| CtcflGene Symbol: Ctcfl Description: CCCTC-binding factor (zinc finger protein)-like Alias: Boris, transcriptional repressor CTCFL, BORIS, Brother of the regulator of imprinted sites, CTCF paralog, CTCF-like protein, likely orthologue of H. sapiens CCCTC-binding factor-like protein (CTCFL) Species: mouse Loukinov D, Pugacheva E, Vatolin S, Pack S, Moon H, Chernukhin I, et al. BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A. 2002;99:6806-11 pubmed ..We named this gene BORIS for Brother of the Regulator of Imprinted Sites. BORIS is present only in the testis, and expressed in a mutually exclusive manner with CTCF .. Nguyen P, Cui H, Bisht K, Sun L, Patel K, Lee R, et al. CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region. Cancer Res. 2008;68:5546-51 pubmed publisher The CTCF paralog BORIS (brother of the regulator of imprinted sites) is an insulator DNA-binding protein thought to play a role in chromatin organization and gene expression... Suzuki T, Kosaka Suzuki N, Pack S, Shin D, Yoon J, Abdullaev Z, et al. Expression of a testis-specific form of Gal3st1 (CST), a gene essential for spermatogenesis, is regulated by the CTCF paralogous gene BORIS. Mol Cell Biol. 2010;30:2473-84 pubmed publisher Previously, it was shown that the CTCF paralogous gene, BORIS (brother of the regulator of imprinted sites) is expressed in male germ cells, but its function in spermatogenesis has not been defined... van de Nobelen S, Rosa Garrido M, Leers J, Heath H, Soochit W, Joosen L, et al. CTCF regulates the local epigenetic state of ribosomal DNA repeats. Epigenetics Chromatin. 2010;3:19 pubmed publisher ..Interestingly, CTCFL, the testis-specific paralog of CTCF, also binds UBF... Jones T, Ogunkolade B, Szary J, Aarum J, Mumin M, Patel S, et al. Widespread expression of BORIS/CTCFL in normal and cancer cells. PLoS ONE. 2011;6:e22399 pubmed publisher b>BORIS (CTCFL) is the paralog of CTCF (CCCTC-binding factor; NM_006565), a ubiquitously expressed DNA-binding protein with diverse roles in gene expression and chromatin organisation... Jelinic P, Stehle J, Shaw P. The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation. PLoS Biol. 2006;4:e355 pubmed ..We demonstrate that CTCFL/BORIS, a paralog of CTCF, is an ICR-binding protein expressed during embryonic male germ cell development, .. Nguyen P, Bar Sela G, Sun L, Bisht K, Cui H, Kohn E, et al. BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression. Mol Cell Biol. 2008;28:6720-9 pubmed publisher ..BORIS (brother of the regulator of imprinted sites) is an insulator DNA-binding protein that is thought to play a role in chromatin organization .. Tamminga J, Kathiria P, Koturbash I, Kovalchuk O. DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation. Cell Cycle. 2008;7:3731-6 pubmed ..We found that miR-709 targets the Brother of the Regulator of Imprinted Sites (BORIS), an important regulator of DNA methylation and imprinting... Kosaka Suzuki N, Suzuki T, Pugacheva E, Vostrov A, Morse H, Loukinov D, et al. Transcription factor BORIS (Brother of the Regulator of Imprinted Sites) directly induces expression of a cancer-testis antigen, TSP50, through regulated binding of BORIS to the promoter. J Biol Chem. 2011;286:27378-88 pubmed publisher ..protease 50 (TSP50) and the testis-specific paralogue of CCCTC-binding factor, BORIS (brother of the regulator of imprinted sites)...
| |
