Gene Symbol: Ctla2a
Description: cytotoxic T lymphocyte-associated protein 2 alpha
Alias: Ctla-2a, protein CTLA-2-alpha
Species: mouse
Products:     Ctla2a

Top Publications

  1. Denizot F, Brunet J, Roustan P, Harper K, Suzan M, Luciani M, et al. Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse activated T cells and mast cells and homologous to cysteine proteinase proregions. Eur J Immunol. 1989;19:631-5 pubmed
  2. Sugita S, Horie S, Nakamura O, Maruyama K, Takase H, Usui Y, et al. Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. J Immunol. 2009;183:5013-22 pubmed publisher
    ..In both EAU models, there was significant suppression of the ocular inflammation. These results indicate that RPE secretes CTLA-2alpha, thereby enabling the bystander T cells to be converted into Treg cells via TGF-beta promotion. ..
  3. Brunet J, Dosseto M, Denizot F, Mattei M, Clark W, Haqqi T, et al. The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14. Nature. 1986;322:268-71 pubmed
  4. Frankfort B, Gelman I. Identification of novel cellular genes transcriptionally suppressed by v-src. Biochem Biophys Res Commun. 1995;206:916-26 pubmed
    ..These data suggest that the down-regulation of some or all of these genes contributes to v-src-induced changes in mitogenic control or cell morphology. ..
  5. Yamamura H, Zhang M, Markwald R, Mjaatvedt C. A heart segmental defect in the anterior-posterior axis of a transgenic mutant mouse. Dev Biol. 1997;186:58-72 pubmed
    ..The hdf mouse mutation also provides a new model system to evaluate the molecular requirements of normal endocardial cushion formation and the segmental interactions that form the adult heart. ..
  6. Greenberg R, Allsopp R, Chin L, Morin G, DePinho R. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene. 1998;16:1723-30 pubmed
    ..The widespread expression of mTERT in primary cells and mouse tissues could explain the increased frequency of spontaneous immortalization of mouse cells in culture and tumorigenesis in vivo. ..
  7. Luziga C, Nakamura O, Deshapriya R, Usui M, Miyaji M, Wakimoto M, et al. Dendritic and axonal localization of cytotoxic T-lymphocyte antigen-2 alpha protein in mouse brain. Brain Res. 2008;1204:40-52 pubmed publisher
    ..The distribution pattern and functional considerations of CTLA-2alpha in the brain are discussed. ..
  8. Sugita S, Yamada Y, Horie S, Nakamura O, Ishidoh K, Yamamoto Y, et al. Induction of T regulatory cells by cytotoxic T-lymphocyte antigen-2? on corneal endothelial cells. Invest Ophthalmol Vis Sci. 2011;52:2598-605 pubmed publisher
    ..These findings indicate that cell surface CTLA-2? contributes to the CE-dependent suppression of bystander T cells. Thus, ocular resident tissue-exposed T cells can be induced to become regulators within the peripheral microenvironment. ..
  9. Zhang L, Yun H, Murray F, Lu R, Wang L, Hook V, et al. Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA. Cell Signal. 2011;23:1611-6 pubmed publisher

More Information


  1. Silva Vilches C, Pletinckx K, Lohnert M, Pavlovic V, Ashour D, John V, et al. Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion. PLoS ONE. 2017;12:e0178114 pubmed publisher
    ..The CT-induced and cAMP-mediated up-regulation of CTLA-2 also may point to a novel immune evasion mechanism of Vibrio cholerae. ..
  2. Nga B, Luziga C, Yamamoto M, Kusakabe K, Yamamoto Y. Identification and characterization of the interactive proteins with cytotoxic T-lymphocyte antigen-2α. Biosci Biotechnol Biochem. 2015;79:587-97 pubmed publisher
    ..A simple cell-based fluorescence assay revealed that CTLA-2α exhibited inhibitory activity toward cathepsin C in live cells, which indicated that CTLA-2α is a novel endogenous inhibitor of cathepsin C. ..
  3. Luziga C, Nga B, Mbassa G, Yamamoto Y. Cathepsin L coexists with Cytotoxic T-lymphocyte Antigen-2 alpha in distinct regions of the mouse brain. Acta Histochem. 2016;118:704-710 pubmed publisher
    ..The functional implication of cathespin L coexistence with CTLA-2? in relation to learning, memory and disease mechanisms is discussed. ..