Ctf1

Summary

Gene Symbol: Ctf1
Description: cardiotrophin 1
Alias: CT-1, cardiotrophin-1
Species: mouse

Top Publications

  1. pmc Cardiotrophin-1 (CT-1): a novel hypertrophic and cardioprotective agent
    D S Latchman
    Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, London, UK
    Int J Exp Pathol 80:189-96. 1999
  2. ncbi Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1
    Fanie Barnabe-Heider
    Developmental Biology, University of Toronto, Toronto M5G 1X8, Canada
    Neuron 48:253-65. 2005
  3. ncbi Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons
    R W Oppenheim
    Department of Neurobiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 21:1283-91. 2001
  4. doi Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model
    M Jiménez-González
    Division of Oncology, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain
    Diabetologia 56:838-46. 2013
  5. doi Absence of cardiotrophin 1 is associated with decreased age-dependent arterial stiffness and increased longevity in mice
    Natalia Lopez-Andres
    Institut National de la Sante et de la Recherche Medicale, U961, Faculty of Medicine, Vandoeuvre les Nancy, France
    Hypertension 61:120-9. 2013
  6. doi A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone
    Natalia Lopez-Andres
    U, Faculty of Medicine, Institut National de la Sante et de la Recherche Medicale, Vandoeuvre les Nancy, France
    Am J Physiol Heart Circ Physiol 301:H2372-82. 2011
  7. doi HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia
    Pablo A Robador
    Division of Cardiovascular Sciences, Center for Applied Medical Research, University of Navarra, Avda Pio XII 55, 31008 Pamplona, Spain
    Cardiovasc Res 92:247-55. 2011
  8. ncbi Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species
    Bernadette Ateghang
    Department of Physiology, University of Giessen, 35392 Giessen, Germany
    J Cell Sci 119:1043-52. 2006
  9. pmc The lack of cardiotrophin-1 alters expression of interleukin-6 and leukemia inhibitory factor mRNA but does not impair cardiac injury response
    Kurt Gritman
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA
    Cytokine 36:9-16. 2006
  10. pmc Cardiotrophin-1 defends the liver against ischemia-reperfusion injury and mediates the protective effect of ischemic preconditioning
    María Iñiguez
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research CIMA, Clinica Universitaria and Medical School, University of Navarra, Pamplona 31008, Spain
    J Exp Med 203:2809-15. 2006

Scientific Experts

  • A L Gard
  • C D Richards
  • Natalia Lopez-Andres
  • Javier Diez
  • Diane Pennica
  • Bettina Holtmann
  • D Pennica
  • María Antonia Fortuño
  • Matilde Bustos
  • Jesus Prieto
  • Michael Sendtner
  • M Jiménez-González
  • Heinrich Sauer
  • Faiez Zannad
  • Patrick Rossignol
  • Pablo A Robador
  • Maria J Moreno-Aliaga
  • Tetsuaki Miyake
  • Cristina Natal
  • Emma C Walker
  • Juan M Marqués
  • Stephan Oberle
  • María Iñiguez
  • Kurt Gritman
  • Bernadette Ateghang
  • Thorsten Maretzky
  • Fanie Barnabe-Heider
  • Maria Wartenberg
  • Damien Derouet
  • Renaud Fay
  • F Jaques
  • P A Halban
  • J Salvador
  • Carlos Labat
  • Athanase Benetos
  • M Barajas
  • Laurent Calvier
  • R M Príncipe
  • A Porciuncula
  • M Iniguez
  • J Escalada
  • S Rodriguez
  • G Abizanda
  • Patrick Lacolley
  • F Prosper
  • V Arce
  • R W Oppenheim
  • Cristina Rodriguez
  • Jose Martinez-Gonzalez
  • Guillermo Zalba
  • Gorka San José
  • Vicente Lahera
  • Victoria Cachofeiro
  • Ana Fortuno
  • Eduardo Larequi
  • Javier Beaumont
  • Beatriz Martín-Fernández
  • Maria U Moreno
  • J Alfredo Martinez
  • Anna Guadall
  • Beatriz Marcos-Gómez
  • Francisco Javier Gil-Bea
  • Benoit Viollet
  • Nerea Pérez-Echarri
  • Ignacio Gimenez
  • M Funamoto
  • Lynn A Megeney
  • Nezeka S Alli
  • Arif Aziz
  • John C McDermott
  • Pasan Fernando
  • Jennifer Knudson
  • Immaculada Colina
  • T John Martin
  • Sueli Pompolo
  • Patricia Restituto
  • D S Latchman
  • Antonio Bazán
  • Idoia Gallego
  • Matthew T Gillespie
  • Nerea Varo
  • Julian M W Quinn
  • Natalie A Sims
  • Carmen Iñigo
  • Ingrid J Poulton
  • Narelle E McGregor
  • Elizabeth H Allan
  • M Armanini
  • Idoia Belza
  • Eduardo Martinez-Ansó

Detail Information

Publications30

  1. pmc Cardiotrophin-1 (CT-1): a novel hypertrophic and cardioprotective agent
    D S Latchman
    Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, London, UK
    Int J Exp Pathol 80:189-96. 1999
    ..CT-1 may therefore be of use as a novel cardio-protective agent, particularly if its hypertrophic effect can be specifically inhibited...
  2. ncbi Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1
    Fanie Barnabe-Heider
    Developmental Biology, University of Toronto, Toronto M5G 1X8, Canada
    Neuron 48:253-65. 2005
    ....
  3. ncbi Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons
    R W Oppenheim
    Department of Neurobiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 21:1283-91. 2001
    ..CT-1 is the first bona fide muscle-derived neurotrophic factor to be identified that is required for the survival of subgroups of developing motoneurons...
  4. doi Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model
    M Jiménez-González
    Division of Oncology, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain
    Diabetologia 56:838-46. 2013
    b>Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in apoptotic protection of cardiomyocytes and heart hypertrophy...
  5. doi Absence of cardiotrophin 1 is associated with decreased age-dependent arterial stiffness and increased longevity in mice
    Natalia Lopez-Andres
    Institut National de la Sante et de la Recherche Medicale, U961, Faculty of Medicine, Vandoeuvre les Nancy, France
    Hypertension 61:120-9. 2013
    b>Cardiotrophin 1 (CT-1), an interleukin 6 family member, promotes fibrosis and arterial stiffness. We hypothesized that the absence of CT-1 influences arterial fibrosis and stiffness, senescence, and life span...
  6. doi A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone
    Natalia Lopez-Andres
    U, Faculty of Medicine, Institut National de la Sante et de la Recherche Medicale, Vandoeuvre les Nancy, France
    Am J Physiol Heart Circ Physiol 301:H2372-82. 2011
    ..CT-1-null mice were resistant to Aldo-induced LVH and fibrosis. These data suggest a key role for CT-1 in cardiac remodeling induced by Aldo independent of changes in blood pressure levels...
  7. doi HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia
    Pablo A Robador
    Division of Cardiovascular Sciences, Center for Applied Medical Research, University of Navarra, Avda Pio XII 55, 31008 Pamplona, Spain
    Cardiovasc Res 92:247-55. 2011
    ..However, no evidence for a direct regulation of CT-1 gene (CTF1) promoter by hypoxia inducible factor-1 (HIF-1) has been provided.
  8. ncbi Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species
    Bernadette Ateghang
    Department of Physiology, University of Giessen, 35392 Giessen, Germany
    J Cell Sci 119:1043-52. 2006
    ..Our results demonstrate that CT-1 expression in ES cells is regulated by ROS and HIF-1alpha and imply a crucial role of CT-1 in the survival and proliferation of ES-cell-derived cardiac cells...
  9. pmc The lack of cardiotrophin-1 alters expression of interleukin-6 and leukemia inhibitory factor mRNA but does not impair cardiac injury response
    Kurt Gritman
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA
    Cytokine 36:9-16. 2006
    ....
  10. pmc Cardiotrophin-1 defends the liver against ischemia-reperfusion injury and mediates the protective effect of ischemic preconditioning
    María Iñiguez
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research CIMA, Clinica Universitaria and Medical School, University of Navarra, Pamplona 31008, Spain
    J Exp Med 203:2809-15. 2006
    ..In conclusion, CT-1 is an essential endogenous defense of the liver against I/R and is a key mediator of the protective effect induced by IP...
  11. ncbi Cardiotrophin-1 is an essential factor in the natural defense of the liver against apoptosis
    Juan M Marqués
    Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Navarra, Spain
    Hepatology 45:639-48. 2007
    ..All of them were down-regulated in CT-1-/- mice and were modulated by CT-1 administration. Treatment of CT-1-/- animals with the calpain inhibitor MDL28170 afforded significant protection against Fas-induced liver injury...
  12. ncbi Cardiotrophin-1 is expressed in adipose tissue and upregulated in the metabolic syndrome
    Cristina Natal
    Division of Cardiovascular Sciences, Center for Applied Medical Research, University of Navarra, Avda Pio XII 55, 31008 Pamplona, Spain
    Am J Physiol Endocrinol Metab 294:E52-60. 2008
    ..2, P < 0.05). Taken together, our data suggest that adipose tissue can be recognized as a source of CT-1, which could account for the high circulating levels of CT-1 in patients with MS...
  13. doi Aldosterone induces cardiotrophin-1 expression in HL-1 adult cardiomyocytes
    Natalia Lopez-Andres
    Centre for Applied Medical Research, Department of Cardiology and Cardiovascular Surgery, University Clinic, Universidad de Navarra, Avenida Pio XII, 55, 31008 Pamplona, Spain
    Endocrinology 149:4970-8. 2008
    ..In summary, ALDO induces CT-1 expression in adult HL-1 cardiomyocytes via genomic and nongenomic mechanisms. CT-1 up-regulation could have relevance in the direct hypertrophic effects of ALDO in cardiomyocytes...
  14. doi Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling
    Emma C Walker
    St Vincent s Institute, Fitzroy, Victoria, Australia
    J Bone Miner Res 23:2025-32. 2008
    ..CT-1 may now be classed as an essential osteoclast-derived stimulus of both bone formation and resorption...
  15. pmc Cardiotrophin-1 maintains the undifferentiated state in skeletal myoblasts
    Tetsuaki Miyake
    Department of Biology, York University, Toronto, Ontario M3J 1P3, Canada
    J Biol Chem 284:19679-93. 2009
    ..The expression pattern of CT-1 in embryonic and post-natal skeletal muscle and in vivo effects of CT-1 on myogenesis implicate CT-1 in the maintenance of the undifferentiated state in muscle progenitor cells...
  16. doi Cardiotrophin-1 is a key regulator of glucose and lipid metabolism
    Maria J Moreno-Aliaga
    Department of Nutrition, Food Sciences, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain
    Cell Metab 14:242-53. 2011
    ..We conclude that CT-1 is a master regulator of fat and glucose metabolism with potential applications for treatment of obesity and insulin resistance...
  17. ncbi Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla
    Stephan Oberle
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 26:1823-32. 2006
    ..Thus, both somatic motoneurons and PSNs in the spinal cord depend on LIFRbeta signaling for their development and maintenance, although PSNs seem to be overall less affected than somatic motoneurons by LIFRbeta deprivation...
  18. pmc ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation
    Thorsten Maretzky
    Biochemical Institute and Department of Dermatology, Christian Albrechts University Kiel, D 24098 Kiel, Germany
    Proc Natl Acad Sci U S A 102:9182-7. 2005
    ..Our data strongly suggest that this protease constitutes a major regulatory element for the multiple functions of E-cadherin under physiological as well as pathological conditions...
  19. ncbi cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of CT-1 gene in ventricle of genetically hypertensive rats
    M Ishikawa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Japan
    Biochem Biophys Res Commun 219:377-81. 1996
    ....
  20. ncbi Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival
    Z Sheng
    Department of Medicine, Center for Molecular Genetics, University of California, San Diego, School of Medicine, La Jolla, 92093 0613, USA
    Development 122:419-28. 1996
    ..Thus, CT-1 may play an autocrine role during cardiac chamber growth and morphogenesis by promoting the survival and proliferation of immature myocytes, most likely via gp130-dependent signaling pathways...
  21. ncbi Cardiotrophin-1, a cytokine present in embryonic muscle, supports long-term survival of spinal motoneurons
    D Pennica
    Department of Molecular Biology, Genentech Incorporated, South San Francisco, California 94080, USA
    Neuron 17:63-74. 1996
    ..CT-1 may be important in normal motoneuron development and as a potential tool for slowing motoneuron degeneration in human diseases...
  22. ncbi Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization
    D Pennica
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080, USA
    Cytokine 8:183-9. 1996
    ..7 kb CT-1 mRNA is expressed in adult human heart, skeletal muscle, ovary, colon, prostate and testis and in fetal kidney and lung. The coding region of CT-1 is contained on three exons and is located on human chromosome 16p11.1-16p11.2...
  23. ncbi Regulation of tissue inhibitor of metalloproteinase-1 in fibroblasts and acute phase proteins in hepatocytes in vitro by mouse oncostatin M, cardiotrophin-1, and IL-6
    C D Richards
    Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    J Immunol 159:2431-7. 1997
    ..These results also suggest that mOSM is an important cytokine in inflammation, through modulation of fibroblast function as well as hepatocyte responses...
  24. ncbi Synergistic effects of schwann- and muscle-derived factors on motoneuron survival involve GDNF and cardiotrophin-1 (CT-1)
    V Arce
    Institut National de la Santé et de la Recherche Médicale INSERM U 382, Marseille, France
    J Neurosci 18:1440-8. 1998
    ..The possibility that they act together on individual motoneurons suggests that the motoneuron must integrate distinct signals from different cellular partners when deciding whether to die or to survive...
  25. ncbi Isolation and characterization of the murine cardiotrophin-1 gene: expression and norepinephrine-induced transcriptional activation
    M Funamoto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871, Japan
    J Mol Cell Cardiol 32:1275-84. 2000
    ..These data suggest that the CT-1 gene expression is regulated, at least partially, by transcriptional machinery...
  26. ncbi Involvement of reactive oxygen species in cardiotrophin-1-induced proliferation of cardiomyocytes differentiated from murine embryonic stem cells
    Heinrich Sauer
    Department of Neurophysiology, University of Cologne, D 50931 Cologne, Germany
    Exp Cell Res 294:313-24. 2004
    ..It is concluded that CT-1 stimulates the proliferation of ES cell-derived cardiomyocytes by signaling pathways that involve ROS as signaling molecules in the signal transduction cascade...
  27. pmc Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor
    Damien Derouet
    Institut National de la Sante et de la Recherche Medicale U564, Centre Hospitalier Universitaire d Angers, 4 rue Larrey, 49033 Angers, France
    Proc Natl Acad Sci U S A 101:4827-32. 2004
    ..Thus, NP is a new ligand for CNTFRalpha, with important implications for murine nervous system development...
  28. ncbi Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system
    A L Gard
    Department of Cell Biology and Neuroscience, 2038 Medical Sciences Building, University of South Alabama College of Medicine, Mobile, AL 36688 0002, USA
    Neuroscience 127:43-52. 2004
    ..A rationale for studies examining CT-1-deficient mice in these respects is provided by the data...
  29. ncbi Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function
    Bettina Holtmann
    The Institute for Clinical Neurobiology, Department of Neurology, D 97080 Wuerzburg, Germany
    J Neurosci 25:1778-87. 2005
    ....
  30. pmc Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy
    D Pennica
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    Proc Natl Acad Sci U S A 92:1142-6. 1995
    ..5-kDa protein, cardiotrophin 1, that potently induces cardiac myocyte hypertrophy in vitro...