Cux1

Summary

Gene Symbol: Cux1
Description: cut-like homeobox 1
Alias: CDP, Cutl1, Cux, Cux-1, protein CASP, CCAAT displacement protein, Cux/CDP homeoprotein, cut-like 1, homeobox protein cut-like 1, homeobox protein cux-1
Species: mouse
Products:     Cux1

Top Publications

  1. Truscott M, Denault J, Goulet B, Leduy L, Salvesen G, Nepveu A. Carboxyl-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells. J Biol Chem. 2007;282:30216-26 pubmed
    Proteolytic processing at the end of the G(1) phase generates a CUX1 isoform, p110, which functions either as a transcriptional activator or repressor and can accelerate entry into S phase...
  2. Coffinier C, Chang S, Nobumori C, Tu Y, Farber E, Toth J, et al. Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proc Natl Acad Sci U S A. 2010;107:5076-81 pubmed publisher
    ..These studies establish an essential function for lamin B2 in neuronal migration and brain development. ..
  3. Sinclair A, Lee J, Goldstein A, Xing D, Liu S, Ju R, et al. Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice. Blood. 2001;98:3658-67 pubmed
    b>CCAAT displacement protein (cux/CDP) is an atypical homeodomain protein that represses expression of several developmentally regulated lymphoid and myeloid genes in vitro, including gp91-phox, immunoglobulin heavy chain, the T-cell ..
  4. Brantley J, Sharma M, Alcalay N, Heuvel G. Cux-1 transgenic mice develop glomerulosclerosis and interstitial fibrosis. Kidney Int. 2003;63:1240-8 pubmed
    b>Cux-1 is a murine homeobox gene that is highly expressed in the nephrogenic zone of the developing kidney...
  5. Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes R, et al. GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci. 2008;28:5817-26 pubmed publisher
    ..Furthermore, a putative ligand of GPR56 is localized in the marginal zone or overlying extracellular matrix. These observations provide compelling evidence that GPR56 functions in regulating pial BM integrity during cortical development...
  6. Feng Y, Walsh C. Mitotic spindle regulation by Nde1 controls cerebral cortical size. Neuron. 2004;44:279-93 pubmed
    ..Our data show that mitotic spindle function and orientation are essential for normal development of mammalian cerebral cortex. ..
  7. Sansregret L, Nepveu A. The multiple roles of CUX1: insights from mouse models and cell-based assays. Gene. 2008;412:84-94 pubmed publisher
    ..Early reports described many phenotypes caused by cut mutations in Drosophila melanogaster. In vertebrates, CUX1 was originally characterized as the CCAAT-displacement protein (CDP)...
  8. Dominguez M, Ayoub A, Rakic P. POU-III transcription factors (Brn1, Brn2, and Oct6) influence neurogenesis, molecular identity, and migratory destination of upper-layer cells of the cerebral cortex. Cereb Cortex. 2013;23:2632-43 pubmed publisher
    ..Finally, we demonstrate that Pou3fs influence multiple stages of neurogenesis by suppressing Notch effector Hes5, and promoting the expression of proneural transcription factors Tbr2 and Tbr1. ..
  9. Meechan D, Tucker E, Maynard T, LaMantia A. Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome. Proc Natl Acad Sci U S A. 2009;106:16434-45 pubmed publisher
    ..Such developmental disruption may alter cortical circuitry and establish vulnerability for developmental disorders, including schizophrenia and autism. ..

More Information

Publications83

  1. Ledford A, Brantley J, Kemeny G, Foreman T, Quaggin S, Igarashi P, et al. Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia. Dev Biol. 2002;245:157-71 pubmed
    b>Cux-1 is a murine homeobox gene that is highly expressed in the developing kidney with expression restricted to the nephrogenic zone...
  2. Torii M, Hashimoto Torii K, Levitt P, Rakic P. Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature. 2009;461:524-8 pubmed publisher
  3. Cadieux C, Harada R, Paquet M, Côté O, Trudel M, Nepveu A, et al. Polycystic kidneys caused by sustained expression of Cux1 isoform p75. J Biol Chem. 2008;283:13817-24 pubmed publisher
    The transcriptional regulator Cux1 (CDP, Cutl1) is aberrantly expressed in mouse models for polycystic kidney disease...
  4. Vanden Heuvel G, Brantley J, Alcalay N, Sharma M, Kemeny G, Warolin J, et al. Hepatomegaly in transgenic mice expressing the homeobox gene Cux-1. Mol Carcinog. 2005;43:18-30 pubmed
    b>Cux-1 is a member of a family of homeobox genes structurally related to Drosophila Cut. Mammalian Cut proteins function as transcriptional repressors of genes specifying terminal differentiation in multiple cell lineages...
  5. Jung H, Nobumori C, Goulbourne C, Tu Y, Lee J, Tatar A, et al. Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013;110:E1923-32 pubmed publisher
    ..Thus, farnesylation of lamin B1--but not lamin B2--is crucial for brain development and for retaining chromatin within the bounds of the nuclear lamina during neuronal migration...
  6. Barnes A, Lilley B, Pan Y, Plummer L, Powell A, Raines A, et al. LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell. 2007;129:549-63 pubmed
    ..Thus, we provide evidence in vivo and in vitro for a multikinase pathway that links extracellular signals to the intracellular machinery required for axon specification. ..
  7. Cubelos B, Sebastián Serrano A, Kim S, Moreno Ortiz C, Redondo J, Walsh C, et al. Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone. Cereb Cortex. 2008;18:1758-70 pubmed
    ..We herein report that the restricted expression of the homeodomain transcription factor Cux-2 in the SVZ regulates the proliferation of intermediate neuronal precursors and the number of upper layer neurons...
  8. Pawlisz A, Feng Y. Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes. PLoS Biol. 2011;9:e1001172 pubmed publisher
  9. Sansregret L, Gallo D, Santaguida M, Leduy L, Harada R, Nepveu A. Hyperphosphorylation by cyclin B/CDK1 in mitosis resets CUX1 DNA binding clock at each cell cycle. J Biol Chem. 2010;285:32834-43 pubmed publisher
    The p110 CUX1 homeodomain protein participates in the activation of DNA replication genes in part by increasing the affinity of E2F factors for the promoters of these genes...
  10. Kim Y, Sharov A, McDole K, Cheng M, Hao H, Fan C, et al. Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science. 2011;334:1706-10 pubmed publisher
    ..Thus, our studies not only disprove several prevailing views of lamin-Bs but also establish a foundation for redefining the function of the nuclear lamina in the context of tissue building and homeostasis...
  11. Sansregret L, Goulet B, Harada R, Wilson B, Leduy L, Bertoglio J, et al. The p110 isoform of the CDP/Cux transcription factor accelerates entry into S phase. Mol Cell Biol. 2006;26:2441-55 pubmed
    The CDP/Cux transcription factor was previously found to acquire distinct DNA binding and transcriptional properties following a proteolytic processing event that takes place at the G1/S transition of the cell cycle...
  12. Nieto M, Monuki E, Tang H, Imitola J, Haubst N, Khoury S, et al. Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex. J Comp Neurol. 2004;479:168-80 pubmed
    ..Expression of two homologues of the Drosophila homeobox Cut gene, Cux-1 and Cux-2, is strikingly specific to the pyramidal neurons of the upper layers (II-IV) of the murine cortex, ..
  13. Luong M, van der Meijden C, Xing D, Hesselton R, Monuki E, Jones S, et al. Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility. Mol Cell Biol. 2002;22:1424-37 pubmed
    ..In this study, we analyzed genetically targeted mice (Cutl1(tm2Ejn), referred to as Delta C) that express a mutant CDP/Cux protein with a deletion of the C terminus, ..
  14. Ellis T, Gambardella L, Horcher M, Tschanz S, Capol J, Bertram P, et al. The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle. Genes Dev. 2001;15:2307-19 pubmed
    The mammalian Cutl1 gene codes for the CCAAT displacement protein (CDP), which has been implicated as a transcriptional repressor in diverse processes such as terminal differentiation, cell cycle progression, and the control of nuclear ..
  15. Kedinger V, Sansregret L, Harada R, Vadnais C, Cadieux C, Fathers K, et al. p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284:27701-11 pubmed publisher
    In this study, we investigated the mechanism by which the CUX1 transcription factor can stimulate cell migration and invasion...
  16. Lizarraga S, Margossian S, Harris M, Campagna D, Han A, Blevins S, et al. Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Development. 2010;137:1907-17 pubmed publisher
    ..Our findings suggest that the reduction in brain size observed in humans with mutations in CDK5RAP2 is associated with impaired centrosomal function and with changes in mitotic spindle orientation during progenitor proliferation. ..
  17. Santaguida M, Nepveu A. Differential regulation of CDP/Cux p110 by cyclin A/Cdk2 and cyclin A/Cdk1. J Biol Chem. 2005;280:32712-21 pubmed
    ..Using a physiological substrate, CDP/Cux, our study confirms this notion...
  18. Tiveron M, Rossel M, Moepps B, Zhang Y, Seidenfaden R, Favor J, et al. Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone. J Neurosci. 2006;26:13273-8 pubmed
    ..Most SDF-1-positive cells are proliferating and express the homeodomain transcription factors Cux1 and Cux2...
  19. Vadnais C, Davoudi S, Afshin M, Harada R, Dudley R, Clermont P, et al. CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage. Nucleic Acids Res. 2012;40:4483-95 pubmed publisher
    The p110 Cut homeobox 1 (CUX1) transcription factor regulates genes involved in DNA replication and chromosome segregation...
  20. Cubelos B, Sebastián Serrano A, Beccari L, Calcagnotto M, Cisneros E, Kim S, et al. Cux1 and Cux2 regulate dendritic branching, spine morphology, and synapses of the upper layer neurons of the cortex. Neuron. 2010;66:523-35 pubmed publisher
    ..studies combined with morphological, molecular, and electrophysiological analysis, we show that the homeobox Cux1 and Cux2 are intrinsic and complementary regulators of dendrite branching, spine development, and synapse formation ..
  21. Pawlisz A, Mutch C, Wynshaw Boris A, Chenn A, Walsh C, Feng Y. Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination. Hum Mol Genet. 2008;17:2441-55 pubmed publisher
    ..Our data suggest that maintaining the shape and cell-cell interactions of radial glial neuroepithelial progenitors by the Lis1-Nde1 complex is essential for their self renewal during the early phase of corticogenesis. ..
  22. Tissir F, Qu Y, Montcouquiol M, Zhou L, Komatsu K, Shi D, et al. Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat Neurosci. 2010;13:700-7 pubmed publisher
    ..Our findings suggest that planar cell polarity signaling is involved in ependymal cilia development and in the pathophysiology of hydrocephalus, with possible implications in other ciliopathies. ..
  23. Alcalay N, Sharma M, Vassmer D, Chapman B, Paul B, Zhou J, et al. Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1. Am J Physiol Renal Physiol. 2008;295:F1725-34 pubmed publisher
    ..Cux1 is a homeobox gene that is related to Drosophila cut and is the murine homolog of human CDP (CCAAT Displacement Protein)...
  24. Kwan K, Lam M, Krsnik Z, Kawasawa Y, Lefebvre V, Sestan N. SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons. Proc Natl Acad Sci U S A. 2008;105:16021-6 pubmed publisher
    ..Thus, SOX5 postmitotically regulates the migration, postmigratory differentiation, and subcortical projections of subplate and deep-layer neurons. ..
  25. Luo R, Jeong S, Jin Z, Strokes N, Li S, Piao X. G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. Proc Natl Acad Sci U S A. 2011;108:12925-30 pubmed publisher
    ..Thus, collagen III regulates the proper lamination of the cerebral cortex by acting as the major ligand of GPR56 in the developing brain. ..
  26. Cadieux C, Fournier S, Peterson A, Bédard C, Bedell B, Nepveu A. Transgenic mice expressing the p75 CCAAT-displacement protein/Cut homeobox isoform develop a myeloproliferative disease-like myeloid leukemia. Cancer Res. 2006;66:9492-501 pubmed
    The p75 CCAAT-displacement protein/Cut homeobox (CDP/Cux) isoform was previously reported to be overexpressed in human breast cancers...
  27. Hulea L, Nepveu A. CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases. Gene. 2012;497:18-26 pubmed publisher
    ChIP-chip and expression analyses indicated that CUX1 transcription factors regulate a large number of genes and microRNAs involved in multiple cellular processes...
  28. Maitra U, Seo J, Lozano M, Dudley J. Differentiation-induced cleavage of Cutl1/CDP generates a novel dominant-negative isoform that regulates mammary gene expression. Mol Cell Biol. 2006;26:7466-78 pubmed
    Cutl1/CCAAT displacement protein (CDP) is a transcriptional repressor of mouse mammary tumor virus (MMTV), a betaretrovirus that is a paradigm for mammary-specific gene regulation...
  29. Schuurmans C, Armant O, Nieto M, Stenman J, Britz O, Klenin N, et al. Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. EMBO J. 2004;23:2892-902 pubmed
    ..Our study thus reveals an unanticipated heterogeneity in the genetic mechanisms specifying the identity of neocortical projection neurons. ..
  30. Rasin M, Gazula V, Breunig J, Kwan K, Johnson M, Liu Chen S, et al. Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci. 2007;10:819-27 pubmed
    ..Thus, by regulating RGC adhesion and polarity, Numb and Numbl are required for the tissue architecture of neurogenic niches and the cerebral cortex. ..
  31. Shen Q, Wang Y, Dimos J, Fasano C, Phoenix T, Lemischka I, et al. The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nat Neurosci. 2006;9:743-51 pubmed
    ..Our data demonstrate that neural stem cells change neuropotency during development and have a window of plasticity when restrictions can be reversed. ..
  32. Teissier A, Waclaw R, Griveau A, Campbell K, Pierani A. Tangentially migrating transient glutamatergic neurons control neurogenesis and maintenance of cerebral cortical progenitor pools. Cereb Cortex. 2012;22:403-16 pubmed publisher
  33. Boudreau F, Rings E, Swain G, Sinclair A, Suh E, Silberg D, et al. A novel colonic repressor element regulates intestinal gene expression by interacting with Cux/CDP. Mol Cell Biol. 2002;22:5467-78 pubmed
    ..Generation of transgenic mice with a mutated SI transgene showed involvement of an overlapping CDP (CCAAT displacement protein)-GATA element in colonic repression of SI throughout postnatal intestinal development...
  34. Wiegreffe C, Simon R, Peschkes K, Kling C, Strehle M, Cheng J, et al. Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c. Neuron. 2015;87:311-25 pubmed publisher
    ..Our data uncover a novel Bcl11a/Sema3c-dependent regulatory pathway used by migrating cortical neurons. ..
  35. Rodríguez Tornos F, Briz C, Weiss L, Sebastián Serrano A, Ares S, Navarrete M, et al. Cux1 Enables Interhemispheric Connections of Layer II/III Neurons by Regulating Kv1-Dependent Firing. Neuron. 2016;89:494-506 pubmed publisher
    ..Here we demonstrate that the TF Cux1 controls the formation of the layer II/III corpus callosum (CC) projections through the developmental ..
  36. Kuo G, Arnaud L, Kronstad O Brien P, Cooper J. Absence of Fyn and Src causes a reeler-like phenotype. J Neurosci. 2005;25:8578-86 pubmed
    ..This implies that Src and Fyn are needed for Reelin-dependent events during brain development...
  37. Paap R, Oosterbroek S, Wagemans C, von Oerthel L, Schellevis R, Vastenhouw van der Linden A, et al. FoxO6 affects Plxna4-mediated neuronal migration during mouse cortical development. Proc Natl Acad Sci U S A. 2016;113:E7087-E7096 pubmed publisher
    ..In conclusion, the presented data provide insights into the molecular mechanisms whereby transcriptional programs drive cortical development. ..
  38. Myshrall T, Moore S, Ostendorf A, Satz J, Kowalczyk T, Nguyen H, et al. Dystroglycan on radial glia end feet is required for pial basement membrane integrity and columnar organization of the developing cerebral cortex. J Neuropathol Exp Neurol. 2012;71:1047-63 pubmed publisher
    ..quot;..
  39. Huang T, Chuang H, Chou W, Chen C, Wang H, Chou S, et al. Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Nat Neurosci. 2014;17:240-7 pubmed publisher
    ..Our study suggests that TBR1 is important in the regulation of amygdalar axonal connections and cognition. ..
  40. Ferguson R, Serafeimidou Pouliou E, Subramanian V. Dynamic expression of the mouse orthologue of the human amyotropic lateral sclerosis associated gene C9orf72 during central nervous system development and neuronal differentiation. J Anat. 2016;229:871-891 pubmed publisher
    ..Our findings have implications for interpreting the pathophysiology caused by the repeat expansions in C9orf72 in mouse models. ..
  41. Rashid M, Belmont J, Carpenter D, Turner C, Olson E. Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation. Development. 2017;144:4002-4014 pubmed publisher
  42. Liang Y. SHARPIN negatively associates with TRAF2-mediated NF?B activation. PLoS ONE. 2011;6:e21696 pubmed publisher
    ..These data suggested that other than activating NF?B signaling by forming ubiquitin ligase complex with RNF31 and RBCK1, SHARPIN may also negatively associate with NF?B activation via interactions with other NF?B members, such as TRAF2. ..
  43. Darsigny M, St Jean S, Boudreau F. Cux1 transcription factor is induced in inflammatory bowel disease and protects against experimental colitis. Inflamm Bowel Dis. 2010;16:1739-50 pubmed publisher
    b>Cux1 is a ubiquitous transcriptional factor that has been associated with cell proliferation, migration, invasion, and differentiation...
  44. Kroll M, Viss E, Lamb J, Horstman J, Powell A, Van Wyk A, et al. Asynchronous expression of the homeodomain protein CUX1 in Sertoli cells and spermatids during spermatogenesis in mice. Biol Reprod. 2011;84:455-65 pubmed publisher
    The homeodomain CUX1 protein exists as multiple isoforms that arise from proteolytic processing of a 200-kDa protein or an alternate splicing or from the use of an alternate promoter...
  45. Higginbotham H, Guo J, Yokota Y, Umberger N, Su C, Li J, et al. Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation. Nat Neurosci. 2013;16:1000-7 pubmed publisher
  46. Xing L, Larsen R, Bjorklund G, Li X, Wu Y, Philpot B, et al. Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex. elife. 2016;5: pubmed publisher
    ..These data demonstrate selective requirements for ERK/MAPK signaling in layer 5 circuit development and general effects on cortical pyramidal neuron excitability. ..
  47. Yang S, Andl T, Grachtchouk V, Wang A, Liu J, Syu L, et al. Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet. 2008;40:1130-5 pubmed publisher
  48. Knock E, Pereira J, Lombard P, Dimond A, Leaford D, Livesey F, et al. The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex. Neural Dev. 2015;10:13 pubmed publisher
  49. Jossin Y, Lee M, Klezovitch O, Kon E, Cossard A, Lien W, et al. Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells. Dev Cell. 2017;41:481-495.e5 pubmed publisher
    ..These findings reveal a mechanism responsible for the physical and functional connection between cell polarity and cell-cell adhesion machineries in mammalian cells. ..
  50. Adolphe C, Nieuwenhuis E, Villani R, Li Z, Kaur P, Hui C, et al. Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation. J Invest Dermatol. 2014;134:1981-1990 pubmed publisher
    ..In general, our findings implicate Ptch receptor redundancy as a key issue in elucidating the cellular origin of Hh-induced tumors. ..
  51. Youssef K, Lapouge G, Bouvrée K, Rorive S, Brohée S, Appelstein O, et al. Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat Cell Biol. 2012;14:1282-94 pubmed publisher
    ..Deletion of ?-catenin in adult SmoM2-expressing cells prevents EHFP reprogramming and tumour initiation. Finally, human basal cell carcinomas also express genes of the Wnt signalling and EHFP signatures...
  52. Harrison S, Nishinakamura R, Jones K, Monaghan A. Sall1 regulates cortical neurogenesis and laminar fate specification in mice: implications for neural abnormalities in Townes-Brocks syndrome. Dis Model Mech. 2012;5:351-65 pubmed publisher
    ..These findings present novel insights into the function of Sall1 in the developing mouse cortex and provide avenues for future research into potential neural deficits in individuals with TBS. ..
  53. Lee Y, Katyal S, Downing S, Zhao J, Russell H, McKinnon P. Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors. Nat Neurosci. 2012;15:819-26 pubmed publisher
    ..Thus, TopBP1 is crucial for maintaining genome integrity in the early progenitors that drive neurogenesis. ..
  54. Adnani L, Langevin L, Gautier E, Dixit R, Parsons K, Li S, et al. Zac1 Regulates the Differentiation and Migration of Neocortical Neurons via Pac1. J Neurosci. 2015;35:13430-47 pubmed publisher
    ..Our studies are relevant because loss of 6q24 maternal imprinting in humans results in elevated ZAC1 expression, which has been associated with neurocognitive defects. ..
  55. Mihalas A, Elsen G, Bedogni F, Daza R, Ramos Laguna K, Arnold S, et al. Intermediate Progenitor Cohorts Differentially Generate Cortical Layers and Require Tbr2 for Timely Acquisition of Neuronal Subtype Identity. Cell Rep. 2016;16:92-105 pubmed publisher
    ..Our findings indicate that upper-layer genesis depends on IPs from many stages of corticogenesis and that Tbr2 regulates the tempo of laminar fate implementation for all cortical layers. ..
  56. Quaggin S, Heuvel G, Golden K, Bodmer R, Igarashi P. Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut. J Biol Chem. 1996;271:22624-34 pubmed
    ..A homologous gene (Cux-1) that encodes a transcriptional repressor has been identified in the mouse and other mammals...
  57. Gorelik A, Sapir T, Haffner Krausz R, Olender T, Woodruff T, Reiner O. Developmental activities of the complement pathway in migrating neurons. Nat Commun. 2017;8:15096 pubmed publisher
    ..Pharmacological activation of the downstream receptors rescue Masp2 and C3 knockdown as well as C3 knockout. Therefore, we propose that the complement pathway is functionally important in migrating neurons of the developing cortex. ..
  58. Wu Z, Li D, Huang Y, Chen X, Huang W, Liu C, et al. Caspr Controls the Temporal Specification of Neural Progenitor Cells through Notch Signaling in the Developing Mouse Cerebral Cortex. Cereb Cortex. 2017;27:1369-1385 pubmed publisher
    ..These findings establish Caspr as a novel key regulator that controls the temporal specification of cell fate in radial glial cells of the developing cerebral cortex through Notch signaling. ..
  59. Lee J, Tu Y, Tatar A, Wu D, Nobumori C, Jung H, et al. Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. Mol Biol Cell. 2014;25:1666-75 pubmed publisher
    ..We conclude that lamins B1 and B2 have unique roles in the developing brain and that increased production of one B-type lamin does not fully complement loss of the other. ..
  60. Houlihan S, Feng Y. The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. elife. 2014;3:e03297 pubmed publisher
    ..These findings suggest that NDE1-mediated heterochromatin replication is indispensible for neuronal differentiation, and that the loss of NDE1 function may lead to genomic neurological disorders. ..
  61. Falk S, Joosten E, Kaartinen V, Sommer L. Smad4 and Trim33/Tif1? redundantly regulate neural stem cells in the developing cortex. Cereb Cortex. 2014;24:2951-63 pubmed publisher
    ..Thus, our data disclose that in different regions of the developing CNS different aspects of the TGF? signaling pathway are required to ensure proper development. ..
  62. Li T, Wang H, Sun Y, Zhao L, Gang Y, Guo X, et al. Transcription factor CUTL1 is a negative regulator of drug resistance in gastric cancer. J Biol Chem. 2013;288:4135-47 pubmed publisher
    ..Here, we investigated how modulation of CUTL1 activity affects the response of gastric cancer to frequently used chemotherapeutic agents...
  63. Kraushar M, Thompson K, Wijeratne H, Viljetić B, Sakers K, Marson J, et al. Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R. Proc Natl Acad Sci U S A. 2014;111:E3815-24 pubmed publisher
    ..Our study identifies a crucial role for HuR in neocortical development as a translational gatekeeper for functionally related mRNA subgroups and polysomal protein specificity. ..
  64. Goebel P, Montalbano A, Ayers N, Kompfner E, Dickinson L, Webb C, et al. High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes. J Immunol. 2002;169:2477-87 pubmed
    ..assay, and for interaction with the MAR-binding proteins cut-like protein x/CCAAT-displacement protein (Cux/CDP), B cell regulator of IgH transcription (Bright), and special AT-rich sequence-binding protein (SATB1) by EMSA...
  65. Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, et al. Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell Rep. 2014;7:1626-1639 pubmed publisher
    ..Our findings demonstrate that mTORC1 plays different roles in developmental and adult stages and contributes to human neurological diseases. ..
  66. Ma T, Zhang Q, Cai Y, You Y, Rubenstein J, Yang Z. A subpopulation of dorsal lateral/caudal ganglionic eminence-derived neocortical interneurons expresses the transcription factor Sp8. Cereb Cortex. 2012;22:2120-30 pubmed publisher
    ..In contrast to MGE-derived interneurons, dLGE/dCGE-derived Sp8+ interneurons follow an outside-in layering pattern, preferentially occupying superficial cortical layers. ..
  67. Wang W, Jossin Y, Chai G, Lien W, Tissir F, Goffinet A. Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling. Nat Commun. 2016;7:10936 pubmed publisher
    ..Thus, Celsr3 and Fzd3 enable immature neurons to respond to Wnt7, upregulate Jag1 and thereby facilitate feedback signals that tune the timing of NPC fate decisions via Notch activation. ..
  68. Zhao X, D Arca D, Lim W, Brahmachary M, Carro M, Ludwig T, et al. The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. Dev Cell. 2009;17:210-21 pubmed publisher
    ..Our results indicate that Huwe1 balances proliferation and neurogenesis in the developing brain and that this pathway is subverted in malignant brain tumors. ..
  69. Quaggin S, Yeger H, Igarashi P. Antisense oligonucleotides to Cux-1, a Cut-related homeobox gene, cause increased apoptosis in mouse embryonic kidney cultures. J Clin Invest. 1997;99:718-24 pubmed
    b>Cux-1 is a murine homeobox gene that is highly and transiently expressed in the developing kidney...
  70. Andres V, Nadal Ginard B, Mahdavi V. Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development. Development. 1992;116:321-34 pubmed
    ..Thus, Clox, like their Drosophila counterparts, are candidate regulators of cell-fate specification in diverse differentiation programs. ..
  71. Maeta K, Edamatsu H, Nishihara K, Ikutomo J, Bilasy S, Kataoka T. Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex. Eneuro. 2016;3: pubmed publisher
    ..These results demonstrate a cell-autonomous role of the Rapgef2/6-Rap1 pathway in maintaining the apical surface AJ structures, which is necessary for the proper development of neural progenitor cells. ..
  72. Wang Z, Goldstein A, Zong R, Lin D, Neufeld E, Scheuermann R, et al. Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator. Mol Cell Biol. 1999;19:284-95 pubmed
    ..library screening with NF-muNR binding sites yielded a cDNA clone encoding an alternatively spliced form of the Cux/CDP homeodomain protein. Cux/CDP fulfills criteria required for NF-muNR identity...
  73. Cubelos B, Briz C, Esteban Ortega G, Nieto M. Cux1 and Cux2 selectively target basal and apical dendritic compartments of layer II-III cortical neurons. Dev Neurobiol. 2015;75:163-72 pubmed publisher
    ..molecular identity of layer II-III neurons of the cerebral cortex is determined by the overlapping expression of Cux1 and Cux2...
  74. Huang C, Chang J, Wu S, Choo K. Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence. J Biol Chem. 2005;280:30681-8 pubmed
    ..assays demonstrated that the 3'-half of DER (DER2) was targeted by the repressor CCAAT-displacement protein (CDP)/Cux. Chromatin immunoprecipitation experiments further demonstrated in vivo CDP-DER association in the blastocyst and ..