Cxcl10

Summary

Gene Symbol: Cxcl10
Description: chemokine (C-X-C motif) ligand 10
Alias: CRG-2, INP10, IP-10, IP10, Ifi10, Scyb10, gIP-10, mob-1, C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, gamma-IP10, interferon activated gene 10, interferon-gamma induced protein CRG-2, small inducible cytokine B subfamily (Cys-X-Cys), member 10, small-inducible cytokine B10
Species: mouse
Products:     Cxcl10

Top Publications

  1. Hyun J, Lee G, Brown J, Grimm G, Tang Y, Mittal N, et al. Anti-interferon-inducible chemokine, CXCL10, reduces colitis by impairing T helper-1 induction and recruitment in mice. Inflamm Bowel Dis. 2005;11:799-805 pubmed
    ..In this study, we investigated the hypothesis that production of the CXC chemokine CXCL10 (interferon [IFN]gamma-inducible protein 10) enhances induction of inflammatory responses in draining lymph nodes (..
  2. Yuan J, Liu Z, Lim T, Zhang H, He J, Walker E, et al. CXCL10 inhibits viral replication through recruitment of natural killer cells in coxsackievirus B3-induced myocarditis. Circ Res. 2009;104:628-38 pubmed publisher
    Coxsackievirus (CV)B3 is the primary cause of viral myocarditis. We previously observed CXC chemokine ligand 10 (CXCL10) upregulation in the myocardium early in infection...
  3. Vasquez R, Soong L. CXCL10/gamma interferon-inducible protein 10-mediated protection against Leishmania amazonensis infection in mice. Infect Immun. 2006;74:6769-77 pubmed
    ..In this study, we examined the roles of CXCL10/gamma interferon-inducible protein 10 (IP-10) and CCL2/monocyte chemoattractant protein 1 (MCP-1) in the ..
  4. Israelsson C, Bengtsson H, Lobell A, Nilsson L, Kylberg A, Isaksson M, et al. Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders. Eur J Neurosci. 2010;31:852-63 pubmed publisher
    ..injury (TBI) in the mouse results in the rapid appearance of scattered clusters of cells expressing the chemokine Cxcl10 in cortical and subcortical areas...
  5. Yoneyama H, Narumi S, Zhang Y, Murai M, Baggiolini M, Lanzavecchia A, et al. Pivotal role of dendritic cell-derived CXCL10 in the retention of T helper cell 1 lymphocytes in secondary lymph nodes. J Exp Med. 2002;195:1257-66 pubmed
    ..induced by Propionibacterium acnes, we show that retention of Th1 cells in the LNs is controlled by a chemokine, CXCL10/interferon (IFN) inducible protein 10 produced by mature dendritic cells (DCs)...
  6. Campanella G, Colvin R, Luster A. CXCL10 can inhibit endothelial cell proliferation independently of CXCR3. PLoS ONE. 2010;5:e12700 pubmed publisher
    b>CXCL10 (or Interferon-inducible protein of 10 kDa, IP-10) is an interferon-inducible chemokine with potent chemotactic activity on activated effector T cells and other leukocytes expressing its high affinity G protein-coupled receptor ..
  7. Campanella G, Lee E, Sun J, Luster A. CXCR3 and heparin binding sites of the chemokine IP-10 (CXCL10). J Biol Chem. 2003;278:17066-74 pubmed
    The chemokine IP-10 (interferon-inducible protein of 10 kDa, CXCL10) binds the G protein-coupled receptor CXCR3, which is found mainly on activated T cells and NK cells, and plays an important role in Th1-type inflammatory diseases...
  8. Lee J, Kim H, Kim K, Jin W, Lee S, Kim H, et al. CXCL10 promotes osteolytic bone metastasis by enhancing cancer outgrowth and osteoclastogenesis. Cancer Res. 2012;72:3175-86 pubmed publisher
    Amplification of the chemokines CXCL10 and RANKL has been suggested to promote osteoclast differentiation and osteolytic bone metastasis, but a function for endogenous CXCL10 in these processes is not well established...
  9. Narumi S, Wyner L, Stoler M, Tannenbaum C, Hamilton T. Tissue-specific expression of murine IP-10 mRNA following systemic treatment with interferon gamma. J Leukoc Biol. 1992;52:27-33 pubmed
    ..Although the function of the IP-10 gene product has not been defined, these results suggest that it may play an important role in the response of both the liver and kidney to systemic inflammation. ..

More Information

Publications86

  1. Suzuki K, Kawauchi Y, Palaniyandi S, Veeraveedu P, Fujii M, Yamagiwa S, et al. Blockade of interferon-gamma-inducible protein-10 attenuates chronic experimental colitis by blocking cellular trafficking and protecting intestinal epithelial cells. Pathol Int. 2007;57:413-20 pubmed
    The role of chemokines, especially CXCL10/interferon-gamma-inducible protein 10 kDa (IP-10), a chemokine to attract CXCR3(+) T-helper 1-type CD4(+) T cells, is largely unknown in the pathophysiology of inflammatory bowel disease; ..
  2. Hsieh M, Lai S, Chen J, Sung J, Lin Y, Wu Hsieh B, et al. Both CXCR3 and CXCL10/IFN-inducible protein 10 are required for resistance to primary infection by dengue virus. J Immunol. 2006;177:1855-63 pubmed
    ..In studies to identify critical CXCR3 ligands, CXCL10/IFN-inducible protein 10-deficient (CXCL10/IP-10(-/-)) mice infected with dengue virus showed a higher mortality ..
  3. Rhode A, Pauza M, Barral A, Rodrigo E, Oldstone M, Von Herrath M, et al. Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development. J Immunol. 2005;175:3516-24 pubmed
    During inflammation, chemokines are conductors of lymphocyte trafficking. The chemokine CXCL10 is expressed early after virus infection...
  4. Sgadari C, Angiolillo A, Cherney B, Pike S, Farber J, Koniaris L, et al. Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo. Proc Natl Acad Sci U S A. 1996;93:13791-6 pubmed
    ..Thus, IP-10 is an antitumor agent that promotes damage in established tumor vasculature and causes tissue necrosis in human Burkitt lymphomas established subcutaneously in athymic mice. ..
  5. Ohmori Y, Hamilton T. Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter. J Biol Chem. 1993;268:6677-88 pubmed
    ..The three defined regulatory elements function in distinct fashion for each of the two stimuli; optimal response to either IFN gamma or LPS requires cooperation between at least two sites. ..
  6. Sarfo B, Wilson N, Bond V, Stiles J. Plasmodium berghei ANKA infection increases Foxp3, IL-10 and IL-2 in CXCL-10 deficient C57BL/6 mice. Malar J. 2011;10:69 pubmed publisher
    ..berghei antigens produced more IL-10 than WT CD4+CD25+ T cells. The results indicate that in the absence of CXCL-10, the resulting up-regulation of Foxp3, IL-10 and IL-2 may be involved in attenuating fatal murine CM. ..
  7. Hintermann E, Bayer M, Pfeilschifter J, Luster A, Christen U. CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation. J Autoimmun. 2010;35:424-35 pubmed publisher
    Chemokines, such as CXCL10, promote hepatic inflammation in chronic or acute liver injury through recruitment of leukocytes to the liver parenchyma...
  8. Dufour J, Dziejman M, Liu M, Leung J, Lane T, Luster A. IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol. 2002;168:3195-204 pubmed
    IFN-gamma-inducible protein 10 (IP-10, CXCL10), a chemokine secreted from cells stimulated with type I and II IFNs and LPS, is a chemoattractant for activated T cells...
  9. Frigerio S, Junt T, Lu B, Gerard C, Zumsteg U, Hollander G, et al. Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat Med. 2002;8:1414-20 pubmed
    ..Thus, in the absence of known etiological agents, CXC receptor 3 represents a novel target for therapeutic interference early in type 1 diabetes. ..
  10. van Weering H, Boddeke H, Vinet J, Brouwer N, de Haas A, Van Rooijen N, et al. CXCL10/CXCR3 signaling in glia cells differentially affects NMDA-induced cell death in CA and DG neurons of the mouse hippocampus. Hippocampus. 2011;21:220-32 pubmed publisher
    The chemokine CXCL10 and its receptor CXCR3 are implicated in various CNS pathologies since interference with CXCL10/CXCR3 signaling alters the onset and progression in various CNS disease models...
  11. Campanella G, Grimm J, Manice L, Colvin R, Medoff B, Wojtkiewicz G, et al. Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activity. J Immunol. 2006;177:6991-8 pubmed
    The chemokine IFN-gamma-inducible protein of 10 kDa (IP-10; CXCL10) plays an important role in the recruitment of activated T lymphocytes into sites of inflammation by interacting with the G protein-coupled receptor CXCR3...
  12. Klein R, Izikson L, Means T, Gibson H, Lin E, Sobel R, et al. IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis. J Immunol. 2004;172:550-9 pubmed
    ..Our data demonstrated that IP-10 was not required for the trafficking of pathogenic T cells into the CNS in EAE but played an unexpected role in determining the threshold of disease susceptibility in the periphery. ..
  13. Campanella G, Tager A, El Khoury J, Thomas S, Abrazinski T, Manice L, et al. Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. Proc Natl Acad Sci U S A. 2008;105:4814-9 pubmed publisher
    ..have been implicated in the development of cerebral malaria, and the IFN-inducible CXCR3 chemokine ligand IP-10 (CXCL10) was recently found to be the only serum biomarker that predicted cerebral malaria mortality in Ghanaian children...
  14. Lalor S, Segal B. Th1-mediated experimental autoimmune encephalomyelitis is CXCR3 independent. Eur J Immunol. 2013;43:2866-74 pubmed publisher
    ..Surprisingly, mice genetically deficient in either CXCR3 or CXCL10 succumb to EAE following active immunization with myelin antigens...
  15. Bujak M, Dobaczewski M, Gonzalez Quesada C, Xia Y, Leucker T, Zymek P, et al. Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction. Circ Res. 2009;105:973-83 pubmed publisher
    Interferon-gamma-inducible protein (IP)-10/CXCL10, an angiostatic and antifibrotic chemokine with an important role in T-cell trafficking, is markedly induced in myocardial infarcts, and may regulate the reparative response...
  16. Tager A, Kradin R, LaCamera P, Bercury S, Campanella G, Leary C, et al. Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10. Am J Respir Cell Mol Biol. 2004;31:395-404 pubmed
    ..Our findings suggest that interruption of fibroblast recruitment may represent a novel therapeutic strategy for pulmonary fibrosis, which could have applicability to a wide range of fibrotic illnesses. ..
  17. Santodomingo Garzon T, Han J, Le T, Yang Y, Swain M. Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice. Hepatology. 2009;49:1267-76 pubmed publisher
    ..Because IFN-gamma induces the production of chemokine (C-X-C motif) ligand 10 (CXCL10), and Tregs can express the cognate receptor for CXCL10 (that is, CXCR3), we considered that CXCL10 might mediate ..
  18. Heller E, Liu E, Tager A, Yuan Q, Lin A, Ahluwalia N, et al. Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation. 2006;113:2301-12 pubmed
    ..Here, we tested the hypothesis that deletion of CXCL10 (IP-10), a chemokine specific for effector T cells that has been localized within atherosclerotic lesions, would ..
  19. Christen U, McGavern D, Luster A, Von Herrath M, Oldstone M. Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease. J Immunol. 2003;171:6838-45 pubmed
  20. Horton M, McKee C, Bao C, Liao F, Farber J, Hodge DuFour J, et al. Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages. J Biol Chem. 1998;273:35088-94 pubmed
    ..These data suggest that the ECM component HA may influence chronic inflammatory states by working in concert with IFN-gamma to alter macrophage chemokine expression. ..
  21. Zhai Y, Shen X, Gao F, Zhao A, Freitas M, Lassman C, et al. CXCL10 regulates liver innate immune response against ischemia and reperfusion injury. Hepatology. 2008;47:207-14 pubmed
    ..focused on the role of TLR4-IRF3 activation pathway products, in particular, chemokine (C-X-C motif) ligand 10 (CXCL10)...
  22. Fujita M, Zhu X, Ueda R, Sasaki K, Kohanbash G, Kastenhuber E, et al. Effective immunotherapy against murine gliomas using type 1 polarizing dendritic cells--significant roles of CXCL10. Cancer Res. 2009;69:1587-95 pubmed publisher
    ..counterparts, mouse DC1s exhibited surface marker profiles of mature DCs and produced high levels of IL-12 and CXCL10. Importantly for their application as cancer vaccines, such DC1s stably retained their type 1 phenotype even when ..
  23. Nakamichi K, Inoue S, Takasaki T, Morimoto K, Kurane I. Rabies virus stimulates nitric oxide production and CXC chemokine ligand 10 expression in macrophages through activation of extracellular signal-regulated kinases 1 and 2. J Virol. 2004;78:9376-88 pubmed
    ..and chemokines revealed that RV virions potentiate the gene expression of iNOS and CXC chemokine ligand 10 (CXCL10), a major chemoattractant of T helper cell type 1...
  24. Hildebrandt G, Corrion L, Olkiewicz K, Lu B, Lowler K, Duffner U, et al. Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. J Immunol. 2004;173:2050-9 pubmed
    ..activated Th1/Tc1 T cell subsets and the expression of its ligands CXCL9 (monokine induced by IFN-gamma (Mig)) and CXCL10 (IFN-gamma-inducible protein 10 (IP-10)) can be induced in a variety of cell types by IFN-gamma alone or in ..
  25. Cuenca A, Wynn J, Kelly Scumpia K, Scumpia P, Vila L, Delano M, et al. Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis. Infect Immun. 2011;79:2746-54 pubmed publisher
    ..Here, we show that in a murine model of neonatal polymicrobial sepsis, CXC ligand 10 (CXCL10) concentrations increase in the blood and peritoneum concordant with the peritoneal recruitment of granulocytes ..
  26. Gao D, Li T, Li X, Chen X, Li Q, Wight Carter M, et al. Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. Proc Natl Acad Sci U S A. 2015;112:E5699-705 pubmed publisher
  27. Peperzak V, Veraar E, Xiao Y, Babala N, Thiadens K, Brugmans M, et al. CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool. J Immunol. 2013;191:3025-36 pubmed publisher
    Various cell types can produce the chemokine CXCL10 in response to IFN-? stimulation...
  28. Chai Q, She R, Huang Y, Fu Z. Expression of neuronal CXCL10 induced by rabies virus infection initiates infiltration of inflammatory cells, production of chemokines and cytokines, and enhancement of blood-brain barrier permeability. J Virol. 2015;89:870-6 pubmed publisher
    ..Since CXCL10 was found to be the most highly expressed chemokine, its temporal and spatial expression were determined in the ..
  29. Velecela V, Lettice L, Chau Y, Slight J, Berry R, Thornburn A, et al. WT1 regulates the expression of inhibitory chemokines during heart development. Hum Mol Genet. 2013;22:5083-95 pubmed publisher
    ..Here, we showed that WT1 is required to repress the expression of the chemokines Ccl5 and Cxcl10 in epicardial cells...
  30. Michalec L, Choudhury B, Postlethwait E, Wild J, Alam R, Lett Brown M, et al. CCL7 and CXCL10 orchestrate oxidative stress-induced neutrophilic lung inflammation. J Immunol. 2002;168:846-52 pubmed
    ..up-regulated lung mRNA of CXCL1,2,3 (mouse growth-related oncogene-alpha and macrophage-inflammatory protein-2), CXCL10 (IFN-gamma-inducible protein-10), CCL3 (macrophage-inflammatory protein-1alpha), CCL7 (monocyte chemoattractant ..
  31. McPhee C, Duncan F, Silva K, King L, HogenEsch H, Roopenian D, et al. Increased expression of Cxcr3 and its ligands, Cxcl9 and Cxcl10, during the development of alopecia areata in the mouse. J Invest Dermatol. 2012;132:1736-8 pubmed publisher
  32. Wuest T, Farber J, Luster A, Carr D. CD4+ T cell migration into the cornea is reduced in CXCL9 deficient but not CXCL10 deficient mice following herpes simplex virus type 1 infection. Cell Immunol. 2006;243:83-9 pubmed
    The role of CXCL9 and CXCL10 in the ocular immune response to herpes simplex virus type 1 (HSV-1) infection was investigated using mice deficient in either CXCL9 or CXCL10...
  33. Katakai T, Hara T, Sugai M, Gonda H, Shimizu A. Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med. 2004;200:783-95 pubmed
    ..These findings suggest that signals from lymphocytes induce FRCs to form the network that supports the movement and interactions of immune effectors within the lymph node. ..
  34. Yoshimatsu G, Kunnathodi F, Saravanan P, Shahbazov R, Chang C, Darden C, et al. Pancreatic β-Cell-Derived IP-10/CXCL10 Isletokine Mediates Early Loss of Graft Function in Islet Cell Transplantation. Diabetes. 2017;66:2857-2867 pubmed publisher
    ..The proinflammatory cytokine interferon-γ-induced protein 10 (IP-10/CXCL10) was among the highest released, and high levels correlated with poor islet transplant outcomes...
  35. Takashima K, Takeda Y, Oshiumi H, Shime H, Okabe M, Ikawa M, et al. STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation. Biochem Biophys Res Commun. 2016;478:1764-71 pubmed publisher
    ..suggested that STING in host immune cells and tumor cells induced distinct profiles of chemokines including CXCL10, CCL5 and IL-33, and both participated in NK cell infiltration and activation in B16D8 tumor...
  36. Peng W, Liu C, Xu C, Lou Y, Chen J, Yang Y, et al. PD-1 blockade enhances T-cell migration to tumors by elevating IFN-? inducible chemokines. Cancer Res. 2012;72:5209-18 pubmed publisher
    ..myeloid-derived suppressor cells present in tumor-bearing mice, we found that it increased expression of IFN-? and CXCL10 at the tumor site...
  37. Schnöder T, Eberhardt J, Koehler M, Bierhoff H, Weinert S, Pandey A, et al. Cell autonomous expression of CXCL-10 in JAK2V617F-mutated MPN. J Cancer Res Clin Oncol. 2017;143:807-820 pubmed publisher
    ..Cytokine array was performed to identify Jak2V617F-related cytokine expression and secretion. CXCL10 mRNA expression was analyzed by qPCR in peripheral blood cells...
  38. Zhang X, Wu W, Xu W, Man K, Wang X, Han J, et al. C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis. Theranostics. 2017;7:2822-2836 pubmed publisher
    C-X-C motif chemokine 10 (CXCL10) is a crucial pro-inflammatory factor in chronic hepatitis. Autophagy dysregulation is known to contribute to hepatic inflammatory injury...
  39. Hallensleben W, Biro L, Sauder C, Hausmann J, Asensio V, Campbell I, et al. A polymorphism in the mouse crg-2/IP-10 gene complicates chemokine gene expression analysis using a commercial ribonuclease protection assay. J Immunol Methods. 2000;234:149-51 pubmed
  40. Tsunoda I, Lane T, Blackett J, Fujinami R. Distinct roles for IP-10/CXCL10 in three animal models, Theiler's virus infection, EAE, and MHV infection, for multiple sclerosis: implication of differing roles for IP-10. Mult Scler. 2004;10:26-34 pubmed
    ..In this review, we compare and contrast the roles of IP-10 between the three animal models for MS, and discuss the relevance to MS patients with different clinical courses. ..
  41. Guo J, Chen L, Ai H, Jing J, Zhou J, Zhang C, et al. A novel fusion protein of IP10-scFv retains antibody specificity and chemokine function. Biochem Biophys Res Commun. 2004;320:506-13 pubmed
    ..A novel fusion protein of IP10-scFv was constructed by fusing mouse IP-10 to V(H) region of single-chain Fv fragment (scFv) against acidic ..
  42. Lefebvre S, Fliniaux I, Schneider P, Mikkola M. Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012;132:1094-102 pubmed publisher
    ..Surprisingly, we identified two ligands of the chemokine receptor cxcR3, cxcl10 and cxcl11, as new hair-specific transcriptional targets of Eda...
  43. Coppieters K, Amirian N, Pagni P, Baca Jones C, Wiberg A, Lasch S, et al. Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic cytotoxic T lymphocytes to pancreatic islets in a virally induced autoimmune diabetes model. Diabetes. 2013;62:2492-9 pubmed publisher
    ..Some studies have suggested that blocking the interaction between the chemokine CXCL10 and its receptor CXCR3 on activated CTLs potently inhibits their recruitment and prevents ?-cell death...
  44. Koli K, Sutinen E, Rönty M, Rantakari P, Fortino V, Pulkkinen V, et al. Gremlin-1 Overexpression in Mouse Lung Reduces Silica-Induced Lymphocyte Recruitment - A Link to Idiopathic Pulmonary Fibrosis through Negative Correlation with CXCL10 Chemokine. PLoS ONE. 2016;11:e0159010 pubmed publisher
    ..reduced Th1 response, there was a downregulation of the mRNA and protein expression of the anti-fibrotic chemokine CXCL10, which has been linked to IPF...
  45. Shen F, Wang S, Yeh T, Tung Y, Hsu S, Chen S. Absence of CXCL10 aggravates herpes stromal keratitis with reduced primary neutrophil influx in mice. J Virol. 2013;87:8502-10 pubmed publisher
    ..study used a murine infection model to investigate the significance of the chemokine CXC chemokine ligand 10 (CXCL10; gamma interferon-inducible protein 10 [IP-10]) in HSK...
  46. Sizemore N, Agarwal A, Das K, Lerner N, Sulak M, Rani S, et al. Inhibitor of kappaB kinase is required to activate a subset of interferon gamma-stimulated genes. Proc Natl Acad Sci U S A. 2004;101:7994-8 pubmed
    ..These results reveal an important additional pathway for IFNgamma-stimulated gene expression in which an NF-kappaB-independent function of IKK is required. ..
  47. Ondondo B, Colbeck E, Jones E, Smart K, Lauder S, Hindley J, et al. A distinct chemokine axis does not account for enrichment of Foxp3(+)  CD4(+) T cells in carcinogen-induced fibrosarcomas. Immunology. 2015;145:94-104 pubmed publisher
    ..that the tumours are characterized by expression of inflammatory chemokines (CCL2, CCL5, CCL7, CCL8, CCL12, CXCL9, CXCL10 and CX3CL1), reflected by an enrichment of activated Foxp3(-) and Foxp3(+) T cells expressing T helper type 1-..
  48. Yoon K, de Paiva C, Qi H, Chen Z, Farley W, Li D, et al. Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Invest Ophthalmol Vis Sci. 2007;48:2561-9 pubmed
    ..Desiccating stress potently stimulates the expression of Th-1 cell-attracting chemokines and chemokine receptors on the ocular surface of C57BL/6 mice. ..
  49. Vinet J, de Jong E, Boddeke H, Stanulovic V, Brouwer N, Granic I, et al. Expression of CXCL10 in cultured cortical neurons. J Neurochem. 2010;112:703-14 pubmed publisher
    ..As neurons also express CXCL10, a main ligand for CXCR3, we have thus investigated in detail the expression pattern of CXCL10 in neurons...
  50. Solomon G, Frederick C, Zhang S, Gaggar A, Harris T, Woodworth B, et al. IP-10 is a potential biomarker of cystic fibrosis acute pulmonary exacerbations. PLoS ONE. 2013;8:e72398 pubmed publisher
    ..IP-10 is induced by airway epithelia following stimulation with bacterial pathogens in a murine model. Additional research regarding IP-10 as a potential biomarker is warranted. ..
  51. Ge Y, Waldemer R, Nalluri R, Nuzzi P, Chen J. RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation. PLoS ONE. 2013;8:e68068 pubmed publisher
  52. Cao L, Zou Y, Zhu J, Fan X, Li J. Ginsenoside Rg1 attenuates concanavalin A-induced hepatitis in mice through inhibition of cytokine secretion and lymphocyte infiltration. Mol Cell Biochem. 2013;380:203-10 pubmed publisher
    ..These data indicate that Rg1 represents a novel agent for the treatment of T lymphocyte-dependent liver injury. ..
  53. Kim J, Choi J, Park S, Yang S, Park J, Shin K, et al. Therapeutic effect of anti-C-X-C motif chemokine 10 (CXCL10) antibody on C protein-induced myositis mouse. Arthritis Res Ther. 2014;16:R126 pubmed publisher
    C-X-C motif chemokine 10 (CXCL10) is a chemokine that plays a critical role in the infiltration of T cells in autoimmune diseases and is reported to be expressed in muscle tissue of polymyositis...
  54. Zhang X, Shen J, Man K, Chu E, Yau T, Sung J, et al. CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis. J Hepatol. 2014;61:1365-75 pubmed publisher
    Perpetuate liver inflammation is crucial in the pathogenesis of non-alcoholic steatohepatitis (NASH). Expression of CXCL10, a pro-inflammatory cytokine, correlates positively with obesity and type 2 diabetes...
  55. Singh U, Singh S, Singh R, Cong Y, Taub D, Lillard J. CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(-/-) mice, which can be abrogated by anti-CXCL10 antibody inhibition. J Interferon Cytokine Res. 2008;28:31-43 pubmed publisher
    We have shown previously that there is a temporal increase in the levels of CXCL10 and CXCR3 mRNA during spontaneous murine colitis...
  56. Chen J, Lu H, Lai S, Campanella G, Sung J, Lu M, et al. Dengue virus induces expression of CXC chemokine ligand 10/IFN-gamma-inducible protein 10, which competitively inhibits viral binding to cell surface heparan sulfate. J Immunol. 2006;177:3185-92 pubmed
    ..We found that CXCL10/IFN-gamma-inducible protein 10 (IP-10) expression was rapidly and transiently induced in liver following infection...
  57. Ha Y, Liu H, Zhu S, Yi P, Liu W, Nathanson J, et al. Critical Role of the CXCL10/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush. Am J Pathol. 2017;187:352-365 pubmed publisher
    ..These cells were identified as T cells, microglia/monocytes, and neutrophils but not B cells. CXCL10 is a chemokine that recruits leukocytes after binding to its receptor C-X-C chemokine receptor (CXCR) 3...
  58. Zhu S, Liu H, Sha H, Qi L, Gao D, Zhang W. PERK and XBP1 differentially regulate CXCL10 and CCL2 production. Exp Eye Res. 2017;155:1-14 pubmed publisher
    ..In this study, we assessed whether photoreceptor cells can produce CCL2 and CXCL10, two important players in inflammation during endoplasmic reticulum (ER) stress...
  59. Gattass C, King L, Luster A, Ashwell J. Constitutive expression of interferon gamma-inducible protein 10 in lymphoid organs and inducible expression in T cells and thymocytes. J Exp Med. 1994;179:1373-8 pubmed
    ..Therefore, in addition to its role as a proinflammatory cytokine, IP-10 may participate in T cell effector function and perhaps T cell development. ..
  60. Gandhapudi S, Chilton P, Mitchell T. TRIF is required for TLR4 mediated adjuvant effects on T cell clonal expansion. PLoS ONE. 2013;8:e56855 pubmed publisher
    ..These results are useful for the continued development of TLR4 based vaccine adjuvants that avoid inflammatory risks while retaining beneficial immune response. ..
  61. Zhang Z, Kaptanoglu L, Tang Y, Ivancic D, Rao S, Luster A, et al. IP-10-induced recruitment of CXCR3 host T cells is required for small bowel allograft rejection. Gastroenterology. 2004;126:809-18 pubmed
  62. Molesworth Kenyon S, Oakes J, Lausch R. A novel role for neutrophils as a source of T cell-recruiting chemokines IP-10 and Mig during the DTH response to HSV-1 antigen. J Leukoc Biol. 2005;77:552-9 pubmed
    ..Collectively, our results support the hypothesis that neutrophil production of T cell-recruiting chemokines contributes to the regulation and amplification of the DTH response. ..
  63. Muzio L, Cavasinni F, Marinaro C, Bergamaschi A, Bergami A, Porcheri C, et al. Cxcl10 enhances blood cells migration in the sub-ventricular zone of mice affected by experimental autoimmune encephalomyelitis. Mol Cell Neurosci. 2010;43:268-80 pubmed publisher
    ..We found that the chemokine Cxcl10 is constitutively expressed by a subset of cells within the SvZ, constituting a primary chemo-attractant signal ..
  64. Barash U, Zohar Y, Wildbaum G, Beider K, Nagler A, Karin N, et al. Heparanase enhances myeloma progression via CXCL10 downregulation. Leukemia. 2014;28:2178-87 pubmed publisher
    ..Consistently, we found that heparanase induction is associated with decreased levels of CXCL10, suggesting that this chemokine exerts tumor-suppressor properties in myeloma...
  65. Craig V, Quintero P, Fyfe S, Patel A, Knolle M, Kobzik L, et al. Profibrotic activities for matrix metalloproteinase-8 during bleomycin-mediated lung injury. J Immunol. 2013;190:4283-96 pubmed publisher
    ..These data indicate therapeutic strategies to reduce lung levels of MMP-8 may limit fibroproliferative responses to injury in the human lung. ..
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    ..The gene expression of interferon (IFN)-?-inducible protein 10 (IP-10/CXCL10), which promotes Th1 responses, in mouse macrophages stimulated with lipopolysaccharide (LPS) and/or IFN-? was ..
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    ..of all miR-15 cluster was decreased in MG, furthermore, miR-15a levels in ocular MG (oMG) were much lower, while CXCL10 production was increased in MG. We display that CXCL10 was a functional target gene of miR-15a in MG...
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    ..Finally, exogenous application of the CXCR3 ligand CXCL10 in the tumor or ectopic expression of CXCL10 by tumor cells increased the numbers of NK cells in the tumors and ..
  69. Furuichi K, Wada T, Kitajikma S, Toyama T, Okumura T, Hara A, et al. IFN-inducible protein 10 (CXCL10) regulates tubular cell proliferation in renal ischemia-reperfusion injury. Nephron Exp Nephrol. 2008;109:c29-38 pubmed publisher
    ..we describe our studies using a neutralizing antibody (Ab) against interferon-inducible protein of 10 kDa (IP-10; CXCL10) that indicate a role for CXCL10 in tubular cell proliferation after renal ischemia-reperfusion injury...
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    ..Hence, our data indicate that Trex2 acts as a critical factor in the pathogenesis of psoriasis by promoting keratinocyte apoptosis and enucleation and thereby influencing skin immune responses. ..
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    ..The chemokine receptor CXCR3 and two of its ligands, CXCL9 and CXCL10, have been identified as important mediators of OB...
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    ..beta-amyloid (Abeta) positive plaques were co-located with the intense IP-10 expression. The finding suggests fractalkine and IP-10 may participate in the pathogenesis of AD; and could be new therapeutic strategies for neuroprotection. ..
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    ..Accompanying the antitumor responses were increases in IFN-gamma, CXCL9, CXCL10, and IL-12...
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    b>CXCL10, or IFN-γ-inducible protein 10, is a biomarker associated with increased risk for Plasmodium falciparum-mediated cerebral malaria (CM)...
  75. Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, et al. Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis. J Immunol. 2015;194:2522-30 pubmed publisher
    ..Further study into the role of testosterone for liver inflammation could lead to novel treatment targets in human autoimmune liver diseases. ..
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    b>CXCL10 is an IFN-inducible chemokine ligand that binds CXCR3, a receptor that is expressed on lymphocytes; CXCL10 shares the CXCR3 receptor with another two ligands, CXCL9 and CXCL11...
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    ..increased numbers of MP CD8+ T cells circulating in nonimmunized Cxcr3-/- and Cxcl10-/- mice compared with wild-type animals...