Gene Symbol: Ctnnbip1
Description: catenin beta interacting protein 1
Alias: 1110008O09Rik, 2310001I19Rik, AW457332, Catnbip1, Icat, beta-catenin-interacting protein 1, inhibitor of beta-catenin and Tcf-4
Species: mouse
Products:     Ctnnbip1

Top Publications

  1. Satoh K, Kasai M, Ishidao T, Tago K, Ohwada S, Hasegawa Y, et al. Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling. Proc Natl Acad Sci U S A. 2004;101:8017-21 pubmed
    Inhibitor of beta-catenin and T cell factor (ICAT) inhibits Wnt signaling by interfering with the interaction between beta-catenin and T cell factor...
  2. Hasegawa Y, Satoh K, Iizuka Kogo A, Shimomura A, Nomura R, Akiyama T, et al. Loss of ICAT gene function leads to arrest of ureteric bud branching and renal agenesis. Biochem Biophys Res Commun. 2007;362:988-94 pubmed
    ICAT, inhibitor of beta-catenin and T cell factor, or Ctnnbip1, is a negative regulator of the Wnt signaling pathway that interferes with the interaction between beta-catenin and T cell factor...
  3. Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, et al. Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev. 2000;14:1741-9 pubmed
    ..Here, we identify a novel beta-catenin-interacting protein, ICAT, that was found to inhibit the interaction of beta-catenin with TCF-4 and represses beta-catenin-TCF-4-mediated ..
  4. Graham T, Clements W, Kimelman D, Xu W. The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. Mol Cell. 2002;10:563-71 pubmed
    ..We have determined the crystal structure at 2.5 A resolution of a complex between beta-catenin and ICAT, a protein that prevents the interaction between beta-catenin and Tcf/Lef family transcription factors...
  5. Quasnichka H, Slater S, Beeching C, Boehm M, Sala Newby G, George S. Regulation of smooth muscle cell proliferation by beta-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression. Circ Res. 2006;99:1329-37 pubmed
    ..cyclin D1 and p21, we inhibited beta-catenin/TCF signaling by adenoviral-mediated over-expression of N-Cadherin, ICAT (an endogenous inhibitor of beta-catenin/TCF signaling), or a dominant negative (dn) mutant of TCF-4...
  6. Zhu M, Chen M, Zuscik M, Wu Q, Wang Y, Rosier R, et al. Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum. 2008;58:2053-64 pubmed publisher
    ..To determine the role of beta-catenin signaling in articular chondrocyte function, we generated Col2a1-ICAT-transgenic mice to inhibit beta-catenin signaling in chondrocytes...
  7. Peng Y, Li H, Li X, Yu S, Xiang H, Peng J, et al. MicroRNA-215 impairs adipocyte differentiation and co-represses FNDC3B and CTNNBIP1. Int J Biochem Cell Biol. 2016;79:104-112 pubmed publisher
    ..Moreover, fibronectin type III domain containing 3B (FNDC3B) and catenin, beta interacting protein 1 (CTNNBIP1) were found to be direct targets of miR-215-5p...
  8. Tutter A, Fryer C, Jones K. Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro. Genes Dev. 2001;15:3342-54 pubmed
    ..LEF-1-beta-cat transactivation in vitro was also repressed by inhibitor of beta-catenin and Tcf-4 (ICAT), a physiological inhibitor of Wnt/Wg signaling that interacts with ARM repeats 11 and 12, and by the nonsteroidal ..
  9. Sekiya T, Nakamura T, Kazuki Y, Oshimura M, Kohu K, Tago K, et al. Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin. Cancer Res. 2002;62:3322-6 pubmed
    ..We have recently identified ICAT, a beta-catenin-interacting protein that interferes with the interaction between beta-catenin and TCF-4, thereby ..

More Information


  1. Strom A, Bonal C, Ashery Padan R, Hashimoto N, Campos M, Trumpp A, et al. Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development. 2007;134:2719-25 pubmed
    ..This provides new insights into the mechanisms of tumor pathogenesis and tumor suppression in the pancreas. ..
  2. Hasegawa Y, Iizuka Kogo A, Akiyama T, Senda T. High expression of Pitx-2 in the ICAT-deficient metanephros leads to developmental arrest. Acta Histochem Cytochem. 2010;43:51-9 pubmed publisher
    b>ICAT (Inhibitor of ?-catenin and T cell factor) inhibits the interaction between ?-catenin and TCF/LEF transcription factor and serves as a negative regulator of Wnt signaling...
  3. Campos M, Sánchez Arévalo Lobo V, Rodolosse A, Gottardi C, Mafficini A, Beghelli S, et al. ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours. Biochem J. 2013;451:395-405 pubmed publisher
    ..Using yeast two-hybrid screening, we identified ICAT (inhibitor of ?-catenin and Tcf4) as a novel Ptf1a interactor...
  4. Mu J, Pang Q, Guo Y, Chen J, Zeng W, Huang Y, et al. Functional implications of microRNA-215 in TGF-?1-induced phenotypic transition of mesangial cells by targeting CTNNBIP1. PLoS ONE. 2013;8:e58622 pubmed publisher
    ..Luciferase reporter assays were used to identify whether catenin-beta interacting protein 1 (CTNNBIP1) is a direct target of miR-215, which was predicted by bioinformatic analysis...
  5. Kanamori M, Sandy P, Marzinotto S, Benetti R, Kai C, Hayashizaki Y, et al. The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J Biol Chem. 2003;278:38758-64 pubmed
    ..These data suggest that TIP-1 may represent a novel regulatory element in the Wnt/beta-catenin signaling pathway. ..
  6. Perez V, Ali Z, Alastalo T, Ikeno F, Sawada H, Lai Y, et al. BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. J Cell Biol. 2011;192:171-88 pubmed publisher
    ..We speculate that, in response to injury, factors that subvert BMP-2-mediated tandem activation of Wnt-?C and Wnt-PCP pathways contribute to obliterative vascular disease in both the systemic and pulmonary circulations. ..
  7. Shin J, Shin Y, Oh S, Yang H, Yu W, Lee J, et al. MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/β-catenin signaling. Cell Death Dis. 2014;5:e1473 pubmed publisher
    ..accumulation in the nucleus, where it couples with T-cell factor (TCF), an association that is disrupted by ICAT (inhibitor of β-catenin and T cell factor)...