, an attaching/effacing ..
  30. Lee E, Park J, Kim D, Kim J, Oh K, Park C, et al. Early up-regulation of CXC-chemokine expression is associated with strong cellular immune responses to murine skin xenografts. Xenotransplantation. 2006;13:328-36 pubmed
    ..Xenografts showed stronger interferon (IFN)-inducible 10-kDa protein (IP-10) and monokine induced by IFN (MIG) mRNA expression levels, which appeared earlier than in the allografts...
  31. Frigerio S, Junt T, Lu B, Gerard C, Zumsteg U, Hollander G, et al. Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat Med. 2002;8:1414-20 pubmed
    ..Thus, in the absence of known etiological agents, CXC receptor 3 represents a novel target for therapeutic interference early in type 1 diabetes. ..
  32. Rashighi M, Agarwal P, Richmond J, Harris T, Dresser K, Su M, et al. CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo. Sci Transl Med. 2014;6:223ra23 pubmed publisher
    ..b>CXCL9 promoted autoreactive T cell global recruitment to the skin but not effector function, whereas CXCL10 was required ..
  33. Molesworth Kenyon S, Oakes J, Lausch R. A novel role for neutrophils as a source of T cell-recruiting chemokines IP-10 and Mig during the DTH response to HSV-1 antigen. J Leukoc Biol. 2005;77:552-9 pubmed
    ..site and a sharp drop in the levels of interferon-inducible protein 10 (IP-10) and monokine induced by IFN-gamma (Mig)...
  34. Ondondo B, Colbeck E, Jones E, Smart K, Lauder S, Hindley J, et al. A distinct chemokine axis does not account for enrichment of Foxp3(+)  CD4(+) T cells in carcinogen-induced fibrosarcomas. Immunology. 2015;145:94-104 pubmed publisher
    ..that the tumours are characterized by expression of inflammatory chemokines (CCL2, CCL5, CCL7, CCL8, CCL12, CXCL9, CXCL10 and CX3CL1), reflected by an enrichment of activated Foxp3(-) and Foxp3(+) T cells expressing T helper ..
  35. Neumann K, Erben U, Kruse N, Wechsung K, Schumann M, Klugewitz K, et al. Chemokine Transfer by Liver Sinusoidal Endothelial Cells Contributes to the Recruitment of CD4+ T Cells into the Murine Liver. PLoS ONE. 2015;10:e0123867 pubmed publisher
    ..In histology, CXCL9 was associated with liver sinusoidal endothelial cells (LSEC) which represent the first contact site for T-cell ..
  36. Crawford M, Zhu Y, Green C, Burdick M, Sanz P, Alem F, et al. Antimicrobial effects of interferon-inducible CXC chemokines against Bacillus anthracis spores and bacilli. Infect Immun. 2009;77:1664-78 pubmed publisher
    ..against bacteria, we sought to determine whether the interferon-inducible Glu-Leu-Arg-negative CXC chemokines CXCL9, CXCL10, and CXCL11 exhibit antimicrobial activities against Bacillus anthracis...
  37. Molesworth Kenyon S, Mates A, Yin R, Strieter R, Oakes J, Lausch R. CXCR3, IP-10, and Mig are required for CD4+ T cell recruitment during the DTH response to HSV-1 yet are independent of the mechanism for viral clearance. Virology. 2005;333:1-9 pubmed
    ..CXCR3 ligands IP-10 and Mig were elevated at the DTH site. Their neutralization significantly reduced DTH ear swelling and CD4+ T cell influx...
  38. Molesworth Kenyon S, Milam A, Rockette A, Troupe A, Oakes J, Lausch R. Expression, Inducers and Cellular Sources of the Chemokine MIG (CXCL 9), During Primary Herpes Simplex Virus Type-1 Infection of the Cornea. Curr Eye Res. 2015;40:800-8 pubmed publisher
    To investigate the production of monokine induced by gamma-interferon (MIG) during a primary Herpes simplex virus type 1 (HSV-1) infection of the cornea...
  39. Ge Y, Waldemer R, Nalluri R, Nuzzi P, Chen J. RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation. PLoS ONE. 2013;8:e68068 pubmed publisher
  40. Thapa M, Welner R, Pelayo R, Carr D. CXCL9 and CXCL10 expression are critical for control of genital herpes simplex virus type 2 infection through mobilization of HSV-specific CTL and NK cells to the nervous system. J Immunol. 2008;180:1098-106 pubmed
    b>CXCL9 and CXCL10 mediate the recruitment of T lymphocytes and NK cells known to be important in viral surveillance...
  41. Ha Y, Liu H, Zhu S, Yi P, Liu W, Nathanson J, et al. Critical Role of the CXCL10/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush. Am J Pathol. 2017;187:352-365 pubmed publisher
    ..These results indicate that leukocyte recruitment in retinal vessels near the ON head is an early event in TON and the CXCL10/CXCR3 axis has a critical role in recruiting leukocytes and inducing RGC death. ..
  42. Sung J, Zhang H, Moseman E, Alvarez D, Iannacone M, Henrickson S, et al. Chemokine guidance of central memory T cells is critical for antiviral recall responses in lymph nodes. Cell. 2012;150:1249-63 pubmed publisher
  43. Sharma S, Yang S, Hillinger S, Zhu L, Huang M, Batra R, et al. SLC/CCL21-mediated anti-tumor responses require IFNgamma, MIG/CXCL9 and IP-10/CXCL10. Mol Cancer. 2003;2:22 pubmed
    ..are accompanied by significant induction of IFNgamma and the CXC chemokines, monokine induced by IFNgamma (MIG/CXCL9) and IFNgamma-inducible protein-10 (IP-10/CXCL10)...
  44. Sahin H, Borkham Kamphorst E, Kuppe C, Zaldivar M, Grouls C, Al samman M, et al. Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice. Hepatology. 2012;55:1610-9 pubmed publisher
    ..attenuation of angiogenesis and associated liver fibrosis by therapeutic treatment with the angiostatic chemokine Cxcl9 was systematically analyzed in vitro and in vivo...
  45. Lu H, Zhu S, Qian L, Xiang D, Zhang W, Nie A, et al. Activated expression of the chemokine Mig after chemotherapy contributes to chemotherapy-induced bone marrow suppression and lethal toxicity. Blood. 2012;119:4868-77 pubmed publisher
    ..This paper reports our observation that the expression of the chemokine monokine induced by IFN-? (Mig) and its receptor CXCR3 was significantly activated in mice after treatment with the chemotherapeutic agent 5-..
  46. Ochiai E, Sa Q, Brogli M, Kudo T, Wang X, Dubey J, et al. CXCL9 is important for recruiting immune T cells into the brain and inducing an accumulation of the T cells to the areas of tachyzoite proliferation to prevent reactivation of chronic cerebral infection with Toxoplasma gondii. Am J Pathol. 2015;185:314-24 pubmed publisher
    ..Here, we examined the role of non-glutamic acid-leucine-arginine CXC chemokine CXCL9 for T-cell recruitment to prevent reactivation of infection with T. gondii...
  47. Yun J, Fischbein M, Whiting D, Irie Y, Fishbein M, Burdick M, et al. The role of MIG/CXCL9 in cardiac allograft vasculopathy. Am J Pathol. 2002;161:1307-13 pubmed
    ..We hypothesized that the chemokine, monokine induced by interferon-gamma (MIG/CXCL9), which induces T lymphocyte migration in vitro, participates in T lymphocyte recruitment in CAV...
  48. Wuest T, Farber J, Luster A, Carr D. CD4+ T cell migration into the cornea is reduced in CXCL9 deficient but not CXCL10 deficient mice following herpes simplex virus type 1 infection. Cell Immunol. 2006;243:83-9 pubmed
    The role of CXCL9 and CXCL10 in the ocular immune response to herpes simplex virus type 1 (HSV-1) infection was investigated using mice deficient in either CXCL9 or CXCL10...
  49. Petro M, Kish D, Guryanova O, Ilyinskaya G, Kondratova A, Fairchild R, et al. Cutaneous tumors cease CXCL9/Mig production as a result of IFN-?-mediated immunoediting. J Immunol. 2013;190:832-41 pubmed publisher
    ..the appearance and rapid growth of tumor variants deficient in producing the T cell chemoattractant chemokine CXCL9/Mig, an important component of antitumor immunity...
  50. New J, Li B, Koh W, Ng H, Tan S, Yap E, et al. T cell infiltration and chemokine expression: relevance to the disease localization in murine graft-versus-host disease. Bone Marrow Transplant. 2002;29:979-86 pubmed
    ..We found that in the spleen and liver MIP-1alpha, MIP-2 and Mig were the predominant chemokines expressed...
  51. Wuest T, Carr D. Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection. J Immunol. 2008;181:7985-93 pubmed
    ..Thus, CXCL10 deficiency results in reduced mobilization of HSV-1-specific CD8(+) T cells as a result of dysregulation of CXCR3 signaling...
  52. Thomas M, Kunkel S, Lukacs N. Regulation of cockroach antigen-induced allergic airway hyperreactivity by the CXCR3 ligand CXCL9. J Immunol. 2004;173:615-23 pubmed
    ..The CXCR3 ligands, CXCL9 (monokine induced by IFN-gamma) and CXCL10 (IFN-inducible protein, 10 kDa), are IFN-gamma-inducible, Th1-type ..
  53. Lefebvre S, Fliniaux I, Schneider P, Mikkola M. Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012;132:1094-102 pubmed publisher
    ..Deficiency in cxcR3 resulted in decreased primary hair follicle density but otherwise normal hair development, indicating that chemokine signaling influences the patterning of primary hair placodes only. ..
  54. Eliasson M, Morgelin M, Farber J, Egesten A, Albiger B. Streptococcus pneumoniae induces expression of the antibacterial CXC chemokine MIG/CXCL9 via MyD88-dependent signaling in a murine model of airway infection. Microbes Infect. 2010;12:565-73 pubmed publisher
    MIG/CXCL9 belongs to the CXC family of chemokines and participates in the regulation of leukocyte-trafficking and angiogenesis...
  55. Ikeda A, Aoki N, Kido M, Iwamoto S, Nishiura H, Maruoka R, et al. Progression of autoimmune hepatitis is mediated by IL-18-producing dendritic cells and hepatic CXCL9 expression in mice. Hepatology. 2014;60:224-36 pubmed publisher
    ..Expression of one CXCR3 ligand, chemokine (C-X-C motif) ligand (CXCL)9, was elevated in the liver. CXCL9-expressing macrophages/Kupffer cells were colocalized with infiltrating T cells, and in vivo administration of ..
  56. MANICONE A, Burkhart K, Lu B, Clark J. CXCR3 ligands contribute to Th1-induced inflammation but not to homing of Th1 cells into the lung. Exp Lung Res. 2008;34:391-407 pubmed publisher
    ..1) antibody ablation of CXCR3 ligands IP10 (CXCL10/interferon-gamma -inducible 10-kDa protein) and MIG (CXCL9/monokine-induced by interferon-gamma), and (2) use of cxcr3(-/-) mice...
  57. Williams A, José R, Brown J, Chambers R. Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production. Am J Physiol Lung Cell Mol Physiol. 2015;308:L539-49 pubmed publisher
    ..pneumoniae infection, compared with young mice, but increased levels of the chemokines CXCL9, CXCL12, CCL3, CCL4, CCL5, CCL11, and CCL17. Moreover, levels of IL-10 were significantly lower in aged animals...
  58. Horton M, McKee C, Bao C, Liao F, Farber J, Hodge DuFour J, et al. Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages. J Biol Chem. 1998;273:35088-94 pubmed
    ..IFN-gamma), an important regulator of macrophage functions, has been shown to induce the C-X-C chemokines Mig and IP-10. These chemokines affect T-cell recruitment and inhibit angiogenesis...
  59. Yoon K, de Paiva C, Qi H, Chen Z, Farley W, Li D, et al. Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Invest Ophthalmol Vis Sci. 2007;48:2561-9 pubmed
    ..concentrations of macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, monokine induced by interferon (MIG)-gamma, and interferon-gamma-inducible protein (IP)-10 in the corneal epithelia and conjunctiva were measured by a ..
  60. Kwak H, Lee S, Jin H, Ha H, Lee S, Takeshita S, et al. Monokine induced by interferon-gamma is induced by receptor activator of nuclear factor kappa B ligand and is involved in osteoclast adhesion and migration. Blood. 2005;105:2963-9 pubmed
    ..study to identify genes targeted by RANKL, we found that monokine induced by the interferon-gamma (IFN-gamma) (MIG) gene was up-regulated in osteoclast precursor cells...
  61. Chung B, Arutyunov A, Ilagan E, Yao N, Wills Karp M, Coulombe P. Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes. J Cell Biol. 2015;208:613-27 pubmed publisher
    ..Among these are the CXCR3 ligands CXCL9, CXCL10, and CXCL11, which together form a signaling axis with an established role in tumorigenesis...
  62. Uranishi M, Iida S, Sanda T, Ishida T, Tajima E, Ito M, et al. Multiple myeloma oncogene 1 (MUM1)/interferon regulatory factor 4 (IRF4) upregulates monokine induced by interferon-gamma (MIG) gene expression in B-cell malignancy. Leukemia. 2005;19:1471-8 pubmed
    ..the expression of four genes including FK506-binding protein 3 (FKBP3), the monokine induced by interferon-gamma(MIG), Fas apoptotic inhibitory molecule (Faim) and Zinc-finger protein 94 was altered in the MUM1-expressing cells...
  63. Mundra J, Jian J, Bhagat P, Liu C. Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner. Sci Rep. 2016;6:21115 pubmed publisher
    ..We identified many chemokines and their receptors, among which CXCL9 and CXCL10 were most prominent, that were significantly induced in PGRN null mice...
  64. Kastenmüller W, Brandes M, Wang Z, Herz J, Egen J, Germain R. Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node. Immunity. 2013;38:502-13 pubmed publisher
    ..A feed-forward CXCL9-dependent circuit provided additional chemotactic cues that further increase local memory cell density...
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    ..found to be associated with the expression of T helper 1-associated CXCR3 ligands, monokine induced by IFN-gamma (Mig), and IFN-gamma-inducible protein of 10 kDa (IP-10)...
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    ..Analysis of chemokine transcripts revealed that CXC chemokine ligand 9 (CXCL9) and CXCL10, as well as CC chemokine ligand 2 (CCL2) and CCL5, were prominently expressed during acute disease, ..
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    The chemokines CXCL9 and CXCL10 bind to the common receptor CXCR3 and are implicated in the pathogenesis of T-cell-mediated immunity in the central nervous system (CNS)...
  68. Ma Y, Miller J, Crandall H, Larsen E, Dunn D, Weiss R, et al. Interval-specific congenic lines reveal quantitative trait Loci with penetrant lyme arthritis phenotypes on chromosomes 5, 11, and 12. Infect Immun. 2009;77:3302-11 pubmed publisher
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    ..We hypothesized that compensatory up-regulation of CXCL9 occurs in the absence of CXCL10...
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    ..The recipient mice were treated with anti-MIG/CXCL9 Ab; graft-infiltrating cells were analyzed for IFN-gamma production...