Ctnnd1

Summary

Gene Symbol: Ctnnd1
Description: catenin (cadherin associated protein), delta 1
Alias: AA409437, AU019353, Catns, Ctnnd, P120, mKIAA0384, catenin delta-1, CAS, cadherin-associated Src substrate, catenin src, p120 catenin, p120(cas), p120(ctn)
Species: mouse
Products:     Ctnnd1

Top Publications

  1. Kurley S, Bierie B, Carnahan R, Lobdell N, Davis M, Hofmann I, et al. p120-catenin is essential for terminal end bud function and mammary morphogenesis. Development. 2012;139:1754-64 pubmed publisher
    Although p120-catenin (p120) is crucial for E-cadherin function, ablation experiments in epithelial tissues from different organ systems reveal markedly different effects...
  2. Chacon Heszele M, Ren D, Reynolds A, Chi F, Chen P. Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120-catenin. Development. 2012;139:968-78 pubmed publisher
    ..The conditional knockout of a component of the adherens junctions, p120-catenin, leads to the reduction of E-cadherin and N-cadherin and to characteristic cochlear CE defects but not ..
  3. MARCIANO D, BRAKEMAN P, Lee C, Spivak N, Eastburn D, Bryant D, et al. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011;138:2099-109 pubmed publisher
    ..Here, we report that absence of the cadherin regulator p120 catenin (p120ctn) from the renal mesenchyme prior to tubule formation leads to decreased cadherin levels with abnormal ..
  4. Nanes B, Chiasson MacKenzie C, Lowery A, Ishiyama N, Faundez V, Ikura M, et al. p120-catenin binding masks an endocytic signal conserved in classical cadherins. J Cell Biol. 2012;199:365-80 pubmed publisher
    b>p120-catenin (p120) binds to the cytoplasmic tails of classical cadherins and inhibits cadherin endocytosis...
  5. Smalley Freed W, Efimov A, Burnett P, Short S, Davis M, Gumucio D, et al. p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest. 2010;120:1824-35 pubmed publisher
    ..Its function is regulated in part by p120-catenin (referred to herein as p120), a cytoplasmic binding partner that directly regulates cadherin stability...
  6. Davis M, Reynolds A. Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland. Dev Cell. 2006;10:21-31 pubmed
    b>p120 catenin is thought to be a key regulator of E-cadherin function and stability, but its role(s) in vivo is poorly understood...
  7. Soto E, Yanagisawa M, Marlow L, Copland J, Perez E, Anastasiadis P. p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression. J Cell Biol. 2008;183:737-49 pubmed publisher
    b>p120 catenin regulates the activity of the Rho family guanosine triphosphatases (including RhoA and Rac1) in an adhesion-dependent manner...
  8. Spring C, Kelly K, O Kelly I, Graham M, Crawford H, Daniel J. The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin. Exp Cell Res. 2005;305:253-65 pubmed
  9. Yanagisawa M, Kaverina I, Wang A, Fujita Y, Reynolds A, Anastasiadis P. A novel interaction between kinesin and p120 modulates p120 localization and function. J Biol Chem. 2004;279:9512-21 pubmed
    b>p120-catenin exists in a membrane-associated cadherin-bound pool, a cytosolic pool that affects Rho GTPases, and a nuclear pool that is thought to associate with the methylation-relevant transcriptional repressor Kaiso...

More Information

Publications82

  1. Franz C, Ridley A. p120 catenin associates with microtubules: inverse relationship between microtubule binding and Rho GTPase regulation. J Biol Chem. 2004;279:6588-94 pubmed
    b>p120 catenin (p120ctn), an armadillo protein and component of the cadherin adhesion complex, has been found recently to induce a dendritic morphology by regulating Rho family GTPases...
  2. Xia X, Carnahan R, Vaughan M, Wildenberg G, Reynolds A. p120 serine and threonine phosphorylation is controlled by multiple ligand-receptor pathways but not cadherin ligation. Exp Cell Res. 2006;312:3336-48 pubmed
    b>p120-catenin (p120) regulates cadherin turnover and is required for cadherin stability...
  3. Elia L, Yamamoto M, Zang K, Reichardt L. p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins. Neuron. 2006;51:43-56 pubmed
    ..We show here a role for p120 catenin (p120ctn) in regulating spine and synapse formation in the developing mouse brain...
  4. Yanagisawa M, Huveldt D, Kreinest P, Lohse C, Cheville J, Parker A, et al. A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease. J Biol Chem. 2008;283:18344-54 pubmed publisher
    b>p120 catenin is a cadherin-associated protein that regulates Rho GTPases and promotes the invasiveness of E-cadherin-deficient cancer cells...
  5. Meng W, Mushika Y, Ichii T, Takeichi M. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell. 2008;135:948-59 pubmed publisher
    ..We propose that the PLEKHA7/Nezha/MT complex regulates the ZA integrity by recruiting KIFC3 to this junctional site. ..
  6. Kim S, Park J, Spring C, Sater A, Ji H, Otchere A, et al. Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. Nat Cell Biol. 2004;6:1212-20 pubmed
    ..Here we demonstrate that the dual-specificity transcriptional repressor Kaiso, first identified in association with p120-catenin, is required for Xenopus gastrulation movements...
  7. Debusk L, Boelte K, Min Y, Lin P. Heterozygous deficiency of delta-catenin impairs pathological angiogenesis. J Exp Med. 2010;207:77-84 pubmed publisher
    ..Because only pathological angiogenesis is sensitive to decreased levels of delta-catenin, this may provide a good target for antiangiogenic therapy. ..
  8. Stairs D, Bayne L, Rhoades B, Vega M, Waldron T, Kalabis J, et al. Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell. 2011;19:470-83 pubmed publisher
    b>p120-catenin (p120ctn) interacts with E-cadherin, but to our knowledge, no formal proof that p120ctn functions as a bona fide tumor suppressor gene has emerged to date. We report herein that p120ctn loss leads to tumor development in mice...
  9. Smalley Freed W, Efimov A, Short S, Jia P, Zhao Z, Washington M, et al. Adenoma formation following limited ablation of p120-catenin in the mouse intestine. PLoS ONE. 2011;6:e19880 pubmed publisher
    b>p120 loss destabilizes E-cadherin and could therefore result in tumor and/or metastasis-promoting activities similar to those caused by E-cadherin downregulation...
  10. Schackmann R, van Amersfoort M, Haarhuis J, Vlug E, Halim V, Roodhart J, et al. Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance. J Clin Invest. 2011;121:3176-88 pubmed publisher
    ..Using a mouse model of human ILC, we show here that cytosolic p120-catenin (p120) regulates tumor growth upon loss of E-cadherin through the induction of anoikis resistance...
  11. Reynolds A, Herbert L, Cleveland J, Berg S, Gaut J. p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo. Oncogene. 1992;7:2439-45 pubmed
    A novel protein tyrosine kinase (PTK) substrate, p120, has been previously implicated in ligand-induced signaling through the epidermal growth factor, platelet-derived growth factor and colony-stimulating factor 1 receptors, and in cell ..
  12. Taulet N, Comunale F, Favard C, Charrasse S, Bodin S, Gauthier Rouvière C. N-cadherin/p120 catenin association at cell-cell contacts occurs in cholesterol-rich membrane domains and is required for RhoA activation and myogenesis. J Biol Chem. 2009;284:23137-45 pubmed publisher
    b>p120 catenin is a major regulator of cadherin stability at cell-cell contacts and a modulator of Rho GTPase activities...
  13. Oas R, Xiao K, Summers S, Wittich K, Chiasson C, Martin W, et al. p120-Catenin is required for mouse vascular development. Circ Res. 2010;106:941-51 pubmed publisher
    b>p120-catenin (p120) is an armadillo family protein that binds to the cytoplasmic domain of classical cadherins and prevents cadherin endocytosis. The role of p120 in vascular development is unknown...
  14. Ichii T, Takeichi M. p120-catenin regulates microtubule dynamics and cell migration in a cadherin-independent manner. Genes Cells. 2007;12:827-39 pubmed
    b>p120-catenin (p120) has been shown to be essential for cadherin stability. Here, we show that p120 is capable of regulating microtubule (MT) dynamics in a cadherin-independent manner...
  15. Castaño J, Solanas G, Casagolda D, Raurell I, Villagrasa P, Bustelo X, et al. Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA. Mol Cell Biol. 2007;27:1745-57 pubmed
    b>p120-catenin is an adherens junction-associated protein that controls E-cadherin function and stability. p120-catenin also binds intracellular proteins, such as the small GTPase RhoA...
  16. Wildenberg G, Dohn M, Carnahan R, Davis M, Lobdell N, Settleman J, et al. p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell. 2006;127:1027-39 pubmed
    ..Here, we describe roles for p120-catenin (p120) and p190RhoGAP that coordinate crosstalk between these systems and regulate cadherin function...
  17. Daniel J, Reynolds A. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol. 1999;19:3614-23 pubmed
    b>p120(ctn) is an Armadillo repeat domain protein with structural similarity to the cell adhesion cofactors beta-catenin and plakoglobin...
  18. Hou J, Shigematsu S, Crawford H, Anastasiadis P, Pessin J. Dual regulation of Rho and Rac by p120 catenin controls adipocyte plasma membrane trafficking. J Biol Chem. 2006;281:23307-12 pubmed
    ..there is a marked reduction in beta-catenin and N-cadherin expression with a relatively small decrease in p120 catenin protein levels...
  19. Daniel J, Spring C, Crawford H, Reynolds A, Baig A. The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. Nucleic Acids Res. 2002;30:2911-9 pubmed
    The p120(ctn)-binding partner Kaiso is a new member of the POZ-zinc finger family of transcription factors implicated in development and cancer...
  20. Perez Moreno M, Davis M, Wong E, Pasolli H, Reynolds A, Fuchs E. p120-catenin mediates inflammatory responses in the skin. Cell. 2006;124:631-44 pubmed
    Although p120-catenin regulates adherens junction (AJ) stability in cultured cells, genetic studies in lower eukaryotes have not revealed a role for this protein in vivo...
  21. Gavard J, Lambert M, Grosheva I, Marthiens V, Irinopoulou T, Riou J, et al. Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J Cell Sci. 2004;117:257-70 pubmed
    ..The expression and localization of p120 at the plasma membrane, associated with an increase in membrane-associated Rac1 was required for both cell ..
  22. Hendley A, Provost E, Bailey J, WANG Y, Cleveland M, Blake D, et al. p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. Dev Biol. 2015;399:41-53 pubmed publisher
    The intracellular protein p120 catenin aids in maintenance of cell-cell adhesion by regulating E-cadherin stability in epithelial cells...
  23. Tian H, Sanders E, Reynolds A, van Roy F, van Hengel J. Ocular anterior segment dysgenesis upon ablation of p120 catenin in neural crest cells. Invest Ophthalmol Vis Sci. 2012;53:5139-53 pubmed publisher
    ..As p120 catenin (ctn) is an important component of cadherin-catenin cell adhesion complexes, we assessed its role in ..
  24. Yao L, Baluk P, Srinivasan R, Oliver G, McDonald D. Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation. Am J Pathol. 2012;180:2561-75 pubmed publisher
    ..These findings demonstrate the plasticity of intercellular junctions in lymphatics during development and inflammation and show that button formation can be promoted by glucocorticoid receptor signaling in lymphatic endothelial cells...
  25. Mann K, Ward J, Yew C, Kovochich A, Dawson D, Black M, et al. Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2012;109:5934-41 pubmed publisher
    ..Kdm6a, and Nsd3, and all SB tumors have at least one mutated gene involved in this process; 20 CCGs, including Ctnnd1, Fbxo11, and Vgll4, are also significantly associated with poor patient survival...
  26. Kim H, Han J, Park J, Oh M, James S, Chang S, et al. Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation. J Biol Chem. 2008;283:977-87 pubmed
    ..These results highlight signaling events in the regulation of delta-catenin-induced dendrogenesis and spine morphogenesis. ..
  27. Zechner D, Fujita Y, Hülsken J, Muller T, Walther I, Taketo M, et al. beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev Biol. 2003;258:406-18 pubmed
    ..beta-Catenin signals are thus essential for the maintenance of proliferation of neuronal progenitors, controlling the size of the progenitor pool, and impinging on the decision of neuronal progenitors to proliferate or to differentiate. ..
  28. Suriben R, Kivimäe S, Fisher D, Moon R, Cheyette B. Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet. 2009;41:977-85 pubmed publisher
    ..We conclude that Dact1 contributes to morphogenesis at the primitive streak by regulating Vangl2 upstream of cell adhesion and the PCP pathway. ..
  29. Teng J, Rai T, Tanaka Y, Takei Y, Nakata T, Hirasawa M, et al. The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol. 2005;7:474-82 pubmed
    ..Furthermore, in KAP3-deficient cells, the subcellular localization of N-cadherin was disrupted. Taken together, these results suggest a potential tumour-suppressing activity for this molecular motor. ..
  30. Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey A. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev. 2003;17:1090-100 pubmed
    ..Our studies indicate that merlin functions as a tumor and metastasis suppressor by controlling cadherin-mediated cell:cell contact. ..
  31. Arikkath J, Israely I, Tao Y, Mei L, Liu X, Reichardt L. Erbin controls dendritic morphogenesis by regulating localization of delta-catenin. J Neurosci. 2008;28:7047-56 pubmed publisher
    ..Knockdown of erbin results in alterations in localization of delta-catenin. These results suggest a critical role for erbin in regulating dendritic morphogenesis by maintaining appropriate localization of delta-catenin. ..
  32. Nunes F, Lopez L, Lin H, Davies C, Azevedo R, Gow A, et al. Distinct subdomain organization and molecular composition of a tight junction with adherens junction features. J Cell Sci. 2006;119:4819-27 pubmed
  33. McCrea P, Park J. Developmental functions of the P120-catenin sub-family. Biochim Biophys Acta. 2007;1773:17-33 pubmed
    ..More recently, attention has been directed towards p120-catenin, which in conjunction with the p120-catenin sub-family members ARVCF- and delta-catenins, are the subjects ..
  34. Fleming A, Ghahramani N, Zhu M, Délot E, Vilain E. Membrane ?-catenin and adherens junctions in early gonadal patterning. Dev Dyn. 2012;241:1782-98 pubmed publisher
    ..for their roles in morphogenesis; we, therefore, examined expression of AJ components including ?-catenin, p120 catenin, and cadherins for possible involvement in sex-specific patterning of the gonad...
  35. Reynolds A, Jenkins N, Gilbert D, Copeland N, Shapiro D, Wu J, et al. The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns). Genomics. 1996;31:127-9 pubmed
    ..The murine p120cas gene (Catns) was assigned to the middle of chromosome 2...
  36. Metzis V, Courtney A, Kerr M, Ferguson C, Rondón Galeano M, Parton R, et al. Patched1 is required in neural crest cells for the prevention of orofacial clefts. Hum Mol Genet. 2013;22:5026-35 pubmed publisher
    ..Importantly, these interactions are critically dependent on Ptch1 function for the prevention of orofacial clefts. ..
  37. Bartlett J, Dobeck J, Tye C, Perez Moreno M, Stokes N, Reynolds A, et al. Targeted p120-catenin ablation disrupts dental enamel development. PLoS ONE. 2010;5: pubmed publisher
    ..b>p120 stabilizes cadherins by preventing their internalization and degradation...
  38. Ghose S, Min Y, Lin P. δ-Catenin activates Rho GTPase, promotes lymphangiogenesis and growth of tumor metastases. PLoS ONE. 2015;10:e0116338 pubmed publisher
    ..Targeting δ-catenin may offer a new way to control tumor metastasis. ..
  39. Epifano C, Megias D, Perez Moreno M. p120-catenin differentially regulates cell migration by Rho-dependent intracellular and secreted signals. EMBO Rep. 2014;15:592-600 pubmed publisher
    ..How these events are coordinated to promote wound repair is not understood. We show that p120 catenin regulates the intrinsic migratory properties of primary mouse keratinocytes, but also influences the migratory ..
  40. Lee M, Ji H, Furuta Y, Park J, McCrea P. p120-catenin regulates REST and CoREST, and modulates mouse embryonic stem cell differentiation. J Cell Sci. 2014;127:4037-51 pubmed publisher
    Although the canonical Wnt pathway and ?-catenin have been extensively studied, less is known about the role of p120-catenin (also known as ?1-catenin) in the nuclear compartment...
  41. Alves C, Sanz A, Park B, Pellissier L, Tanimoto N, Beck S, et al. Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013;22:35-50 pubmed publisher
    ..The data suggest an essential role for CRB2 in proper lamination of the photoreceptor layer and suppression of proliferation of late-born retinal progenitor cells...
  42. Nelson D, Manhardt C, Kamath V, Sui Y, Santamaria Pang A, Can A, et al. Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation. Biol Open. 2013;2:439-47 pubmed publisher
    ..The data suggest that there are temporally and spatially discreet progenitor populations that contribute to salivary gland development and homeostasis. ..
  43. Lindqvist M, Horn Z, Bryja V, Schulte G, Papachristou P, Ajima R, et al. Vang-like protein 2 and Rac1 interact to regulate adherens junctions. J Cell Sci. 2010;123:472-83 pubmed publisher
    ..We propose that Vangl2 affects cell adhesion and the cytoskeleton by recruiting Rac1 and targeting its activity in the cell to adherens junctions. ..
  44. Na J, Lykke Andersen K, Torres Padilla M, Zernicka Goetz M. Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling. Dev Biol. 2007;302:40-9 pubmed
    ..This suggests that perturbing Dvl function interferes with cell-cell adhesion through the non-canonical Wnt pathway in blastocysts. ..
  45. Wang Y, Minshall R, Schwartz D, Hu G. Cyclic stretch induces alveolar epithelial barrier dysfunction via calpain-mediated degradation of p120-catenin. Am J Physiol Lung Cell Mol Physiol. 2011;301:L197-206 pubmed publisher
    ..b>p120-catenin is an adherens junction-associated protein that regulates cell-cell adhesion...
  46. Muccioli M, Qaisi D, Herman K, Plageman T. Lens placode planar cell polarity is dependent on Cdc42-mediated junctional contraction inhibition. Dev Biol. 2016;412:32-43 pubmed publisher
    ..We postulate that invagination of the lens placode requires careful orchestration of these opposing processes which are mediated by the planar polarization of junctional proteins. ..
  47. Wang Q, Lu T, Adams E, Lin J, Lin J. Intercalated disc protein, mXin?, suppresses p120-catenin-induced branching phenotype via its interactions with p120-catenin and cortactin. Arch Biochem Biophys. 2013;535:91-100 pubmed publisher
    ..Here, we showed that mXin? also interacted with p120-catenin and cortactin...
  48. He Y, Kim H, Ryu T, Lee K, Choi W, Kim K, et al. C-Src-mediated phosphorylation of ?-catenin increases its protein stability and the ability of inducing nuclear distribution of ?-catenin. Biochim Biophys Acta. 2014;1843:758-68 pubmed publisher
    ..Taken together, these results indicate that c-Src can enhance the oncogenic function of ?-catenin in prostate cancer cells. ..
  49. Adolphe C, Junker J, Lyubimova A, van Oudenaarden A, Wainwright B. Patched Receptors Sense, Interpret, and Establish an Epidermal Hedgehog Signaling Gradient. J Invest Dermatol. 2017;137:179-186 pubmed publisher
    ..Taken together, these data show that both Ptch1 and Ptch2 play a crucial role in sensing the concentration of Hedgehog ligand and regulating the appropriate dose-dependent response. ..
  50. Karakasheva T, Waldron T, Eruslanov E, Kim S, Lee J, O Brien S, et al. CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer. Cancer Res. 2015;75:4074-85 pubmed publisher
    ..Using an unbiased global gene expression approach in conditional p120-catenin knockout mice (L2-cre;p120ctn(f/f)), a model of oral-esophageal cancer, we have identified CD38 as playing ..
  51. Mo Y, Reynolds A. Identification of murine p120 isoforms and heterogeneous expression of p120cas isoforms in human tumor cell lines. Cancer Res. 1996;56:2633-40 pubmed
    p120cas (CAS) is a protein tyrosine kinase substrate that associates directly with the cytoplasmic tail of the cell-cell adhesion molecule E-cadherin...
  52. Yuan Y, Singh D, Arikkath J. Mef2 promotes spine elimination in absence of ?-catenin. Neurosci Lett. 2013;536:10-3 pubmed publisher
    ..These results establish a molecular mechanism by which excessive spines in the absence of ?-catenin may be eliminated and may point toward pharmacological therapy for the Cri du chat syndrome. ..
  53. Petrova Y, Spano M, Gumbiner B. Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion. Mol Biol Cell. 2012;23:2092-108 pubmed publisher
    ..Activation also induces p120-catenin dephosphorylation, as well as changes in the cadherin cytoplasmic domain...
  54. Johnson E, Seachrist D, DeLeon Rodriguez C, Lozada K, Miedler J, Abdul Karim F, et al. HER2/ErbB2-induced breast cancer cell migration and invasion require p120 catenin activation of Rac1 and Cdc42. J Biol Chem. 2010;285:29491-501 pubmed publisher
    ..The ability of ErbB2 to activate these small GTPases necessitated expression of p120 catenin, which is itself up-regulated by signaling through ErbB2 and the tyrosine kinase Src...
  55. Perez Moreno M, Song W, Pasolli H, Williams S, Fuchs E. Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer. Proc Natl Acad Sci U S A. 2008;105:15399-404 pubmed publisher
    ..Here, we show that conditional targeting of p120 catenin in mice leads to progressive development of skin neoplasias associated with intrinsic NF-kappaB activation...
  56. Sakao Y, Kawai T, Takeuchi O, Copeland N, Gilbert D, Jenkins N, et al. Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting. Genomics. 2000;67:1-7 pubmed
    ..These findings indicate that Psmc3 and Psmc4 have similar and essential roles in early embryogenesis and further that both ATPases have noncompensatory functions in vivo. ..
  57. Giampietro C, Taddei A, Corada M, Sarra Ferraris G, Alcalay M, Cavallaro U, et al. Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells. Blood. 2012;119:2159-70 pubmed publisher
    ..report here that VE-cadherin negatively controls junctional localization and expression of N-cadherin by limiting p120-catenin availability and reducing ?-catenin transcriptional activity...
  58. Hartsock A, Nelson W. Competitive regulation of E-cadherin juxtamembrane domain degradation by p120-catenin binding and Hakai-mediated ubiquitination. PLoS ONE. 2012;7:e37476 pubmed publisher
    b>p120-Catenin binding to, and Hakai-mediated ubiquitination of the E-cadherin juxtamembrane domain (JMD) are thought to be involved in regulating E-cadherin internalization and degradation...
  59. Dudok J, Murtaza M, Henrique Alves C, Rashbass P, Wijnholds J. Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon. Neurosci Res. 2016;108:12-23 pubmed publisher
    ..We show that CRB2 is required for maintenance of the apical polarity complex during development of the cortex and regulation of cell division, and that loss of CRB2 results in cortical abnormalities. ..
  60. Hosking C, Ulloa F, Hogan C, Ferber E, Figueroa A, Gevaert K, et al. The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol Biol Cell. 2007;18:1918-27 pubmed
    In epithelial cells, p120 catenin (p120) localizes at cell-cell contacts and regulates adhesive function of the cadherin complex...
  61. Semb H, Christofori G. The tumor-suppressor function of E-cadherin. Am J Hum Genet. 1998;63:1588-93 pubmed
  62. Weis V, Knowles B, Choi E, Goldstein A, Williams J, Manning E, et al. Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum. Cell Mol Gastroenterol Hepatol. 2016;2:131-157 pubmed
    ..However, the diarrheal pathology after MYO5B loss is due to deficits in transporter presentation at the apical membrane in duodenal enterocytes. ..
  63. van Hengel J, Vanhoenacker P, Staes K, van Roy F. Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression. Proc Natl Acad Sci U S A. 1999;96:7980-5 pubmed
    The Armadillo protein p120(ctn) associates with the cytoplasmic domain of cadherins and accumulates at cell-cell junctions...
  64. Montonen O, Aho M, Uitto J, Aho S. Tissue distribution and cell type-specific expression of p120ctn isoforms. J Histochem Cytochem. 2001;49:1487-96 pubmed
  65. Tunggal J, Helfrich I, Schmitz A, Schwarz H, Gunzel D, Fromm M, et al. E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 2005;24:1146-56 pubmed
    ..Surprisingly, our results indicate that E-cadherin is specifically required for tight junction, but not desmosome, formation and this appears to involve signalling rather than cell contact formation. ..
  66. Xie Z, Yuan Y, Jiang Y, Shrestha C, Chen Y, Liao L, et al. p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice. J Cell Physiol. 2017;232:1360-1367 pubmed publisher
    Previous studies have shown that dietary calcium suppresses oral carcinogenesis, but the mechanism is unclear. p120-catenin (p120) is a cytoplasmic protein closely associated with E-cadherin to form the E-cadherin-β-catenin complex and ..
  67. Liu H, Komiya S, Shimizu M, Fukunaga Y, Nagafuchi A. Involvement of p120 carboxy-terminal domain in cadherin trafficking. Cell Struct Funct. 2007;32:127-37 pubmed
    b>P120 plays an essential role in cadherin turnover. The molecular mechanism involved, however, remains only partially understood...
  68. Mukai A, Hashimoto N. Regulation of pre-fusion events: recruitment of M-cadherin to microrafts organized at fusion-competent sites of myogenic cells. BMC Cell Biol. 2013;14:37 pubmed publisher
    ..However, Rac1 activity was unnecessary for recruitment of M-cadherin to lipid rafts. We found that p120 catenin (p120) binds to M-cadherin exclusively in lipid rafts of differentiating myogenic cells...
  69. Kanno M, Isa Y, Aoyama Y, Yamamoto Y, Nagai M, Ozawa M, et al. P120-catenin is a novel desmoglein 3 interacting partner: identification of the p120-catenin association site of desmoglein 3. Exp Cell Res. 2008;314:1683-92 pubmed publisher
    b>P120-catenin (p120ctn) is an armadillo-repeat protein that directly binds to the intracytoplasmic domains of classical cadherins...
  70. Wang Y, Malik A, Sun Y, Hu S, Reynolds A, Minshall R, et al. Innate immune function of the adherens junction protein p120-catenin in endothelial response to endotoxin. J Immunol. 2011;186:3180-3187 pubmed publisher
    ..In this study, we investigated the role of p120-catenin (p120), a constituent of endothelial adherens junctions, in regulating the innate immune function of lungs...
  71. Mizoguchi T, Ikeda S, Watanabe S, Sugawara M, Itoh M. Mib1 contributes to persistent directional cell migration by regulating the Ctnnd1-Rac1 pathway. Proc Natl Acad Sci U S A. 2017;114:E9280-E9289 pubmed publisher
    ..Furthermore, we explored novel Mib1 substrates for cell migration and found that Mib1 ubiquitinates Ctnnd1. Mib1-mediated ubiquitination of Ctnnd1 K547 attenuated Rac1 activation in cultured cells...
  72. Perrin Tricaud C, Rutishauser U, Tricaud N. P120 catenin is required for thickening of Schwann cell myelin. Mol Cell Neurosci. 2007;35:120-9 pubmed
    ..These data show that p120ctn is necessary in the myelinating Schwann cell for the formation of mature adherens junctions and a normal myelin sheath. ..
  73. Orlichenko L, Geyer R, Yanagisawa M, Khauv D, Radisky E, Anastasiadis P, et al. The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin. J Biol Chem. 2010;285:19153-61 pubmed publisher
    ..to many common regulators of Rho family GTPases but that it does display enhanced binding to SmgGDS, RACK1, and p120 catenin (p120(ctn)), proteins involved in cell-cell adhesion, motility, and transcriptional regulation...