Gene Symbol: CtIP
Description: retinoblastoma binding protein 8, endonuclease
Alias: 9930104E21Rik, CtIP, RBBP-8, RIM, SAE2, DNA endonuclease RBBP8, ctBP-interacting protein, retinoblastoma binding protein 8, sporulation in the absence of SPO11 protein 2 homolog
Species: mouse
Products:     CtIP

Top Publications

  1. Chen P, Liu F, Cai S, Lin X, Li A, Chen Y, et al. Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Mol Cell Biol. 2005;25:3535-42 pubmed
    b>CtIP interacts with a group of tumor suppressor proteins including RB (retinoblastoma protein), BRCA1, Ikaros, and CtBP, which regulate cell cycle progression through transcriptional repression as well as chromatin remodeling...
  2. Chinnadurai G. CtIP, a candidate tumor susceptibility gene is a team player with luminaries. Biochim Biophys Acta. 2006;1765:67-73 pubmed
    b>CtIP is a nuclear protein conserved among vertebrates that was discovered as a cofactor of the transcriptional corepressor CtBP...
  3. Bothmer A, Rommel P, Gazumyan A, Polato F, Reczek C, Muellenbeck M, et al. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med. 2013;210:115-23 pubmed publisher
    ..We find that resection depends on both CtBP-interacting protein (CtIP, Rbbp8) and exonuclease 1 (Exo1)...
  4. Zhang Y, Jasin M. An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway. Nat Struct Mol Biol. 2011;18:80-4 pubmed publisher
    ..Here we show that depletion of CtIP, a DNA end-resection factor, results in a substantial decrease in chromosomal translocation frequency in mouse ..
  5. Lee Theilen M, Matthews A, Kelly D, Zheng S, Chaudhuri J. CtIP promotes microhomology-mediated alternative end joining during class-switch recombination. Nat Struct Mol Biol. 2011;18:75-9 pubmed publisher
    ..Here, we show that the DNA end-processing factor CtIP is required for microhomology-directed A-NHEJ during CSR...
  6. Helmink B, Tubbs A, Dorsett Y, Bednarski J, Walker L, Feng Z, et al. H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature. 2011;469:245-9 pubmed publisher
    ..H2AX prevents nucleases other than Artemis from processing hairpin-sealed coding ends; in the absence of H2AX, CtIP can efficiently promote the hairpin opening and resection of DNA ends generated by RAG cleavage...
  7. Reczek C, Szabolcs M, Stark J, Ludwig T, Baer R. The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression. J Cell Biol. 2013;201:693-707 pubmed publisher
    The CtIP protein facilitates homology-directed repair (HDR) of double-strand DNA breaks (DSBs) by initiating DNA resection, a process in which DSB ends are converted into 3'-ssDNA overhangs...
  8. McCarthy E, Celebi J, Baer R, Ludwig T. Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability. Mol Cell Biol. 2003;23:5056-63 pubmed
  9. Makharashvili N, Tubbs A, Yang S, Wang H, Barton O, Zhou Y, et al. Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection. Mol Cell. 2014;54:1022-33 pubmed publisher
    ..CtIP) is known to function in 5' strand resection during homologous recombination, similar to the budding yeast Sae2 protein, but its role in this process is unclear...

More Information


  1. Patel A, Anderson J, Kraft D, Finnon R, Finnon P, Scudamore C, et al. The Influence of the CTIP Polymorphism, Q418P, on Homologous Recombination and Predisposition to Radiation-Induced Tumorigenesis (mainly rAML) in Mice. Radiat Res. 2016;186:638-649 pubmed publisher
    ..to radiation-induced AML (rAML): C-terminal binding protein (CTBP)-interacting protein (CTIP)/retinoblastoma binding protein 8 (RBBP8)...
  2. Snow J, Orkin S. Translational isoforms of FOG1 regulate GATA1-interacting complexes. J Biol Chem. 2009;284:29310-9 pubmed publisher
  3. Woodworth M, Greig L, Liu K, Ippolito G, Tucker H, Macklis J. Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers. Cell Rep. 2016;15:999-1012 pubmed publisher
    ..Therefore, Ctip1 couples subtype and area specification, enabling specific functional areas to organize precise ratios of appropriate output projections. ..
  4. Polato F, Callen E, Wong N, Faryabi R, Bunting S, Chen H, et al. CtIP-mediated resection is essential for viability and can operate independently of BRCA1. J Exp Med. 2014;211:1027-36 pubmed publisher
    ..DNA ends into 3' ssDNA overhangs; helicases such as BLM, which unwind DNA; and other proteins such as BRCA1 and CtIP whose functions remain unclear...
  5. Badie S, Carlos A, Folio C, Okamoto K, Bouwman P, Jonkers J, et al. BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres. EMBO J. 2015;34:410-24 pubmed publisher
    ..Here, we show that the tumour suppressor BRCA1, together with its interacting partner CtIP, both acting in end resection, also promotes end-joining of uncapped telomeres...
  6. Reczek C, Shakya R, Miteva Y, Szabolcs M, Ludwig T, Baer R. The DNA resection protein CtIP promotes mammary tumorigenesis. Oncotarget. 2016;7:32172-83 pubmed publisher
    Many DNA repair factors act to suppress tumor formation by preserving genomic stability. Similarly, the CtIP protein, which interacts with the BRCA1 tumor suppressor, is also thought to have tumor suppression activity...
  7. Gomez Cabello D, Checa Rodríguez C, Abad M, Serrano M, Huertas P. CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells. Stem Cell Reports. 2017;8:432-445 pubmed publisher
    ..Moreover, the resection factor CtIP is essential for cell reprogramming and establishment of iPSCs, probably to repair reprogramming-induced DNA damage...
  8. Nakamura K, Kosugi I, Lee D, Hafner A, Sinclair D, Ryo A, et al. Prolyl isomerase Pin1 regulates neuronal differentiation via ?-catenin. Mol Cell Biol. 2012;32:2966-78 pubmed publisher
  9. Liu F, Lee W. CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression. Mol Cell Biol. 2006;26:3124-34 pubmed
    ..Previously we showed that the presence of CtIP is essential for G(1)/S transition in primary mouse blastocysts, as well as in NIH 3T3 cells...
  10. Darakhshan F, Badie C, Moody J, Coster M, Finnon R, Finnon P, et al. Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay. Carcinogenesis. 2006;27:311-8 pubmed
    ..This study demonstrates the strength of utilizing surrogate endpoints of cancer susceptibility in the mapping of mouse loci and identifies additional loci that may affect radiation cancer risk. ..