Cxcl9

Summary

Gene Symbol: Cxcl9
Description: chemokine (C-X-C motif) ligand 9
Alias: BB139920, CMK, Mig, MuMIG, Scyb9, crg-10, C-X-C motif chemokine 9, M119, gamma interferon-induced monokine, gamma-interferon-induced monokine, monokine induced by gamma interferon, monokine induced by interferon-gamma, protein m119, small inducible cytokine B subfamily (Cys-X-Cys), member 9, small-inducible cytokine B9
Species: mouse

Top Publications

  1. ncbi Innate responses to systemic infection by intracellular bacteria trigger recruitment of Ly-6Chigh monocytes to the brain
    Douglas A Drevets
    Department of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA
    J Immunol 181:529-36. 2008
  2. pmc Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient mice
    Giuseppe Caso
    Department of Surgery, Stony Brook University, Stony Brook, NY
    J Hematol Oncol 2:7. 2009
  3. doi Monocyte and neutrophil recruitment during oral Salmonella infection is driven by MyD88-derived chemokines
    Anna Rydström
    Department of Microbiology and Immunology, Goteborg University, Goteborg, Sweden
    Eur J Immunol 39:3019-30. 2009
  4. pmc A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines
    J M Farber
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 87:5238-42. 1990
  5. pmc CD4+ T cell migration into the cornea is reduced in CXCL9 deficient but not CXCL10 deficient mice following herpes simplex virus type 1 infection
    Todd Wuest
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cell Immunol 243:83-9. 2006
  6. ncbi Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress
    Kyung Chul Yoon
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 48:2561-9. 2007
  7. pmc Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection
    Todd R Wuest
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Immunol 181:7985-93. 2008
  8. doi CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation
    Oliver Giegold
    Pharmazentrum Frankfurt Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, D 60590 Frankfurt am Main, Germany
    J Immunol 190:3696-705. 2013
  9. doi Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice
    Hacer Sahin
    Medical Department III, University Hospital Aachen, Aachen, Germany
    Hepatology 55:1610-9. 2012
  10. doi Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development
    Sylvie Lefebvre
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Invest Dermatol 132:1094-102. 2012

Research Grants

  1. Role of CXCR3 in Th1-Mediated Lung Injury
    ANNE MANICONE; Fiscal Year: 2004
  2. Novel Immune Pathways for Lung Cancer Therapy
    Sherven Sharma; Fiscal Year: 2009
  3. Alcohol, Pulmonary Cytokines, and Host Defense
    Kyle Happel; Fiscal Year: 2007
  4. Lymphocyte Exit from Tissues: Control and Significance to Host Defense
    GUDRUN DEBES; Fiscal Year: 2007
  5. Epilysin in Lung Immunity
    ANNE MANICONE; Fiscal Year: 2007
  6. SLC/6Ckine Immunotherapy for Cancer
    Sherven Sharma; Fiscal Year: 2006
  7. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
  8. Novel Immune Pathways for Lung Cancer Therapy
    Sherven Sharma; Fiscal Year: 2010

Scientific Experts

  • Wolfgang Kastenmuller
  • Dorothy E Pazin
  • Giuseppe Caso
  • Joshua M Rosenblum
  • ANNE M MANICONE
  • Kyle I Happel
  • W S Modi
  • Douglas A Drevets
  • H E Wasmuth
  • Anton V Gorbachev
  • Sherven Sharma
  • GUDRUN PHILOMENA DEBES
  • Andrew D Luster
  • Joshua M Farber
  • Daniel J J Carr
  • Joanna R Groom
  • Jung Hwan Sung
  • Bao Lu
  • Robert M Strieter
  • Robert L Fairchild
  • Benjamin D Medoff
  • Marianne Petro
  • Oliver Giegold
  • Hacer Sahin
  • Sylvie Lefebvre
  • Ulrich H von Andrian
  • Huili Lu
  • Yue Jin Liang
  • David Whiting
  • Mette Eliasson
  • Asa Andersson
  • Matthew A Crawford
  • James J Yun
  • Anna Rydström
  • Michael B Auerbach
  • Arnhild Schrage
  • Todd R Wuest
  • Bo Zhang
  • Gabriele S V Campanella
  • Manoj Thapa
  • Jun Abe
  • Michael Muse
  • Sally L Carter
  • Andrew M Tager
  • Seddon Y Thomas
  • Thomas E Lane
  • Kyung Chul Yoon
  • Zamaneh Mikhak
  • Todd Wuest
  • Eun Mi Lee
  • Jenny L Hardison
  • Marie D Burdick
  • Bridget L Colvin
  • M Uranishi
  • Sara Molesworth-Kenyon
  • Han Bok Kwak
  • S J Molesworth-Kenyon
  • Xianying Zeng
  • Steven L Kunkel
  • Gerhard C Hildebrandt
  • Molly S Thomas
  • Patricia C Fulkerson
  • Gustavo Valbuena
  • Michael C Fishbein
  • Abbas Ardehali
  • Miki Hiroi
  • John Belperio
  • Maureen R Horton
  • Simona Frigerio
  • Matthew K Park
  • J Y New
  • Cornelia Richter
  • Matthias Schröder
  • Heinfried H Radeke
  • Olga A Guryanova
  • Galina Ilyinskaya
  • Danielle Kish
  • Anna Kondratova
  • Josef M Pfeilschifter
  • Martina Herrero San Juan
  • Nadine Ogrissek
  • Christoph Grouls
  • Thorsten R Mempel
  • Wei Han
  • Mirko Moreno Zaldivar
  • James J Moon
  • David Alvarez
  • Fabian Kiessling
  • Wu Zhang
  • Juan C de la Torre

Detail Information

Publications63

  1. ncbi Innate responses to systemic infection by intracellular bacteria trigger recruitment of Ly-6Chigh monocytes to the brain
    Douglas A Drevets
    Department of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA
    J Immunol 181:529-36. 2008
    ..IFN-gamma-/- mice showed diminished mRNA expression for monocyte-attracting chemokines, and significantly less CXCL9 and CXCL10 protein in the brain compared with normal mice...
  2. pmc Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient mice
    Giuseppe Caso
    Department of Surgery, Stony Brook University, Stony Brook, NY
    J Hematol Oncol 2:7. 2009
    ..We hypothesized that Egr-1 knockout mice might exhibit reduced tumor growth, possibly due to a reduced capacity to respond to angiogenic signals from a growing tumor...
  3. doi Monocyte and neutrophil recruitment during oral Salmonella infection is driven by MyD88-derived chemokines
    Anna Rydström
    Department of Microbiology and Immunology, Goteborg University, Goteborg, Sweden
    Eur J Immunol 39:3019-30. 2009
    ..Here, we show that CCL2, CXCL9 and CXCL2 mRNA are up-regulated in PP and MLN coincident with the first arrival of monocytes and neutrophils...
  4. pmc A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines
    J M Farber
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 87:5238-42. 1990
    ..It is proposed that the gene encoding this protein be called mig, for monokine induced by gamma interferon.
  5. pmc CD4+ T cell migration into the cornea is reduced in CXCL9 deficient but not CXCL10 deficient mice following herpes simplex virus type 1 infection
    Todd Wuest
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cell Immunol 243:83-9. 2006
    The role of CXCL9 and CXCL10 in the ocular immune response to herpes simplex virus type 1 (HSV-1) infection was investigated using mice deficient in either CXCL9 or CXCL10...
  6. ncbi Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress
    Kyung Chul Yoon
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 48:2561-9. 2007
    ..To evaluate the effects of desiccating ocular surface stress on the expression of chemokines and their receptors by the corneal epithelium and conjunctiva of C57BL/6 and BALB/c mice...
  7. pmc Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection
    Todd R Wuest
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Immunol 181:7985-93. 2008
    ..Thus, CXCL10 deficiency results in reduced mobilization of HSV-1-specific CD8(+) T cells as a result of dysregulation of CXCR3 signaling...
  8. doi CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation
    Oliver Giegold
    Pharmazentrum Frankfurt Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, D 60590 Frankfurt am Main, Germany
    J Immunol 190:3696-705. 2013
    ..Effects of combined stimulation by murine CXCL9 and CXCL12, ligands of CXCR3 and CXCR4, respectively, were analyzed using a murine central memory Th1 cell clone...
  9. doi Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice
    Hacer Sahin
    Medical Department III, University Hospital Aachen, Aachen, Germany
    Hepatology 55:1610-9. 2012
    ..attenuation of angiogenesis and associated liver fibrosis by therapeutic treatment with the angiostatic chemokine Cxcl9 was systematically analyzed in vitro and in vivo...
  10. doi Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development
    Sylvie Lefebvre
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Invest Dermatol 132:1094-102. 2012
    ..Deficiency in cxcR3 resulted in decreased primary hair follicle density but otherwise normal hair development, indicating that chemokine signaling influences the patterning of primary hair placodes only...
  11. pmc Gene profile of chemokines on hepatic stellate cells of schistosome-infected mice and antifibrotic roles of CXCL9/10 on liver non-parenchymal cells
    Yue Jin Liang
    Department of Pathogen Biology, Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
    PLoS ONE 7:e42490. 2012
    ..i) when the egg granulomatous response was not obviously evoked in the liver. However, some of them like CXCL9, CXCL10 and CXCL11 were subsequently decreased at 6 weeks p.i when the granulomatous response reached the peak...
  12. doi Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow
    Dorothy E Pazin
    Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    Dev Dyn 241:1816-26. 2012
    ..Here, we use microarray analysis to compare knee and elbow formation to identify factors involved in the development of specific joints...
  13. pmc Chemokine guidance of central memory T cells is critical for antiviral recall responses in lymph nodes
    Jung Hwan Sung
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Cell 150:1249-63. 2012
    ....
  14. pmc CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation
    Joanna R Groom
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Immunity 37:1091-103. 2012
    ..By using a CXCR3 ligand reporter mouse, we found that stromal cells predominately expressed the chemokine ligand CXCL9 whereas hematopoietic cells expressed CXCL10 in LNs...
  15. doi Cutaneous tumors cease CXCL9/Mig production as a result of IFN-γ-mediated immunoediting
    Marianne Petro
    Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 190:832-41. 2013
    ..the appearance and rapid growth of tumor variants deficient in producing the T cell chemoattractant chemokine CXCL9/Mig, an important component of antitumor immunity...
  16. pmc Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node
    Wolfgang Kastenmuller
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 38:502-13. 2013
    ..A feed-forward CXCL9-dependent circuit provided additional chemotactic cues that further increase local memory cell density...
  17. pmc Interferon-inducible protein 10, but not monokine induced by gamma interferon, promotes protective type 1 immunity in murine Klebsiella pneumoniae pneumonia
    Xianying Zeng
    Department of Pathology, Division of Pulmonary and Critical Care Medicine, 6301 MSRB III, University of Michigan Medical Center, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Infect Immun 73:8226-36. 2005
    ..chemokines that lack the ELR motif, including interferon-inducible protein 10 [IP-10 (CXCL10)] and monokine induced by gamma interferon (IFN-gamma) [MIG (CXCL9)], have been shown to mediate the generation of type 1 immune responses...
  18. doi Activated expression of the chemokine Mig after chemotherapy contributes to chemotherapy-induced bone marrow suppression and lethal toxicity
    Huili Lu
    Laboratory of Regeneromics, School of Pharmacy, Shanghai Jiaotong University, Shanghai, China
    Blood 119:4868-77. 2012
    ..This paper reports our observation that the expression of the chemokine monokine induced by IFN-γ (Mig) and its receptor CXCR3 was significantly activated in mice after treatment with the chemotherapeutic agent 5-..
  19. doi IL-7 promotes CXCR3 ligand-dependent T cell antitumor reactivity in lung cancer
    Asa Andersson
    Department of Medicine, University of California Los Angeles Lung Cancer Research Program, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 182:6951-8. 2009
    ..Accompanying the antitumor responses were increases in IFN-gamma, CXCL9, CXCL10, and IL-12...
  20. pmc The role of MIG/CXCL9 in cardiac allograft vasculopathy
    James J Yun
    Division of Cardiothoracic Surgery, Department of Surgery, University of California at Los Angeles, Los Angeles, California, USA
    Am J Pathol 161:1307-13. 2002
    ..We hypothesized that the chemokine, monokine induced by interferon-gamma (MIG/CXCL9), which induces T lymphocyte migration in vitro, participates in T lymphocyte recruitment in CAV...
  21. pmc Monokine induced by interferon-gamma (MIG/CXCL9) is derived from both donor and recipient sources during rejection of class II major histocompatibility complex disparate skin allografts
    Michael B Auerbach
    NB3 59, Department of Immunology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195 0001, USA
    Am J Pathol 174:2172-81. 2009
    Chemokines, including monokine induced by interferon-gamma (Mig/CXCL9), are produced both in allografts and during the direct T-cell infiltration that mediates graft rejection...
  22. pmc Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans
    Hermann E Wasmuth
    Department of Medicine III, University Hospital Aachen, Aachen, Germany
    Gastroenterology 137:309-19, 319.e1-3. 2009
    ..We investigated the roles of the chemokine CXCL9 and its receptor CXCR3 in liver fibrosis.
  23. pmc Antimicrobial effects of interferon-inducible CXC chemokines against Bacillus anthracis spores and bacilli
    Matthew A Crawford
    Department of Medicine, Division of Infectious Diseases, University of Virginia Health Sciences System, Charlottesville, VA 22908, USA
    Infect Immun 77:1664-78. 2009
    ..against bacteria, we sought to determine whether the interferon-inducible Glu-Leu-Arg-negative CXC chemokines CXCL9, CXCL10, and CXCL11 exhibit antimicrobial activities against Bacillus anthracis...
  24. ncbi The transcriptional coactivator CREB-binding protein cooperates with STAT1 and NF-kappa B for synergistic transcriptional activation of the CXC ligand 9/monokine induced by interferon-gamma gene
    Miki Hiroi
    Department of Basic Dental Science, Center for Molecular Biology, Meikai University School of Dentistry, 1 1 Keyakidai, Sakado, Saitama 350 0283, Japan
    J Biol Chem 278:651-60. 2003
    ..CREB-binding protein (CBP) mediated the STAT1/NF-kappaB synergy for transcription of the gene for CXC ligand 9 (CXCL9), an interferon-gamma (IFN-gamma)-inducible chemokine...
  25. pmc Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus
    Jun Abe
    Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 173:1682-92. 2008
    ..Taken together, we conclude that T(reg) cells in BWF1 mice are not predisposed to functional incompetence but rather are present in a highly activated state...
  26. pmc Insertion of the CXC chemokine ligand 9 (CXCL9) into the mouse hepatitis virus genome results in protection from viral-induced encephalitis and hepatitis
    Michael Muse
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92619 3900, USA
    Virology 382:132-44. 2008
    The role of the CXC chemokine ligand 9 (CXCL9) in host defense following infection with mouse hepatitis virus (MHV) was determined...
  27. pmc CXCR3 ligands contribute to Th1-induced inflammation but not to homing of Th1 cells into the lung
    ANNE M MANICONE
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Exp Lung Res 34:391-407. 2008
    ..1) antibody ablation of CXCR3 ligands IP10 (CXCL10/interferon-gamma -inducible 10-kDa protein) and MIG (CXCL9/monokine-induced by interferon-gamma), and (2) use of cxcr3(-/-) mice...
  28. pmc CXC chemokine ligand (CXCL) 9 and CXCL10 are antagonistic costimulation molecules during the priming of alloreactive T cell effectors
    Joshua M Rosenblum
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 184:3450-60. 2010
    ..The CXCR3-binding chemokines CXCL9 and CXCL10 recruit donor-reactive T cells to the allograft, but their role during the priming of donor-reactive T ..
  29. doi Streptococcus pneumoniae induces expression of the antibacterial CXC chemokine MIG/CXCL9 via MyD88-dependent signaling in a murine model of airway infection
    Mette Eliasson
    Lund University and Lund University Hospital, Department of Clinical Sciences, Section for Respiratory Medicine, and Allergology, Lund, Sweden
    Microbes Infect 12:565-73. 2010
    MIG/CXCL9 belongs to the CXC family of chemokines and participates in the regulation of leukocyte-trafficking and angiogenesis...
  30. ncbi Assignment of the mouse and cow CXC chemokine genes
    W S Modi
    SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD, USA
    Cytogenet Cell Genet 81:213-6. 1998
    ..2 cM proximal to a group comprising Ifi10, Mig, and Scyb5...
  31. ncbi Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages
    M R Horton
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 273:35088-94. 1998
    ..IFN-gamma), an important regulator of macrophage functions, has been shown to induce the C-X-C chemokines Mig and IP-10. These chemokines affect T-cell recruitment and inhibit angiogenesis...
  32. ncbi Interleukin-10 gene transfer activates interferon-gamma and the interferon-gamma-inducible genes Gbp-1/Mag-1 and Mig-1 in mammary tumors
    H Sun
    Greenebaum Cancer Center, University of Maryland, Baltimore 21201, USA
    Int J Cancer 80:624-9. 1999
    ..The other cDNA corresponds to the chemokine Mig-1 (monokine induced by IFN-gamma)...
  33. pmc Interleukin-18, interferon-gamma, IP-10, and Mig expression in Epstein-Barr virus-induced infectious mononucleosis and posttransplant lymphoproliferative disease
    J Setsuda
    Laboratory of Pathology, Hematopathology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Pathol 155:257-65. 1999
    ..Here we report that PTLD tissues express significantly lower levels of IL-18, interferon-gamma (IFN-gamma), Mig, and RANTES compared to lymphoid tissues diagnosed with acute EBV-induced infectious mononucleosis, as assessed by ..
  34. ncbi WECHE: a novel hematopoietic regulatory factor
    O Ohneda
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Immunity 12:141-50. 2000
    ..WECHE hindered the growth of yolk sac-derived endothelial cells. WECHE was also chemotactic for bone marrow cells. Thus, WECHE is a novel chemokine that regulates hematopoietic differentiation...
  35. ncbi MIG (CXCL9) chemokine gene therapy combines with antibody-cytokine fusion protein to suppress growth and dissemination of murine colon carcinoma
    J M Ruehlmann
    The Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA
    Cancer Res 61:8498-503. 2001
    ..by a recombinant antibody-IL-2 fusion protein (huKS1/4-IL-2) with gene therapy by the murine chemokine MIG (CXCL9) markedly reduced s.c...
  36. ncbi T cell infiltration and chemokine expression: relevance to the disease localization in murine graft-versus-host disease
    J Y New
    Departments of Microbiology, Faculty of Medicine, National University of Singapore, Republic of Singapore
    Bone Marrow Transplant 29:979-86. 2002
    ..We found that in the spleen and liver MIP-1alpha, MIP-2 and Mig were the predominant chemokines expressed...
  37. ncbi The CXC chemokine murine monokine induced by IFN-gamma (CXC chemokine ligand 9) is made by APCs, targets lymphocytes including activated B cells, and supports antibody responses to a bacterial pathogen in vivo
    Matthew K Park
    Inflammation Biology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:1433-43. 2002
    ..as a chemotactic factor for resting memory and activated T cells, both CD4(+) and CD8(+), and responsiveness to MuMig correlated with surface expression of MuCXCR3...
  38. ncbi NF-kappa B activation mediates the cross-talk between extracellular matrix and interferon-gamma (IFN-gamma) leading to enhanced monokine induced by IFN-gamma (MIG) expression in macrophages
    Maureen R Horton
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 277:43757-62. 2002
    ..induce macrophage expression of chemokines, cytokines, and growth factors as well greatly enhance IFN-gamma-induced MIG expression...
  39. doi Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines
    Arnhild Schrage
    Medizinische Klinik I, Campus Charité Benjamin Franklin, Berlin, Germany
    Hepatology 48:1262-72. 2008
    ..LSEC significantly enhanced the chemotactic effect of CXC-motif chemokine ligand 12 (CXCL12) and CXCL9, but not of CXCL16 or CCL20, on naive and memory CD4(+) T cells of a T helper 1, T helper 2, or interleukin-10-..
  40. ncbi Chemotactic responses of IL-4-, IL-10-, and IFN-gamma-producing CD4+ T cells depend on tissue origin and microbial stimulus
    Gudrun F Debes
    Experimental Rheumatology, Medical Clinic, Charite University Medicine Berlin, Berlin, Germany
    J Immunol 176:557-66. 2006
    ..IFN-gamma-expressing T cells as well as populations of IL-4+ or IL-10+ T cells migrated to the CXCR3 ligand, CXCL9. All cytokine-producing T cell subsets strongly migrated to the CXCR4 ligand, CXCL12...
  41. pmc Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group
    Gustavo Valbuena
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Am J Pathol 163:1357-69. 2003
    ..The expression of the CXCR3 ligands CXCL9 and CXCL10 was significantly higher than the other chemokines investigated...
  42. ncbi CXCL9 antagonism further extends prolonged cardiac allograft survival in CCL19/CCL21-deficient mice
    Bridget L Colvin
    Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Transplant 5:2104-13. 2005
    ..Anti-CXCL9/Mig was administered for 2 weeks post-transplant to determine whether impairment of activated T-cell migration ..
  43. ncbi Multiple myeloma oncogene 1 (MUM1)/interferon regulatory factor 4 (IRF4) upregulates monokine induced by interferon-gamma (MIG) gene expression in B-cell malignancy
    M Uranishi
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Leukemia 19:1471-8. 2005
    ..the expression of four genes including FK506-binding protein 3 (FKBP3), the monokine induced by interferon-gamma(MIG), Fas apoptotic inhibitory molecule (Faim) and Zinc-finger protein 94 was altered in the MUM1-expressing cells...
  44. ncbi CXCR3, IP-10, and Mig are required for CD4+ T cell recruitment during the DTH response to HSV-1 yet are independent of the mechanism for viral clearance
    Sara Molesworth-Kenyon
    Department of Microbiology and Immunology, University of South Alabama, Mobile, AL 36607, USA
    Virology 333:1-9. 2005
    ..CXCR3 ligands IP-10 and Mig were elevated at the DTH site. Their neutralization significantly reduced DTH ear swelling and CD4+ T cell influx...
  45. ncbi A novel role for neutrophils as a source of T cell-recruiting chemokines IP-10 and Mig during the DTH response to HSV-1 antigen
    S J Molesworth-Kenyon
    Department of Microbiology and Immunology, University of South Alabama, Mobile, AL 36607, USA
    J Leukoc Biol 77:552-9. 2005
    ..site and a sharp drop in the levels of interferon-inducible protein 10 (IP-10) and monokine induced by IFN-gamma (Mig)...
  46. ncbi Monokine induced by interferon-gamma is induced by receptor activator of nuclear factor kappa B ligand and is involved in osteoclast adhesion and migration
    Han Bok Kwak
    National Research Laboratory for Bone Metabolism, College of Dentistry, Chosun University, Gwangju, Korea
    Blood 105:2963-9. 2005
    ..study to identify genes targeted by RANKL, we found that monokine induced by the interferon-gamma (IFN-gamma) (MIG) gene was up-regulated in osteoclast precursor cells...
  47. ncbi Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome
    Gerhard C Hildebrandt
    Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 173:2050-9. 2004
    ..is a chemokine receptor that is expressed on activated Th1/Tc1 T cell subsets and the expression of its ligands CXCL9 (monokine induced by IFN-gamma (Mig)) and CXCL10 (IFN-gamma-inducible protein 10 (IP-10)) can be induced in a ..
  48. ncbi Regulation of cockroach antigen-induced allergic airway hyperreactivity by the CXCR3 ligand CXCL9
    Molly S Thomas
    Department of Pathology, University of Michigan, 1309 Catherine, Ann Arbor, MI 48109, USA
    J Immunol 173:615-23. 2004
    ..The CXCR3 ligands, CXCL9 (monokine induced by IFN-gamma) and CXCL10 (IFN-inducible protein, 10 kDa), are IFN-gamma-inducible, Th1-type ..
  49. ncbi Chemokine monokine induced by IFN-gamma/CXC chemokine ligand 9 stimulates T lymphocyte proliferation and effector cytokine production
    David Whiting
    Department of Surgery, Division of Cardiothoracic Surgery, David Geffen School of Medicine, University of California Los Angeles, UCLA Medical Center, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    J Immunol 172:7417-24. 2004
    ..The recipient mice were treated with anti-MIG/CXCL9 Ab; graft-infiltrating cells were analyzed for IFN-gamma production...
  50. pmc The chemokines CXCL9 and CXCL10 promote a protective immune response but do not contribute to cardiac inflammation following infection with Trypanosoma cruzi
    Jenny L Hardison
    Department of Molecular Biology and Biochemistry, 3205 McGaugh Hall, University of California at Irvine, Irvine, CA 92697 3900, USA
    Infect Immun 74:125-34. 2006
    ..Analysis of chemokine transcripts revealed that CXC chemokine ligand 9 (CXCL9) and CXCL10, as well as CC chemokine ligand 2 (CCL2) and CCL5, were prominently expressed during acute disease, ..
  51. ncbi STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells
    Zamaneh Mikhak
    Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 176:4959-67. 2006
    ..STAT1 controls the recruitment of Th1 cells through the induction of CXCL9, CXCL10, CXCL11, and CXCL16, whose expression levels in the lung were markedly decreased in STAT1-/- mice...
  52. pmc Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria
    Gabriele S V Campanella
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 105:4814-9. 2008
    ..We show that the CXCR3 chemokine ligands IP-10 and Mig (CXCL9) were highly induced in the brains of mice with murine cerebral malaria caused by Plasmodium berghei ANKA...
  53. ncbi CXCR3 mediates region-specific antiviral T cell trafficking within the central nervous system during West Nile virus encephalitis
    Bo Zhang
    Division of Infectious Diseases, Children s Hospital of Boston, Boston, MA, USA
    J Immunol 180:2641-9. 2008
    ..These results indicate that WNV differentially induces CXCL10 within neuronal populations and suggest a novel model for nonredundancy in chemokine-mediated inflammation among CNS compartments...
  54. pmc CXCL9 and CXCL10 expression are critical for control of genital herpes simplex virus type 2 infection through mobilization of HSV-specific CTL and NK cells to the nervous system
    Manoj Thapa
    Department of Microbiology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    J Immunol 180:1098-106. 2008
    b>CXCL9 and CXCL10 mediate the recruitment of T lymphocytes and NK cells known to be important in viral surveillance...
  55. ncbi Induction of the genes for Cxcl9 and Cxcl10 is dependent on IFN-gamma but shows differential cellular expression in experimental autoimmune encephalomyelitis and by astrocytes and microglia in vitro
    Sally L Carter
    School of Molecular and Microbial Biosciences, The University of Sydney, NSW, Australia
    Glia 55:1728-39. 2007
    The chemokines CXCL9 and CXCL10 bind to the common receptor CXCR3 and are implicated in the pathogenesis of T-cell-mediated immunity in the central nervous system (CNS)...
  56. pmc Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide
    Kyle I Happel
    Louisiana State University Health Sciences Center, Alcohol Research Center, Section of Pulmonary Critical Care, 1901 Perdido Street, Suite 3205, New Orleans, LA 70112, USA
    Alcohol 41:325-33. 2007
    ..t.) LPS challenge for the ELR- CXC chemokines monokine induced by gamma (MIG or CXCL9), interferon-inducible protein 10 (IP-10 or CXCL10), and interferon-inducible T cell alpha chemoattractant (I-TAC ..
  57. ncbi Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis
    Simona Frigerio
    Pediatric Immunology, Department of Research and the University Children s Hospital, Basel, Switzerland
    Nat Med 8:1414-20. 2002
    ..In mice deficient for this receptor, the onset of type 1 diabetes is substantially delayed. Thus, in the absence of known etiological agents, CXC receptor 3 represents a novel target for therapeutic interference early in type 1 diabetes...
  58. pmc SLC/CCL21-mediated anti-tumor responses require IFNgamma, MIG/CXCL9 and IP-10/CXCL10
    Sherven Sharma
    Department of Medicine, UCLA Lung Cancer Research Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Mol Cancer 2:22. 2003
    ..We have previously shown that SLC/CCL21-mediated anti-tumor responses are accompanied by significant induction of IFNgamma and the CXC chemokines, monokine induced by IFNgamma (MIG/CXCL9) and IFNgamma-inducible protein-10 (IP-10/CXCL10).
  59. ncbi CXC chemokine ligand 9/monokine induced by IFN-gamma production by tumor cells is critical for T cell-mediated suppression of cutaneous tumors
    Anton V Gorbachev
    Department of Immunology, Cleveland Clinic, Cleveland, OH 44195, USA
    J Immunol 178:2278-86. 2007
    ..We retrieved an in vivo growing MCA205 fibrosarcoma and isolated tumor cell clones that produce both CXCL9/monokine induced by IFN-gamma (Mig) and CXCL10/IFN-gamma-inducible protein 10 following stimulation with IFN-gamma ..
  60. ncbi Early up-regulation of CXC-chemokine expression is associated with strong cellular immune responses to murine skin xenografts
    Eun Mi Lee
    Xenotransplantation Research Center and Transplantation Research Institute, Seoul National University Hospital, Seoul, Korea
    Xenotransplantation 13:328-36. 2006
    ....
  61. ncbi CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 176:7087-95. 2006
    ..The chemokine receptor CXCR3 and two of its ligands, CXCL9 and CXCL10, have been identified as important mediators of OB...
  62. pmc Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9)
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
    Proc Natl Acad Sci U S A 101:1987-92. 2004
    ..found to be associated with the expression of T helper 1-associated CXCR3 ligands, monokine induced by IFN-gamma (Mig), and IFN-gamma-inducible protein of 10 kDa (IP-10)...

Research Grants12

  1. Role of CXCR3 in Th1-Mediated Lung Injury
    ANNE MANICONE; Fiscal Year: 2004
    ..The goal of this project is to determine the role of CXCR3 (+) myeloid cells in Thl-mediated lung injury, which will lead to a better understanding of other Th1-associated diseases. ..
  2. Novel Immune Pathways for Lung Cancer Therapy
    Sherven Sharma; Fiscal Year: 2009
    ....
  3. Alcohol, Pulmonary Cytokines, and Host Defense
    Kyle Happel; Fiscal Year: 2007
    ..The didactic program and basic research experiences in this mentored proposal are designed to catalyze the applicant's development into an independent investigator in the field of alcoholism and pulmonary host defenses. ..
  4. Lymphocyte Exit from Tissues: Control and Significance to Host Defense
    GUDRUN DEBES; Fiscal Year: 2007
    ..Defining the molecules involved in tissue exit and knowing the importance of tissue exit in the defense against pathogens will reveal new control points in the regulation of tissue inflammation as well as local immunity. ..
  5. Epilysin in Lung Immunity
    ANNE MANICONE; Fiscal Year: 2007
    ..End of Abstract) ..
  6. SLC/6Ckine Immunotherapy for Cancer
    Sherven Sharma; Fiscal Year: 2006
    ..B) The importance of cytokines IFN gamma, IL-10, GM-CSF, IL-12, MIG and IP10 in SLC- mediated anti-tumor responses will be assessed. 2...
  7. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
    ..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
  8. Novel Immune Pathways for Lung Cancer Therapy
    Sherven Sharma; Fiscal Year: 2010
    ....