Gene Symbol: Ctnna3
Description: catenin (cadherin associated protein), alpha 3
Alias: 4930429L08Rik, 4933408A16, Catna3, Vr22, catenin alpha-3, alpha T-catenin, alpha-catenin-like protein, cadherin-associated protein, ctnna3
Species: mouse
Products:     Ctnna3

Top Publications

  1. Janssens B, Mohapatra B, Vatta M, Goossens S, Vanpoucke G, Kools P, et al. Assessment of the CTNNA3 gene encoding human alpha T-catenin regarding its involvement in dilated cardiomyopathy. Hum Genet. 2003;112:227-36 pubmed
    ..genomic clones, combined with database sequence analysis, we have been able to determine the structure of the CTNNA3 and Ctnna3 genes, encoding human and mouse alpha T-catenin, respectively...
  2. Vite A, Zhang C, Yi R, Emms S, Radice G. α-Catenin-dependent cytoskeletal tension controls Yap activity in the heart. Development. 2018;145: pubmed publisher
    ..the relationship between ICD maturation and proliferation, αE-catenin (Ctnna1) and αT-catenin (Ctnna3) genes were deleted to generate cardiac-specific α-catenin double knockout (DKO) mice...
  3. Fumoto K, Takigawa Imamura H, Sumiyama K, Kaneiwa T, Kikuchi A. Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition. Development. 2017;144:151-162 pubmed publisher
  4. Folmsbee S, Wilcox D, Tyberghein K, De Bleser P, Tourtellotte W, van Hengel J, et al. ?T-catenin in restricted brain cell types and its potential connection to autism. J Mol Psychiatry. 2016;4:2 pubmed publisher
    ..Recent genetic association studies have linked the cadherin-based adherens junction protein alpha-T-catenin (?T-cat, CTNNA3) with the development of autism...
  5. Tyberghein K, Goossens S, Haigh J, van Roy F, van Hengel J. Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice. Placenta. 2012;33:554-60 pubmed publisher
    Transcriptional activation of CTNNA3, encoding ?T-catenin, by the Y153H mutated form of the human STOX1 transcription factor was proposed to be responsible for altered fetal trophoblast invasion into the maternal endometrium during ..
  6. Goossens S, Janssens B, Vanpoucke G, De Rycke R, van Hengel J, van Roy F. Truncated isoform of mouse alphaT-catenin is testis-restricted in expression and function. FASEB J. 2007;21:647-55 pubmed
    ..In contrast to the standard full-length alphaT-catenin protein, this shortened isoform-X can bind to l-afadin, an important component of the nectin/afadin/ponsin adhesion complex that reportedly is essential for spermatogenesis. ..
  7. Talhouk R, Mroue R, Mokalled M, Abi Mosleh L, Nehme R, Ismail A, et al. Heterocellular interaction enhances recruitment of alpha and beta-catenins and ZO-2 into functional gap-junction complexes and induces gap junction-dependant differentiation of mammary epithelial cells. Exp Cell Res. 2008;314:3275-91 pubmed publisher
    ..This was concomitant with reduced nuclear beta-catenin, suggesting that differentiation in heterocellular cultures involves sequestration of beta-catenin in GJ complexes. ..
  8. Daneman R, Agalliu D, Zhou L, Kuhnert F, Kuo C, Barres B. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A. 2009;106:641-6 pubmed publisher
    ..Taken together these experiments reveal an essential role for Wnt/beta-catenin signaling in driving CNS-specific angiogenesis and provide molecular evidence that angiogenesis and BBB formation are in part linked. ..
  9. Choi H, Pokutta S, Cadwell G, Bobkov A, Bankston L, Liddington R, et al. ?E-catenin is an autoinhibited molecule that coactivates vinculin. Proc Natl Acad Sci U S A. 2012;109:8576-81 pubmed publisher
    ..The data also imply that ?E-catenin must be activated in order to bind to vinculin...

More Information


  1. Mashimo T, Erven A, Spiden S, Guenet J, Steel K. Two quantitative trait loci affecting progressive hearing loss in 101/H mice. Mamm Genome. 2006;17:841-50 pubmed
    ..Finally, we found some evidence of epistatic interaction between Phl1 and Phl2. ..
  2. Gavard J, Lambert M, Grosheva I, Marthiens V, Irinopoulou T, Riou J, et al. Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J Cell Sci. 2004;117:257-70 pubmed
    ..These results provide additional information on the mechanisms by which cadherin coordinates adhesion with dynamic changes in the cytoskeleton to control cell shape and intercellular junction organization. ..
  3. Li J, Goossens S, van Hengel J, Gao E, Cheng L, Tyberghein K, et al. Loss of ?T-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia. J Cell Sci. 2012;125:1058-67 pubmed publisher
    ..To investigate the role of ?T-catenin in the heart, gene targeting technology was used to delete the Ctnna3 gene, encoding ?T-catenin, in the mouse...
  4. Mazahery A, Suzuki K, Nagafuchi A, Miyajima M, Nakagata N, Orvis G, et al. Functional analysis of ectodermal ?-catenin during external genitalia formation. Congenit Anom (Kyoto). 2013;53:34-41 pubmed publisher
    ..Thus, ?-catenin is shown to perform dual functions, initially as an adhesion molecule and later on as a possible transcription factor. ..
  5. Folmsbee S, Morales Nebreda L, van Hengel J, Tyberghein K, van Roy F, Budinger G, et al. The cardiac protein αT-catenin contributes to chemical-induced asthma. Am J Physiol Lung Cell Mol Physiol. 2015;308:L253-8 pubmed publisher
    ..These data suggest that αT-cat may contribute to asthma through a mechanism independent of inflammation and related to heart and pulmonary vein dysfunction. ..
  6. Goossens S, Janssens B, Bonne S, De Rycke R, Braet F, van Hengel J, et al. A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs. J Cell Sci. 2007;120:2126-36 pubmed
    ..This could explain the devastating effect of plakophilin-2 mutations on cell junction stability in intercalated discs, which lead to cardiac muscle malfunction. ..
  7. Oidovsambuu O, Nyamsuren G, Liu S, Göring W, Engel W, Adham I. Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia. PLoS ONE. 2011;6:e25908 pubmed publisher
    ..These results suggest that VSIG1 is required for the establishment of glandular versus squamous epithelia in the stomach. ..
  8. Janssens B, Goossens S, Staes K, Gilbert B, van Hengel J, Colpaert C, et al. alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion. J Cell Sci. 2001;114:3177-88 pubmed
    ..We propose that alphaT-catenin is necessary for the formation of stretch-resistant cell-cell adhesion complexes, in particular, muscle cells. ..