Ctcf

Summary

Gene Symbol: Ctcf
Description: CCCTC-binding factor
Alias: AW108038, transcriptional repressor CTCF, 11-zinc finger protein, CTCFL paralog
Species: mouse
Products:     Ctcf

Top Publications

  1. Wu D, Li T, Lu Z, Dai W, Xu M, Lu L. Effect of CTCF-binding motif on regulation of PAX6 transcription. Invest Ophthalmol Vis Sci. 2006;47:2422-9 pubmed
    Previous studies indicate that the CCCTC binding transcription factor (CTCF) regulates homeobox PAX6 gene transcription in corneal epithelial cells...
  2. Jelinic P, Stehle J, Shaw P. The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation. PLoS Biol. 2006;4:e355 pubmed
    ..We demonstrate that CTCFL/BORIS, a paralog of CTCF, is an ICR-binding protein expressed during embryonic male germ cell development, coinciding with the timing of ICR ..
  3. Pant V, Mariano P, Kanduri C, Mattsson A, Lobanenkov V, Heuchel R, et al. The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains. Genes Dev. 2003;17:586-90 pubmed
    ..Igf2 allele has been proposed to depend on a methylation-sensitive chromatin insulator organized by the 11 zinc finger protein CTCF at the H19 imprinting control region (ICR)...
  4. Donohoe M, Zhang L, Xu N, Shi Y, Lee J. Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell. 2007;25:43-56 pubmed
    ..Although no proven trans-acting factors have been identified, a likely candidate is Ctcf, a chromatin insulator with essential function in autosomal imprinting...
  5. Guastafierro T, Cecchinelli B, Zampieri M, Reale A, Riggio G, Sthandier O, et al. CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery. J Biol Chem. 2008;283:21873-80 pubmed publisher
    ..Here we show that transient ectopic overexpression of CCCTC-binding factor (CTCF) induces PAR accumulation, PARP-1, and CTCF poly(ADP-ribosyl)ation in the same mouse fibroblasts...
  6. Degner S, Verma Gaur J, Wong T, Bossen C, Iverson G, Torkamani A, et al. CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. Proc Natl Acad Sci U S A. 2011;108:9566-71 pubmed publisher
    ..Because CCCTC-binding factor (CTCF) has been demonstrated to be involved in long-range chromosomal interactions, we hypothesized that CTCF may promote ..
  7. Chao W, Huynh K, Spencer R, Davidow L, Lee J. CTCF, a candidate trans-acting factor for X-inactivation choice. Science. 2002;295:345-7 pubmed
    ..Here, we identify the insulator and transcription factor, CTCF, as a candidate trans-acting factor for X-chromosome selection...
  8. Li T, Hu J, Qiu X, Ling J, Chen H, Wang S, et al. CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop. Mol Cell Biol. 2008;28:6473-82 pubmed publisher
    b>CTCF is a zinc finger DNA-binding protein that regulates the epigenetic states of numerous target genes...
  9. Wan L, Pan H, Hannenhalli S, Cheng Y, Ma J, Fedoriw A, et al. Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. Development. 2008;135:2729-38 pubmed publisher
    b>CTCF is a multifunctional nuclear factor involved in epigenetic regulation...
  10. Parelho V, Hadjur S, Spivakov M, Leleu M, Sauer S, Gregson H, et al. Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell. 2008;132:422-33 pubmed publisher
    ..occupy a subset of DNase I hypersensitive sites, many of which contain sequence motifs resembling the consensus for CTCF, a DNA-binding protein with enhancer blocking function and boundary-element activity...

Detail Information

Publications82

  1. Wu D, Li T, Lu Z, Dai W, Xu M, Lu L. Effect of CTCF-binding motif on regulation of PAX6 transcription. Invest Ophthalmol Vis Sci. 2006;47:2422-9 pubmed
    Previous studies indicate that the CCCTC binding transcription factor (CTCF) regulates homeobox PAX6 gene transcription in corneal epithelial cells...
  2. Jelinic P, Stehle J, Shaw P. The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation. PLoS Biol. 2006;4:e355 pubmed
    ..We demonstrate that CTCFL/BORIS, a paralog of CTCF, is an ICR-binding protein expressed during embryonic male germ cell development, coinciding with the timing of ICR ..
  3. Pant V, Mariano P, Kanduri C, Mattsson A, Lobanenkov V, Heuchel R, et al. The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains. Genes Dev. 2003;17:586-90 pubmed
    ..Igf2 allele has been proposed to depend on a methylation-sensitive chromatin insulator organized by the 11 zinc finger protein CTCF at the H19 imprinting control region (ICR)...
  4. Donohoe M, Zhang L, Xu N, Shi Y, Lee J. Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell. 2007;25:43-56 pubmed
    ..Although no proven trans-acting factors have been identified, a likely candidate is Ctcf, a chromatin insulator with essential function in autosomal imprinting...
  5. Guastafierro T, Cecchinelli B, Zampieri M, Reale A, Riggio G, Sthandier O, et al. CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery. J Biol Chem. 2008;283:21873-80 pubmed publisher
    ..Here we show that transient ectopic overexpression of CCCTC-binding factor (CTCF) induces PAR accumulation, PARP-1, and CTCF poly(ADP-ribosyl)ation in the same mouse fibroblasts...
  6. Degner S, Verma Gaur J, Wong T, Bossen C, Iverson G, Torkamani A, et al. CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. Proc Natl Acad Sci U S A. 2011;108:9566-71 pubmed publisher
    ..Because CCCTC-binding factor (CTCF) has been demonstrated to be involved in long-range chromosomal interactions, we hypothesized that CTCF may promote ..
  7. Chao W, Huynh K, Spencer R, Davidow L, Lee J. CTCF, a candidate trans-acting factor for X-inactivation choice. Science. 2002;295:345-7 pubmed
    ..Here, we identify the insulator and transcription factor, CTCF, as a candidate trans-acting factor for X-chromosome selection...
  8. Li T, Hu J, Qiu X, Ling J, Chen H, Wang S, et al. CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop. Mol Cell Biol. 2008;28:6473-82 pubmed publisher
    b>CTCF is a zinc finger DNA-binding protein that regulates the epigenetic states of numerous target genes...
  9. Wan L, Pan H, Hannenhalli S, Cheng Y, Ma J, Fedoriw A, et al. Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. Development. 2008;135:2729-38 pubmed publisher
    b>CTCF is a multifunctional nuclear factor involved in epigenetic regulation...
  10. Parelho V, Hadjur S, Spivakov M, Leleu M, Sauer S, Gregson H, et al. Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell. 2008;132:422-33 pubmed publisher
    ..occupy a subset of DNase I hypersensitive sites, many of which contain sequence motifs resembling the consensus for CTCF, a DNA-binding protein with enhancer blocking function and boundary-element activity...
  11. Han L, Lee D, SZABO P. CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region. Mol Cell Biol. 2008;28:1124-35 pubmed
    ..b>CTCF protein binding in the ICR is required in the maternal chromosome for insulating Igf2 from the shared enhancers, ..
  12. Splinter E, Heath H, Kooren J, Palstra R, Klous P, Grosveld F, et al. CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev. 2006;20:2349-54 pubmed
    b>CTCF (CCCTC-binding factor) binds sites around the mouse beta-globin locus that spatially cluster in the erythroid cell nucleus...
  13. SZABO P, Tang S, Silva F, Tsark W, Mann J. Role of CTCF binding sites in the Igf2/H19 imprinting control region. Mol Cell Biol. 2004;24:4791-800 pubmed
    ..In somatic cells, the hypomethylated maternally inherited ICR binds the insulator protein CTCF at four sites and blocks activity of the proximal Igf2 promoter by insulating it from its distal enhancers...
  14. Lutz M, Burke L, Barreto G, Goeman F, Greb H, Arnold R, et al. Transcriptional repression by the insulator protein CTCF involves histone deacetylases. Nucleic Acids Res. 2000;28:1707-13 pubmed
    The highly conserved zinc-finger protein, CTCF, is a candidate tumor suppressor protein that binds to highly divergent DNA sequences...
  15. Ishihara K, Oshimura M, Nakao M. CTCF-dependent chromatin insulator is linked to epigenetic remodeling. Mol Cell. 2006;23:733-42 pubmed
    ..Here, we show that the SNF2-like chromodomain helicase protein CHD8 interacts with the insulator binding protein CTCF. Chromatin immunoprecipitation analysis revealed that CHD8 was present at known CTCF target sites, such as the ..
  16. Ling J, Li T, Hu J, Vu T, Chen H, Qiu X, et al. CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1. Science. 2006;312:269-72 pubmed
    ..Omission of CCCTC-binding factor (CTCF) or deletion of the maternal ICR abrogated this association and altered Wsb1/Nf1 gene expression...
  17. Yu W, Ginjala V, Pant V, Chernukhin I, Whitehead J, Docquier F, et al. Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nat Genet. 2004;36:1105-10 pubmed
    ..We show that the chromatin insulator protein CTCF carries a post-translational modification: poly(ADP-ribosyl)ation...
  18. Filippova G, Fagerlie S, Klenova E, Myers C, Dehner Y, Goodwin G, et al. An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol Cell Biol. 1996;16:2802-13 pubmed
    We have isolated and analyzed human CTCF cDNA clones and show here that the ubiquitously expressed 11-zinc-finger factor CTCF is an exceptionally highly conserved protein displaying 93% identity between avian and human amino acid ..
  19. Loukinov D, Pugacheva E, Vatolin S, Pack S, Moon H, Chernukhin I, et al. BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A. 2002;99:6806-11 pubmed
    b>CTCF, a conserved, ubiquitous, and highly versatile 11-zinc-finger factor involved in various aspects of gene regulation, forms methylation-sensitive insulators that regulate X chromosome inactivation and expression of imprinted genes...
  20. Fedoriw A, Stein P, Svoboda P, Schultz R, Bartolomei M. Transgenic RNAi reveals essential function for CTCF in H19 gene imprinting. Science. 2004;303:238-40 pubmed
    ..Insulin-like growth factor 2 expression involves binding of the vertebrate insulator protein, CCCTC binding factor (CTCF), to the maternally hypomethylated differentially methylated domain (DMD)...
  21. Filippova G, Cheng M, Moore J, Truong J, Hu Y, Nguyen D, et al. Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. Dev Cell. 2005;8:31-42 pubmed
    ..We report that the 5' end of Jarid1c, a mouse escape gene adjacent to an inactivated gene, binds CTCF, displays high levels of histone H3 acetylation, and functions as a CTCF-dependent chromatin insulator...
  22. Degner S, Wong T, Jankevicius G, Feeney A. Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development. J Immunol. 2009;182:44-8 pubmed
    ..5 Mb in each locus, in proximity to DJ(H) or J(kappa) genes. CCCTC-binding factor (CTCF) is a transcription factor that regulates gene expression by long-range chromosomal looping...
  23. MacPherson M, Beatty L, Zhou W, Du M, Sadowski P. The CTCF insulator protein is posttranslationally modified by SUMO. Mol Cell Biol. 2009;29:714-25 pubmed publisher
    The CTCF protein is a highly conserved zinc finger protein that is implicated in many aspects of gene regulation and nuclear organization. Its functions include the ability to act as a repressor of genes, including the c-myc oncogene...
  24. Heath H, Ribeiro de Almeida C, Sleutels F, Dingjan G, van de Nobelen S, Jonkers I, et al. CTCF regulates cell cycle progression of alphabeta T cells in the thymus. EMBO J. 2008;27:2839-50 pubmed publisher
    The 11-zinc finger protein CCCTC-binding factor (CTCF) is a highly conserved protein, involved in imprinting, long-range chromatin interactions and transcription...
  25. Schoenherr C, Levorse J, Tilghman S. CTCF maintains differential methylation at the Igf2/H19 locus. Nat Genet. 2003;33:66-9 pubmed
    ..One candidate regulator of methylation, the zinc-finger protein CTCF, binds to the imprinting control region (ICR) of the genes Igf2 (encoding insulin-like growth factor 2) and H19 (..
  26. Xu N, Donohoe M, Silva S, Lee J. Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein. Nat Genet. 2007;39:1390-6 pubmed
    ..However, a common denominator among them is the presence of the protein Ctcf, a chromatin insulator that we find to be essential for pairing...
  27. Burke L, Zhang R, Bartkuhn M, Tiwari V, Tavoosidana G, Kurukuti S, et al. CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin. EMBO J. 2005;24:3291-300 pubmed
    ..For the zinc-finger protein CTCF, a role in interpreting and propagating epigenetic states and in separating expression domains has been documented...
  28. Pant V, Kurukuti S, Pugacheva E, Shamsuddin S, Mariano P, Renkawitz R, et al. Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance. Mol Cell Biol. 2004;24:3497-504 pubmed
    ..shown that maternal inheritance of mutated (three of the four) target sites for the 11-zinc finger protein CTCF leads to loss of Igf2 imprinting...
  29. MacPherson M, Sadowski P. The CTCF insulator protein forms an unusual DNA structure. BMC Mol Biol. 2010;11:101 pubmed publisher
    The CTCF insulator protein is a highly conserved zinc finger protein that has been implicated in many aspects of gene regulation and nuclear organization. The protein has been hypothesized to organize the human genome by forming DNA loops...
  30. Kurukuti S, Tiwari V, Tavoosidana G, Pugacheva E, Murrell A, Zhao Z, et al. CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A. 2006;103:10684-9 pubmed
    ..the H19 imprinting control region (ICR) directs the silencing of the maternally inherited Igf2 allele through a CTCF-dependent chromatin insulator...
  31. Min H, Kong K, Lee J, Hong C, Seo S, Roh T, et al. CTCF-mediated Chromatin Loop for the Posterior Hoxc Gene Expression in MEF Cells. IUBMB Life. 2016;68:436-44 pubmed publisher
    ..CCCTC-binding factor (CTCF)-mediated chromatin organization is now recognized as a crucial epigenetic mechanism for transcriptional regulation...
  32. Sams D, Nardone S, Getselter D, Raz D, Tal M, Rayi P, et al. Neuronal CTCF Is Necessary for Basal and Experience-Dependent Gene Regulation, Memory Formation, and Genomic Structure of BDNF and Arc. Cell Rep. 2016;17:2418-2430 pubmed publisher
    CCCTC-binding factor (CTCF) is an organizer of higher-order chromatin structure and regulates gene expression. Genetic studies have implicated mutations in CTCF in intellectual disabilities...
  33. Tang M, Chen B, Lin T, Li Z, Pardo C, Pampo C, et al. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci U S A. 2011;108:15231-6 pubmed publisher
    ..Here we show that the chromatin insulator-binding factor CTCF binds to the proximal promoter of VEGF...
  34. Delgado Olguin P, Brand Arzamendi K, Scott I, Jungblut B, Stainier D, Bruneau B, et al. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. J Biol Chem. 2011;286:12483-94 pubmed publisher
    b>CTCF nuclear factor regulates many aspects of gene expression, largely as a transcriptional repressor or via insulator function. Its roles in cellular differentiation are not clear. Here we show an unexpected role for CTCF in myogenesis...
  35. Busslinger G, Stocsits R, van der Lelij P, Axelsson E, Tedeschi A, Galjart N, et al. Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl. Nature. 2017;544:503-507 pubmed publisher
    Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin into chromatin loops and topologically associated domains, which have important roles in gene regulation and recombination...
  36. Burke L, Hollemann T, Pieler T, Renkawitz R. Molecular cloning and expression of the chromatin insulator protein CTCF in Xenopus laevis. Mech Dev. 2002;113:95-8 pubmed
    The zinc finger protein CTCF has been shown to mediate multiple functions connected to gene repression. Transcriptional inhibition as well as enhancer blocking and chromatin insulation are documented for CTCF in men, mice and chickens...
  37. Prickett A, Barkas N, McCole R, Hughes S, Amante S, Schulz R, et al. Genome-wide and parental allele-specific analysis of CTCF and cohesin DNA binding in mouse brain reveals a tissue-specific binding pattern and an association with imprinted differentially methylated regions. Genome Res. 2013;23:1624-35 pubmed publisher
    DNA binding factors are essential for regulating gene expression. CTCF and cohesin are DNA binding factors with central roles in chromatin organization and gene expression...
  38. Lee D, Singh P, Tsai S, Oates N, Spalla A, Spalla C, et al. CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia. PLoS Genet. 2010;6:e1001224 pubmed publisher
    ..the chromatin bias, and also the delayed methylation establishment in the maternal allele, depended on functional CTCF insulator binding sites in the ICR...
  39. Seitan V, Faure A, Zhan Y, McCord R, Lajoie B, Ing Simmons E, et al. Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments. Genome Res. 2013;23:2066-77 pubmed publisher
    ..In addition, cohesin associates with active enhancers and promoters and with CTCF to form long-range interactions important for gene regulation...
  40. Bhattacharya A, Chen C, Ho S, Mitchell J. Upstream distal regulatory elements contact the Lmo2 promoter in mouse erythroid cells. PLoS ONE. 2012;7:e52880 pubmed publisher
    ..Binding of CTCF and cohesin which support chromatin loops at other loci were also found within the dCR and at the Lmo2 proximal ..
  41. Yu N, Kim H, Shim J, Kim S, Kim D, Kwak C, et al. A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission. Sci Rep. 2016;6:22892 pubmed publisher
    ..Moreover, mLLP interacts with CCCTC-binding factor (CTCF) as well as transcriptional machineries and modulates gene expression involved in neuronal growth...
  42. Sun S, Del Rosario B, Szanto A, Ogawa Y, Jeon Y, Lee J. Jpx RNA activates Xist by evicting CTCF. Cell. 2013;153:1537-51 pubmed publisher
    ..In pre-XCI cells, CTCF protein represses Xist transcription...
  43. McGill B, Barve R, Maloney S, Strickland A, Rensing N, Wang P, et al. Abnormal Microglia and Enhanced Inflammation-Related Gene Transcription in Mice with Conditional Deletion of Ctcf in Camk2a-Cre-Expressing Neurons. J Neurosci. 2018;38:200-219 pubmed publisher
    CCCTC-binding factor (CTCF) is an 11 zinc finger DNA-binding domain protein that regulates gene expression by modifying 3D chromatin structure. Human mutations in CTCF cause intellectual disability and autistic features...
  44. Farrell C, West A, Felsenfeld G. Conserved CTCF insulator elements flank the mouse and human beta-globin loci. Mol Cell Biol. 2002;22:3820-31 pubmed
    A binding site for the transcription factor CTCF is responsible for enhancer-blocking activity in a variety of vertebrate insulators, including the insulators at the 5' and 3' chromatin boundaries of the chicken beta-globin locus...
  45. Chen L, Zhao L, Alt F, Krangel M. An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between V? and D? Gene Segments. J Immunol. 2016;197:3188-3197 pubmed
    Chromatin looping mediated by the CCCTC binding factor (CTCF) regulates V(D)J recombination at Ag receptor loci...
  46. Mikkelsen T, Xu Z, Zhang X, Wang L, Gimble J, Lander E, et al. Comparative epigenomic analysis of murine and human adipogenesis. Cell. 2010;143:156-69 pubmed publisher
    We report the generation and comparative analysis of genome-wide chromatin state maps, PPAR? and CTCF localization maps, and gene expression profiles from murine and human models of adipogenesis...
  47. Soshnikova N, Montavon T, Leleu M, Galjart N, Duboule D. Functional analysis of CTCF during mammalian limb development. Dev Cell. 2010;19:819-30 pubmed publisher
    CCCTC-binding factor (CTCF) is a nuclear zinc-finger protein that displays insulating activity in a variety of biological assays...
  48. Yang F, Deng X, Ma W, Berletch J, Rabaia N, Wei G, et al. The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation. Genome Biol. 2015;16:52 pubmed publisher
    ..Similar to Dxz4, Firre is X-linked and expressed from a macrosatellite repeat locus associated with a cluster of CTCF and cohesin binding sites, and is preferentially located adjacent to the nucleolus...
  49. Fitzpatrick G, Pugacheva E, Shin J, Abdullaev Z, Yang Y, Khatod K, et al. Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1. Mol Cell Biol. 2007;27:2636-47 pubmed
    ..we demonstrate by electrophoretic mobility shift assays and chromatin immunoprecipitation the existence of two CTCF binding sites within KvDMR1 that are occupied in vivo only on the unmethylated paternally derived allele...
  50. Arpanahi A, Brinkworth M, Iles D, Krawetz S, Paradowska A, Platts A, et al. Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences. Genome Res. 2009;19:1338-49 pubmed publisher
    ..with gene regulatory regions, including many promoter sequences and sequences recognized by CCCTC-binding factor (CTCF). Similar differential packaging of promoters is observed in the spermatozoal chromatin of both mouse and man...
  51. Wang F, Han J, Wang L, Jing Y, Zhu Z, Hui D, et al. CCCTC-Binding Factor Transcriptionally Targets Wdr5 to Mediate Somatic Cell Reprogramming. Stem Cells Dev. 2017;26:743-750 pubmed publisher
    ..However, it remains unclear whether other factors are also involved in this process. Here, we show that CTCF is an upstream regulator of Wdr5: It physically associates with Wdr5 and further transcriptionally controls its ..
  52. Kim T, Kim M, Lee J, Kim S, Je J, Lee Y, et al. CCCTC-binding factor controls the homeostatic maintenance and migration of Langerhans cells. J Allergy Clin Immunol. 2015;136:713-24 pubmed publisher
    Langerhans cells (LCs) are skin-resident dendritic cells (DCs) that orchestrate skin immunity. CCCTC-binding factor (CTCF) is a highly conserved DNA-binding protein that regulates higher-order chromatin organization and is involved in ..
  53. Childress P, Stayrook K, Alvarez M, Wang Z, Shao Y, Hernandez Buquer S, et al. Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis. Mol Endocrinol. 2015;29:1269-85 pubmed publisher
    ..These data suggest that Nmp4 suppresses bone anabolism, in part, by regulating IGF-binding protein expression. Changes in Nmp4 status may lead to improvements in osteoprogenitor response to therapeutic cues. ..
  54. de Wit E, Vos E, Holwerda S, Valdes Quezada C, Verstegen M, Teunissen H, et al. CTCF Binding Polarity Determines Chromatin Looping. Mol Cell. 2015;60:676-84 pubmed publisher
    CCCTC-binding factor (CTCF) is an architectural protein involved in the three-dimensional (3D) organization of chromatin...
  55. Qiu Z, Song C, Malakouti N, Murray D, Hariz A, Zimmerman M, et al. Functional interactions between NURF and Ctcf regulate gene expression. Mol Cell Biol. 2015;35:224-37 pubmed publisher
    ..occupancy at nucleosome-free regions (NFRs), many of which are located at sites occupied by the multivalent factors Ctcf and cohesin...
  56. Narendra V, Bulajic M, Dekker J, Mazzoni E, Reinberg D. CTCF-mediated topological boundaries during development foster appropriate gene regulation. Genes Dev. 2016;30:2657-2662 pubmed publisher
    ..Here, we show that deletion of CTCF (CCCTC-binding factor)-binding sites at TAD and sub-TAD topological boundaries that form within the HoxA and HoxC ..
  57. Hansen A, Pustova I, Cattoglio C, Tjian R, Darzacq X. CTCF and cohesin regulate chromatin loop stability with distinct dynamics. elife. 2017;6: pubmed publisher
    Folding of mammalian genomes into spatial domains is critical for gene regulation. The insulator protein CTCF and cohesin control domain location by folding domains into loop structures, which are widely thought to be stable...
  58. Austin J, Lu P, Majumder P, Ahmed R, Boss J. STAT3, STAT4, NFATc1, and CTCF regulate PD-1 through multiple novel regulatory regions in murine T cells. J Immunol. 2014;192:4876-86 pubmed publisher
    ..Together these data add multiple novel distal regulatory regions and pathways to the control of PD-1 expression and provide a molecular mechanism by which proinflammatory cytokines, such as IL-6 or IL-12, can augment PD-1 expression. ..
  59. Zampieri M, Guastafierro T, Calabrese R, Ciccarone F, Bacalini M, Reale A, et al. ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites. Biochem J. 2012;441:645-52 pubmed publisher
    ..Our previous findings indicated that Ctcf (CCCTC-binding factor) may be an important player in key events whereby PARylation controls the unmethylated status ..
  60. Kitchen N, Schoenherr C. Sumoylation modulates a domain in CTCF that activates transcription and decondenses chromatin. J Cell Biochem. 2010;111:665-75 pubmed publisher
    b>CTCF is a multipurpose transcription factor with activation, repression, and insulator activity. It also participates in regulating chromatin architecture by maintaining open chromatin and mediating long-range chromosomal interactions...
  61. Nakahashi H, Kieffer Kwon K, Resch W, Vian L, Dose M, Stavreva D, et al. A genome-wide map of CTCF multivalency redefines the CTCF code. Cell Rep. 2013;3:1678-1689 pubmed publisher
    The "CTCF code" hypothesis posits that CTCF pleiotropic functions are driven by recognition of diverse sequences through combinatorial use of its 11 zinc fingers (ZFs)...
  62. Faure A, Schmidt D, Watt S, Schwalie P, Wilson M, Xu H, et al. Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 2012;22:2163-75 pubmed publisher
    The cohesin protein complex contributes to transcriptional regulation in a CTCF-independent manner by colocalizing with master regulators at tissue-specific loci...
  63. Thakur N, Tiwari V, Thomassin H, Pandey R, Kanduri M, Göndör A, et al. An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region. Mol Cell Biol. 2004;24:7855-62 pubmed
    ..Double-stranded RNA (dsRNA)-mediated RNA interference is unlikely to be involved, as the ICR is active irrespective of the simultaneous production of dsRNA from the genes it silences. ..
  64. Ye A, He H, Kim J. PEG3 binds to H19-ICR as a transcriptional repressor. Epigenetics. 2016;11:889-900 pubmed
    ..to the results, PEG3 binds to a specific sequence motif located between the 3rd and 4th CTCF binding sites of the H19-ICR. PEG3 also binds to the active maternal allele of the H19-ICR...
  65. Amelio A, McAnany P, Bloom D. A chromatin insulator-like element in the herpes simplex virus type 1 latency-associated transcript region binds CCCTC-binding factor and displays enhancer-blocking and silencing activities. J Virol. 2006;80:2358-68 pubmed
    ..revealed that (i) the long and short repeats and the unique-short region of the HSV-1 genome contain clustered CTCF (CCCTC-binding factor) motifs, (ii) CTCF motif clusters similar to those in HSV-1 are conserved in other ..
  66. Stadhouders R, Thongjuea S, Andrieu Soler C, Palstra R, Bryne J, van den Heuvel A, et al. Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development. EMBO J. 2012;31:986-99 pubmed publisher
    ..to harbour the transition site from transcription initiation to elongation, which takes place around a conserved CTCF site. Upon erythroid differentiation, Myb expression is downregulated and the ACH destabilized...
  67. Magdinier F, Yusufzai T, Felsenfeld G. Both CTCF-dependent and -independent insulators are found between the mouse T cell receptor alpha and Dad1 genes. J Biol Chem. 2004;279:25381-9 pubmed
    ..report that one of these sites, not previously examined, strongly binds the insulator protein CCTC-binding factor (CTCF) in vitro and in vivo and can function in an enhancer blocking assay...
  68. Sekimata M, Pérez Melgosa M, Miller S, Weinmann A, Sabo P, Sandstrom R, et al. CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. Immunity. 2009;31:551-64 pubmed publisher
    ..IFNG) transcription, which is embedded within the human IL26 gene, compromised of a single CCCTC-binding factor (CTCF) binding site and retained in all mammals, even surviving near-complete evolutionary deletion of the equivalent ..
  69. Battistelli C, Busanello A, Maione R. Functional interplay between MyoD and CTCF in regulating long-range chromatin interactions during differentiation. J Cell Sci. 2014;127:3757-67 pubmed publisher
    ..Here, we show that CTCF, the best characterized organizer of long-range chromatin interactions, binds to both the p57(kip2) promoter and ..
  70. Lin S, Ferguson Smith A, Schultz R, Bartolomei M. Nonallelic transcriptional roles of CTCF and cohesins at imprinted loci. Mol Cell Biol. 2011;31:3094-104 pubmed publisher
    ..in transcriptional regulation and insulation through genome-wide colocalization with the insulator protein CTCF, including involvement at the imprinted H19/Igf2 locus...
  71. Nikolic T, Movita D, Lambers M, Ribeiro de Almeida C, Biesta P, Kreefft K, et al. The DNA-binding factor Ctcf critically controls gene expression in macrophages. Cell Mol Immunol. 2014;11:58-70 pubmed publisher
    ..The DNA binding zinc-finger protein CCCTC-binding factor (Ctcf) is a crucial regulator of long-range chromatin interactions and coordinates specific communication between ..
  72. Wang L, Wu X, Shi T, Lu L. Epidermal growth factor (EGF)-induced corneal epithelial wound healing through nuclear factor ?B subtype-regulated CCCTC binding factor (CTCF) activation. J Biol Chem. 2013;288:24363-71 pubmed publisher
    ..study aimed to understand the role of NF?B in EGF-induced corneal epithelial wound healing through regulation of CTCF activity, which plays important roles in cell motility and migration to promote wound healing...
  73. Kim L, Esplugues E, Zorca C, Parisi F, Kluger Y, Kim T, et al. Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells. Mol Cell. 2014;54:56-66 pubmed publisher
    ..Deletion of either of these sites or Oct-1 gene impairs the association. Oct-1 and CTCF bind their cognate sites cooperatively, and CTCF deficiency similarly impairs the association...
  74. Spencer R, Del Rosario B, Pinter S, Lessing D, Sadreyev R, Lee J. A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to initiation of X-chromosome inactivation. Genetics. 2011;189:441-54 pubmed publisher
    ..Here, we investigate the region and discover a conserved element, RS14, that presents a strong binding site for Ctcf protein...
  75. Ideraabdullah F, Abramowitz L, Thorvaldsen J, Krapp C, Wen S, Engel N, et al. Novel cis-regulatory function in ICR-mediated imprinted repression of H19. Dev Biol. 2011;355:349-57 pubmed publisher
    ..b>CTCF binding sites and DNA methylation at the ICR have previously been identified as key cis-acting elements required ..
  76. Isbel L, Prokopuk L, Wu H, Daxinger L, Oey H, Spurling A, et al. Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse. elife. 2016;5: pubmed publisher
    ..ChIP-seq was performed in adult cerebellum and Wiz peaks were found at promoters and transcription factor CTCF binding sites...
  77. Navarro P, Page D, Avner P, Rougeulle C. Tsix-mediated epigenetic switch of a CTCF-flanked region of the Xist promoter determines the Xist transcription program. Genes Dev. 2006;20:2787-92 pubmed
    ..We show here that a precisely defined Xist promoter region flanked by CTCF is maintained by Tsix in a heterochromatic-like state in undifferentiated embryonic stem (ES) cells and shifts to a ..
  78. Qi C, Kim Y, Xiang S, Abdullaev Z, Torrey T, Janz S, et al. Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms. Int J Mol Sci. 2012;13:6204-19 pubmed publisher
    ..identified a multiprotein complex comprised of ARF-BP1, ARF, p53, MYC and the multifunctional DNA-binding factor, CTCF, which is involved in the transcriptional regulation of MYC, p53 and ARF...
  79. Ribeiro de Almeida C, Heath H, Krpic S, Dingjan G, van Hamburg J, Bergen I, et al. Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression. J Immunol. 2009;182:999-1010 pubmed
    ..this report, we investigated the role in Th2 differentiation of the transcription regulator CCCTC-binding factor (CTCF). Chromatin immunoprecipitation analysis revealed multiple CTCF binding sites in the Th2 cytokine locus...
  80. Teif V, Beshnova D, Vainshtein Y, Marth C, Mallm J, Hofer T, et al. Nucleosome repositioning links DNA (de)methylation and differential CTCF binding during stem cell development. Genome Res. 2014;24:1285-95 pubmed publisher
    ..DNA methylation (5mC), hydroxymethylation (5hmC), nucleosome repositioning, and binding of the transcription factor CTCF during this process...