Csk

Summary

Gene Symbol: Csk
Description: c-src tyrosine kinase
Alias: AW212630, C-Src kinase, p50CSK, protein-tyrosine kinase MPK-2, tyrosine-protein kinase CSK
Species: mouse

Top Publications

  1. ncbi The role of c-Src in platelet-derived growth factor alpha receptor internalization
    Kirill Avrov
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Cell Res 291:426-34. 2003
  2. pmc Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor
    Dominique Davidson
    Laboratory of Molecular Oncology, IRCM, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Mol Cell Biol 23:2017-28. 2003
  3. doi The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src
    Chitose Oneyama
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Cell 30:426-36. 2008
  4. ncbi Constitutive activation of Src family kinases in mouse embryos that lack Csk
    S Nada
    Laboratory of Molecular Oncology, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Cell 73:1125-35. 1993
  5. pmc Activation of c-Src and Fyn kinases by protein-tyrosine phosphatase RPTPalpha is substrate-specific and compatible with lipid raft localization
    Nathalie Vacaresse
    Biotech Research and Innovation Center, Copenhagen Biocenter, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark
    J Biol Chem 283:35815-24. 2008
  6. pmc The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1
    Laurence Veracini
    Centre de Recherche en Biochimie Macromoléculare, Centre National de la Recherche Scientifique UMR5237, Universities of Montpellier I and II, 34293 Montpellier, France
    J Cell Biol 182:603-14. 2008
  7. ncbi Proteomic identification of ZO-1/2 as a novel scaffold for Src/Csk regulatory circuit
    Kazunobu Saito
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 366:969-75. 2008
  8. pmc Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development
    Shengli Xu
    Laboratory of Immunology, Center for Molecular Medicine, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Lab 6 15, Proteos, Singapore 138673, Singapore
    Mol Cell Biol 25:8486-95. 2005
  9. ncbi Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells
    Evan Ingley
    Cell Signalling Group, Western Australian Institute for Medical Research, Perth, WA 6000 Australia
    J Biol Chem 281:31920-9. 2006
  10. pmc Association of Csk to VE-cadherin and inhibition of cell proliferation
    Ulf Baumeister
    Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
    EMBO J 24:1686-95. 2005

Research Grants

  1. Bcl-2 & Branching Morphogenesis
    Christine Sorenson; Fiscal Year: 2007
  2. Regulation of Tumor Cell Differentiation by Src Kinases
    MALCOLM MEYN; Fiscal Year: 2007

Scientific Experts

  • Laleh Sinai
  • M C Gye
  • Hiromi Hosako
  • Christine Sorenson
  • Jianguo Gu
  • C Schmedt
  • Evan Ingley
  • B A Rikke
  • Malcolm A Meyn
  • Cynthia Corley Mastick
  • Masato Okada
  • Chitose Oneyama
  • Shigeyuki Nada
  • Kazunobu Saito
  • Tomoya Hikita
  • Reiko Yagi
  • Alexander Tarakhovsky
  • Netanya Y Spencer
  • Jessica G Borger
  • Xin Yun Huang
  • Hong Chang
  • Isabel Martinez Ferrando
  • Sabine Lindquist
  • D J Shields
  • Aaron T Place
  • Jun Zhong
  • Henrik Molina
  • Akhilesh Pandey
  • Julie Zikherman
  • Takuma Matsubara
  • Mohammad Aminur Rahman
  • Burkhart Schraven
  • Shi Pan
  • Ingvild B Johnsen
  • Marianna D'Arco
  • Ramars Amanchy
  • Tzu Jen Kao
  • Laurence Veracini
  • Zhanfei Wang
  • H L Bennett
  • Kengo Enya
  • Olivier Destaing
  • Atsuko Takatsuka
  • Holly Epple
  • Willian F Zambuzzi
  • Nathalie Vacaresse
  • Yasuo Uchiyama
  • Philip A Cole
  • A Yogi
  • Min Jin Lim
  • Kazuhisa Honda
  • Mehran Amoui
  • Anastasios Georgakopoulos
  • K S Madhusoodanan
  • Deirdre McGarrigle
  • Amanda H McDaniel
  • Vaclav Horejsi
  • C Machka
  • Shengli Xu
  • Daisuke Aki
  • Ulf Baumeister
  • S Nada
  • Haiming Cao
  • Li Juan Duan
  • Richard M Thomas
  • Dominique Davidson
  • Kirill Avrov
  • Hiroko Sekimoto
  • Debra Y Dunlap
  • Koubun Yasuda
  • William E Lowry
  • David J Evans
  • Thomas J Lynch
  • Andrew Filby
  • Ziying Yan
  • Meihui Luo
  • Yulong Zhang
  • Weihong Zhou
  • M Okada
  • Duane Abbott
  • Qiang Li
  • John F Engelhardt
  • Rose Zamoyska
  • Botond Banfi
  • Vikram Katju
  • N G Copeland
  • Nadia Okolowsky
  • Raghothama Chaerkady
  • N A Jenkins
  • Laurent Balenci

Detail Information

Publications78

  1. ncbi The role of c-Src in platelet-derived growth factor alpha receptor internalization
    Kirill Avrov
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Cell Res 291:426-34. 2003
    ..Our findings suggest a role for SFKs in regulating the permissiveness for internalization of the alphaPDGFR...
  2. pmc Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor
    Dominique Davidson
    Laboratory of Molecular Oncology, IRCM, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Mol Cell Biol 23:2017-28. 2003
    ..In resting human T cells, PAG is tyrosine phosphorylated and associated with Csk, an inhibitor of Src-related protein tyrosine kinases...
  3. doi The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src
    Chitose Oneyama
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Cell 30:426-36. 2008
    The tyrosine kinase c-Src is upregulated in various human cancers irrespective of its negative regulator Csk, but the regulatory mechanisms remain unclear...
  4. ncbi Constitutive activation of Src family kinases in mouse embryos that lack Csk
    S Nada
    Laboratory of Molecular Oncology, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Cell 73:1125-35. 1993
    b>Csk is a novel cytoplasmic protein-tyrosine kinase that has been shown to inactivate members of the Src family of protein-tyrosine kinases in vitro...
  5. pmc Activation of c-Src and Fyn kinases by protein-tyrosine phosphatase RPTPalpha is substrate-specific and compatible with lipid raft localization
    Nathalie Vacaresse
    Biotech Research and Innovation Center, Copenhagen Biocenter, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark
    J Biol Chem 283:35815-24. 2008
    ..Finally, RPTPalpha-induced phosphorylation of Paxillin and Cbp/PAG induces recruitment of the SFK inhibitory kinase Csk, indicative of negative feedback loops limiting SFK activation by RPTPalpha...
  6. pmc The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1
    Laurence Veracini
    Centre de Recherche en Biochimie Macromoléculare, Centre National de la Recherche Scientifique UMR5237, Universities of Montpellier I and II, 34293 Montpellier, France
    J Cell Biol 182:603-14. 2008
    ..member of the transmembrane adaptor protein family, is known to negatively regulate SFK signaling though binding to Csk. We report that PAG modulates PDGFR levels in caveolae and SFK mitogenic signaling through a Csk-independent ..
  7. ncbi Proteomic identification of ZO-1/2 as a novel scaffold for Src/Csk regulatory circuit
    Kazunobu Saito
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 366:969-75. 2008
    ..a proteomic analysis of tyrosine phosphorylated proteins that interact with c-Src and/or its negative regulator Csk. The c-Src interacting proteins were affinity-purified from Src transformed cells using the Src SH2 domain as a ..
  8. pmc Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development
    Shengli Xu
    Laboratory of Immunology, Center for Molecular Medicine, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Lab 6 15, Proteos, Singapore 138673, Singapore
    Mol Cell Biol 25:8486-95. 2005
    The ubiquitously expressed transmembrane adaptor Csk-binding protein (Cbp) recruits Csk to lipid rafts, where the latter exerts its negative regulatory effect on the Src family of protein tyrosine kinases...
  9. ncbi Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells
    Evan Ingley
    Cell Signalling Group, Western Australian Institute for Medical Research, Perth, WA 6000 Australia
    J Biol Chem 281:31920-9. 2006
    ..Src kinase-binding protein (Cbp), an adaptor protein that recruits negative regulators C-terminal Src kinase (Csk)/Csk-like protein-tyrosine kinase (Ctk)...
  10. pmc Association of Csk to VE-cadherin and inhibition of cell proliferation
    Ulf Baumeister
    Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
    EMBO J 24:1686-95. 2005
    ..for proteins that could be involved in VE-cadherin signaling, we found the cytosolic C-terminal Src kinase (Csk), a negative regulator of Src family kinases...
  11. ncbi Csk controls antigen receptor-mediated development and selection of T-lineage cells
    C Schmedt
    Laboratory for Lymphocyte Signalling, University of Cologne, Germany
    Nature 394:901-4. 1998
    ..Here we show that the inactivation of the negative regulator of Src-family PTKs, carboxy-terminal Src kinase (Csk), in immature thymocytes abrogates the requirement for preTCR, alphabetaTCR and major histocompatibility complex (..
  12. pmc Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase
    J A Gross
    Howard Hughes Medical Institute, University of Washington, Seattle 98195
    J Exp Med 181:463-73. 1995
    ..src-family kinases p56lck and p59fyn play pivotal roles during lymphocyte development, it seemed plausible that p50csk might contribute to these regulatory circuits...
  13. ncbi Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice
    A Imamoto
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030
    Cell 73:1117-24. 1993
    ..To analyze the significance of this regulation during development, we have generated mice deficient in Csk, a kinase that phosphorylates this tyrosine, by gene targeting in embryonic stem cells...
  14. pmc Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner
    Netanya Y Spencer
    Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 305:G84-94. 2013
    ..We conclude that c-Src and NADPH oxidase components are necessary for redox-mediated production of TNF-α following liver I/R and that hepatocytes play an important role in this process...
  15. doi Impaired social memories in 129P2 inbred mice are rescued by reduced Csk expression
    L Sinai
    Mount Sinai Hospital, Toronto, ON, Canada
    Genes Brain Behav 11:559-67. 2012
    The C-terminal Src kinase (Csk) is an essential signaling factor guiding central nervous system (CNS) development...
  16. pmc Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics
    Isabel Martinez Ferrando
    Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Proteomics 11:355-69. 2012
    ....
  17. doi Differential polarization of C-terminal Src kinase between naive and antigen-experienced CD8+ T cells
    Jessica G Borger
    Institute of Immunology and Infection Research, The University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    J Immunol 190:3089-99. 2013
    ..Ag-experienced CD8(+) T cells in colocalization of the SFKs and their negative regulator, C-terminal Src kinase (Csk)...
  18. doi Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1
    Hong Chang
    Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Canada
    Dev Biol 370:187-97. 2012
    ..These data reveal the cooperative interactions between signalling cascades involving c-src and Ptch1 and suggest that Hh-signalling may be permissive for c-src/Esr1-dependent mammary gland morphogenesis...
  19. ncbi Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis
    H L Bennett
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Oncogene 27:2693-704. 2008
    ..Overall, these findings demonstrate a novel mechanism whereby Gab2 may promote metastatic spread and indicate that Gab2 may play several roles during breast cancer progression...
  20. pmc The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts
    Olivier Destaing
    Department of Orthopaedics, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Biol Cell 19:394-404. 2008
    ..Thus, Src is an essential regulator of podosome structure, dynamics and organization...
  21. ncbi Suppression of c-Src activity stimulates muscle differentiation via p38 MAPK activation
    Min Jin Lim
    Department of Biochemistry and Molecular Biology BK21 project, Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea
    Arch Biochem Biophys 465:197-208. 2007
    ..Concomitant inhibition of c-Src and p38 MAPK activities blocked muscle differentiation in both media. In conclusion, suppression of c-Src activity stimulates muscle differentiation by activating p38 MAPK uni-directionally...
  22. ncbi Endothelin-1, but not Ang II, activates MAP kinases through c-Src independent Ras-Raf dependent pathways in vascular smooth muscle cells
    A Yogi
    Kidney Research Centre, University of Ottawa Ottawa Health Research Institute, 451 Smyth Rd, Ottawa, ON, KIH 8M5
    Arterioscler Thromb Vasc Biol 27:1960-7. 2007
    ..Here we sought to determine whether upstream regulators of mitogen-activated protein kinases (MAPKs) are differentially regulated by ET-1 and Ang II focusing on the role of c-Src and the small GTPase Ras...
  23. ncbi Epidermal hyperplasia and papillomatosis in mice with a keratinocyte-restricted deletion of csk
    Kazuhisa Honda
    Department of Biomedical Engineering and Orthopaedic Research Center ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Carcinogenesis 28:2074-81. 2007
    ..in vivo, we have generated a mouse model with a keratinocyte-restricted deletion of the SFK-negative regulator csk (Csk-K5 mice)...
  24. pmc C-terminal Src kinase controls development and maintenance of mouse squamous epithelia
    Reiko Yagi
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    EMBO J 26:1234-44. 2007
    Carboxy-terminal Src kinase (Csk) is a negative regulator of Src family kinases, which play pivotal roles in controlling cell adhesion, migration, and cancer progression...
  25. pmc A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot
    Amanda H McDaniel
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 17:1078-92. 2006
    ..with functional significance to the body fatness phenotype (Il18, Acat1, Cyp19a1, Crabp1, Man2c1, Neil1, Mpi1, Csk, Lsm16, Adpgk, Bbs4, Hexa, Thsd4, Dpp8, Anxa2, and Lipc)...
  26. ncbi Alveolar macrophages from septic mice promote polymorphonuclear leukocyte transendothelial migration via an endothelial cell Src kinase/NADPH oxidase pathway
    Zhanfei Wang
    Critical Illness Research, Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada
    J Immunol 181:8735-44. 2008
    ..Collectively, our findings indicate that the PMN transendothelial migration induced by septic AMphi is dependent on the generation of superoxide in endothelial cells via the Src kinase/NADPH oxidase signaling pathway...
  27. doi Cbp recruitment of Csk into lipid rafts is critical to c-Src kinase activity and bone resorption in osteoclasts
    Takuma Matsubara
    Department molecular and cellular biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Bone Miner Res 25:1068-76. 2010
    ..To address this, we first examined the expression levels and subcellular localization of Csk, a negative regulatory kinase for c-Src...
  28. doi Functional dissection of transformation by c-Src and v-Src
    Chitose Oneyama
    Department of Oncogene Research, Research Institute of Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Genes Cells 13:1-12. 2008
    ..To verify the role of c-Src, we analyzed the transforming ability of c-Src in mouse embryonic fibroblasts that lack Csk, a negative regulator of Src family kinases...
  29. doi Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility
    Atsuko Takatsuka
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Dev Biol 315:474-88. 2008
    ..To verify their in vivo roles during development, we generated mutant mice in which Csk, a negative regulator of SFKs, was inactivated in neural crest lineages using the Protein zero promoter in a Cre-..
  30. pmc Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells
    Malcolm A Meyn
    University of Pittsburgh School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, PA 15213 2536, USA
    Sci Signal 2:ra64. 2009
    ..These results show that distinct SFK signaling pathways regulate mES cell fate and demonstrate that the formation of primitive ectoderm is regulated by the activity of c-Src...
  31. pmc Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signaling
    Ramars Amanchy
    McKusick Nathans Institute of Genetic Medicine, Departments of Biological Chemistry, Oncology and Pathology, Johns Hopkins University, Baltimore, MD 21205, USA
    Mol Oncol 3:439-50. 2009
    ..In validation experiments, we demonstrated that PDGF indeed induced the phosphorylation of a subset of candidate Src-family kinase substrates - Calpain 2, Eps15 and Trim28 - in a c-Src-dependent fashion...
  32. pmc The C-terminal Src inhibitory kinase (Csk)-mediated tyrosine phosphorylation is a novel molecular mechanism to limit P2X3 receptor function in mouse sensory neurons
    Marianna D'Arco
    Neurobiology Sector and Italian Institute of Technology Unit, International School for Advanced Studies SISSA, 34014 Trieste, Italy
    J Biol Chem 284:21393-401. 2009
    ..In view of the structural modeling between the Src region phosphorylated by the C-terminal Src inhibitory kinase (Csk) and the intracellular C terminus domain of the P2X(3) receptor, we investigated how Csk might regulate receptor ..
  33. pmc The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling
    Ingvild B Johnsen
    Department of Laboratory Medicine, Children s and Women s Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim N 7006, Norway
    J Biol Chem 284:19122-31. 2009
    ..The interaction between c-Src and TRAF3 was found to occur within the RING domain of TRAF3. Taken together, our results suggest that c-Src enhances RIG-I-mediated signaling, acting at the level of TRAF3...
  34. doi Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells
    Shi Pan
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Arterioscler Thromb Vasc Biol 29:895-901. 2009
    ..Because tyrosine phosphorylation is a key regulatory pathway for VEGF-mediated endothelial cell (EC) responses, we investigated tyrosine phosphorylation of G6PD and the role of the nonreceptor tyrosine kinase Src...
  35. doi Modulation of Src activity by low molecular weight protein tyrosine phosphatase during osteoblast differentiation
    Willian F Zambuzzi
    Department of Biochemistry, Laboratory of Bioassays and Signal Transduction, Institute of Biology, University of Campinas, Campinas, SP, Brazil
    Cell Physiol Biochem 22:497-506. 2008
    ..In this work, we examined the expression and activity of Src and low molecular weight protein tyrosine phosphatase (LMWPTP) during osteoblast differentiation and assessed the modulation of Src kinase by LMWPTP...
  36. pmc CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development
    Julie Zikherman
    Division of Rheumatology, University of California San Francisco, San Francisco, CA 94143, USA
    Immunity 32:342-54. 2010
    The kinase-phosphatase pair Csk and CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn...
  37. pmc Oncogenic Ras/Src cooperativity in pancreatic neoplasia
    D J Shields
    Department of Pathology, Moore s UCSD Cancer Center, San Diego, CA, USA
    Oncogene 30:2123-34. 2011
    ..demonstrate that in the context of oncogenic Kras, activation of c-Src through deletion of C-terminal Src kinase (CSK) results in the development of invasive pancreatic ductal adenocarcinoma (PDA) by 5-8 weeks...
  38. pmc Cooperative role of caveolin-1 and C-terminal Src kinase binding protein in C-terminal Src kinase-mediated negative regulation of c-Src
    Aaron T Place
    Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Mol Pharmacol 80:665-72. 2011
    In the present study, we assessed the cooperative roles of C-terminal Src kinase (Csk) binding protein (Cbp) and Caveolin-1 (Cav-1) in the mechanism of Src family tyrosine kinase (SFK) inhibition by Csk...
  39. pmc Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation
    Sabine Lindquist
    Department of Neurology, Hannover Medical School, Hannover, Germany
    PLoS ONE 6:e23978. 2011
    ..We show here that the phosphoprotein associated with glycosphigolipid-enriched microdomains (PAG)/Csk binding protein (Cbp) modulates SFK activity in the brain...
  40. pmc Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase
    Holly Epple
    Washington University School of Medicine, Department of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Mol Cell Biol 28:3610-22. 2008
    ..Based on these results, we propose that PLCgamma2 influences Src activation by mediating the localization of Src to the integrin complex and thereby regulating integrin-mediated functions in the osteoclast...
  41. pmc Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling
    Anastasios Georgakopoulos
    Department of Psychiatry, Mount Sinai School of Medicine, NYU, New York, NY 10029, USA
    EMBO J 25:1242-52. 2006
    ..This peptide binds Src and inhibits its association with inhibitory kinase Csk, allowing autophosphorylation of Src at residue tyr418...
  42. ncbi Role of tyrosine kinase Csk in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration
    Deirdre McGarrigle
    Department of Physiology, Cornell University Weill Medical College, New York, NY 10021, USA
    J Biol Chem 281:10583-8. 2006
    Tyrosine kinase Csk is essential for mouse embryonic development. Csk knock-out mice died at early stages of embryogenesis (around embryonic day 10). The molecular mechanism for this defect is not completely understood...
  43. ncbi Dual roles of the C-terminal Src kinase (Csk) during developmental vascularization
    Li Juan Duan
    Center for Vascular Biology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3501, USA
    Blood 103:1370-2. 2004
    Here we report that C-terminal Src kinase (Csk), a tyrosine kinase that negatively regulates the activity of Src and related kinases, is important for vascular development...
  44. pmc S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion
    Mohammad Aminur Rahman
    From the Division of Cancer Biology, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    J Biol Chem 285:3806-14. 2010
    ..These results identify a novel signaling pathway that links NO and Src family kinases to cancer cell invasion and metastasis...
  45. ncbi Effects of src-deficiency on the expression of in vivo toxicity of TCDD in a strain of c-src knockout mice procured through six generations of backcrossings to C57BL/6 mice
    Debra Y Dunlap
    Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
    Toxicology 172:125-41. 2002
    ..These findings suggest that the absence of c-src expression indeed affects the development of selected, TCDD-induced toxic endpoints that are related to wasting syndrome...
  46. pmc Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk)
    C Schmedt
    Laboratory for Lymphocyte Signaling, The Rockefeller University, New York, New York 10021, USA
    J Exp Med 193:815-26. 2001
    The deletion of COOH-terminal Src kinase (Csk), a negative regulator of Src family protein tyrosine kinases (PTKs), in immature thymocytes results in the development of alpha/beta T lineage cells in T cell receptor (TCR) beta-deficient ..
  47. ncbi A major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9
    Y Kohara
    Department of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science, Japan
    Immunogenetics 53:15-21. 2001
    ..These candidates are Thy1, Cd3d, Cd3e, Cd3g, Il10ra, 1118, and Csk, all of which could be involved in allergic responses through effects on T-cell function...
  48. ncbi Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene
    I Pecker
    Department of Human Genetics, Tel Aviv University, Ramat Aviv, 69978, Israel
    Genomics 35:39-45. 1996
    ..Fluorescence in situ hybridization and linkage analysis located the Atm gene on mouse chromosome 9, band 9C, in a region homologous to the ATM region on human chromosome 11q22-q23...
  49. ncbi Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity
    T Kawai
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Oncogene 18:3471-80. 1999
    ..These results indicate that DAPK2 is an additional member of DAP kinase family involved in apoptotic signaling...
  50. pmc Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells
    J F Cloutier
    McGill Cancer Centre, McGill University, Montreal, Canada
    EMBO J 15:4909-18. 1996
    b>p50csk is a tyrosine protein kinase (TPK) that represses the activity of Src family TPKs...
  51. ncbi Mouse nicotinamide N-methyltransferase gene: molecular cloning, structural characterization, and chromosomal localization
    L Yan
    Department of Pharmacology, Mayo Medical School Mayo Clinic Mayo Foundation, Rochester, MN 55905, USA
    DNA Cell Biol 17:659-67. 1998
    ..Cloning and structural characterization of the mouse Nnmt gene will make it possible to study molecular genetic mechanisms involved in the expression of this important methyltransferase...
  52. ncbi The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas
    F Rausa
    Department of Biochemistry and Molecular Biology, University of Illinois at Chicago 60612 7334, USA
    Dev Biol 192:228-46. 1997
    ..We discuss these expression patterns with respect to specification of hepatocytes and differentiation of the endocrine and exocrine pancreas...
  53. ncbi Role of Csk in neural differentiation of the embryonic carcinoma cell line P19
    Y Takayama
    Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Japan
    FEBS Lett 406:11-6. 1997
    To examine the neural function of Csk (C-terminal Src kinase), a membrane-targeted form of Csk (Src/Csk) and its kinase-defective variant (DK-Src/Csk) were expressed in the embryonic carcinoma cell line P19...
  54. pmc The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts
    L Laviola
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 99:830-7. 1997
    ..In conclusion, Grb10 interacts preferentially with insulin vs. IGF-I receptors in intact cells and, thus, may have a role in mediating insulin receptor-specific cellular responses...
  55. ncbi Two distinct protein isoforms are encoded by ntk, a csk-related tyrosine protein kinase gene
    L M Chow
    McGill Cancer Centre, McGill University, Montreal, Canada
    Oncogene 9:3437-48. 1994
    Recently, we and others have cloned cDNAs encoding a second member of the Csk family of inhibitory tyrosine protein kinases, which we have termed Ntk...
  56. ncbi Mutation of csk, encoding the C-terminal Src kinase, reduces Pseudomonas aeruginosa internalization by mammalian cells and enhances bacterial cytotoxicity
    David J Evans
    Morton D Sarver Laboratory for Cornea and Contact Lens Research, School of Optometry, University of California at Berkeley, Berkeley, California 94720, USA
    Microb Pathog 33:135-43. 2002
    ..aeruginosa invasion. Using fibroblasts homozygous for mutation of csk (-/-), we tested the hypothesis that mutation of csk, encoding a negative regulator of Src-family tyrosine kinases, ..
  57. pmc Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family
    S Klages
    Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543
    Proc Natl Acad Sci U S A 91:2597-601. 1994
    We used the polymerase chain reaction with degenerate oligonucleotide primers to search for Csk-related kinases...
  58. ncbi Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling
    C Machka
    Institute of Experimental Genetics, GSF National Research Center, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Gene Expr Patterns 6:94-101. 2005
    ..The large set of regulated genes identified in this differential expression profiling approach is an important resource for further functional studies...
  59. ncbi Identification of major tyrosine-phosphorylated proteins in Csk-deficient cells
    S Nada
    Division of Protein Metabolism, Osaka University, Japan
    Oncogene 9:3571-8. 1994
    b>Csk is a non-receptor protein-tyrosine kinase that acts as a negative regulator of Src family tyrosine kinases. Csk-deficient mouse embryos exhibited developmental defects including inability to turn and impaired formation of neural tube...
  60. ncbi Expression of p50 C-terminal Src kinase (Csk) in mouse testis
    M C Gye
    Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Korea
    Arch Androl 50:287-93. 2004
    C-terminal Src Kinase (Csk) is a cytoplasmic tyrosine kinase that phosphorylates a critical tyrosine residue in each of the Src family kinases to inhibit their activities...
  61. pmc The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src
    K Neet
    Graduate Program in Neurosciences, University of California, San Diego, La Jolla 92093, USA
    Mol Cell Biol 15:4908-20. 1995
    b>CSK is a predominantly cytosolic protein-tyrosine kinase (PTK) that negatively regulates Src family PTKs by phosphorylation of a conserved tyrosine near their C termini. Little is known about how CSK itself is regulated...
  62. ncbi Quantitative trait Loci specifying the response of body temperature to dietary restriction
    Brad A Rikke
    Institute for Behavioral Genetics, University of Colorado at Boulder, USA
    J Gerontol A Biol Sci Med Sci 59:118-25. 2004
    ..Importantly, the genes underlying such QTLs would be causal factors affecting these responses and could be identified by positional cloning...
  63. ncbi Oxidative stress activates both Src-kinases and their negative regulator Csk and induces phosphorylation of two targeting proteins for Csk: caveolin-1 and paxillin
    Haiming Cao
    Department of Biochemistry, University of Nevada, Reno, NV 89557, USA
    Exp Cell Res 294:159-71. 2004
    b>Csk negatively regulates Src family kinases (SFKs). In lymphocytes, Csk is constitutively active, and is transiently inactivated in response to extracellular stimuli, allowing activation of SFKs...
  64. ncbi C-terminal SRC kinase controls acute inflammation and granulocyte adhesion
    Richard M Thomas
    University College London, Department of Immunology and Molecular Pathology, The Windeyer Institute of Medical Sciences, 46 Cleveland Street, London W1T 4JF, United Kingdom
    Immunity 20:181-91. 2004
    To establish whether the widely expressed regulator of Src family kinases Csk contributes to the control of acute inflammation in vivo, we inactivated csk in granulocytes by conditional mutagenesis (Cre/loxP)...
  65. ncbi Specific and redundant roles of Src and Fyn in organizing the cytoskeleton
    S M Thomas
    Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Nature 376:267-71. 1995
    Mouse embryos lacking Csk, a negative regulator of Src family kinases, exhibit defects in neurulation and die at mid-gestation...
  66. ncbi C-terminal Src kinase (CSK) modulates insulin-like growth factor-I signaling through Src in 3T3-L1 differentiation
    Hiroko Sekimoto
    Department of Pediatrics, Brown Medical School and Rhode Island Hospital, Providence, Rhode Island 02903, USA
    Endocrinology 144:2546-52. 2003
    ..C-terminal Src kinase (CSK), a ubiquitously expressed nonreceptor tyrosine kinase, negatively regulates the Src family kinases by ..
  67. ncbi Csk regulates integrin-mediated signals: involvement of differential activation of ERK and Akt
    Jianguo Gu
    Division of Protein Chemistry, Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 303:973-7. 2003
    b>Csk phosphorylates Src family tyrosine kinases and down-regulates their activities in vitro and in vivo...
  68. ncbi Non-receptor tyrosine kinases in mammalian neurogenesis
    S Aizawa
    Laboratory of Molecular Oncology Tsukuba Life Science Center, Ibaraki, Japan
    Princess Takamatsu Symp 24:323-37. 1994
    ..We earlier isolated a new cytoplasmic protein tyrosine kinase, Csk, and showed that it inactivates uniquely all members of non-receptor tyrosine kinases in vitro...
  69. pmc Ntk: a Csk-related protein-tyrosine kinase expressed in brain and T lymphocytes
    L M Chow
    McGill Cancer Centre, McGill University, Montreal, PQ, Canada
    Proc Natl Acad Sci U S A 91:4975-9. 1994
    ..phosphorylation of a conserved carboxyl-terminal tyrosine by another cytoplasmic protein-tyrosine kinase termed p50csk. In this study, we characterize Ntk, a protein-tyrosine kinase bearing striking similarities to p50csk...
  70. doi SRC family kinases are required for limb trajectory selection by spinal motor axons
    Tzu Jen Kao
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Neurosci 29:5690-700. 2009
    ..Inhibition of SFK activity by C-terminal Src kinase (Csk) overexpression in chick LMC axons using in ovo electroporation resulted in LMC axons selecting the inappropriate ..
  71. ncbi An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain
    P Gilardi-Hebenstreit
    Laboratoire de Genetique Moleculaire, Centre National de la Recherche Scientifique URA 1302, Paris, France
    Oncogene 7:2499-506. 1992
    ..These data are consistent with a role of the Sek gene product in a signal transduction process involved in pattern formation in the hindbrain...
  72. pmc A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse
    N B Akhmedov
    Jules Stein Eye Institute, University of California School of Medicine, Los Angeles, CA 90095 7000, USA
    Proc Natl Acad Sci U S A 97:5551-6. 2000
    ..Our findings demonstrate that mPNR expression is critical for the normal development and function of the photoreceptor cells...
  73. ncbi Csk, a critical link of g protein signals to actin cytoskeletal reorganization
    William E Lowry
    Department of Physiology, Cornell University, Weill Medical College, New York, New York 10021, USA
    Dev Cell 2:733-44. 2002
    ..Here we report that, in tyrosine kinase Csk-deficient mouse embryonic fibroblast cells, G protein (Gbetagamma, Galpha(12), Galpha(13), and Galpha(q))-induced, ..
  74. pmc Csk mediates G-protein-coupled lysophosphatidic acid receptor-induced inhibition of membrane-bound guanylyl cyclase activity
    K S Madhusoodanan
    Department of Physiology, Cornell University, Weill Medical College, New York, New York 10021, USA
    Biochemistry 45:3396-403. 2006
    ..Here we report that the nonreceptor-tyrosine-kinase Csk is an essential component of the intracellular modulation of atrial natriuretic peptide (ANP)-stimulated activation ..
  75. ncbi Modulation of TLR signalling by the C-terminal Src kinase (Csk) in macrophages
    Daisuke Aki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Fukuoka 812 8582, Japan
    Genes Cells 10:357-68. 2005
    ..Among these proteins, we characterized C-terminal Src kinase (Csk), which negatively regulates Src-like kinases in RAW 264.7 cells using RNAi knockdown technology...
  76. ncbi A transmembrane osteoclastic protein-tyrosine phosphatase regulates osteoclast activity in part by promoting osteoclast survival through c-Src-dependent activation of NFkappaB and JNK2
    Mehran Amoui
    The Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Arch Biochem Biophys 463:47-59. 2007
    ..In conclusion, PTP-oc activates osteoclast activity in part by promoting osteoclast survival through the PTP-oc-mediated c-Src-dependent activation of NFkappaB and JNK2...
  77. ncbi Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells
    Koubun Yasuda
    Department of Oncogenesis, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Immunol 169:2813-7. 2002
    In resting T cells, Csk is constitutively localized in lipid rafts by virtue of interaction with a phosphorylated adaptor protein, Csk-binding protein (Cbp)/phosphoprotein associated with glycolipid-enriched microdomains, and sets an ..
  78. ncbi The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25
    E Armstrong
    Department of Virology, University of Helsinki, Finland
    Cytogenet Cell Genet 60:119-20. 1992
    We have previously reported the cloning of a novel cytoplasmic tyrosine kinase, CSK. This tyrosine kinase has been shown to downregulate the tyrosine kinase activity of the c-src oncoprotein through tyrosine phosphorylation of the c-src ..

Research Grants6

  1. Bcl-2 & Branching Morphogenesis
    Christine Sorenson; Fiscal Year: 2007
    ..Therefore, understanding the normal functions of bcl-2 during nephrogenesis and the consequences of its interaction with paxillin will give us important insight into kidney morphogenesis and pathogenesis. ..
  2. Regulation of Tumor Cell Differentiation by Src Kinases
    MALCOLM MEYN; Fiscal Year: 2007
    ..Understanding these pathways can aid in the design of novel therapeutic agents with the hope of expanding this type of therapy to new types of cancer. ..