Cx3cl1

Summary

Gene Symbol: Cx3cl1
Description: chemokine (C-X3-C motif) ligand 1
Alias: AB030188, ABCD-3, AI848747, CX3C, Cxc3, D8Bwg0439e, Scyd1, fractalkine, C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, neurotactin, small inducible cytokine subfamily D, 1, small-inducible cytokine D1
Species: mouse
Products:     Cx3cl1

Top Publications

  1. Rancan M, Bye N, Otto V, Trentz O, Kossmann T, Frentzel S, et al. The chemokine fractalkine in patients with severe traumatic brain injury and a mouse model of closed head injury. J Cereb Blood Flow Metab. 2004;24:1110-8 pubmed
    The potential role of the chemokine Fractalkine (CX3CL1) in the pathophysiology of traumatic brain injury (TBI) was investigated in patients with head trauma and in mice after experimental cortical contusion...
  2. Gevrey J, Isaac B, Cox D. Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine). J Immunol. 2005;175:3737-45 pubmed
    CX3CL1 (fractalkine), the only member of the delta subclass of chemokines, is a known chemotactic factor for monocytes/macrophages as well as NK cells and T lymphocytes...
  3. Rossi D, Hardiman G, Copeland N, Gilbert D, Jenkins N, Zlotnik A, et al. Cloning and characterization of a new type of mouse chemokine. Genomics. 1998;47:163-70 pubmed
    ..Bazan et al. (1997, Nature 385, 640-644). Termed fractalkine, this molecule constitutes a fourth or delta chemokine structural type that displays a novel CX3C sequence ..
  4. Maggi L, Trettel F, Scianni M, Bertollini C, Eusebi F, Fredholm B, et al. LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R). J Neuroimmunol. 2009;215:36-42 pubmed publisher
    We have examined how the chemokine fractalkine/CX(3)CL1 influences long-term potentiation (LTP) in CA1 mouse hippocampal slices. Field potentials (fEPSPs) were recorded upon electrical stimulation of Schaffer collaterals...
  5. Piccinin S, Di Angelantonio S, Piccioni A, Volpini R, Cristalli G, Fredholm B, et al. CX3CL1-induced modulation at CA1 synapses reveals multiple mechanisms of EPSC modulation involving adenosine receptor subtypes. J Neuroimmunol. 2010;224:85-92 pubmed publisher
    ..role of adenosine receptor (AR) subtypes in the modulation of glutamatergic neurotransmission by the chemokine fractalkine (CX3CL1) in mouse hippocampal CA1 neurons...
  6. Tarozzo G, Bortolazzi S, Crochemore C, Chen S, Lira A, Abrams J, et al. Fractalkine protein localization and gene expression in mouse brain. J Neurosci Res. 2003;73:81-8 pubmed
    Few chemokines are expressed constitutively in the brain at detectable levels; amongst them is fractalkine. We analyzed the distribution of fractalkine in the mouse brain with the aim of giving a neuroanatomical support to the study of ..
  7. Xuan W, Liao Y, Chen B, Huang Q, Xu D, Liu Y, et al. Detrimental effect of fractalkine on myocardial ischaemia and heart failure. Cardiovasc Res. 2011;92:385-93 pubmed publisher
    b>Fractalkine (FKN) is a newly identified membrane-bound chemokine; its role in myocardial ischaemia and heart failure is largely unknown...
  8. Kim K, Vallon Eberhard A, Zigmond E, Farache J, Shezen E, Shakhar G, et al. In vivo structure/function and expression analysis of the CX3C chemokine fractalkine. Blood. 2011;118:e156-67 pubmed publisher
    The CX3C chemokine family is composed of only one member, CX3CL1, also known as fractalkine, which in mice is the sole ligand of the G protein-coupled, 7-transmembrane receptor CX3CR1...
  9. Noda M, Doi Y, Liang J, Kawanokuchi J, Sonobe Y, Takeuchi H, et al. Fractalkine attenuates excito-neurotoxicity via microglial clearance of damaged neurons and antioxidant enzyme heme oxygenase-1 expression. J Biol Chem. 2011;286:2308-19 pubmed publisher
    ..Here, we show that the soluble CX3C chemokine fractalkine (sFKN), which is secreted from neurons that have been damaged by glutamate, promotes microglial phagocytosis of ..

More Information

Publications84

  1. Wan Y, Evans R. Rosiglitazone activation of PPARgamma suppresses fractalkine signaling. J Mol Endocrinol. 2010;44:135-42 pubmed publisher
    ..b>Fractalkine (FKN) and FKN receptor (FR) play an important role in the immune responses by regulating leukocyte migration ..
  2. Huang D, Shi F, Jung S, Pien G, Wang J, Salazar Mather T, et al. The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J. 2006;20:896-905 pubmed
    ..livers of wild-type (WT) and CX3CR1(GFP/GFP) mice with cytomegalovirus hepatitis was equivalent, indicating that CX3CL1 mediated chemoattraction of NK cells was relatively specific for the CNS...
  3. Ishida Y, Gao J, Murphy P. Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function. J Immunol. 2008;180:569-79 pubmed
    ..In this study, we report that in a mouse model of excisional skin wound healing the chemokine CX3CL1 and its receptor CX3CR1 were both highly induced at wound sites; CX3CL1 colocalized with macrophages and ..
  4. Cook D, Chen S, Sullivan L, Manfra D, Wiekowski M, Prosser D, et al. Generation and analysis of mice lacking the chemokine fractalkine. Mol Cell Biol. 2001;21:3159-65 pubmed
    b>Fractalkine (CX(3)CL1) is the first described chemokine that can exist either as a soluble protein or as a membrane-bound molecule. Both forms of fractalkine can mediate adhesion of cells expressing its receptor, CX(3)CR1...
  5. Lesnik P, Haskell C, Charo I. Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis. J Clin Invest. 2003;111:333-40 pubmed
    ..b>Fractalkine (FK) is a structurally unusual chemokine that can act either as a soluble chemotactic factor or as a ..
  6. Morganti J, Nash K, Grimmig B, Ranjit S, Small B, Bickford P, et al. The soluble isoform of CX3CL1 is necessary for neuroprotection in a mouse model of Parkinson's disease. J Neurosci. 2012;32:14592-601 pubmed publisher
    The chemokine CX3CL1/fractalkine is expressed by neurons as a transmembrane-anchored protein that can be cleaved to yield a soluble isoform...
  7. Lauro C, Cipriani R, Catalano M, Trettel F, Chece G, Brusadin V, et al. Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death. Neuropsychopharmacology. 2010;35:1550-9 pubmed publisher
    b>Fractalkine/CX3CL1 is a neuron-associated chemokine, which modulates microglia-induced neurotoxicity activating the specific and unique receptor CX3CR1...
  8. Park J, Song K, Ha H. Fractalkine increases mesangial cell proliferation through reactive oxygen species and mitogen-activated protein kinases. Transplant Proc. 2012;44:1026-8 pubmed publisher
    ..One unique feature of fractalkine (CX3CL1) is its existence as both a membrane-tethered and a soluble form...
  9. Vukovic J, Colditz M, Blackmore D, Ruitenberg M, Bartlett P. Microglia modulate hippocampal neural precursor activity in response to exercise and aging. J Neurosci. 2012;32:6435-43 pubmed publisher
  10. Andrzejewski M, Koelsch A, Kogel T, Dreymueller D, Schwarz N, Ludwig A. Distinct role of the intracellular C-terminus for subcellular expression, shedding and function of the murine transmembrane chemokine CX3CL1. Biochem Biophys Res Commun. 2010;395:178-84 pubmed publisher
    The transmembrane chemokine CX3CL1 is expressed on the endothelial surface and promotes leukocyte adhesion and transmigration by receptor interaction via its extracellular chemokine domain...
  11. Landsman L, Bar On L, Zernecke A, Kim K, Krauthgamer R, Shagdarsuren E, et al. CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood. 2009;113:963-72 pubmed publisher
    CX(3)CR1 is a chemokine receptor with a single ligand, the membrane-tethered chemokine CX(3)CL1 (fractalkine)...
  12. Hughes P, Botham M, Frentzel S, Mir A, Perry V. Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. Glia. 2002;37:314-27 pubmed
    In this study, we investigate the expression of fractalkine (CX3CL1) and the fractalkine receptor (CX3CR1) in the naive rat and mouse central nervous system (CNS)...
  13. Pan Y, Lloyd C, Zhou H, Dolich S, Deeds J, Gonzalo J, et al. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature. 1997;387:611-7 pubmed
    ..screening of a murine choroid plexus complementary DNA library, we identified a new chemokine, designated neurotactin. Unlike other chemokines, neurotactin has a unique cysteine pattern, Cys-X-X-X-Cys, and is predicted to be a ..
  14. Teupser D, Pavlides S, Tan M, Gutierrez Ramos J, Kolbeck R, Breslow J. Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root. Proc Natl Acad Sci U S A. 2004;101:17795-800 pubmed
    b>Fractalkine (CX3CL1) is of particular interest in atherogenesis because it can serve as an adhesion molecule and a chemokine. Fractalkine and its receptor CX3CR1 are expressed in atherosclerotic lesions of humans and mice...
  15. Cardona A, Pioro E, Sasse M, Kostenko V, Cardona S, Dijkstra I, et al. Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci. 2006;9:917-24 pubmed
    Microglia, the resident inflammatory cells of the CNS, are the only CNS cells that express the fractalkine receptor (CX3CR1)...
  16. Cipriani R, Villa P, Chece G, Lauro C, Paladini A, Micotti E, et al. CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents. J Neurosci. 2011;31:16327-35 pubmed publisher
    The chemokine CX3CL1 and its receptor CX3CR1 are constitutively expressed in the nervous system...
  17. Lauro C, Di Angelantonio S, Cipriani R, Sobrero F, Antonilli L, Brusadin V, et al. Activity of adenosine receptors type 1 Is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons. J Immunol. 2008;180:7590-6 pubmed
    The chemokine fractalkine (CX(3)CL1) is constitutively expressed by central neurons, regulating microglial responses including chemotaxis, activation, and toxicity...
  18. Wildenberg M, van Helden Meeuwsen C, Drexhage H, Versnel M. Altered fractalkine cleavage potentially promotes local inflammation in NOD salivary gland. Arthritis Res Ther. 2008;10:R69 pubmed publisher
    ..NOD mice also exhibit an increased frequency of mature, fractalkine receptor (CX3C chemokine receptor [CX3CR]1) expressing monocytes, which are considered to be precursors for ..
  19. Voronova A, Yuzwa S, Wang B, Zahr S, Syal C, Wang J, et al. Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain. Neuron. 2017;94:500-516.e9 pubmed publisher
    ..Modeling of the interneuron-precursor paracrine interaction using transcriptome data identifies the cytokine fractalkine as responsible for the pro-oligodendrocyte effect in culture...
  20. Goto Y, Aoyama M, Sekiya T, Kakita H, Waguri Nagaya Y, Miyazawa K, et al. CXCR4+ CD45- Cells are Niche Forming for Osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 Signaling Pathways in Bone Marrow. Stem Cells. 2016;34:2733-2743 pubmed publisher
    ..cell derived factor 1 (SDF-1), chemokine (C-X-C motif) ligand 7 (CXCL7), and chemokine (C-X3-C motif) ligand 1 (CX3CL1). Furthermore, an SDF-1-specific antibody strongly suppressed OC formation in RAW264...
  21. Kostadinova F, Baba T, Ishida Y, Kondo T, Popivanova B, Mukaida N. Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice. J Leukoc Biol. 2010;88:133-43 pubmed publisher
    ..Concomitantly, DSS ingestion enhanced the expression of a potent macrophage-tropic chemokine, CX3CL1/fractalkine, and its receptor, CX3CR1, in the colon...
  22. Tsuji D, Kuroki A, Ishibashi Y, Itakura T, Kuwahara J, Yamanaka S, et al. Specific induction of macrophage inflammatory protein 1-alpha in glial cells of Sandhoff disease model mice associated with accumulation of N-acetylhexosaminyl glycoconjugates. J Neurochem. 2005;92:1497-507 pubmed
    ..T expressed and secreted), MCP-1 (monocyte chemotactic protein-1), SLC (secondary lymphoid-tissue chemokine), fractalkine and SDF-1 (stromal derived factor-1), were detected...
  23. Kanazawa N, Nakamura T, Tashiro K, Muramatsu M, Morita K, Yoneda K, et al. Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells. Eur J Immunol. 1999;29:1925-32 pubmed
    ..In this study we isolated mouse fractalkine and macrophage-derived chemokine (MDC) belonging to CX3C (delta) and CC chemokine families, respectively, from ..
  24. Ondondo B, Colbeck E, Jones E, Smart K, Lauder S, Hindley J, et al. A distinct chemokine axis does not account for enrichment of Foxp3(+)  CD4(+) T cells in carcinogen-induced fibrosarcomas. Immunology. 2015;145:94-104 pubmed publisher
    ..are characterized by expression of inflammatory chemokines (CCL2, CCL5, CCL7, CCL8, CCL12, CXCL9, CXCL10 and CX3CL1), reflected by an enrichment of activated Foxp3(-) and Foxp3(+) T cells expressing T helper type 1-associated ..
  25. Suzuki M, El Hage N, Zou S, Hahn Y, Sorrell M, Sturgill J, et al. Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death. Mol Neurodegener. 2011;6:78 pubmed publisher
    b>Fractalkine/CX3CL1 and its cognate receptor CX3CR1 are abundantly expressed in the CNS...
  26. Hiroyama T, Iwama A, Nakamura Y, Nakauchi H. Fractalkine shares signal sequence with TARC: gene structures and expression profiles of two chemokine genes. Genomics. 2001;75:3-5 pubmed
    In the process of cloning the gene (Scyd1) encoding the mouse CX3C chemokine fractalkine, we identified a novel cDNA that encodes a chimeric molecule termed fracTARC...
  27. Zhang J, Hu H, Palma N, Harrison J, Mubarak K, Carrie R, et al. Hypoxia-induced endothelial CX3CL1 triggers lung smooth muscle cell phenotypic switching and proliferative expansion. Am J Physiol Lung Cell Mol Physiol. 2012;303:L912-22 pubmed publisher
    ..Here, we investigated the role of CX3CL1/CX3CR1 system in endothelial-SMC cross talk in response to hypoxia...
  28. Schwaeble W, Stover C, Schall T, Dairaghi D, Trinder P, Linington C, et al. Neuronal expression of fractalkine in the presence and absence of inflammation. FEBS Lett. 1998;439:203-7 pubmed
    b>Fractalkine is the only as yet known member of a novel class of chemokines...
  29. Staumont Sallé D, Fleury S, Lazzari A, Molendi Coste O, Hornez N, Lavogiez C, et al. CX?CL1 (fractalkine) and its receptor CX?CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin. J Exp Med. 2014;211:1185-96 pubmed publisher
    ..Among chemokines and chemokine receptors associated with inflammation, increased levels of CX3CL1 (fractalkine) and its unique receptor, CX3CR1, have been observed in human AD...
  30. Ueha S, Murai M, Yoneyama H, Kitabatake M, Imai T, Shimaoka T, et al. Intervention of MAdCAM-1 or fractalkine alleviates graft-versus-host reaction associated intestinal injury while preserving graft-versus-tumor effects. J Leukoc Biol. 2007;81:176-85 pubmed
    ..We here demonstrate that intervention of MAdCAM-1 (mucosal vascular addressin cell adhesion molecule-1) or fractalkine/CX3CL1 after the expansion of allo-reactive donor CD8 T cells selectively inhibits the recruitment of effector ..
  31. Duan R, Yang X, Chen Z, Lu M, Morris C, Winblad B, et al. Decreased fractalkine and increased IP-10 expression in aged brain of APP(swe) transgenic mice. Neurochem Res. 2008;33:1085-9 pubmed
    ..In the present study, we examined the expression of chemokines, fractalkine, interferon-inducible protein-10 (IP-10) and macrophage inflammatory protein-1alpha (MIP-1alpha) by ..
  32. Mills J, Alabanza L, Mahamed D, Bynoe M. Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis. J Neuroinflammation. 2012;9:193 pubmed
    ..lymphocyte migration into the CNS by inducing the expression of the specialized chemokine/adhesion molecule CX3CL1 at the choroid plexus...
  33. Raspe C, Hocherl K, Rath S, Sauvant C, Bucher M. NF-?B-mediated inverse regulation of fractalkine and CX3CR1 during CLP-induced sepsis. Cytokine. 2013;61:97-103 pubmed publisher
    b>Fractalkine is a unique member of the CX3C chemokine family by unfolding its potential through the chemokine (C-X3-C motif) receptor 1 (CX3CR1) with dual function acting both as an adhesion molecule and a soluble chemokine...
  34. Becker F, Holthoff C, Anthoni C, Rijcken E, Alexander J, Gavins F, et al. Downregulation of CX3CR1 ameliorates experimental colitis: evidence for CX3CL1-CX3CR1-mediated immune cell recruitment. Int J Colorectal Dis. 2017;32:315-324 pubmed publisher
    ..Therefore, the objective of this study was to describe CX3CL1-CX3CR1-mediated signaling in the induction of immune cell recruitment during experimental murine colitis...
  35. Koziolek M, Müller G, Zapf A, Patschan D, Schmid H, Cohen C, et al. Role of CX3C-chemokine CX3C-L/fractalkine expression in a model of slowly progressive renal failure. Nephrol Dial Transplant. 2010;25:684-98 pubmed publisher
    ..as well as the reactive oxygen species (ROS) H(2)O(2) were identified by qRT-PCR as inductors of CX(3)C-L/fractalkine (FKN) in tubular epithelial cells...
  36. Hoshiko M, Arnoux I, Avignone E, Yamamoto N, Audinat E. Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex. J Neurosci. 2012;32:15106-11 pubmed publisher
    ..Here, we analyzed the role of CX3CR1, a microglial receptor activated by the neuronal chemokine CX3CL1 (or fractalkine) which controls key functions of microglial cells...
  37. Katakai T, Hara T, Sugai M, Gonda H, Shimizu A. Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med. 2004;200:783-95 pubmed
    ..These findings suggest that signals from lymphocytes induce FRCs to form the network that supports the movement and interactions of immune effectors within the lymph node. ..
  38. Kruse J, Bomhoff Wijdenes I, Poele J, Stewart F. Fractalkine: an important candidate for directing periglomerular leukocyte accumulation in irradiated mouse kidneys. Acta Oncol. 2007;46:945-50 pubmed
    ..The chemokine fractalkine has recently been identified as a key mediator of leukocyte adhesion that functions without the requirement of ..
  39. Kumar A, Metharom P, Schmeckpeper J, Weiss S, Martin K, Caplice N. Bone marrow-derived CX3CR1 progenitors contribute to neointimal smooth muscle cells via fractalkine CX3CR1 interaction. FASEB J. 2010;24:81-92 pubmed publisher
    ..Moreover, CX(3)CR1-fractalkine (FKN) interaction in vivo is essential for smooth muscle cell differentiation of bone marrow-derived progenitor ..
  40. Koizumi K, Saitoh Y, Minami T, Takeno N, Tsuneyama K, Miyahara T, et al. Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption. J Immunol. 2009;183:7825-31 pubmed publisher
    ..Chemokines are known to regulate cell migration and adhesion. CX3CL1 (also called fractalkine) is a unique membrane-bound chemokine that has dual functions for cells expressing its receptor CX3CR1: a ..
  41. Amsellem V, Abid S, Poupel L, Parpaleix A, Rodero M, Gary Bobo G, et al. Roles for the CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine Systems in Hypoxic Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2017;56:597-608 pubmed publisher
    ..Interactions between the CCL2/CCR2 and CX3CL1/CX3CR1 chemokine systems that guide phagocyte infiltration are incompletely understood...
  42. Rius C, Piqueras L, Gonzalez Navarro H, Albertos F, Company C, Lopez Gines C, et al. Arterial and venous endothelia display differential functional fractalkine (CX3CL1) expression by angiotensin-II. Arterioscler Thromb Vasc Biol. 2013;33:96-104 pubmed publisher
    ..To investigate the mechanisms underlying this dissimilar response, the involvement of fractalkine (CX(3)CL1) was explored...
  43. Tardáguila M, Mira E, García Cabezas M, Feijoo A, Quintela Fandino M, Azcoitia I, et al. CX3CL1 promotes breast cancer via transactivation of the EGF pathway. Cancer Res. 2013;73:4461-73 pubmed publisher
    ..We studied the influence of the chemokine CX3CL1/fractalkine in de novo breast cancer formation using HER2/neu transgenic mice...
  44. Zhou R, Gong A, Chen D, Miller R, Eischeid A, Chen X. Histone deacetylases and NF-kB signaling coordinate expression of CX3CL1 in epithelial cells in response to microbial challenge by suppressing miR-424 and miR-503. PLoS ONE. 2013;8:e65153 pubmed publisher
    ..We reported here that histone deacetylases (HDACs) and NF-kB signaling coordinate expression of CX3CL1 in epithelial cells following Cryptosporidium parvum infection...
  45. Yu Y, Fong A, Combadiere C, Gao J, Murphy P, Patel D. Defective antitumor responses in CX3CR1-deficient mice. Int J Cancer. 2007;121:316-22 pubmed
    Innate immunity is critically important for tumor surveillance and regulating tumor metastasis. Fractalkine (FKN, CX3CL1), operating through the receptor CX3CR1, is an effective chemoattractant and adhesion receptor for NK cells and ..
  46. Zieger M, Ahnelt P, Uhrin P. CX3CL1 (fractalkine) protein expression in normal and degenerating mouse retina: in vivo studies. PLoS ONE. 2014;9:e106562 pubmed publisher
    We aimed to investigate fractalkine (CX3CL1) protein expression in wild type (wt) retina and its alterations during retinal degeneration in mouse model (rd10) of retinitis pigmentosa...
  47. Martinez Hervas S, Vinue A, Núñez L, Andrés Blasco I, Piqueras L, Real J, et al. Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis. Cardiovasc Res. 2014;103:324-36 pubmed publisher
    ..signal-regulated kinase (ERK)-dependent pathway in VSMCs augmented expression of the inflammatory chemokine fractalkine (CX3CL1) and its receptor CX3CR1, previously involved in atheroma plaque vulnerability...
  48. Ren W, Jackson N, Song W, Shi T, Flynn J, Markel D. Implant wear induced inflammation is mitigated in CX3CR1(-/-) mice. J Orthop Res. 2014;32:1037-43 pubmed publisher
    ..Blocking of CX3CR1 pathway may represent a viable therapeutic approach to the prevention and treatment of patients with aseptic loosening. ..
  49. Nash K, Moran P, Finneran D, Hudson C, Robinson J, Morgan D, et al. Fractalkine over expression suppresses α-synuclein-mediated neurodegeneration. Mol Ther. 2015;23:17-23 pubmed publisher
    ..are several signals produced by neurons that have an anti-inflammatory action on microglia, including CX3CL1 (fractalkine)...
  50. Inui M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T. Protective roles of CX3CR1-mediated signals in toxin A-induced enteritis through the induction of heme oxygenase-1 expression. J Immunol. 2011;186:423-31 pubmed publisher
    ..Concomitantly, intraileal gene expression of CX3CL1/fractalkine (FKN) and its receptor, CX3CR1, was enhanced...
  51. Aoyama T, Inokuchi S, Brenner D, Seki E. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology. 2010;52:1390-400 pubmed publisher
    ..The expression of CX3CR1 and its ligand, CX3CL1, is up-regulated in chronic liver diseases such as chronic hepatitis C...
  52. Zeng Y, Huebener N, Fest S, Weixler S, Schroeder U, Gaedicke G, et al. Fractalkine (CX3CL1)- and interleukin-2-enriched neuroblastoma microenvironment induces eradication of metastases mediated by T cells and natural killer cells. Cancer Res. 2007;67:2331-8 pubmed
    b>Fractalkine (FKN) is a unique CX3C chemokine (CX3CL1) known to induce both adhesion and migration of leukocytes mediated by a membrane-bound and a soluble form, respectively...
  53. Flierl U, Schafer A. Fractalkine--a local inflammatory marker aggravating platelet activation at the vulnerable plaque. Thromb Haemost. 2012;108:457-63 pubmed publisher
    ..chemokine receptors on platelets have been described previously, amongst them CX(3)CR1, the receptor for fractalkine. The unique chemokine fractalkine (CX(3)CR1, FKN) exists as a soluble as well as a membrane-anchored ..
  54. Liu Y, Wu X, Luo Q, Huang S, Yang Q, Wang F, et al. CX3CL1/CX3CR1-mediated microglia activation plays a detrimental role in ischemic mice brain via p38MAPK/PKC pathway. J Cereb Blood Flow Metab. 2015;35:1623-31 pubmed publisher
    The exact roles of activated microglia and fractalkine (CX3CL1)/fractalkine receptor (CX3CR1) signaling are not fully understood in brain ischemic injury and the findings reported are controversial...
  55. Hagbi Levi S, Grunin M, Elbaz Hayoun S, Tal D, Obolensky A, Hanhart J, et al. Retinal Phenotype following Combined Deletion of the Chemokine Receptor CCR2 and the Chemokine CX3CL1 in Mice. Ophthalmic Res. 2016;55:126-34 pubmed publisher
    ..We report the generation and retinal phenotype of mice with a reverse CCR2/CX3CL1 gene deficiency as a suggested model for age-related macular degeneration (AMD)...
  56. Lee S, Xu G, Jay T, Bhatta S, Kim K, Jung S, et al. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. J Neurosci. 2014;34:12538-46 pubmed publisher
    ..Notably, deficiency for the microglial CX3CR1 receptor has opposing effects on Aβ and MAPT pathologies. CX3CL1, the neuronally derived cognate ligand for CX3CR1, signals both in membrane-anchored and soluble forms...
  57. Wang Y, Wang Y, Song S, Liang H, Ji A. Icariin inhibits atherosclerosis progress in Apoe null mice by downregulating CX3CR1 in macrophage. Biochem Biophys Res Commun. 2016;470:845-50 pubmed publisher
    ..Also icariin reduced CX3CR1 and CX3CL1 protein levels in the artery wall...
  58. Saitoh Y, Koizumi K, Sakurai H, Minami T, Saiki I. RANKL-induced down-regulation of CX3CR1 via PI3K/Akt signaling pathway suppresses Fractalkine/CX3CL1-induced cellular responses in RAW264.7 cells. Biochem Biophys Res Commun. 2007;364:417-22 pubmed
    ..7 cells. CX3CL1 (also called Fractalkine) receptor, CX3CR1 mRNA expression, was rapidly reduced by treatment with RANKL in contrast to the increased ..
  59. He M, Moochhala S, Adhikari S, Bhatia M. Administration of exogenous fractalkine, a CX3C chemokine, is capable of modulating inflammatory response in cecal ligation and puncture-induced sepsis. Shock. 2009;31:33-9 pubmed publisher
    b>Fractalkine (FTK) is a unique member of the CX3C chemokine family by acting through the CX3CR1 receptor. Membrane-bound FTK acts like an adhesion molecule, whereas soluble FTK (sFTK) acts as a classic chemokine ligand...
  60. Grizenkova J, Akhtar S, Brandner S, Collinge J, Lloyd S. Microglial Cx3cr1 knockout reduces prion disease incubation time in mice. BMC Neurosci. 2014;15:44 pubmed publisher
    ..In the central nervous system the chemokine Cx3cl1 (Fractalkine) is expressed by neurons and its exclusive receptor Cx3cr1 is expressed solely on microglia...
  61. Green S, Han K, Chen Y, Almazan F, Charo I, Miller Y, et al. The CC chemokine MCP-1 stimulates surface expression of CX3CR1 and enhances the adhesion of monocytes to fractalkine/CX3CL1 via p38 MAPK. J Immunol. 2006;176:7412-20 pubmed
    The membrane-anchored form of CX3CL1 has been proposed as a novel adhesion protein for leukocytes...
  62. Zhang H, Guo C, Wu D, Zhang A, Gu T, Wang L, et al. Hydrogen sulfide inhibits the development of atherosclerosis with suppressing CX3CR1 and CX3CL1 expression. PLoS ONE. 2012;7:e41147 pubmed publisher
    ..potential role of H(2)S in atherosclerosis and the underlying mechanism with respect to chemokines (CCL2, CCL5 and CX3CL1) and chemokine receptors (CCR2, CCR5, and CX3CR1) in macrophages. Mouse macrophage cell line RAW 264...
  63. Chen Q, Wei H, Sun R, Zhang J, Tian Z. Therapeutic RNA silencing of Cys-X3-Cys chemokine ligand 1 gene prevents mice from adenovirus vector-induced acute liver injury. Hepatology. 2008;47:648-58 pubmed
    ..by an adenovirus is likely associated with elevated expression of the Cys-X3-Cys chemokine ligand 1 (CX(3)CL1)/fractalkine (FKN) protein at the site of inflammation...
  64. Pallandre J, Krzewski K, Bedel R, Ryffel B, Caignard A, Rohrlich P, et al. Dendritic cell and natural killer cell cross-talk: a pivotal role of CX3CL1 in NK cytoskeleton organization and activation. Blood. 2008;112:4420-4 pubmed publisher
    ..Here, the role of CX3CL1 (fractalkine), a chemokine expressed on mature dendritic cells (mDCs) has been investigated...
  65. Nakatani K, Yoshimoto S, Iwano M, Asai O, Samejima K, Sakan H, et al. Fractalkine expression and CD16+ monocyte accumulation in glomerular lesions: association with their severity and diversity in lupus models. Am J Physiol Renal Physiol. 2010;299:F207-16 pubmed publisher
    b>Fractalkine (Fkn) is expressed on injured endothelial cells and is a membrane-bound chemokine that attracts cells expressing its receptor, CX3CR1, including CD16(+) monocytes (CD16(+) Mos)...
  66. Suzuki F, Nanki T, Imai T, Kikuchi H, Hirohata S, Kohsaka H, et al. Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice. J Immunol. 2005;175:6987-96 pubmed
    ..In the affected muscles of EAM mice, CX3CL1 (fractalkine) was expressed on the infiltrated mononuclear cells and endothelial cells, and its corresponding receptor, ..
  67. Shimizu K, Furuichi K, Sakai N, Kitagawa K, Matsushima K, Mukaida N, et al. Fractalkine and its receptor, CX3CR1, promote hypertensive interstitial fibrosis in the kidney. Hypertens Res. 2011;34:747-52 pubmed publisher
    Hypertension promotes and escalates kidney injury, including kidney fibrosis. Fractalkine/CX3CL1 is a unique chemokine that works as a leukocyte chemoattractant and an adhesion molecule...
  68. Johnson L, Jackson D. The chemokine CX3CL1 promotes trafficking of dendritic cells through inflamed lymphatics. J Cell Sci. 2013;126:5259-70 pubmed publisher
    ..Here, we report that the transmembrane chemokine CX3CL1 (fractalkine) is induced in inflamed lymphatic endothelium, both in vitro in TNF-?-treated human dermal lymphatic ..
  69. Nishinakamura R, Matsumoto Y, Nakao K, Nakamura K, Sato A, Copeland N, et al. Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. Development. 2001;128:3105-15 pubmed
    ..Sall1 is therefore essential for ureteric bud invasion, the initial key step for metanephros development. ..
  70. Park H, Cox D. Syk regulates multiple signaling pathways leading to CX3CL1 chemotaxis in macrophages. J Biol Chem. 2011;286:14762-9 pubmed publisher
    Several studies have clearly established the importance of the interaction between macrophages and CX3CL1 in the progression of disease...
  71. Zabel M, Zhao L, Zhang Y, Gonzalez S, Ma W, Wang X, et al. Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa. Glia. 2016;64:1479-91 pubmed publisher
    ..Significantly, increasing CX3CL1-CX3CR1 signaling in the rd10 retina via exogenous intravitreal delivery of recombinant CX3CL1 was effective in (1) ..
  72. Lu P, Li L, Kuno K, Wu Y, Baba T, Li Y, et al. Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression. J Immunol. 2008;180:4283-91 pubmed
    ..To address these points, we herein examined corneal neovascularization after alkali injury in mice deficient in fractalkine receptor/CX3CR1, which is normally expressed by macrophages...
  73. Fuster Matanzo A, Jurado Arjona J, Benvegnù S, Garcia E, Martín Maestro P, Gómez Sintes R, et al. Glycogen synthase kinase-3? regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: implications for Alzheimer's disease. Cell Mol Life Sci. 2017;74:1153-1163 pubmed publisher
    ..we demonstrate how changes in GSK-3? activity and/or levels regulate the production and subsequent secretion of fractalkine, a chemokine involved in the immune response that has been linked to AD and to other different neurological ..
  74. Ren T, Chen Q, Tian Z, Wei H. Down-regulation of surface fractalkine by RNA interference in B16 melanoma reduced tumor growth in mice. Biochem Biophys Res Commun. 2007;364:978-84 pubmed
    It is reported that membrane-bound form of CX3CL1/fractalkine (FKN) promotes cell-cell adhesion by binding with its unique receptor CX3CR1, and membrane fractalkine works as an adhesion molecule for the communication between tumor cells ..
  75. Kikuchi T, Andarini S, Xin H, Gomi K, Tokue Y, Saijo Y, et al. Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila. Infect Immun. 2005;73:5350-7 pubmed
    ..For this study, we focused on a potent chemoattractant for lymphocytes, fractalkine/CX3CL1, and observed that the fractalkine expression of DCs was somewhat up-regulated when they encountered L...