Gene Symbol: Cxcl11
Description: chemokine (C-X-C motif) ligand 11
Alias: Cxc11, H174, I-tac, Ip9, Itac, Scyb11, Scyb9b, b-R1, betaR1, C-X-C motif chemokine 11, interferon-inducible T-cell alpha chemoattractant, small inducible cytokine subfamily B (Cys-X-Cys), member 11, small-inducible cytokine B11
Species: mouse
Products:     Cxcl11

Top Publications

  1. Yang C, Wei L, Pfeffer S, Du Z, Murti A, Valentine W, et al. Identification of CXCL11 as a STAT3-dependent gene induced by IFN. J Immunol. 2007;178:986-92 pubmed
    ..The present study explored the involvement of STAT3 in the IFN-induced expression of the gene encoding the CXCL11 chemokine...
  2. Ha Y, Liu H, Zhu S, Yi P, Liu W, Nathanson J, et al. Critical Role of the CXCL10/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush. Am J Pathol. 2017;187:352-365 pubmed publisher
    ..These results indicate that leukocyte recruitment in retinal vessels near the ON head is an early event in TON and the CXCL10/CXCR3 axis has a critical role in recruiting leukocytes and inducing RGC death. ..
  3. Chung B, Arutyunov A, Ilagan E, Yao N, Wills Karp M, Coulombe P. Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes. J Cell Biol. 2015;208:613-27 pubmed publisher
    ..Among these are the CXCR3 ligands CXCL9, CXCL10, and CXCL11, which together form a signaling axis with an established role in tumorigenesis...
  4. Hamilton N, Mahalingam S, Banyer J, Ramshaw I, Thomson S. A recombinant vaccinia virus encoding the interferon-inducible T-cell alpha chemoattractant is attenuated in vivo. Scand J Immunol. 2004;59:246-54 pubmed
    ..The data presented here show that I-TAC can have an important role during virus infections and that vaccinia has evolved ways to avoid inducing I-TAC expression. ..
  5. Petkovic V, Moghini C, Paoletti S, Uguccioni M, Gerber B. I-TAC/CXCL11 is a natural antagonist for CCR5. J Leukoc Biol. 2004;76:701-8 pubmed
    ..ligand 9 (CXCL9), IFN-inducible protein 10/CXCL10, and IFN-inducible T cell alpha chemoattractant (I-TAC)/CXCL11, attract CXCR3+ cells such as CD45RO+ T lymphocytes, B cells, and natural killer cells...
  6. Qi Z, Wang J, Han X, Yang J, Zhao G, Cao Y. Listr1 locus regulates innate immunity against Listeria monocytogenes infection in the mouse liver possibly through Cxcl11 polymorphism. Immunogenetics. 2014;66:231-42 pubmed publisher
    ..Analysis of genes within the Listr1 locus identified a frameshift mutation in the Cxcl11 gene of the C57BL/6 strain that prevents production of the mature chemokine CXCL11...
  7. Widney D, Xia Y, Lusis A, Smith J. The murine chemokine CXCL11 (IFN-inducible T cell alpha chemoattractant) is an IFN-gamma- and lipopolysaccharide-inducible glucocorticoid-attenuated response gene expressed in lung and other tissues during endotoxemia. J Immunol. 2000;164:6322-31 pubmed
    ..CXCL11/I-TAC is supported by phylogenetic analysis and by radiation hybrid mapping of murine I-TAC (gene symbol Scyb11) to mouse chromosome 5 close to the genes for monokine induced by IFN-gamma (MIG) and IP10...
  8. Zohar Y, Wildbaum G, Novak R, Salzman A, Thelen M, Alon R, et al. CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis. J Clin Invest. 2014;124:2009-22 pubmed publisher
    ..expressed on CD4+ T cells, and canonically binds 3 structurally related chemokines: CXCL9, CXCL10, and CXCL11. Here we have shown that CXCL10/CXCR3 interactions drive effector Th1 polarization via STAT1, STAT4, and STAT5 ..
  9. Smith J, Wadleigh D, Xia Y, Mar R, Herschman H, Lusis A. Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5. Immunogenetics. 2002;54:599-603 pubmed
    ..The sequence and mapping data suggest that the human ENA78-PBP-PF4 and GCP2- psi PBP-PF4V1 loci arose from an evolutionarily recent duplication of an ancestral locus related to the murine Lix-Pbp-Pf4 locus. ..

More Information


  1. Meyer M, Hensbergen P, van der Raaij Helmer E, Brandacher G, Margreiter R, Heufler C, et al. Cross reactivity of three T cell attracting murine chemokines stimulating the CXC chemokine receptor CXCR3 and their induction in cultured cells and during allograft rejection. Eur J Immunol. 2001;31:2521-7 pubmed
    ..murine gene homologous to the human T cell attracting chemokine CXC receptor ligand 11 (CXCL11, also termed I-TAC, SCYB11, ss-R1, H174, IP-9)...
  2. Sierro F, Biben C, Martínez Muñoz L, Mellado M, Ransohoff R, Li M, et al. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A. 2007;104:14759-64 pubmed
    ..Our results reveal a specialized role for CXCR7 in endothelial biology and valve development and highlight the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CXCR4. ..
  3. Yates C, Whaley D, Y Chen A, Kulesekaran P, Hebda P, Wells A. ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair. Am J Pathol. 2008;173:643-52 pubmed publisher
    ..equivalently binds four different ELR-devoid CXC chemokines (ie, PF4/CXCL4, IP-10/CXCL10, MIG/CXCL9, and IP-9/CXCL11), we sought to identify the ligand that coordinates epidermal coverage with the maturation of the underlying ..
  4. Crawford M, Zhu Y, Green C, Burdick M, Sanz P, Alem F, et al. Antimicrobial effects of interferon-inducible CXC chemokines against Bacillus anthracis spores and bacilli. Infect Immun. 2009;77:1664-78 pubmed publisher
    ..we sought to determine whether the interferon-inducible Glu-Leu-Arg-negative CXC chemokines CXCL9, CXCL10, and CXCL11 exhibit antimicrobial activities against Bacillus anthracis...
  5. Severin I, Gaudry J, Johnson Z, Kungl A, Jansma A, Gesslbauer B, et al. Characterization of the chemokine CXCL11-heparin interaction suggests two different affinities for glycosaminoglycans. J Biol Chem. 2010;285:17713-24 pubmed publisher
    ..In this study we characterized the GAG-binding epitopes of the chemokine I-TAC/CXCL11. Four separate clusters of basic residues were mutated to alanine and tested for their ability to bind to GAGs in ..
  6. Lefebvre S, Fliniaux I, Schneider P, Mikkola M. Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012;132:1094-102 pubmed publisher
    ..Surprisingly, we identified two ligands of the chemokine receptor cxcR3, cxcl10 and cxcl11, as new hair-specific transcriptional targets of Eda...
  7. Li S, Pettersson U, Hoorelbeke B, Kolaczkowska E, Schelfhout K, Martens E, et al. Interference with glycosaminoglycan-chemokine interactions with a probe to alter leukocyte recruitment and inflammation in vivo. PLoS ONE. 2014;9:e104107 pubmed publisher
    ..COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were ..
  8. Happel K, Rudner X, Quinton L, Movassaghi J, Clark C, Odden A, et al. Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide. Alcohol. 2007;41:325-33 pubmed
    ..interferon-inducible protein 10 (IP-10 or CXCL10), and interferon-inducible T cell alpha chemoattractant (I-TAC or CXCL11). Male C57BL/6 or C3H/HeN mice were given an intraperitoneal injection of ethanol (3...
  9. Meyer M, Erdel M, Duba H, Werner E, Werner Felmayer G. Cloning, genomic sequence, and chromosome mapping of Scyb11, the murine homologue of SCYB11 (alias betaR1/H174/SCYB9B/I-TAC/IP-9/CXCL11). Cytogenet Cell Genet. 2000;88:278-82 pubmed
    ..related to MIG and SCYB10 was recently characterized and termed SCYB11 (alias betaR1/H174/SCYB9B/I-TAC/IP-9/CXCL11)...
  10. Roebrock K, Sunderkotter C, Münck N, Wolf M, Nippe N, Barczyk K, et al. Epidermal expression of I-TAC (Cxcl11) instructs adaptive Th2-type immunity. FASEB J. 2014;28:1724-34 pubmed publisher
    ..We found a marked up-regulation of the chemokine I-TAC (Cxcl11) during the first 2 d of infection in the epidermis of susceptible but not of resistant mice...